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A Novel Nano/Micro-Fibrous Scaffold by Melt-Spinning Method for Bone Tissue Engineering

Journal of Bionic Engineering 2015年第1期12卷 117-128页

作者： Liguo Cui Ning zhang Weiwei Cui peibiao zhang Xuesi Chen Key Laboratory of Polymer Ecobiomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100039 China Department of Bone and Joint Surgery First Hospital of Jilin University Changchun 130021 China School of Public Health Jilin University Changchun 130021 China

In order to architecturally and functionally mimic native Extracellular Matrix （ECM）, a novel micro/nano-fibrous scaffold of hydroxyapetite/poly（lactide-co-glycolide）（HA/PLGA） composite was successfully prepared by melt-spinning method. A porous three-dimensional scaffold fabricated by melt-molding particulate-leaching method was used as control. This kind of scaffold comprising both nanofiber and microfiber had an original structure including a nano-network favorable for cell adhe- sion, and a micro-fiber providing a strong skeleton for support. The microfibers and nanofibers were blended homogeneously in scaffold and the compression strength reached to 6.27 MPa, which was close to human trabecular bone. The typical mi- cro/nano-fibrous structure was more benefcial for the proliferation and differentiation of Bone Mesenehymal Stem Cells （BMSCs）. The calcium deposition and Alkaline Phosphatase （ALP） activity were evaluated by the differentiation of BMSCs, and the results indicated that the temporary ECM was very beneficial for the differentiation of BMSCs into maturing osteoblasts. For repairing rabbit radius defects in vivo, micro/nano-fibrous scaffold was used for the purpose of rapid bone remodeling in the defect area. The results showed that a distinct bony callus of bridging was observed at 12 weeks post-surgery and the expression of osteogenesis-related genes （bone-morphogenetic protein-2, Osteonectin, collagen-I） increased because of the ECM-like structure. Based on the results, the novel micro/nano-fibrous scaffold might be a promising candidate for bone tissue engi- neering.

关键词： PLGA-based scaffold melt-spinning nano/micro-fibers bone tissue engineering

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Preparation of Mesoporous Nano-Hydroxyapatite Using a Surfactant Template Method for Protein Delivery

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Journal of Bionic Engineering 2012年第2期9卷 224-233页

作者： Xiaodong Wu Xiaofeng Song Dongsong Li Jianguo Liu peibiao zhang Xuesi Chen Department of Bone and Joint Surgery First Hospital of Jilin UniversityChangchun 130021P R.China Key Laboratory of Polymer Ecobiomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangehun 130022P.R.China

Mesoporous nano-hydroxyapatite （n-HA） has gained more and more attention as drug storage and release hosts. The aim of this study is to observe the effect of the ratio of surfactant to the theoretical yield of HA on the mesoporous n-HA, then to reveal the effect of the mesoporous nanostructure on protein delivery. The mesoporous n-HA was synthesized using the wet precipitation in the presence of cetyltrimethylammonium bromide （CTAB） at ambient temperature and normal atmospheric pressure. The morphology, size, crystalline phase, chemical composition and textural characteristics of the product were well characterized by X-ray Powder Diffraction （XRD）, Fourier Transform Infrared Spectroscopy （FTIR）, Scanning Electron Microscopy （SEM）, Transmission Electron Microscopy （TEM）, Dynamic Light Scattering （DLS） and N2 adsorption/desorption, respectively. The protein adsorption/release studies were also carried out by using Bovine Serum Albumin （BSA） as a model protein. The results reveal that the mesoporous n-HA synthesized with CTAB exhibits high pure phase, low crystallinity and the typical characteristics of the mesostructure. The BSA loading increases with the specific surface area and the pore volume of n-HA, and the release rates of BSA are different due to their different pore sizes and pore structures, n-HA synthesized with 0.5% CTAB has the highest BSA loading and the slowest release rate because of its highest surface area and smaller pore size. These mesoporous n-HA materials demonstrate a potential application in the field of protein delivery due to their bioactive, biocompatible and mesoporous properties.

