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Effect of laser-discrete-quenching on bonding properties of electroplated grinding wheel with AISI 1045 steel substrate and nickel bond

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Chinese Journal of Aeronautics 2021年第6期34卷 79-89页

作者： Cong MAO peihao cai Yongle HU Yujie ZHONG Jishuang WEI Zhuming BI Yifeng JIANG Linfeng XIAO Mingjun ZHANG College of Automotive and Mechanical Engineering Changsha UniversityCollege of Automotive and Mechanical EngineeringChangsha University of Science and TechnologyChangsha 410114China Hunan Provincial Key Laboratory of Intelligent Manufacturing Technology for High performance Mechanical Equipment Changsha University of Science and TechnologyChangsha 410114China Department of Civil and Mechanical Engineering Purdue University Fort WayneFort WayneIN 46805USA

To improve the bonding strength between the nickel bond and the hub of the electroplated diamond grinding wheel,a hybrid technique was proposed to combine laser prequenching steel substrate and post-electroplating *** validate the effectiveness of the proposed technique,AISI 1045 substrate was *** bonding properties between the electroplated nickel coating and substrate with or without laser-discrete-quenching were discussed comparatively by scratch,indentation,and thermal shock *** results show that the prequenching treatment leads to phase transformation of AISI 1045 microstructure from the mixed pearlite and ferrite phases into the martensitic *** the martensitic phase is characterized as a high corrosion resistance,the interface of substrate/coating is smooth and flat in the prequenched zone,and the coating is bonded well with the steel *** contrast to the steel substrate without pre-quenching treatment,the proposed technique significantly enhanced the bonding strengths of the electroplated *** one hand,the average hardness of electroplated nickel-coating on the laser pre-quenched zone is increased by 18.7%,and the scratch depth with the same load become narrower and *** the other hand,the coefficient of friction(CoF)and the vibration amplitude are reduced,and the coating is bonded effectively with the substrate to inhibit the crack initialization at the *** prevents effectively the coating from peeling off and improves significantly the thermal shock resistance property.

关键词： Laser-discrete-quenching Bonding properties Electroplated grinding wheel AISI 1045 substrate Nickel coating

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Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration

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Bioactive Materials 2023年第3期21卷 267-283页

作者： peihao cai Shunyi Lu Jieqin Yu Lan Xiao Jiayi Wang Haifeng Liang Lei Huang Guanjie Han Mengxuan Bian Shihao Zhang Jian Zhang Changsheng Liu Libo Jiang Yulin Li The Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryEngineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China Department of Orthopaedic Surgery Zhongshan HospitalFudan UniversityShanghai200032China Centre for Biomedical Technologies School of MechanicalMedical and Process EngineeringQueensland University of TechnologyBrisbane4059Australia

Injectable materials show their special merits in regeneration of damaged/degenerated bones in minimally-invasive *** calcium phosphate bone cement(CPC)has attracted broad attention for its bioactivity,as compared to non-degradable polymethyl methacrylate ***,its brittleness,poor anti-washout property and uncontrollable biodegradability are the main challenges to limit its further clinical application mainly because of its stone-like dense structure and fragile inorganic-salt ***,we developed a kind of injectable CPC bone cement with porous structure and improved robustness by incorporating poly(lactide-co-glycolic acid)(PLGA)nanofiber into CPC,with carboxymethyl cellulose(CMC)to offer good injectability as well as anti-wash-out ***,the introduction of PLGA and CMC also enabled a formation of initial porous structure in the cements,where PLGA nanofiber endowed the cement with a dynamically controllable biodegradability which provided room for cell movement and bone ***-estingly,the reinforced biodegradable cement afforded a sustainable provision of Ca^(2+)bioactive components,together with its porous structure,to improve synergistically new bone formation and osteo-integration in vivo by using a rat model of femur condyle *** study on regenerative mechanisms indicated that the good minimally-invasive bone regeneration may come from the synergistic enhanced osteogenic effect of calcium ion enrichment and the improved revascularization capacity contributed from the porosity as well as the lactic acid released from PLGA *** results indicate the injectable bone cement with high strength,anti-washout property and controllable biodegradability is a promising candidate for bone regeneration in a minimally-invasive approach.

