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Hot Deformation Behavior and Processing Maps of As-cast Mn18Cr18N Steel

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Journal of Wuhan University of Technology(Materials Science) 2017年第4期32卷 935-943页

作者：陈慧琴 wang zhenxing qin fengming jia peijie zhao xiaodong School of Materials Science and Engineering Taiyuan Universityof Science and Technology Taiyuan 030024China

Hot deformation behavior of as-cast Mn18Cr18 N austenitic stainless steel was studied in the temperature range of 950-1200 ℃ and strain rate range of 0.001-1 s^（-1） using isothermal hot compression tests. The true stress-strain curves of the steel were characterized by hardening and subsequent softening and varied with temperatures and strain rates. The hot deformation activation energy of the steel was calculated to be 657.4 k J/mol, which was higher than that of the corresponding wrought steel due to its as-cast coarse columnar grains and heterogeneous structure. Hot processing maps were developed at different plastic strains, which exhibited two domains with peak power dissipation efficiencies at 1150 ℃/0.001 s^（-1） and 1200 ℃/1 s^（-1）, respectively. The corresponding microstructures were analyzed by optical microscopy（OM）, scanning electron microscopy（SEM）, and electron backscatter diffraction（EBSD）. It has been confirmed that dynamic recrystallization（DRX） controlled by dislocation slipping and climbing mechanism occurs in the temperature and strain rate range of 1050-1200 ℃ and 0.001-0.01 s^（-1）; And DRX controlled by twinning mechanism occurs in the temperature and strain rate range of 1100-1200 ℃, 0.1-1 s^（-1）. These two DRX domains can serve as the hot working windows of the as-cast steel at lower strain rates and at higher strain rates, respectively. The processing maps at different strains also exhibit that the instability region decreases with increasing strain. The corresponding microstructures and the less tensile ductility in the instability region imply that the flow instability is attributed to flow localization accelerated by a few layers of very fine recrystallized grains along the original grain boundaries.

关键词： Mn18Cr18N steel hot deformation hot processing map dynamic recrystallization hot workability

Results of flexible 3D-conformal radiotherapy for patients with diffuse malignant pleural mesothelioma and comparative study of this technique with conventional radiotherapy

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The Chinese-German Journal of Clinical Oncology 2008年第5期7卷 292-295页

作者： Fengwei Wang Siwei Zhu Xinzhuo Wang Yumei Cai Chao Zhang Qiang Yao Yukun Qing peijie jia Weilian Li Department of Radiation Oncology Tianjin People＇s Hospital Tianjin 300130 China

Objective： To observe the effects of the new technique of flexible 3D-conformal radiotherapy with combination of photon and electron （3DCRT） in the treatment of the patients with diffuse malignant pleural mesothelioma （MPM）, and carry out the comparative study between flexible 3DCRT and hemithoracic conventional radiotherapy （CRT）. Methods： From January 2004 to October 2007, 8 patients with MPM were treated with flexible 3DCRT. 5 patients had received cycles of chemotherapy before radiation. New technique of flexible 3DCRT with combination of photon and electron was used in our study, and DT 32.2-64 Gy with conventional split were delivered. CRT technique was mimicked to compare with 3DCRT technique to predict the possibility of lung damage in two methods. Results： One patient reached CR and other 7 patients got PR after radiation. Two patients died during the follow-up. The median survival time （MST） was 15.4 months and it was 18.8 months for sequential chemotherapy and radiotherapy group and 9.7 months for radiotherapy alone group. The V20, V30, and ipsilateral and contralateral median lung dosage （MLD） were 20.5%, 15.6%, 18.8 Gy and 2.2 Gy respectively when the flexible 3DCRT technique was used, whereas they were 36.8%, 27.9%, 31.1 Gy and 1.2 Gy respectively when the CRT technique was used. They were statistically different for the lung V20, V30 and ipsilateral MLD between the two techniques （P 〈 0.01）, whereas there was no different for the contralateral MLD （P = 0.08）. All patients received radiation were found to have lung fibrosis and classified as grades 1-2 radiation pneumonitis. The quality of life was increased from score 2.83 to 3.76 and it was significantly different （P 〈 0.01）. Conclusion： MPM is moderately sensitive to radiation. The flexible 3DCRT technique is feasible in the treatment of MPM and lung damage is reduced apparently comparing with the CRT technique. The quality of life of patients with MPM is improved after irradiation.

