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A K~+-sensitive AND-gate dual-mode probe for simultaneous tumor imaging and malignancy identification

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National Science Review 2022年第7期9卷 127-136页

作者： Qiyue Wang Fangyuan Li Zeyu Liang Hongwei Liao Bo Zhang peihua lin Xun Liu Shen Hu Jiyoung Lee Daishun ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical Sciences Zhejiang University World Laureates Association (WLA) Laboratories Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational Medicine Shanghai Jiao Tong University Department of Obstetrics The Second Affiliated Hospital of Zhejiang University School of Medicine

Although molecular imaging probes have the potential to non-invasively diagnose a tumor,imaging probes that can detect a tumor and simultaneously identify tumor malignancy remain ***,we demonstrate a potassium ion(K+) sensitive dual-mode nanoprobe(KDMN) for non-invasive tumor imaging and malignancy identification,which operates via a cascaded ’AND’ logic gate controlled by inputs of magnetic resonance imaging(MRI) and fluorescence imaging(FI) *** encapsulate commercial K~+ indicators into the hollow cavities of magnetic mesoporous silica nanoparticles,which are subsequently coated with a K+-selective membrane that exclusively permits the passage of K+while excluding other *** KDMN can readily accumulate in tumors and enhance the MRI contrast after systemic *** information of the tumor lesion is thus accessible via MRI and forms the first layer of the ’AND’ ***,the KDMN selectively captures K+and prevents interference from other cations,triggering a K~+-activated FI signal as the second layer of the ’AND’ gate in the case of a malignant tumor with a high extracellular K~+*** dual-mode imaging approach effectively eliminates false positive or negative diagnostic results and allows for non-invasive imaging of tumor malignancy with high sensitivity and accuracy.

关键词： dual-mode imaging probe fluorescence imaging MRI tumor malignancy identification potassium ion

Designed fabrication of mesoporous silica-templated self-assembled theranostic nanomedicines

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Science China Chemistry 2021年第2期64卷 204-217页

作者： Fangyuan Li&Daishun ling Yang Du Zheng Chen Ji Young Lee peihua lin Fan Xia Yunan Guan Fangyuan Li Daishun ling Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Biomedical Engineering of the Ministry of Education College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou 310027China Hangzhou Institute of Innovative Medicine College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Theranostic nanosystems that integrate diagnosis and therapy have garnered increasing attention for personalized *** integration of the versatile nanoparticles to fabricate self-assembled theranostic nanomedicines becomes increasingly important in current medical *** silica nanoparticles(MSN)with their highly attractive physicochemical properties and favorable morphological attributes represent ideal templates for the controlled assembly and integration of functional nanomaterials to fabricate self-assembled theranostic *** rationally designed combination strategy and heterostructure will improve the overall bioavailability and preserve the unique property of each *** this review,the cutting-edge strategies for the designed fabrication of MSN-templated self-assembled nanomedicines are *** categorize MSN-based nanomedicines by their unique heterostructures,including core-shell,yolk-shell,core-satellite,heterodimer and core-shell-satellite structures,and discuss the controlled assembly approaches as well as the intriguing applications for disease ***,a perspective on the challenges in the clinical translation of self-assembled theranostic nanomedicines is highlighted.

关键词： self-assembly theranostics heterostructure mesoporous silica nanomedicines

Synthesis and Spectrum Characteristic of New Organic Fluorescence Dyes of Four Pyrazoline Compounds

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复旦学报（自然科学版） 2005年第5期44卷 887-888页

作者： Guan Bai peihua lin Junfen Li Du xin Li Chuan Dong College of Chemistry and Chemical Engineering Shanxi University Taiyuan 030006 China

Pyrazoline derivatives are formed by benzeno-hydrazone cyclization. Because cyclization leads to double bond hindering , the compounds show stronger fluorescence. The pyrazoline has N atom which attends conjugation by donating electron, and it has higher hole-transport efficiency and some photoelectron characteristics,so it has been widely used as hole-transport materials in the electrophotography and Electroluminescence fields[1-4]. Pyrazoline derivatives are not only excellent hole-trasfer performance but also have excellent emitting blueness property[5].