关键词： hydroxyapatite nanoparticles mesostructure cetyltrimethylammonium bromide drug delivery

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Porous polyetheretherketone microcarriers fabricated via hydroxylation together with cellderived mineralized extracellular matrix coatings promote cell expansion and bone regeneration

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Regenerative Biomaterials 2021年第2期8卷 149-162页

作者： Shuo Sun Zixue Jiao Yu Wang Zhenxu Wu Haowei Wang Qingming Ji Yi Liu Zongliang Wang peibiao zhang Department of Spine Surgery The First Hospital of Jilin University1 Xinmin StreetChangchun 130021China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022China

Porous microcarriers have aroused increasing attention recently by facilitating oxygen and nutrient transfer,supporting cell attachment and growth with sufficient cell seeding *** this study,porous polyetheretherketone(PEEK)microcarriers coated with mineralized extracellular matrix(mECM),known for their chemical,mechanical and biological superiority,were developed for orthopedic *** PEEK microcarriers were derived from smooth microcarriers using a simple wet-chemistry strategy involving the reduction of carbonyl *** treatment simultaneously modified surface topology and chemical ***,the microstructure,protein absorption,cytotoxicity and bioactivity of the obtained porous microcarriers were *** deposition of mECM through repeated recellularization and decellularization on the surface of porous MCs further promoted cell proliferation and osteogenic ***,the mECM coated porous microcarriers exhibited excellent bone regeneration in a rat calvarial defect repair model in vivo,suggesting huge potential applications in bone tissue engineering.

关键词： polyetheretherketone porous microcarriers mineralized extracellular matrix cell expansion bone regeneration

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Biomimetic polyetheretherketone microcarriers with specific surface topography and self-secreted extracellular matrix for large-scale cell expansion

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Regenerative Biomaterials 2020年第1期7卷 109-118页

作者： Qingming Ji ZongliangWang Zixue Jiao Yu Wang Zhenxu Wu Peng Wang Yuhang Zhu Shuo Sun Yi Liu peibiao zhang Department of Spine Surgery The First Hospital of Jilin UniversityChangchun 130021PR China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022PR China University of Science and Technology of China Hefei 230026PR China Department of Orthopedics China-Japan Union HospitalJilin UniversityChangchun 130033PR China

Reusable microcarriers with appropriate surface topography,mechanical properties,as well as biological modification through decellularization facilitating repeated cell culture are crucial for tissue engineering ***,we report the preparation of topological polyetheretherketone(PEEK)microcarriers via gas-driven and solvent exchange method followed by hydrothermal treatment at high temperature and *** hydrothermal treated for 8 h,the resulting topological PEEK microcarriers exhibit walnut-like surface topography and good sphericity as well as uniform size distribution of 350.24619.44 *** the average width between ravine-patterned surface of PEEK microcarriers is 7806290 *** repeated steam sterilization by autoclaving for three times,topological PEEK microcarriers show nearly identical results compared with previous ones indicating strong tolerance to high temperature and *** is a unique advantage for large-scale cell expansion and clinical ***,PEEK microcarriers with special topography possess higher protein adsorption *** addition,the reutilization and biofunctionalization with repeated decellularization of topological PEEK microcarriers show highly beneficial for cell adhesion and ***,our study is of great importance for new generation microcarriers with micro-and nano-scale surface feature for a broad application prospect in tissue engineering.

关键词： PEEK topological microcarriers recycle decellularization cell adhesion

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Dual-response of multi-functional microsphere system to ultrasound and microenvironment for enhanced bone defect treatment

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Bioactive Materials 2024年第2期32卷 304-318页

作者： Qingxu Song Dianwei Wang Haoyu Li Zongliang Wang Songjia Sun Zhenyu Wang Yi Liu Sien Lin Gang Li Shaokun zhang peibiao zhang Department of Spine Surgery The First Hospital of Jilin UniversityChangchun130021China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China Department of Dermatology Second Hospital of Jilin UniversityChangchun130022China Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences Prince of Wales HospitalThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China

Using bone tissue engineering strategies to achieve bone defect repair is a promising ***,the repair process outcomes are often *** we properly designed a multi-functional microsphere system,which could deliver bioactive proteins under the dual response of ultrasound and microenvironment,release microenvironment-responsive products on demand,reverse bone injury microenvironment,regulate the immune microenvironment,and achieve excellent bone defect treatment *** particular,the MnO_(2) introduced into the poly(lactic-co-glycolic acid)(PLGA)microspheres during synthesis could consume the acid produced by the degradation of PLGA to protect bone morphogenetic protein-2(BMP-2).More importantly,MnO_(2) could consume reactive oxygen species(ROS)and produce Mn^(2+)and oxygen(O_(2)),further promoting the repair of bone defects while reversing the ***,the reversal of the bone injury microenvironment and the depletion of ROS promoted the polarization of M1 macrophages to M2 macrophages,and the immune microenvironment was ***,the ultrasound(US)irradiation used during treatment also allowed the on-demand release of microenvironment-responsive *** multi-functional microsphere system combines the effects of on-demand delivery,reversal of bone injury microenvironment,and regulation of the immune microenvironment,providing new horizons for the clinical application of protein delivery and bone defect repair.

