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Genetic diversity of food-medicinal Lycium *** China:Insights from chloroplast genome

Chinese Herbal Medicines 2024年第3期16卷 401-411页

作者： Ruyu Yao Bin Wang Michael Heinrich Qiuling Wang peigen xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikou 570311China Research Group‘Pharmacognosy and Phytotherapy’ UCL School of PharmacyUniversity of LondonLondon WC1N1AXUnited Kingdom Kunming Institute of Botany Chinese Academy of SciencesKunming 650201China

Objective:Goji(fruits of Lycium spp.)is commonly consumed as food and *** increasing market demand for goji has led to its wide cultivation and broad breeding,which might cause loss of genetic *** study aims to uncover the genetic diversity of the cultivated and wild ***:The chloroplast genome(CPG)of 34 accessions of Chinese food-medicinal Lycium spp.,including the popular cultivars and their wild relatives,was re-sequenced and assembled,based on which the genetic diversity was ***:Sequence structural comparison shows that CPG is comparatively conserved within *** analysis indicates that CPG is sufficient for the discrimination of Lycium species;combined with nuclear ribosomal internal transcribed spacer(Nr ITS)sequences,materials with mixed genetic backgrounds can be *** diversity analysis reveals that the modern cultivars are probably with a common maternal parent,while the wild accessions are with higher level of genetic ***:For the first time this study reveals the intraspecies genetic diversity of Lycium *** CPG,highlighting the urgent conservation demand of wild genetic resources of *** study also demonstrates that CPG provides crucial evidence for identification of Lycium species with mixed genetic backgrounds and highlights the importance of the wild relatives in genetic diversity *** CPG-based technology will contribute to the sustainable development of medicinal plants broadly.

关键词： chloroplast genome cultivar food-medicine genetic diversity goji wild relative

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Analysis on patents of health care products with substances of medicine food homology in China

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Chinese Herbal Medicines 2024年第3期16卷 412-421页

作者： Haibo Liu Yanfeng Wang Jiali Huang Zhengqi Dong peigen xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Key Laboratory of Traditional Chinese Medicine Patent Information Resources State Administration of Traditional Chinese MedicineBeijing 100080China Beijing Academy of Science and Technology Beijing 100048China

Objective:The concept of substances of medicine food homology(SMFH)has garnered significant attention in recent *** study conducts a systematic analysis of patent literature related to SMFH,and elucidates the development trends,technical hotspots,and the overall patent protection landscape of SMFH in China over the past two ***:The patent search focused on the SMFH varieties as the objects of inquiry,with retrieval conducted in patent ***,the acquired data underwent processing,analysis,and ***:While the technical threshold for pharmaceutical applications surpasses that of the food service sector,the former may assume a prominent role in the *** and development(R&D)activities in the southeast of China demonstrate robust activity than other *** and scientific research institutions exhibit substantial advantages in patent applications compared with individuals and hold greater potential for future ***:The findings of this patent analysis indicate that China’s SMFH industry are presently undergoing a transition from an extensive model to a high-quality *** quality and technical standards of SMFH products are consistently ***,there is a need for more stringent patent application requirements to align with the evolving development needs.

关键词： patent analysis patent pattern substances of medicine food homology traditional Chinesemedicine

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Transcriptome-wide analysis of PIP reductase gene family identified a phenylpropene synthase crucial for the biosynthesis of dibenzocyclooctadiene lignans in Schisandra chinensis

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Synthetic and Systems Biotechnology 2024年第1期9卷 78-87页

作者： Tingyan Qiang Yu Chen Bin Li Yuqing Dong Xueping Wei Jiushi Liu Bengang Zhang Haitao Liu peigen xiao State Key Laboratory of Basis and New Drug Development of Natural and Nuclear Drugs Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing100193China b College of Traditional Chinese Medicine Hebei UniversityBaoding071000China

Phenylpropenes,such as isoeugenol and eugenol,are produced as defend compounds,floral attractants,and flavor constituents by phenylpropene synthases belonging to the PIP reductase ***,isoeugenol is proposed to be involved in the biosynthesis of dibenzocyclooctadiene lignans,the main active compounds of Schisandra chinensis(Turcz.)***(SCF).***,a woody vine plant,is widely used for its medicinal,horticultural,edible,and economic *** this study,nine ScPIP genes were identified and characterized from the transcriptome datasets of *** expression profiles revealed that ScPIP genes were differentially expressed during different developmental stages of *** ScPIPs were selected and cloned as candidate genes encoding phenylpropene synthases according to phylogenetic ***1 was proved to function as isoeugenol synthase(IGS)and designated as ScIGS1 through in vivo functional characterization in Escherichia *** localization analysis demonstrated that ScIGS1 was localized in both the cytoplasm and *** three-dimensional(3D)model of ScIGS1 was obtained using homology ***-directed mutagenesis experiments revealed that the substitution of residues at positions 110 and 113 impacted the product specificity of ScIGS1 and the mutation of Lys157 to Ala abolishing catalytic ***,the kcat values of mutants were lower than that of ScIGS1 using a deep learning *** conclusion,this study provides a basis for further research on PIP reductases and the biosynthetic pathway of dibenzocyclooctadiene lignans.

