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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang peifeng li Hai Zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Incorporating contextual evidence to improve implicit discourse relation recognition in Chinese

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Frontiers of Computer Science 2024年第3期18卷 91-104页

作者： Sheng XU peifeng li Qiaoming ZHU School of Computer Science and Technology Soochow UniversitySuzhou 215000China

The discourse analysis task,which focuses on understanding the semantics of long text spans,has received increasing attention in recent *** a critical component of discourse analysis,discourse relation recognition aims to identify the rhetorical relations between adjacent discourse units(e.g.,clauses,sentences,and sentence groups),called arguments,in a *** works focused on capturing the semantic interactions between arguments to recognize their discourse relations,ignoring important textual information in the surrounding ***,in many cases,more than capturing semantic interactions from the texts of the two arguments are needed to identify their rhetorical relations,requiring mining more contextual *** this paper,we propose a method to convert the RST-style discourse trees in the training set into dependency-based trees and train a contextual evidence selector on these transformed *** this way,the selector can learn the ability to automatically pick critical textual information from the context(i.e.,as evidence)for arguments to assist in discriminating their *** we encode the arguments concatenated with corresponding evidence to obtain the enhanced argument ***,we combine original and enhanced argument representations to recognize their *** addition,we introduce auxiliary tasks to guide the training of the evidence selector to strengthen its selection *** experimental results on the Chinese CDTB dataset show that our method outperforms several state-of-the-art baselines in both micro and macro F1 scores.

关键词： discourse parsing discourse relation recognition contextual evidence selection

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In situ atomic-scale analysis of Rayleigh instability in ultrathin gold nanowires

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Nano Research 2018年第2期11卷 625-632页

作者： Shang Xu peifeng li Yang Lu Department of Mechanical and Biomedical Engineering City University of Hong Kong Kowloon Hong Kong China Institute of Applied Mechanics Zhejiang University Hangzhou China Hong Kong Branch of National Precious Metals Material Engineering Research Center (NPMM) 83 Tat Chee Avenue Kowloon Hong Kong China

Comprehensive understanding of the structural/morphology stability of ultrathin （diameter 〈 10 nm） gold nanowires under real service conditions （such as under Joule heating） is a prerequisite for the reliable implementation of these emerging building blocks into functional nanoelectronics and mechatronics systems. Here, by using the in situ transmission electron microscopy （TEM） technique, we discovered that the Rayleigh instability phenomenon exists in ultrathin gold nanowires upon moderate heating. Through the controlled electron beam irradiation-induced heating mechanism （with 〈 100 ~C temperature rise）, we further quantified the effect of electron beam intensity and its dependence on Rayleigh instability in altering the geometry and morphology of the ultrathin gold nanowires. Moreover, in situ high-resolution TEM （HRTEM） observations revealed surface atomic diffusion process to be the dominating mechanism for the morphology evolution processes. Our results, with unprecedented details on the atomic-scale picture of Rayleigh instability and its underlying physics, provide critical insights on the thermal/structural stability of gold nanostructures down to a sub-10 nm level which may pave the way for their interconnect applications in future ultra- large-scale integrated ciroaits.

关键词： ultrathin gold nanowire in situ transmissionelectron microscopy (TEM) Rayleigh instability thermal instability interconnect

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Aerodynamic Design Methodology for Blended Wing Body Transport

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Chinese Journal of Aeronautics 2012年第4期25卷 508-516页

作者： li peifeng ZHANG Binqian CHEN Yingchun YUAN Changsheng liN Yu College of Aeronautics Northwestern Polytechnical University Xi 'an 710072 China Shanghai Aircraft Design and Research lnstitute Commercial Aircraft Corporation of China Ltd. Shanghai200232 China

This paper puts forward a design idea for blended wing body（BWB）.The idea is described as that cruise point,maximum lift to drag point and pitch trim point are in the same flight *** to this design idea,design objectives and constraints are *** applying low and high fidelity aerodynamic analysis tools,BWB aerodynamic design methodology is established by the combination of optimization design and inverse design *** lift to drag ratio,pitch trim and acceptable buffet margin can be achieved by this design *** 300-passenger BWB configuration based on static stability design,as compared with initial configuration,the maximum lift to drag ratio and pitch trim are achieved at cruise condition,zero lift pitching moment is positive,and buffet characteristics is *** burn of 300-passenger BWB configuration is also significantly reduced as compared with conventional civil *** aerodynamic design is carried out under the constraints of BWB design requirements,the design configuration fulfills the demands for interior layout and provides a solid foundation for continuous work.

