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Against all odds:The road to success in the development of human immune reconstitution mice

Animal Models and Experimental Medicine 2024年第4期7卷 460-470页

作者： Yixiao Bin Jing Ren Haowei Zhang Tianjiao Zhang peijuan liu Zhiqian Xin Haijiao Yang Zhuan Feng Zhinan Chen Hai Zhang School of Basic Medical Sciences Shaanxi University of Chinese MedicineXianyangChina Department of Cell Biology National Translational Science Center for Molecular MedicineFourth Military Medical UniversityXi'anChina State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical UniversityXi'anChina Department of Occupational&Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public HealthFourth Military Medical UniversityXi'anChina

The mouse genome has a high degree of homology with the human genome,and its physiological,biochemical,and developmental regulation mechanisms are similar to those of humans;therefore,mice are widely used as experimental ***,it is undeniable that interspecies differences between humans and mice can lead to experimental *** differences in the immune system have become an impor-tant factor limiting current immunological *** application of immunodefi-cient mice provides a possible solution to these *** transplanting human immune cells or tissues,such as peripheral blood mononuclear cells or hematopoietic stem cells,into immunodeficient mice,a human immune system can be reconstituted in the mouse body,and the engrafted immune cells can elicit human-specific immune *** have been actively exploring the development and differen-tiation conditions of host recipient animals and grafts in order to achieve better im-mune *** genetic engineering methods,immunodeficient mice can be further modified to provide a favorable developmental and differentiation microenvironment for the *** initially only being able to reconstruct single T lymphocyte lineages,it is now possible to reconstruct lymphoid and myeloid cells,providing important research tools for immunology-related *** this review,we compare the differences in immune systems of humans and mice,describe the devel-opment history of human immune reconstitution from the perspectives of immuno-deficient mice and grafts,and discuss the latest advances in enhancing the efficiency of human immune cell reconstitution,aiming to provide important references for im-munological related researches.

关键词： hematopoietic stem cell human immune reconstitution immune response immunodeficient mice peripheral blood mononuclear cell transplantation

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Application of the Trivex system in the treatment of primary severe superficial varicose veins of the lower extremity

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Journal of Interventional Medicine 2019年第4期2卷 146-149页

作者： Wenshui Yu Jing liu Hongwei Yang Zuhui Wang Yongdi Xia peijuan liu Guoxian Zhu Department of Vascular Surgery The First Affiliated Hospital of ShenZhen UniversityShenZhen No.2 HospitalShenZhen518036China Department of Interventional Radiography The First Affiliated Hospital of ShenZhen UniversityShenZhen No.2 HospitalShenZhen518036China

Purpose:The aim of this study was to evaluate the clinical effects of the Trivex system in the treatment of primary severe superficial varicose veins of the lower extremity and compare Trivex to the point-form-stripping combined with foam sclerotherapy(FS).Methods:A total of 64 patients(35 females,29 males;mean age,57?11 years[range,29–79 years])with primary severe superficial varicose veins of the lower extremity involving 64 legs were included between October 2015 and July *** maximum diameter of the vein branches was>20 mm,which appeared to be cystic dilatation and forms large-scale in the crus or the *** patients underwent high ligation and endovenous laser ablation or stripping of the trunk under general *** surgical time,pain/phlebitis,number of incisions,amount of bleeding,recurrence of varicose vein,incidence of surgical site infections(SSIs),satisfaction score,and improvement in clinical symptoms were evaluated respectively with the patients in two groups:Group A,with patients who underwent treatment with the Trivex system,and Group B,patients who underwent treatment by point-form-stripping combined with ***:All procedures were performed *** average operative time in Group A was 56?11 min,whereas that of Group B was 90?33 min,which was a significant difference(p0.05).Conclusions:This study shows that patients benefited from both treatment ***,primary severe superficial varicose veins of the lower e

关键词： Varicose veins Trivex system Point-form-stripping Foam sclerotherapy

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An Improved Thermal Conductivity Measurement Scheme for Macroscopic Graphitic Films Using the Laser Flash Method

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Journal of Thermal Science 2024年第4期33卷 1480-1490页

作者： ZHANG peijuan MING Xin liu Yingjun WANG Xuelong SHI Hang HAO Yuanyuan LU Jiahao liu Zheng LAI Haiwen ZHANG Ying GAO Weiwei XU Zhen GAO Chao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceZhejiang UniversityHangzhou310027China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan030032China Special Equipment Safety Supervision and Inspection Institute of Jiangsu Province National Graphene Products Quality Inspection and Testing Center(Jiangsu)Wuxi214174China Hangzhou Gaoxi Technol Co. LtdHangzhou311113China China Academy of Aerospace Aerodynamics Beijing100074China

Achieving efficient thermal management urges to exploit high-thermal-conductivity materials to satisfy the boosted demand of heat *** is critical to adopt standardized characterization protocols to evaluate the intrinsic thermal conductivity of thermal management ***,for the most representative laser flash method,the lack of standard measurement methodology and systematic description on the thermal diffusivity and influencing factors has led to significant deviations and confusion of the thermal conduction performance in the emerging thermal management ***,the measurement error factors of thermal diffusivity by the common laser flash analyzer(LFA)are *** high-thermal-conductivity graphitic film(GF)as a typical case,the key factors are analyzed to guide the measurement protocol of related carbon-based thermal management *** basic principle of the LFA measurement,actual pre-processing conditions,instrument parameters setting,and data analysis are elaborated for accurate ***,the graphene thick films and common isotropic materials are also extended to meet various thermal measurement *** on the existing practical problems,we propose a feasible test flow to achieve a unified and standardized thermal conductivity measurement,which is beneficial to the rapid development of carbon-based thermal management materials.