关键词： diffuse malignant pleural mesothelioma (MPM) 3D-conformal radiotherapy (3DCRT) radiation damage radiation pneumonitis

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工作环境烟草暴露与肺癌发生危险的系统评价

中国肺癌杂志 2011年第4期14卷 345-350页

作者：王新卓秦玉坤谷俊东王凤玮贾培杰王辉姚嫱朱思伟天津市人民医院肿瘤科天津300121 天津市人民医院胸外科天津300121

背景与目的已有的研究表明:工作环境烟草暴露与非吸烟人群肺癌发生有密切关系并不十分明确,本研究旨在探讨工作环境烟草暴露与非吸烟人群肺癌发生危险的关系。方法通过计算机检索Medline(1954年-2010年8月)、CENT L(the Cochrane centra... 详细信息

背景与目的已有的研究表明:工作环境烟草暴露与非吸烟人群肺癌发生有密切关系并不十分明确,本研究旨在探讨工作环境烟草暴露与非吸烟人群肺癌发生危险的关系。方法通过计算机检索Medline(1954年-2010年8月)、CENT L(the Cochrane central register of controlledtrials)(2010issue3)、EMBASE(1970年-2010年8月)中国生物医学文献数据库系统(CBM)(1978年-2010年8月)、中国期刊全文数据库(CNKI)(1979年-2010年8月)、中文科技期刊全文数据库(VIP)(1989年-2010年8月)等数据库,收集国内外公开发表的关于工作环境烟草暴露与非吸烟人群肺癌发生关系的研究文献,应用统计软件Stata11.0进行数据分析,计算其合并优势比(oddsratio,OR)和95%置信区间(con dence interval,CI)。采用Begg法对发表偏倚进行量化检测。结果最终纳入分析的文章共有22篇,合并分析结果表明工作环境烟草暴露使非吸烟人群肺癌发生率增加了25%(OR=1.25,95%CI:1.13-1.39,P<0.001),使非吸烟女性肺癌的发生率增加了22%(OR=1.22,95%CI:1.05-1.42,P=0.011);工作环境烟草暴露导致非吸烟男性肺癌的发生率增加了54%,但无统计学意义(OR=1.54,95%CI:0.74-3.18,P=0.247)。结论工作环境烟草暴露是非吸烟人群肺癌发生的一个危险因素,非吸烟女性工作环境的烟草暴露与肺癌的发生关系密切。

关键词：肺肿瘤环境烟草系统评价

中药合剂“振明正生”对三株人肿瘤细胞裸鼠移植瘤抑制作用的观察

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现代肿瘤医学 2012年第1期20卷 46-48页

作者：应简子贾培杰姚嫱赵钧铭李长虹天津市人民医院天津300121 中国医学科学院北京协和医学院血液学研究所血液病医院实验血液学国家重点实验室天津300020

目的:观察中药合剂"振明正生"(ZMZS)对人肿瘤细胞的抑制作用。方法:BALB/c裸鼠分别接种人白血病细胞系(K562)、鼻咽癌细胞系(CN1)和胰腺癌细胞系(P3),2×106/只。接种后24小时开始给药,实验组裸鼠每天口服中药合剂0.2ml/只,连续4周。对... 详细信息

目的:观察中药合剂"振明正生"(ZMZS)对人肿瘤细胞的抑制作用。方法:BALB/c裸鼠分别接种人白血病细胞系(K562)、鼻咽癌细胞系(CN1)和胰腺癌细胞系(P3),2×106/只。接种后24小时开始给药,实验组裸鼠每天口服中药合剂0.2ml/只,连续4周。对照组裸鼠口服生理盐水0.2ml/只。每周测量动物肿瘤大小,计算肿瘤生长抑制率。结果:经过3或4周的治疗,中药合剂"振明正生"对K562、CN1和P3有明显抑制作用。结论:中药合剂"振明正生"对三株人肿瘤细胞裸鼠移植瘤有显著的治疗效果。

关键词：中药合剂人肿瘤细胞裸鼠移植瘤抑制率

基于FAERS的贝伐珠单抗相关药品不良事件信号挖掘

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中国药业 2024年第14期33卷 109-113页

作者：庞培杰殷鑫刘天宇贾映东川北医学院四川南充637000 四川省遂宁市中心医院四川遂宁629000

目的促进贝伐珠单抗的临床安全使用。方法通过美国食品和药物管理局不良事件报告系统(FAERS)提取2014年1月1日至2023年5月1日以贝伐珠单抗为首要怀疑药物的药品不良事件(ADE)报告,借助OpenVigil 2.1在线工具进行数据挖掘;采用报告比值... 详细信息