关键词： blended wing body aerodynamic configurations computational fluid dynamics optimization design inverse design

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Green heating:Theory and practice

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Science China(Technological Sciences) 2015年第12期58卷 2003-2015页

作者： YANG YongPing li peifeng GE ZhiHua TIAN Jia WANG Ningling SONG ZhiPing School of Energy Power and Mechanical Engineering North China Electric Power University Beijing Municipal Institute of City Planning & Design

Energy conservation in heating systems has great influence on overall sustainable development strategy. Heating technology, especially combined heat and power(CHP, cogeneration), has been attracting increased interest and rapidly developing in recent years. However, the theoretical potential of heating from the perspective of thermodynamics has not been clearly illustrated. This paper presents a theoretical analysis of heating systems based on the 1st and 2nd laws of thermodynamics using the specific fuel consumption(SFC) analysis method, clarifies the theoretical potential limitation of heating systems and illustrates the process of reversible heating on the basis of the total energy system. A novel concept(green heating, GH) and a new indicator(green-heating index, GH Index) are scientifically defined to characterise different options for heating and to quantitatively evaluate their fuel consumption levels. Thereafter, the fuel consumptions of four typical space heating modes are compared and discussed to present the application of GH theory and validate the power of the proposed concept and index. Furthermore, two different CHP technologies are analyzed with an instantiation case, and a novel CHP system is recommended, which may scientifically support the development of heating technology and further improve the processes of energy-saving and CO2 reduction.

关键词： green heating combined heat and power space heating specific fuel consumption exergy thermodynamics

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Underlying mechanisms and clinical potential of circRNAs in glioblastoma

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Oncology Research 2023年第4期31卷 449-462页

作者： LEI ZHANG YUAN ZHANG HUIJUAN GAO XIN li peifeng li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266021China

Glioblastoma(GBM)is the most malignant form of glioma and is difficult to diagnose,leading to high mortality *** RNAs(circRNAs)are noncoding RNAs with a covalently closed loop *** are involved in various pathological processes and have been revealed to be important regulators of GBM *** exert their biological effects by 4 different mechanisms:serving as sponges of microRNAs(miRNAs),serving as sponges of RNA binding proteins(RBPs),modulating parental gene transcription,and encoding functional *** the 4 mechanisms,sponging miRNAs is *** good stability,broad distribution and high specificity make circRNAs promising biomarkers for GBM *** this paper,we summarized the current understanding of the characteristics and action mechanisms of circRNAs,illustrated the underlying regulatory mechanisms of circRNAs in GBM progression and explored the possible diagnostic role of circRNAs in GBM.

关键词： CircRNAs GBM Underlying mechanisms Clinical value

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A literature review of perishable medical resource management

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Frontiers of Engineering Management 2023年第4期10卷 710-726页

作者： Chao Zhang peifeng li Qiao-chu He Fan Wang School of Business Southern University of Science and TechnologyShenzhen518055China Business School Sun Yat-sen UniversityGuangzhou 510275China

In recent decades,healthcare providers have faced mounting pressure to effectively manage highly perishable and limited medical *** article offers a comprehensive review of supply chain management pertaining to such resources,which include transplantable organs and healthcare *** review encompasses 93 publications from 1990 to 2022,illustrating a discernible upward trajectory in annual *** surveyed literature is categorized into three levels:Strategic,tactical,and *** problem attributes and methodologies are analyzed through the assessment of pertinent publications for each problem ***,research on service innovation,decision analytics,and supply chain resilience elucidates potential areas for future research.