关键词： BMP-2 Multi-functional microsphere Bone defect repair Bone injury microenvironment Immune microenvironment

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Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

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Bioactive Materials 2020年第4期5卷 1004-1017页

作者： Teng Wan Zixue Jiao Min Guo Zongliang Wang Yizao Wan Kaili Lin Qinyi Liu peibiao zhang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022PR China Department of Orthopaedics The Second HospitalJilin UniversityChangchun130041PR China Institute of Advanced Materials East China Jiaotong UniversityNanchang330013PR China Department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai200011PR China University of Science and Technology of China Hefei230026PR China

Fabricating a desired porous structure on the surface of biomedical polyetheretherketone(PEEK)implants for enhancing biological functions is crucial and difficult due to its inherent chemical *** this study,a porous surface of PEEK implants was fabricated by controllable sulfonation using gaseous sulfur trioxide(SO3)for different time(5,15,30,60 and 90 min).Micro-topological structure was generated on the surface of sulfonated PEEK implants preserving original mechanical *** protein absorption capacity and apatite forming ability was thus improved by the morphological and elemental change with higher degree of *** combination of the appropriate micromorphology and bioactive sulfonate components,the cell adhesion,migration,proliferation and extracellular matrix secretion were obviously enhanced by the SPEEK-15 samples which were sulfonated for 15 *** from this study revealed that controllable sulfonation by gaseous SO3 would be an extraordinarily strategy for improving osseointegration of PEEK implants by adjusting the microstructure and chemical composition while maintaining excellent mechanical properties.

关键词： Polyetheretherketone Sulfonation Micro-topology Mechanical strength Osteointegration

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Important topics in the future of biomaterials and stem cells for bone tissue engineering

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Regenerative Biomaterials 2015年第2期2卷 153-158页

作者： peibiao zhang QingSan Zhu Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesChangchun130022P.R.China Department of Orthopaedics China-Japan Union HospitalJilin UniversityChangchun130033P.R.China

Fundamental and clinical experts from Japan,Korea and China,warmly gathered on the beautiful ice and snow city—Changchun,the capital of Jilin Province,China—during 23-26 January 2015,to present their research findings and participated in discussion relating to progress in biomaterials,stem cells and bone tissue *** International Symposium on Recent Trend of Biomaterials and Stem Cells for Bone Tissue Engineering(BTE 2015)was hosted by the Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,and co-organized by the Department of Orthopaedics,China-Japan Union Hospital,Jilin University.

关键词： Changchun beautiful biomaterials

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Improved hemostatic effects by Fe^(3+)modified biomimetic PLLA cotton-like mat via sodium alginate grafted with dopamine

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Bioactive Materials 2021年第8期6卷 2346-2359页

作者： Caili Lv Linlong Li Zixue Jiao Huanhuan Yan Zongliang Wang Zhenxu Wu Min Guo Yu Wang peibiao zhang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun130022PR China School of Applied Chemistry and Engineering University of Science and Technology of China96 Jinzhai RoadHefeiAnhui230026PR China University of Chinese Academy of Sciences 19 Yuquan RoadBeijing100049PR China

The development of an excellent,bioabsorbable hemostatic material for deep wound remains a *** this work,a biodegradable cotton-like biomimetic fibrous mat of poly(L-lactic acid)(PLLA)was made by melt ***,SD composite was prepared by cross-linking sodium alginate(SA)with dopamine(DA).It was immobilized on the fibre surface,which inspired by mussel ***,Fe^(3+)was loaded onto the 0.5SD/PLLA composite by chelation with the carboxyl of alginate and phenolic hydroxy of *** haemostasis experiment found that the hemostatic time 47 s in ***,the bleeding volume was 0.097 g and hemostatic time was 23 s when 20Fe^(3+)-0.5SD/PLLA was applied in the haemostasis of the rat *** a result of its robust hydrophilicity and bouffant cotton-like structure,it could absorb a large water from blood,which could concentrate the component of blood and reduce the clotting ***,the addition of Fe^(3+)in the 0.5SD/PLLA had a significant effect on improve hemostatic *** also displayed excellent antibacterial property for Escherichia coli and Staphylococcus ***,it possesses superior hemocompatibility,cytocompatibility and ***,20Fe^(3+)-0.5SD/PLLA has high potential application in haemostasis for clinical settings due to its outstanding properties.