关键词： thermal management graphitic film laser flash method thermal conductivity thermal diffusivity

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Highly Thermally Conductive and Structurally Ultra‑Stable Graphitic Films with Seamless Heterointerfaces for Extreme Thermal Management

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Nano-Micro Letters 2024年第3期16卷 383-397页

作者： peijuan Zhang Yuanyuan Hao Hang Shi Jiahao Lu Yingjun liu Xin Ming Ya Wang Wenzhang Fang Yuxing Xia Yance Chen Peng Li Ziqiu Wang Qingyun Su Weidong Lv Ji Zhou Ying Zhang Haiwen Lai Weiwei Gao Zhen Xu Chao Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang ProvinceZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032People’s Republic of China Beijing Spacecrafts Manufacturing Co. LtdBeijing Friendship Road 104Haidian DistrictBeijing 100094People’s Republic of China Beijing Institute of Space Mechanics and Electricity Beijing Friendship Road 104Haidian DistrictBeijing 100094People’s Republic of China China Academy of Aerospace Aerodynamics Beijing 100074People’s Republic of China Hangzhou Gaoxi Technol Co. LtdHangzhou 311113People’s Republic of China International Research Center for X Polymers International CampusZhejiang UniversityHaining 314400People’s Republic of China

Highly thermally conductive graphitic film(GF)materials have become a competitive solution for the thermal management of high-power electronic ***,their catastrophic structural failure under extreme alternating thermal/cold shock poses a significant challenge to reliability and ***,we present the first investigation into the structural failure mechanism of GF during cyclic liquid nitrogen shocks(LNS),which reveals a bubbling process characterized by“permeation-diffusion-deformation”*** overcome this long-standing structural weakness,a novel metal-nanoarmor strategy is proposed to construct a Cu-modified graphitic film(GF@Cu)with seamless *** well-designed interface ensures superior structural stability for GF@Cu after hundreds of LNS cycles from 77 to 300 ***,GF@Cu maintains high thermal conductivity up to 1088 W m^(−1)K^(−1)with degradation of less than 5%even after 150 LNS cycles,superior to that of pure GF(50%degradation).Our work not only offers an opportunity to improve the robustness of graphitic films by the rational structural design but also facilitates the applications of thermally conductive carbon-based materials for future extreme thermal management in complex aerospace electronics.

关键词： Highly thermally conductive Structurally ultra-stable Graphitic film Extreme thermal management Liquid nitrogen bubbling

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腰椎间盘突出症术后并发症的防治

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中国现代医生 2011年第7期49卷 89-90页

作者：刘培倦广东省南雄市人民医院广东南雄512400

目的探讨腰椎间盘突出症术后并发症的原因和预防措施。方法对267例腰椎间盘突出症手术患者资料进行回顾性分析。结果 13例出现并发症,发生率4.87%。其中早期并发症8例,占61.54%;晚期并发症5例,占38.46%。结论合理选择适应证、严格无菌... 详细信息

目的探讨腰椎间盘突出症术后并发症的原因和预防措施。方法对267例腰椎间盘突出症手术患者资料进行回顾性分析。结果 13例出现并发症,发生率4.87%。其中早期并发症8例,占61.54%;晚期并发症5例,占38.46%。结论合理选择适应证、严格无菌操作和熟练掌握手术技巧是预防腰椎间盘突出症术后并发症的关键。

关键词：腰椎间盘突出症并发症预防与治疗

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远动终端装置的现状和对设计新产品的要求

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电网技术 1998年第10期22卷 22-25页

作者：刘佩娟陆天健国家电力公司电力科学研究院

远动终端产品在我国迅速发展。文章阐述了当前使用的产品存在的一些问题，以及对设计开发新产品的几点要求。

关键词：远动终端调度自动化自动化装置产品设计

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国外有关实用功率定义的讨论

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电网技术 1998年第2期22卷 68-71页

作者：谭文恕纪昌敏刘佩娟电力部电力科学研究院

国外有关实用功率定义的讨论谭文恕纪昌敏刘佩娟电力部电力科学研究院，１０００８５北京清河ＤＩＳＣＵＳＳＩＯＮＯＮＤＥＦＩＮＩＴＩ０ＮＳＯＦＰＲＡＣＴＩＣＡＬＰＯＷＥＲＩＮＯＴＨＥＲＣＯＵＮＴＲＩＥＳＴａｎＷｅｎｓｈｕＪ... 详细信息

国外有关实用功率定义的讨论谭文恕纪昌敏刘佩娟电力部电力科学研究院，１０００８５北京清河ＤＩＳＣＵＳＳＩＯＮＯＮＤＥＦＩＮＩＴＩ０ＮＳＯＦＰＲＡＣＴＩＣＡＬＰＯＷＥＲＩＮＯＴＨＥＲＣＯＵＮＴＲＩＥＳＴａｎＷｅｎｓｈｕＪｉＣｈａｎｇｍｉｎＬｉｕＰｅｉｊｕ...