关键词： perishable medical resources organ transplant healthcare products decision analytics operations management

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Superior adsorption performance of graphitic carbon nitride nanosheets for both cationic and anionic heavy metals from wastewater

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Chinese Journal of Chemical Engineering 2019年第2期27卷 305-313页

作者： Gang Xiao Yaoqiang Wang Shengnan Xu peifeng li Chen Yang Yu Jin Qiufeng Sun Haijia Su State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering (BAIC-SM) Beijing University of Chemical Technology

Water pollution caused by highly toxic Cd(II), Pb(II), and Cr(VI) is a serious problem. In the present work,a green and low-cost adsorbent of g-C_3N_4 nanosheets was developed with superior capacity for both cationic and anionic heavy metals. The adsorbent was easily fabricated through one-step calcination of guanidine hydrochloride with thickness less than 1.6 nm and specific surface area of 111.2 m^2·g^(-1). Kinetic and isotherm studies suggest that the adsorption is an endothermic chemisorption process, occurring on the energetically heterogeneous surface based on a hybrid mechanism of multilayer and monolayer adsorption. The tri-s-triazine units and surface N-containing groups of g-C_3N_4 nanosheets are proposed to be responsible for the adsorption *** study on pH demonstrates that electrostatic interaction plays an important role. The maximum adsorption capacity of Cd(II), Pb(II), and Cr(VI) on g-C_3N_4 nanosheets is 123.205 mg·g^(-1), 136.571 mg·g^(-1),and 684.451 mg·g^(-1), respectively. The better adsorption performance of the adsorbent than that of the recently reported nanomaterials and low-cost adsorbents proves its great application potential in the removal of heavy metal contaminants from wastewater. The present paper developed a promising adsorbent which will certainly find applications in wastewater treatment and also provides guiding significance in designing adsorption processes.

关键词： g-C3N4 nanosheets Nanomaterials Adsorption Heavy metals Wastewater

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Multiple-quantum-well perovskite for hole-transport-layer-free light-emitting diodes

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Chinese Chemical Letters 2022年第2期33卷 1017-1020页

作者： peifeng li Jie Wang Hong Chen Hao Zhang Cheng li Wenjie Xu Renzhi li lin Zhu Nana Wang Jianpu Wang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211816China School of Electronic Science and Engineering Xiamen UniversityXiamen 361005China Future Display Institute of Xiamen Xiamen 361005China

We demonstrate hole-transport-layer-free light-emitting diodes(LEDs) based on solution-processed multiple-quantum-well(MQW) perovskite. The MQW perovskite can self-assemble to a unique structure of vertically graded distribution with two-dimensional layered perovskite covered by three-dimensionallike perovskite at top, which can naturally form a barrier of electron transporting to the anode interface,thereby enhancing the charge capture efficiency. This leads to hole-transport-layer-free MQW perovskite LEDs reaching an external quantum efficiency(EQE) of 9.0% with emission peak at 528 nm, which is over6 times of LEDs based on three-dimensional perovskite with the same device structure, representing the record EQE of hole-transport-layer-free perovskite LED.

关键词： Perovskite light-emitting diodes Hole-transport-layer-free device Multiple-quantum-well perovskite Green emission

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Effects of NO and Different Media on the Growth of Prorocentrum micans

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Journal of Ocean University of China 2006年第3期5卷 239-242页

作者： ZHANG Zhengbin li peifeng liU Chunying Institute of Marine Chemistry Ocean University of China Qingdao 266003 P. R. China

Prorocentrum micans was cultivated in different media including f/2, f/4, f/8, f/20, f/25, f/50, f/100 and f/200. Results showed that media influence the growth of P. micans. The biomass of P. micans in rich nutrition medium was much higher than in poor nutrition medium. Nitric oxide can promote or inhibit the growth of P. micans in all media. Nitric oxide at the concentration of 1.4 × 10^- 6 mol L^-1 promoted the growth of P. micans significantly when added only once during the cultivation. When added twice a day, nitric oxide at the concentration of 1.4 × 10^- 9 mol L^-1 promoted the growth of P. micans significantly, while nitric oxide at the concentrations of 1.4 × 10^- 5 mol L ^-1 and 1.4 × 10^- 6 mol L ^-1 inhibited the growth. Therefore, nitric oxide, media and the ways to add nitric oxide influenced the growth of P. micans respectively.

关键词： nitric oxide (NO) media Prorocentrum micans effect

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