关键词：邻二氮杂环戊烯光谱特性有机物荧光性环化作用

Removal of rubidium from brine by an integrated film of sulfonated polysulfone/graphene/potassium copper ferricyanide

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Chinese Journal of Chemical Engineering 2024年第5期69卷 112-121页

作者： Huanxi Xu peihua lin Pei-Jun Liu Hai-Gang Liu Hui-Bin Guo Chao-Xiang Wu Ming Fang Xu Zhang Guan-Ping Jin Anhui Province Engineering Research Center of Flexible and Intelligent Materials School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China Chemical Design and Research Institute Co. LTD of Qinghai ProvinceQinghai Engineering and Technology Research Center of Fine ChemicalXining 810008China

A novel integrated film of sulfonated polysulfone/graphene/potassium copper ferricyanide(KCuFC/SPSG)was used for selectively extracting rubidium ion(Rb^(+))from *** form KCuFC/SPSG,the precursor film of sulfonated polysulfone/graphene(SPSG)was synthesized by phase conversion process,which was alternately immersed in 0.1 mol·L^(-1)CuSO_(4)/K_(4)[Fe(CN)_(6)]by in-situ adsorption coupled co-precipitation *** data such as nuclear magnetic resonance spectrometer,Fourier transform infrared spectroscope,X-ray photoelectron spectroscope,X-ray diffraction,scanning electron microscope,and energy dispersive spectroscopy all verified that abundant KCuFC were uniformly located on the *** resulting KCuFC/SPSG was used in film separation *** the solution was fed into the system,the Rb^(+)could be selectively adsorption by KCuFC/*** the saturation adsorption,0.5 mol·L^(-1)NH_(4)Cl/HCl was fed into the film cell,Rb^(+)could be quickly desorbed by ion-exchange between Rb^(+)and NH_(4)^(+)in the lattice of *** purpose of separating and recovering Rb^(+)from the brine can be achieved after the repeated *** effects of pH,adsorption time,and interferential ions on the adsorption capacity of Rb^(+)were investigated by batch *** adsorption behavior fits the pseudo-second order kinetic process,while KCuFC has a higher adsorption capacity(Langmuir maximum sorption 165.4 mg·g^(-1)).In addition,KCuFC/SPSG shows excellent selectivity for Rb^(+)even in complex brine ***/SPSG could maintain 93.5%extraction efficiency after five adsorption/desorption cycles.

关键词： Rubidium extraction Potassium copper ferricyanide Sulfonated polysulfone Graphene oxide Adsorption

Nanotechnology enabled metal-ion-based disease diagnostics

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Science Bulletin 2020年第19期65卷 1587-1589页

作者： peihua lin Jiyoung Lee Ying Chen Fangyuan Li Daishun ling Institute of Pharmaceutics and Hangzhou Institute of Innovative Medicine College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Biomedical Engineering of Ministry of Education College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou 310058China

Potassium ion(K^+)is one of the most essential ingredients of life that plays a vital regulatory role in numerous cellular processes,whose dyshomeostasis is featured in the occurrence and development of various diseases including neurodegenerative diseases and cancers[1].Consequently,in situ real-time imaging of K^+ dynamic changes is an excellent option to visualize the progress of ***,it is very challenging to achieve such a goal due to the following limitations of conventional imaging sensors[2].

关键词：疾病诊断纳米科技 limitations

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优化语文教学策略培养学生健全人格

成才之路 2024年第5期 85-88页

作者：林培华福建省莆田市湄洲湾北岸经济开发区东埔中心小学福建莆田351153

培养学生健全人格,无论对学生自身成长而言还是对社会发展而言都具有积极意义。语文学科的贯穿性和形象性、浸润性和无形化等特点,非常适合培养学生健全人格。作为语文教师,要明确健全人格的内涵,并充分发挥语文学科的培养优势,立足文本... 详细信息

培养学生健全人格,无论对学生自身成长而言还是对社会发展而言都具有积极意义。语文学科的贯穿性和形象性、浸润性和无形化等特点,非常适合培养学生健全人格。作为语文教师,要明确健全人格的内涵,并充分发挥语文学科的培养优势,立足文本,寻找生活中的榜样,关注主体,使学生感同身受,同时重视实践,引导学生体验文本内涵,积极创设情境,增强学生的情感体验,抓住时机进行交流讨论,积极探索学生健全人格培养的新方式,促进学生健康成长、全面发展。

关键词：小学语文健全人格贯穿性形象性浸润性无形化情境实践

某工程地下室底板大体积混凝土跳仓法施工技术

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施工技术 2009年第4期38卷 85-87页

作者：林沛华许少杰葛毓东广东省第二建筑工程公司广东广州510160 广州广星房地产实业开发有限公司广东广州510060

综合考虑后浇带施工方法存在的问题以及跳仓法施工优点,广州世纪云顶雅苑工程地下室超长、超宽底板大体积混凝土采用跳仓法施工技术。指出跳仓法施工的注意事项:仓块宜小不宜大;仓间混凝土浇筑时间间隔宜长不宜短;水泥用量宜少不宜多;... 详细信息