关键词： PLLA Melt spinning Sodium alginate Fe^(3+) Hemostasis Antibacterial

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介孔纳米羟基磷灰石/左旋聚乳酸复合材料的制备及性能

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复合材料学报 2015年第6期32卷 1681-1687页

作者：王宗良张宁王宇章培标中国科学院长春应用化学研究所生态环境高分子材料重点实验室长春130022 中国科学院大学北京100049 山东大学第二医院足踝外科济南250033

为考察介孔纳米羟基磷灰石(MHA)/左旋聚乳酸(PLLA)复合材料的性能,以十六烷基三甲基溴化铵(CTAB)为模板合成MHA,采用溶液相分离结合粒子沥滤法制备了不同纳米粒子含量的MHA/PLLA多孔支架复合材料,考察了其抗压缩性能和淬断面微观结构。... 详细信息

为考察介孔纳米羟基磷灰石(MHA)/左旋聚乳酸(PLLA)复合材料的性能,以十六烷基三甲基溴化铵(CTAB)为模板合成MHA,采用溶液相分离结合粒子沥滤法制备了不同纳米粒子含量的MHA/PLLA多孔支架复合材料,考察了其抗压缩性能和淬断面微观结构。采用溶液浇注法制备了MHA/PLLA复合膜,并对其拉伸性能和拉伸断面微观结构进行了研究。FTIR、XRD、TEM和氮气吸附测试等结果显示:合成的MHA具有典型的晶体结构、介孔结构和较高的比表面积。力学测试结果显示:在发生10%压缩形变时,填料含量为1%、5%和10%的MHA/PLLA多孔支架复合材料的抗压缩强度随填料含量增加而提高,与相应含量的纳米羟基磷灰石(HA)/PLLA多孔支架复合材料相比,分别提高了约37.0%、67.7%和144.7%。在填料含量为5%和10%时,MHA/PLLA复合膜的拉伸强度较HA/PLLA复合膜分别提高约38.7%和46.1%,拉伸模量分别提高约35.4%和14.5%。而且MHA/PLLA复合膜具有更高的断裂伸长率,填料含量为1%、5%和10%时断裂伸长率分别较HA/PLLA复合膜提高约91.3%、79.7%和96.1%。FESEM结果显示:尤其当填料含量较高时,MHA/PLLA多孔支架复合材料或复合膜中填料粒子分布较HA/PLLA中均匀。结果表明:与HA/PLLA复合材料相比,随着MHA含量增加,MHA/PLLA复合材料具有更好的力学性能,MHA在PLLA基体中分布相对更均匀。

关键词：左旋聚乳酸介孔材料羟基磷灰石力学性能复合材料

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n-Ag/AD/PLGA功能性材料的制备及生物学性能

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高等学校化学学报 2016年第1期37卷 195-200页

作者：崔巍巍高田林卢应章培标刘娅李波吉林大学公共卫生学院长春130021 吉林大学第一医院长春130021 中国科学院长春应用化学研究所长春130022

利用静电纺丝技术制备了纳米银（n-Ag）/山莨菪碱（AD）/聚乳酸-乙醇酸（PLGA）功能性材料.通过场发射扫描电子显微镜（ESEM）和傅里叶变换红外光谱（FTIR）研究了材料的微观结构及组成,评价了材料的体外药物释放、抑菌性、细胞相容性... 详细信息

利用静电纺丝技术制备了纳米银（n-Ag）/山莨菪碱（AD）/聚乳酸-乙醇酸（PLGA）功能性材料.通过场发射扫描电子显微镜（ESEM）和傅里叶变换红外光谱（FTIR）研究了材料的微观结构及组成,评价了材料的体外药物释放、抑菌性、细胞相容性及细胞毒性.FTIR结果表明,山莨菪碱已担载到n-Ag/AD/PLGA材料中,且随着山莨菪碱含量的增加,n-Ag/AD/PLGA材料内纤维的平均直径逐渐增大.药物释放试验结果证明,山莨菪碱可以逐渐释放.当山莨菪碱的质量分数为1%~5%时,n-Ag/AD/PLGA材料无毒性,且有助于小鼠L929成纤维细胞的生长和增殖.研究结果表明,n-Ag/AD/PLGA材料具有良好的抗菌性能和细胞相容性,担载的山莨菪碱可有效释放,为糖尿病足部感染的临床治疗提供新的人工敷料.

关键词：静电纺丝敷料纳米银聚乳酸-乙醇酸山莨菪碱

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