关键词： Schisandra chinensis(Turcz.)baill. Dibenzocyclooctadiene lignans PIP reductase family Phenylpropenes Isoeugenol synthase

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Rhizosphere microbial markers (micro-markers): A new physical examination indicator for traditional Chinese medicines

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Chinese Herbal Medicines 2024年第2期16卷 180-189页

作者： Kailin Yang Yaping Zheng Kangmeng Sun Xinyan Wu Zheng Zhang Chunnian He peigen xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationBeijing 100193China

Rhizosphere microorganisms,as one of the most important components of the soil microbiota and plant holobiont,play a key role in the medicinal plant-soil ecosystem,which are closely related to the growth,adaptability,nutrient absorption,stress tolerance and pathogen resistance of host *** recent years,with the wide application of molecular biology and omics technologies,the outcomes of rhizosphere microorganisms on the health,biomass production and secondary metabolite biosynthesis of medicinal plants have received extensive ***,whether or to what extent rhizosphere microorganisms can contribute to the construction of the quality evaluation system of Chinese medicinal materials is still *** on the significant role of rhizosphere microbes in the survival and quality formation of medicinal plants,this paper proposed a new concept of rhizosphere microbial markers(micro-markers),expounded the relevant research methods and ideas of applying the new concept,highlighted the importance of micro-markers in the quality evaluation and control system of traditional Chinese medicines(TCMs),and introduced the potential value in soil environmental assessment,plant pest control and quality assessment of *** provides reference for developing ecological planting of TCMs and ensuring the production of high quality TCMs by regulating rhizosphere microbial communities.

关键词： physical examination indicator quality evaluation quality formation of medicinal plants rhizosphere microorganisms rhizosphere microbial markers

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Prediction of sites under adaptive evolution in flavin-containing monooxygenases: Selection pattern revisited

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Chinese Science Bulletin 2011年第12期56卷 1246-1255页

作者： HAO DaCheng xiao peigen Biotechnology Institute Dalian Jiaotong University Dalian 116028 China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193 China

Flavin-containing monooxygenase (FMO), like cytochrome P450 (CYP), is a monooxygenase that uses the reducing equivalents of NADPH to reduce one atom of molecular oxygen to water, while the other atom is used to oxidize the substrate. Recently, it was shown that some CYP isoforms have been subject to positive selection. However, it is unknown whether the highly conserved phase I detoxification enzyme, FMO, has undergone similar positive Darwinian selection. We used maximum-likelihood models of codon substitution, evolutionary fingerprinting, and cross species comparison to investigate the occurrence of adaptive evolution in FMO sequences. We used recent genomic data from a range of species, including vertebrates and invertebrates. We present the evidence for the occurrence of adaptive evolution in mammalian FMO 3, 4, 5, and fugu FMOs but not in mammalian FMO 1, FMO 2, frog FMOs, other fish FMOs and invertebrate FMOs. The sites under adaptive evolution were significantly associated with the insertion domain in mammalian FMO 5. We identified specific amino acid sites in FMOs 3–5 that are likely targets for selection based on the patterns of parallel amino acid change. The most likely role of adaptive evolution is the repair of mutations that permitted optimal NADP+ binding and improved catalytic efficiency. The occurrence of positive selection during the evolution of phase I detoxification enzymes such as FMOs 3–5 and fugu FMO suggests the occurrence of both high selection pressure acting on species within their unique habitats and significant changes in intensity and direction (forms of xenobiotics and drugs) resulting from changes in microhabitat and food.