关键词： Injectable calcium phosphate cement Biodegradable PLGA nanofiber Angiogenesis Osseointegration Minimally-invasive bone regeneration

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Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration

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Bioactive Materials 2021年第10期6卷 3461-3472页

作者： Shihao Zhang Yamin Li Xiaofeng Qiu Anqi Jiao Wei Luo Xiajie Lin Xiaohui Zhang Zeren Zhang Jiachan Hong peihao cai Yuhong Zhang Yan Wu Jie Gao Changsheng Liu Yulin Li The Key Laboratory for Ultrafine Materials of Ministry of Education State Key Laboratory of Bioreactor EngineeringEngineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China Institute of Translational Medicine Shanghai UniversityShanghai200444China Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy Mudanjiang Medical UniversityMudanjiang157011China Shanghai Jiaotong University Affiliated Sixth People’s Hospital Shanghai200233China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan430062China

Facing the high incidence of skin diseases,it is urgent to develop functional materials with high bioactivity for wound healing,where reactive oxygen species(ROS)play an important role in the wound healing process mainly via adjustment of immune response and *** this study,we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease ***,redox-sensitive poly(N-isopropylacrylamide-acrylic acid)(PNA)nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as *** resulting nanogels were then incorporated into the nanofibrous membrane of poly(L-lactic acid)(PLLA)via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance *** vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA *** vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process,where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy.

关键词： Polylactide Nanofibrous membrane Redox sensitivity ROS-Balance capacity Skin regeneration

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miR-26b-5p通过抑制REST表达调节胶质瘤细胞生长和侵袭

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医学分子生物学杂志 2020年第1期17卷 40-45页

作者：邱锋王荟龚立陈佳蔡佩浩上海中医药大学附属曙光医院神经外科上海市201203 上海中医药大学附属曙光医院病理科上海市201203

目的探究miR-26b-5p通过抑制抑制元素1-沉默转录因子(repressor element 1-silencing transcrip-tion factor,REST)表达调节胶质瘤细胞生长和侵袭情况.方法逆转录-聚合酶链反应检测miR-26b-5p和REST表达水平;荧光素酶报告实验检测miR-26b-5p和REST的靶向关系;Hoechst染色检测细胞凋亡;Colony形成法检测细胞增殖;Transwell检测细胞侵袭;蛋白免疫印迹检测细胞Ki67、MMP-9、cleaved caspase-3蛋白表达水平.结果miR-26b-5p和REST存在直接靶向作用关系,与Control组比较,mimic组细胞增殖数、侵袭数和Ki67、MMP-9表达明显降低,凋亡率与cleaved caspase-3表达明显升高,inhibitor组细胞增殖数、侵袭数和Ki67、MMP-9表达明显升高,凋亡率与cleaved caspase-3表达明显降低.结论miR-26b-5p可以通过抑制对REST的表达调节胶质瘤细胞生长、侵袭、凋亡能力.

关键词：抑制元素1-沉默转录因子 miRNA 细胞增殖细胞侵袭

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73例外伤性颅骨缺损不同时期的修补效果

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神经病学与神经康复学杂志 2006年第2期3卷 86-88页

作者：蔡佩浩顾国山许乐宜孔令军沈知彼上海中医药大学附属曙光医院神经外科上海200021

目的报告73例外伤致颅骨缺损修补的疗效,比较不同时期修补患者的生活质量,探讨颅骨缺损修补的时机。方法73例中43例于伤后1～3月行颅骨修补术(早期组),30例于颅骨缺损后3～6个月行颅骨修补术(正常组),比较手术并发症发生率和术后6个月... 详细信息

目的报告73例外伤致颅骨缺损修补的疗效,比较不同时期修补患者的生活质量,探讨颅骨缺损修补的时机。方法73例中43例于伤后1～3月行颅骨修补术(早期组),30例于颅骨缺损后3～6个月行颅骨修补术(正常组),比较手术并发症发生率和术后6个月生活质量。结果 73例均一期愈合。早期组术后并发症较正常组无增加,但早期组伤后6个月生活质量较正常组明显上升(P<0.01)。结论颅脑外伤手术后,切口愈合好,减压窗凹陷患者,于去颅骨瓣后1～3个月修补效果优于3～6个月修补者。

关键词：颅脑外伤颅骨缺损早期颅骨修补

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早期应用激素对PBSI患者生存及预后的改善作用分析

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西南国防医药 2013年第12期23卷 1292-1294页

作者：邱锋蔡佩浩孔令军顾国山贺晓生上海曙光医院神经外科上海201203 第四军医大学西京医院神经外科

目的探讨早期应用激素对原发性脑干损伤（PBSI）患者生存及预后改善的效果.方法收集上海曙光医院2009年6月～2013年6月收治的PBSI患者100例,按收治的时间分为实验组与对照组,每组各50例.对照组给予常规治疗,实验组在确诊后即应用甲基... 详细信息