目的促进贝伐珠单抗的临床安全使用。方法通过美国食品和药物管理局不良事件报告系统(FAERS)提取2014年1月1日至2023年5月1日以贝伐珠单抗为首要怀疑药物的药品不良事件(ADE)报告,借助OpenVigil 2.1在线工具进行数据挖掘;采用报告比值比(ROR)法和贝叶斯置信区间递进神经网络(BCPNN)法联合检验ADE信号,利用《监管活动医学词典》(MedDRA)25.1中的首选语(PT)和系统器官分类(SOC)对ADE信号进行归类与分析。结果共获得以贝伐珠单抗为首要怀疑药物的ADE报告60 675份,涉及患者60 675例,上报地区主要为北美洲(48.78%)和亚洲(29.00%);严重ADE报告中,以死亡报告数最多(14 358例,23.66%)。605个PT信号涉及ADE报告20 127份(患者20 127例),可归入21个SOC,信号数排前3的SOC分别为胃肠系统疾病(89个),良性、恶性及性质不明的肿瘤(包括囊状和息肉状肿瘤,68个)及眼器官疾病(66个);ADE例数排前3的SOC分别为全身性疾病及给药部位各种反应(3 059例)、血液及淋巴系统疾病(2 813例)和血管与淋巴管类疾病(2 235例)。ADE报告例数排前5的PT分别为疾病进展(1 279例)、高血压(1 072例)、贫血(585例)、骨髓抑制(583例)和蛋白尿(569例)。结论临床医师在用药期间除关注贝伐珠单抗的常见ADE外,应重点关注其导致的高血压、蛋白尿、骨髓抑制、出血、胃肠穿孔、间质性肺病等严重ADE。

关键词：贝伐珠单抗美国食品和药物管理局不良事件报告系统药品不良事件信号挖掘报告比值比法贝叶斯置信区间递进神经网络法

Canine ACL reconstruction with an injectable hydroxyapatite/collagen paste for accelerated healing of tendon-bone interface

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Bioactive Materials 2023年第2期20卷 1-15页

作者： Qingsong jiang Liren Wang Zhanhong Liu Jinlei Su Yajun Tang peijie Tan Xiangdong Zhu Kai Zhang Xing Ma jia jiang Jinzhong Zhao Hai Lin Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan University29 Wangjiang RoadChengduSichuanChina Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital600 Yishan RoadShanghaiChina Department of Orthopaedics First Affiliated Hospital of Xi’an Jiaotong University277 West Yanta RoadXi’anShaanxiChina

Healing of an anterior cruciate ligament(ACL)autologous graft in a bone tunnel occurs through the formation of fibrovascular scar tissue,which is structurally and compositionally inferior to normal fibrocartilaginous insertion and thus may increase the reconstruction failure and the rate of failure *** this study,an injectable hydroxyapatite/type I collagen(HAp/Col I)paste was developed to construct a suitable local microenvironment to accelerate the healing of bone-tendon *** characterization demonstrated that the HAp/Col I paste was injectable,uniform and *** in vitro cell culture illustrated that the paste could promote MC3T3-E1 cells proliferation and osteogenic *** results of a canine ACL reconstruction study showed that the reconstructive ACL had similar texture and color as the native *** average width of the tunnel,total bone volume,bone volume/tissue volume and trabecular number acquired from micro-CT analysis suggested that the healing of tendon-bone interface in experimental group was better than that in control *** biomechanical test showed the maximal loads in experimental group achieved approximately half of native ACL’s maximal load at 24 *** to histological examination,Sharpey fibers could be observed as early as 12 weeks postoperatively while a typical four-layer transitional structure of insertion site was regenerated at 48 weeks in the experimental *** injectable HAp/Col I paste provided a biomimetic scaffold and microenvironment for early cell attachment and proliferation,further osteogenic expression and extracellular matrix deposition,and in vivo structural and functional regeneration of the tendon-bone interface.