关键词：适应性进化单加氧酶选择模式网站细胞色素P450 无脊椎动物 FMOs 预测

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Anemone medicinal plants:ethnopharmacology,phytochemistry and biology

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Acta Pharmaceutica Sinica B 2017年第2期7卷 146-158页

作者： Da-Cheng Hao xiaojie Gu peigen xiao Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

The Ranunculaceae genus Anemone(order Ranunculales),comprising more than 150 species,mostly herbs,has long been used in folk medicine and worldwide *** medicinal compounds have been found in Anemone plants,especially triterpenoid saponins,some of which have shown anti-cancer *** Anemone compounds and extracts display immunomodulatory,antiinflammatory,antioxidant,and antimicrobial *** than 50 species have ethnopharmacological uses,which provide clues for modern drug *** compounds exert anticancer and other bioactivities via multiple ***,a comprehensive review of the Anemone medicinal resources is *** here summarize the ethnomedical knowledge and recent progress on the chemical and pharmacological diversity of Anemone medicinal plants,as well as the emerging molecular mechanisms and functions of these medicinal *** phylogenetic relationships of Anemone species were reconstructed based on nuclear ITS and chloroplast *** molecular phylogeny is largely congruent with the morphology-based *** used medicinal herbs are distributed in each subgenus and section,and chemical and biological studies of more unexplored taxa are *** expression profiling and relevant "omics" platforms could reveal differential effects of ***,transcriptomics,proteomics,and metabolomics should be highlighted in deciphering novel therapeutic mechanisms and utilities of Anemone phytometabolites.

关键词： Anemone Ethnomedicine Chemodiversity Bioactivity Molecular mechanism Pharmacophylogeny

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Phenotype prediction of nonsynonymous single nucleotide polymorphisms in human phase II drug/xenobiotic metabolizing enzymes: perspectives on molecular evolution

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Science China(Life Sciences) 2010年第10期53卷 1252-1262页

作者： HAO DaCheng xiao peigen CHEN ShiLin Laboratory of Biotechnology College of EnvironmentDalian Jiaotong UniversityDalian 116028China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China

Nonsynonymous single nucleotide polymorphisms (nsSNPs) in coding regions can lead to amino acid changes that might alter the protein’s function and account for susceptibility to disease and altered drug/xenobiotic response. Many nsSNPs have been found in genes encoding human phase II metabolizing enzymes; however, there is little known about the relationship between the genotype and phenotype of nsSNPs in these enzymes. We have identified 923 validated nsSNPs in 104 human phase II enzyme genes from the Ensembl genome database and the NCBI SNP database. Using PolyPhen, Panther, and SNAP algorithms, 44%?59% of nsSNPs in phase II enzyme genes were predicted to have functional impacts on protein function. Predictions largely agree with the available experimental annotations. 68% of deleterious nsSNPs were correctly predicted as damaging. This study also identified many amino acids that are likely to be functionally critical, but have not yet been studied experimentally. There was significant concordance between the predicted results of Panther and PolyPhen, and between SNAP non-neutral predictions and PolyPhen scores. Evolutionarily non-neutral (destabilizing) amino acid substitutions are thought to be the pathogenetic basis for the alteration of phase II enzyme activity and to be associated with disease susceptibility and drug/xenobiotic toxicity. Furthermore, the molecular evolutionary patterns of phase II enzymes were characterized with regards to the predicted deleterious nsSNPs.

关键词： phenotype PolyPhen Panther SNAP SNP phase II drug/xenobiotic metabolizing enzyme

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Chemical and biological research of Clematis medicinal resources

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Chinese Science Bulletin 2013年第10期58卷 1120-1129页

作者： HAO DaCheng GU xiaoJie xiao peigen PENG Yong Biotechnology Institute School of EnvironmentDalian Jiaotong University Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine of Ministry of Education Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences

Clematis is a botanical source for various pharmaceutically active components,which has long been used in conventional medicine since the beginning of Chinese *** interest in Clematis medicinal resources has led to additional discoveries of triterpenoid saponins,flavonoids,coumarins,alkaloids and many other compounds in various Clematis species,and to investigations on their chemotaxonomy,molecular phylogeny and *** continuation with our studies on Clematis chemistry and biology,we review the chemistry,chemotaxonomy,molecular biology and phylogeny of Clematis and their relevance to drug efficacy and drug *** databases and technology have been used in literature search in order to characterize the global scientific *** is essential to study more species for both the sustainable utilization of Clematis medicinal resources and finding novel compounds with potential clinical *** biology and omics technologies will play an increasingly important role in future medicinal research involving bioactive compounds of Clematis.