关键词：电力系统实用功率定义谐波控制稳定性

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我院银杏达莫注射液不良反应分析

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天津药学 2014年第6期26卷 25-26页

作者：刘佩娟天津港口医院天津300456

目的:了解本院银杏达莫注射液不良反应的特点及发生规律,为临床合理用药提供参考。方法:采用分析、归纳、总结的方法,对本院上报国家药品不良反应检测中心在2012年1月—2014年2月共28例银杏达莫注射液不良反应进行回顾性分析。结果:银... 详细信息

目的:了解本院银杏达莫注射液不良反应的特点及发生规律,为临床合理用药提供参考。方法:采用分析、归纳、总结的方法,对本院上报国家药品不良反应检测中心在2012年1月—2014年2月共28例银杏达莫注射液不良反应进行回顾性分析。结果:银杏达莫注射液不良反应表现以恶心、呕吐、头晕、皮肤过敏反应为主,50岁以上为多发人群。结论:中药注射液成分复杂,应加强银杏达莫注射液不良反应的监控,促进合理用药。

关键词：银杏达莫注射液不良反应合理用药

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改良Stoppa入路治疗髋臼前部骨折

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中华创伤骨科杂志 2017年第2期19卷 173-175页

作者：李贵坚陈亚洲刘培倦罗佳武广东省南雄市人民医院骨科 512400

目的探讨采用改良Stoppa入路治疗髋臼前部骨折的临床疗效。方法回顾性分析2011年1月至2014年12月期间收治的22例髋臼前部骨折患者资料。男14例，女8例；年龄为18-49岁，平均36．6岁。骨折LetourneI-Judet分型：髋臼前壁骨折9例，前柱骨... 详细信息

目的探讨采用改良Stoppa入路治疗髋臼前部骨折的临床疗效。方法回顾性分析2011年1月至2014年12月期间收治的22例髋臼前部骨折患者资料。男14例，女8例；年龄为18-49岁，平均36．6岁。骨折LetourneI-Judet分型：髋臼前壁骨折9例，前柱骨折12例，横形骨折1例。所有患者均采用改良Stoppa入路直视下复位骨折，透视证实骨折复位满意后用重建钢板固定。记录患者的手术时间、手术切口长度、术中出血量、骨折复位质量、患髋功能及术后并发症发生情况等。结果本组患者的切口长度为6-15cm，平均9．5cm；术中出血量为100-1000mL，平均550mL；手术时间为40-160min，平均126．2min。22例患者术后获12-18个月（平均15．5个月）随访。骨折复位质量按Matta评分标准评定：优18例，良3例，差1例，优良率为95．5％。末次随访时根据髋关节Harris评分标准评定患髋功能：优12例，良9例，差1例，优良率为95．5％。1例患者术后发生创伤性关节炎。随访期间无骨折复位丢失、钢板螺钉松动或断裂等并发症发生。结论改良Stoppa入路治疗髋臼前部骨折具有手术切151小、解剖清晰、可直视下复位固定骨折、手术时间短、术中出血量少及术后并发症少等优点，临床疗效可靠。

关键词：髋臼骨折骨折固定术,内 Stoppa入路

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不同灌木林地土壤蓄水性能及渗透性能的研究

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山东水利 2007年第12期 17-19,33页

作者：刘培娟隋栋梁孙金芬诸城市水利水产局山东诸城262200

通过对三里庄库区内葛藤、桑树、胡枝子和黄荆四种灌木林地土壤的蓄水性能和渗透性能进行研究,结果表明:四种灌木林地土壤的蓄水能力和渗透能力均明显高于荒坡地。在雨季,四种灌木林地0～20cm土壤层的土壤含水量均高于20～40cm层;四种... 详细信息

通过对三里庄库区内葛藤、桑树、胡枝子和黄荆四种灌木林地土壤的蓄水性能和渗透性能进行研究,结果表明:四种灌木林地土壤的蓄水能力和渗透能力均明显高于荒坡地。在雨季,四种灌木林地0～20cm土壤层的土壤含水量均高于20～40cm层;四种灌木林地0～20cm和20～40cm土壤层的蓄水能力从大到小的顺序均为葛藤林>黄荆林>桑树林>胡枝子林。四种灌木林地土壤的渗透系数从大到小依次为葛藤林>黄荆林>桑树林>胡枝子林。

关键词：库区灌木林土壤蓄水量渗透性

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