目的探讨早期应用激素对原发性脑干损伤（PBSI）患者生存及预后改善的效果.方法收集上海曙光医院2009年6月～2013年6月收治的PBSI患者100例,按收治的时间分为实验组与对照组,每组各50例.对照组给予常规治疗,实验组在确诊后即应用甲基强的松龙治疗.分别于住院后4～7 d监测两组的颅内压,对两组的格拉斯哥结果评分（GOS）、格拉斯哥昏迷评分（GCS）、语言障碍程度和运动功能障碍的程度进行评分,并进行比较.结果与对照组比较,实验组的神经功能恢复速度较快且恢复的程度更好,两组间的差异有统计学意义（P＜0.05或P＜0.01）.结论早期应用甲基强的松龙治疗PBSI,对改善患者的生存率、抑制继发性损伤及改善患者的预后都有积极的意义.

关键词：原发性脑干损伤甲基强的松龙早期预后

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鼠神经生长因子治疗老年脑出血临床疗效及对患者血清NSE、hs-CRP、TNF-α、IL-8、MMP-9影响

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脑与神经疾病杂志 2019年第4期27卷 242-246页

作者：许乐宜孔令军龚立蔡佩浩费智敏王静予上海中医药大学附属曙光医院神经外科上海201203

目的探析鼠神经生长因子(mNGF)治疗老年脑出血临床疗效及对患者血清神经元特异性烯醇化酶(NSE)、白介素(IL)-8、肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)、金属基质蛋白酶(MMP)-9和生活质量影响。方法选取本院2017年5月至2018年6... 详细信息

目的探析鼠神经生长因子(mNGF)治疗老年脑出血临床疗效及对患者血清神经元特异性烯醇化酶(NSE)、白介素(IL)-8、肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)、金属基质蛋白酶(MMP)-9和生活质量影响。方法选取本院2017年5月至2018年6月收治的老年脑出血患者58例,双盲法数字随机分组,对照组(29例)给予降血压、营养细胞、依达拉奉及尼莫地平等常规用药,观察组(29例)则常规用药基础联合m NGF治疗,比较两组血清神经元特异性烯醇化酶(NSE)、炎性因子,评价临床疗效及生活质量。结果两组治疗4w后hs-CRP、TNF-α、IL-8、MMP-9、NSE、NIHSS评分、血肿量及水肿面积均明显低于治疗前(P<0.05),且观察组hs-CRP、TNF-α、IL-8、MMP-9、NSE、NIHSS评分、血肿量及水肿面积改善幅度明显优于对照组(P<0.05);观察组治疗有效率明显高于对照组(P<0.05)。两组治疗4w后Barthel指数、SIS评分均明显高于治疗前(P<0.05),且观察组Barthel指数、SIS评分提高幅度明显优于对照组(P<0.05)。结论老年脑出血患者采取m NGF治疗效果良好,可减轻炎症反应,血肿吸收及缓解水肿,促进神经功能恢复,改善生活质量。

关键词：脑出血鼠神经生长因子神经元特异性烯醇化酶炎症因子

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芒硝外敷治疗去骨瓣术后脑水肿的影像学观察

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神经病学与神经康复学杂志 2007年第1期4卷 14-16页

作者：邱锋顾国山蔡佩浩王静予许乐宜孔令军沈知彼上海曙光医院神经外科上海200021 上海曙光医院神经外科上海200021 上海曙光医院神经外科上海200021 上海曙光医院神经外科上海200021 上海曙光医院神经外科上海200021 上海曙光医院神经外科上海200021 上海曙光医院神经外科上海200021

目的报告46例颅脑手术去骨瓣减压后脑水肿治疗的疗效评估,比较术后减压窗外敷芒硝与否患者的CT值变化,探讨芒硝外敷治疗脑水肿的疗效.方法对46例颅脑手术去骨瓣患者脑水肿进行治疗,其中30例在常规甘露醇治疗的基础上加用芒硝外敷于减... 详细信息

目的报告46例颅脑手术去骨瓣减压后脑水肿治疗的疗效评估,比较术后减压窗外敷芒硝与否患者的CT值变化,探讨芒硝外敷治疗脑水肿的疗效.方法对46例颅脑手术去骨瓣患者脑水肿进行治疗,其中30例在常规甘露醇治疗的基础上加用芒硝外敷于减压窗(综合组),16例在常规甘露醇治疗的基础上用普通消毒敷料外敷于减压窗(西药组),比较术后一周水肿区CT值的改变.结果 46例患者中两组各死亡1例.综合组治疗后一周水肿区CT值较西药组有明显好转,且有统计学意义(P＜0.01);两组肾功能损害未见明显差异(P＞0.05).结论颅脑手术后减压窗芒硝外敷治疗脑水肿,是常规治疗方法的有效补充,能够缓解脑水肿的发生发展.