综合考虑后浇带施工方法存在的问题以及跳仓法施工优点,广州世纪云顶雅苑工程地下室超长、超宽底板大体积混凝土采用跳仓法施工技术。指出跳仓法施工的注意事项:仓块宜小不宜大;仓间混凝土浇筑时间间隔宜长不宜短;水泥用量宜少不宜多;混凝土养护宜早不宜迟等。同时给出了混凝土配合比、温度控制措施以及施工缝做法,成功解决了大体积底板因混凝土收缩应力及水泥水化热作用而出现的裂缝问题,也解决了大方量混凝土连续浇筑施工的技术问题。

关键词：混凝土跳仓法大体积混凝土底板施工技术

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铝铁锡共聚物的合成及其特性研究

环境化学 2001年第1期20卷 48-53页

作者：赵春禄张明明刘振儒林培华周汾涛山西大学环境科学系太原030006

合成制备了铝铁锡共聚物,测定分析了其水解共聚合和熟化过程中的ｐＨ变化,并通过扫描电镜和混凝实验对共聚物的晶形貌像和絮凝作用进行了研究．结果表明:Ｓｎ４＋具有比Ｆｅ３＋,Ａｌ３＋更强的水解活性,它有使共聚物的分子趋于均一的... 详细信息

合成制备了铝铁锡共聚物,测定分析了其水解共聚合和熟化过程中的ｐＨ变化,并通过扫描电镜和混凝实验对共聚物的晶形貌像和絮凝作用进行了研究．结果表明:Ｓｎ４＋具有比Ｆｅ３＋,Ａｌ３＋更强的水解活性,它有使共聚物的分子趋于均一的作用;铝铁锡共聚物的最佳配比为:ＮＡｌ:ＮＦｅ:ＮＳｎ＝５:５:３,最佳水解度Ｂ*＝２．０,此共聚物具有比ＣＰＡＦ更优良的絮凝性能．

关键词：特性水解聚合絮凝剂铝铁锡共聚物合成

饲料中添加太子参提取液对大黄鱼成活和生长的影响

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水产学杂志 2020年第2期33卷 40-44页

作者：阮少江黄伟卿倪建成周逢芳林培华叶祖云福建省特色药用植物工程技术研究中心福建宁德352100 宁德师范学院生命科学学院福建宁德352100 宁德市鼎诚水产有限公司福建宁德352100

在水温24~26℃下,将体质量(34.05±8.23)g的大黄鱼Larimichthys crocea饲养在循环水养殖系统1.5T的桶中,投喂添加0.5%、1.0%、1.5%和2.0%太子参Pseudostellaria heterophylla提取液的饲料,分析其对大黄鱼成活率、生长和形体指标的影响... 详细信息

在水温24~26℃下,将体质量(34.05±8.23)g的大黄鱼Larimichthys crocea饲养在循环水养殖系统1.5T的桶中,投喂添加0.5%、1.0%、1.5%和2.0%太子参Pseudostellaria heterophylla提取液的饲料,分析其对大黄鱼成活率、生长和形体指标的影响。太子参粉末置圆底底烧瓶中,加80%乙醇,水浴90℃回流提取3h,趁热过滤,残渣用95℃超纯水浸提4h后过滤,两次滤液混合、浓缩,去除水分,即为太子参提取液(浓度为40mg/mL)。120d的饲养结果显示:太子参提取液显著提高了大黄鱼养殖成活率(P<0.05),1.0%组的养殖成活率(88.1±5.3)%最高;太子参提取液对大黄鱼有促生长和改良形体指标的功效,后期更为明显,试验120d时,0.5%组大黄鱼体重绝对增加率[(0.25±0.004)g/d]、绝对增长率[(0.026±0.006)cm/d]和增积量(0.0067±0.0004)显著大于其他组(P<0.05),肥满度(1.43±0.49)%和肝体比(1.54±0.31)%显著低于对照组(P<0.05),脏体比[(1.00±0.14)%]显著低于其他各组(P<0.05)。结果表明,太子参提取液能提高大黄鱼的成活率、食物的消化吸收率,添加量在0.5%~1.0%之间为宜,且投喂时间越长,效果越佳。

关键词：太子参提取液大黄鱼饲料添加剂成活率生长性能