关键词：化学分类学分子生物学药用资源威灵仙生物活性化合物传统医学检索技术分子系统学

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Research progress of Chinese herbal medicine compounds and their bioactivities:Fruitful 2020

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Chinese Herbal Medicines 2022年第2期14卷 171-186页

作者： xiaojie Gu Dacheng Hao peigen xiao Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

Traditional Chinese medicines(TCMs)have continued to be a treasure *** study of chemodiversity and versatility of bioactivities has always been an important content of *** is amazing progress in the discovery and research of natural components with novel structures and significant bioactivities in *** this paper we review 271 valuable natural products,including terpenoids,steroids,flavonoids,phenylpropanoids,phenolics,nitrogen containing compounds and essential oil,etc.,isolated and identified from TCMs published in journals of Chinese Traditional and Herbal Drugs(Zhong Cao Yao)and Chinese Herbal Medicines(CHMs),and focus on their structures,source organisms,and relevant bioactivities,paying special attention to structural characteristics of novel compounds and newly revealed pharmacological properties of known *** is worth noting that natural products with antitumor activity still constitute the primary object of *** the reported compounds,two new triterpenoids,i.e.,ursolic acid 3-O-β-cis-caffeate and mollugoside E,display remarkable cytotoxicity against PC-9 and HL-60 cell lines,*** known phenolic compounds,i.e.,pyoluteorin,4-hydroxy-3-methoxy cinnamaldehyde and 3,7-dimethoxy-5-hydroxy-1,4-phenanthrenequinone,exhibit significant cytotoxicity against multiple cell *** studies on the free radical scavenging activity of reported compounds are currently *** vitro,three known phenolic compounds,i.e.,3,4-Odicaffeoylquinic acid methyl ester,3,4,5-O-tricaffeoylquinic acid methyl ester and arbutin,had more considerable antioxidant activities than vitamin *** anti-inflammatory,anti-diabetic,hypolipidemic,neuroprotective and antimicrobial activities of isolated compounds are also *** structural characteristics and bioactivities of TCM compounds highlighted here reflect the enormous progress of CHM research in 2020 and will play a positive role in the future drug discovery and de

关键词： chemical constituents medicinal plants natural products pharmacological activities traditional Chinese medicine

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中国社区老年人夜间睡眠状况与慢性病共病的关联研究

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中国全科医学 2024年第4期27卷 440-446页

作者：夏高艳刘明齐雨欣肖培根丁小姣宁容容叶险峰河南中医药大学针灸推拿学院河南省郑州市450046 河南中医药大学第三附属医院康复科河南省郑州市450008

背景随着中国老龄化浪潮的快速推进,慢性病共病已对公共卫生和临床提出了重要挑战。夜间睡眠状况(睡眠时长和质量)对于调节老年人的身体新陈代谢和生理功能至关重要,但当前针对夜间睡眠状况与慢性病共病的相关研究仅局限于部分地区或中... 详细信息

背景随着中国老龄化浪潮的快速推进,慢性病共病已对公共卫生和临床提出了重要挑战。夜间睡眠状况(睡眠时长和质量)对于调节老年人的身体新陈代谢和生理功能至关重要,但当前针对夜间睡眠状况与慢性病共病的相关研究仅局限于部分地区或中青年人群,中国社区老年人夜间睡眠状况与慢性病共病罹患风险之间的关系尚不明确。目的探讨中国社区老年人夜间睡眠状况与慢性病共病罹患风险的关联。方法本研究于2023年4月选取2018年中国老年健康和家庭幸福调查研究(CLHLS-HF)数据中11917名社区老年人为研究对象。采用多因素Logistic回归分析探讨社区老年人睡眠时长和睡眠质量与慢性病共病罹患风险的关联,采用比值比(OR)和95%可信区间(95%CI)表示;并采用基于Logistic回归分析的限制性立方样条(RCS)方法分析社区老年人睡眠时长与慢性病共病罹患风险的剂量-反应关系。结果11917名社区老年人中,平均年龄为(84.4±11.4)岁,年龄范围为65.0~117.0岁。研究对象包括6477名(54.35%)女性和5440名(45.65%)男性。多因素Logistic回归分析结果显示,在调整性别、年龄、地区、受教育年限等协变量后,与夜间睡眠时长为6~8 h的老年人相比,夜间睡眠时长较短(<6 h)的老年人与较高的慢性病共病罹患风险有关(OR=1.51,95%CI=1.36~1.67,P<0.05);与睡眠质量较好的老年人相比,睡眠质量一般(OR=1.34,95%CI=1.22~1.46,P<0.05)和睡眠质量较差(OR=2.14,95%CI=1.91~2.40,P<0.05)的老年人与较高的慢性病共病罹患风险有关。RCS图结果显示,睡眠时长与慢性病共病罹患风险呈“U”形非线性关联,最佳睡眠时长约为7 h。结论睡眠时长<6 h、睡眠质量为一般或差的社区老年人与慢性病共病罹患风险增加有关,社区老年人最佳的睡眠时长约为7 h,正常的睡眠时长和良好的睡眠质量对于预防慢性病共病发生具有重要意义。

关键词：老年人慢性病共病睡眠时长睡眠质量关联性研究

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