关键词：脑水肿芒硝外敷

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柴胡加龙骨牡蛎汤加减治疗脑震荡后综合征临床疗效评价

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上海中医药大学学报 2020年第3期34卷 22-25页

作者：邱锋夏振威蔡佩浩顾国山王静予许乐宜孔令军费智敏龚立上海中医药大学附属曙光医院神经外科上海201203 上海东方肝胆外科医院中西医结合科上海201805

目的:观察柴胡加龙骨牡蛎汤加减治疗脑震荡后综合征(PCS)的临床疗效。方法:纳入64例PCS患者,采用随机数字表分为治疗组和对照组,每组32例。两组患者均给予常规对症治疗,在此基础上,治疗组患者予柴胡加龙骨牡蛎汤加减治疗,治疗周期为2个... 详细信息

目的:观察柴胡加龙骨牡蛎汤加减治疗脑震荡后综合征(PCS)的临床疗效。方法:纳入64例PCS患者,采用随机数字表分为治疗组和对照组,每组32例。两组患者均给予常规对症治疗,在此基础上,治疗组患者予柴胡加龙骨牡蛎汤加减治疗,治疗周期为2个月。采用Rivermead脑震荡后综合征症状问卷评分量表进行患者的临床症状评分,比较两组患者治疗前后的症状总积分,评价临床疗效;采用匹兹堡睡眠质量指数(PSQI)评价患者的睡眠质量;采用焦虑自评量表(SAS)、抑郁自评量表(SDS)评价患者的焦虑、抑郁程度。结果:①治疗后,治疗组的临床总有效率为93.8%,对照组为78.1%,治疗组的疗效优于对照组(P<0.05)。②治疗后,两组患者的症状总积分较治疗前均显著降低(P<0.05),且治疗组患者的积分明显低于对照组(P<0.05)。③治疗后,治疗组患者的PSQI评分较治疗前明显降低(P<0.05),且治疗组患者的PSQI评分低于对照组(P<0.05)。④治疗后,治疗组患者的焦虑、抑郁程度较治疗前明显改善(P<0.05),且治疗组患者的焦虑、抑郁程度优于对照组(P<0.05)。结论:柴胡加龙骨牡蛎汤加减治疗PCS,能够有效改善患者的症状、睡眠及焦虑、抑郁情绪,值得进一步研究。

关键词：脑震荡后综合征柴胡加龙骨牡蛎汤中医药疗法

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Effect of integrated Traditional Chinese and Western Medicine on Gout

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Journal of Traditional Chinese Medicine 2021年第5期41卷 806-816页

作者： LIU Wei WU Yuanhao XUE Bin JIN Yue ZHANG Shumin LI peihao XIE Qing WANG Aihua GAO Jingyue cai Yue ZHANG Bo LIU Xiaoya WANG Yi DUAN Ran Department of Rheumatology and Immunology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China Tianjin Key Laboratory of Translational Research of Traditional Chinese Medicine Prescription and Syndrome Tianjin 300381China

OBJECTIVE:To evaluate the curative effect of integrated Traditional Chinese and Western Medicine on gout,and to investigate the therapy timing and exact treatment options of integrated ***:Totally 860 patients were enrolled,including 460 patients with intermittent gout,200 patients with active Traditional Chinese Medicine(TCM)syndrome(TCM syndrome score≥6)and200 patients with stable TCM syndrome(score<6).They were randomly divided into intervention and control *** control group was treated according to Western Medicine *** intervention group was treated with integrated Traditional Chinese and Western *** efficacy of TCM syndrome,joint pain score,joint swelling score,ESR,C-reactive protein,serum uric acid,liver and kidney function,and the duration of remission of TCM syndrome were compared between the two groups before and after ***:For the patients with stable TCM syndrome,there was no significant difference in the effective rate and inefficiency between the intervention group and the control *** the active type,the effective rate of the intervention group is better than the control group *** the stable type,there was no significant difference between the intervention group and the control group in improving the scores of joint pain and swelling,reducing the level of ESR,C-reactive protein,serum uric acid and improving liver and kidney *** the active type,the differences between the two groups were *** stable stage of gout in the intervention group was longer than the control ***:For the gout patients with stable TCM syndrome in the acute stage of gout,we can use TCM treatment or Western Medicine alternatively;for the patients with active TCM syndrome,the scheme of combination of Traditional Chinese and Western Medicine can be applied,with the better curative effect than any medicine alone.

关键词： gout integrative medicine diagnosis and treatment system curative effect

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