关键词： Anterior cruciate ligament reconstruction Tendon-bone healing Injectable paste Hydroxyapatite Collagen

Sr和 Na在AI-Si合金中的变质行为及机理的研究

维普期刊数据库评论

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机械工程学报 2000年第2期36卷 81-84页

作者：李培杰曾大本贾均李庆春清华大学机械系北京100084 哈尔滨工业大学

研究了Ｓｒ、Ｎａ在ＡＩ－Ｓｉ熔体中的氧化动力学，应用原子杂化轨道理论分析了Ｓｒ、Ｎａ与ＡＩ－Ｓｉ熔体的作用机理。研究结果表明，Ｓｒ比Ｎａ具有更长的变质有效期，其原因是Ｓｒ比Ｎａ具有更加稳定的原子杂化轨道，而并非完全由... 详细信息

研究了Ｓｒ、Ｎａ在ＡＩ－Ｓｉ熔体中的氧化动力学，应用原子杂化轨道理论分析了Ｓｒ、Ｎａ与ＡＩ－Ｓｉ熔体的作用机理。研究结果表明，Ｓｒ比Ｎａ具有更长的变质有效期，其原因是Ｓｒ比Ｎａ具有更加稳定的原子杂化轨道，而并非完全由工艺因素决定。

关键词：氧化动力学变质行为铝硅合金锶钠

EFFECT OF MELT SUPERHEATING ON MICROSTRUCTURE AND MECHANICAL PROPERTIES OF A357 ALLOY

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中国有色金属学会会刊：英文版 1997年第3期7卷 95-99页

作者： Li Peiyong 1, 2 , jia Jun, Guo Jingjie, Li peijie, Shao Gaoliang 1 School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001 2 Beijing Research Institute of Aeronautical Materials, Beijing 100095

ＥＦＦＥＣＴＯＦＭＥＬＴＳＵＰＥＲＨＥＡＴＩＮＧＯＮＭＩＣＲＯＳＴＲＵＣＴＵＲＥＡＮＤＭＥＣＨＡＮＩＣＡＬＰＲＯＰＥＲＴＩＥＳＯＦＡ３５７ＡＬＬＯＹ①ＬｉＰｅｉｙｏｎｇ１，２，ＪｉａＪｕｎ，ＧｕｏＪｉｎｇｊｉｅ，Ｌｉ... 详细信息

ＥＦＦＥＣＴＯＦＭＥＬＴＳＵＰＥＲＨＥＡＴＩＮＧＯＮＭＩＣＲＯＳＴＲＵＣＴＵＲＥＡＮＤＭＥＣＨＡＮＩＣＡＬＰＲＯＰＥＲＴＩＥＳＯＦＡ３５７ＡＬＬＯＹ①ＬｉＰｅｉｙｏｎｇ１，２，ＪｉａＪｕｎ，ＧｕｏＪｉｎｇｊｉｅ，ＬｉＰｅｉｊｉｅ，ＳｈａｏＧａｏｌｉａ...

关键词： melt superheating microstructure mechanical property A357 alloy

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红石岩堰塞坝力学参数随机场模拟研究

人民长江 2022年第8期53卷 173-178页

作者：贾宇峰葛培杰相彪陈永康大连理工大学海岸和近海工程国家重点实验室辽宁大连116024 大连理工大学工程抗震研究所辽宁大连116024 云南农业大学水利学院云南昆明650201

空间变异性是天然土体固有的一种属性,现场试验结果表明鲁甸地震形成的红石岩堰塞坝新堆积体具有明显的空间变异性,传统均值材料数值模型无法准确描述这种变异性。采用空间随机场理论根据现场勘测试验数据和室内三轴试验参数构建了红石... 详细信息

空间变异性是天然土体固有的一种属性,现场试验结果表明鲁甸地震形成的红石岩堰塞坝新堆积体具有明显的空间变异性,传统均值材料数值模型无法准确描述这种变异性。采用空间随机场理论根据现场勘测试验数据和室内三轴试验参数构建了红石岩堰塞坝的随机场模型,对该堆积体岩土力学相关参数进行了随机模拟。研究结果表明:红石岩新堆积体的邓肯-张E-B模型参数K、n、K_(b)和m服从对数正态分布;新堆积体随机场的竖向相关距离为2.84 m,水平相关距离为33.94 m;新模型能较好地模拟堆积体参数的空间变异性。

关键词：空间随机场土石混合料相关距离三轴试验红石岩堰塞坝