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Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review

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World Journal of Gastroenterology 2013年第23期19卷 3555-3561页

作者： Yu-Feng Liao Wei zhu Dong-pei Li Xiao zhu Department of Laboratory Medicine Ningbo No.2 Hospital Molecular Pathology Platform Key Laboratory of Molecular Diagnosis Guangdong Medical College Institute of Molecular Medicine and Genetics Georgia Health Sciences University

Ischemia/reperfusion (I/R) injury of the gut is a significant problem in a variety of clinical settings and is associated with a high morbidity and mortality. Although the mechanisms involved in the pathogenesis of gut I/R injury have not been fully elucidated, it is generally believed that oxidative stress with subsequent inflammatory injury plays an important role. Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme, followed by production of CO, biliverdin, and free iron. The HO system is believed to confer cytoprotection by inhibiting inflammation, oxidation, and apoptosis, and maintaining microcirculation. HO-1, an inducible form of HO, serves a vital metabolic function as the rate-limiting step in the heme degradation pathway, and affords protection in models of intestinal I/R injury. HO-1 system is an important player in intestinal I/R injury condition, and may offer new targets for the management of this condition.

关键词： Heme oxygenase Ischemia/reperfusion injury Oxidative stress Cytoprotection Gut

A New Monoterpene Glucoside from the Leaves of Betula platyphylla suk.

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Chinese Chemical Letters 2001年第4期12卷 343-344页

作者： su Juan WANG Yue Hu pei Hui Ming HUA Department of Natural Products Chemistry Shenyang Pharmaceutical UniversityShenyang 110015

A new monoterpene glucoside. (2E,67.)-2.6-dimethyl-8-beta -D-glucosyloxy-2,6-octadienoic acid, was isolated from the leaves of Betula platyphylla suk. The structure was established by spectroscopic data.

关键词： Betula platyphylla suk. monoterpene glucoside leaves.

Copper modified platinum electrode for amperometric detection of spectinomycin sulfate by anion-exchange chromatography

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Chinese Chemical Letters 2009年第10期20卷 1245-1247页

作者： Ling Ling Xi pei Min Zhang Yan zhu Department of Chemistry Xixi Campus Zhejiang University Hangzhou 310028 China

A La^3＋-Cu/Pt modified electrode was fabricated by electrodepositing process in CuS04 solution by adding a small amount of lanthium compound, and it was employed for direct current （DC） amperometric detection of spectinomycin by anion-exchange chromatography. Without derivatization, this method can simultaneously determine the main component and impurities in spectinomycin pharmaceutical raw material. Ease of preparation, being applied in DC detection mode and good catalytic stability confirmed the interests of this modified electrode as amperometric sensor for the determination of spectinomycin.

关键词： Copper/platinum chemically modified electrode High performance anion-exchange chromatography Direct current amperometricdetection Spectinomycin

Late-chronic cardiotoxicity and heart failure caused by ibrutinib:a case report and literature review

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Journal of Geriatric Cardiology 2021年第4期18卷 307-311页

作者： Jian zhu su-Yan BIAN Department of Cardiology the Second Medical CenterNational Clinical Research Center of Geriatric DiseaseBeijing Key Laboratory of Chronic Heart Failure Precision MedicineChinese PLA General HospitalBeijingChina

Richter syndrome (RS) is a rare transformation of relatively low-grade malignant chronic lymphocytic leukemia (CLL) to more aggressive lymphoma. The most common form of RS is transformation to diffuse large B-cell lymphoma (> 95%) and much less frequently (<1%)to Hodgkin lymphoma (HL), plasma blast lymphoma, or other rare lymphomas.

关键词： lymphoma Richter lymphocytic

Dimension and frequency of bar formation in a braided river

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International Journal of Sediment Research 2013年第3期28卷 358-367页

作者： Hsuan-pei AN su-chin CHEN Hsun-chuan CHAN Yi Hsu Department of Soil and Water Conservation National ChungHsing University

This paper presents flume and field observations of a bank-confined braided *** features,including plan form configuration,channel width,and main channel migration,were examined by a series of *** measurements of channel morphology,provided a basis to estimate the relationship between noncumulative frequency of bars and bar *** results from the Dajia River,located in Central Western Taiwan,were presented to provide a reference data set for comparing the laboratory and field *** results indicate that the relationship between bar length and width can be predicted by a simple best-fit power function relating to self-similarity *** Hurst index by Walsh and Hicks(2002) provides acceptable predictions of the bar length and width observed in the experiments and confirmed by the field *** and field results both show that large river width yields a uniform distribution of bar areas with the similar discharge,leading to a large value of exponent(ft) in the *** river width is confirmed to be a critical parameter in the main channel shift.A small increase in channel width likely increased rapidly the shift cycle.

关键词： Braided river Bank confinement Bar morphology

Co-occurrence of genes for antibiotic resistance and arsenic biotransformation in paddy soils

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Journal of Environmental Sciences 2023年第3期125卷 701-711页

作者： Huiling Cui Dong zhu Longjun Ding YifeiWang Jianqiang su Guilan Duan Yongguan zhu State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China

Paddy soils are potential hotspots of combined contamination with arsenic(As) and antibiotics, which may induce co-selection of antibiotic resistance genes(ARGs) and As biotransformation genes (ABGs), resulting in dissemination of antimicrobial resistance and modification in As biogeochemical cycling. So far, little information is available for these coselection processes and specific patterns between ABGs and ARGs in paddy soils. Here, the16S rRNA amplicon sequencing and high-throughput quantitative PCR and network analysis were employed to investigate the dynamic response of ABGs and ARGs to As stress and manure application. The results showed that As stress increased the abundance of ARGs and mobile genetic elements (MGEs), resulting in dissemination risk of antimicrobial resistance. Manure amendment increased the abundance of ABGs, enhanced As mobilization and methylation in paddy soil, posing risk to food safety. The frequency of the co-occurrence between ABGs and ARGs, the host bacteria carrying both ARGs and ABGs were increased by As or manure treatment, and remarkably boosted in soils amended with both As and manure. Multidrug resistance genes were found to have the preference to be co-selected with ABGs, which was one of the dominant co-occurring ARGs in all treatments, and manure amendment increased the frequency of Macrolide-Lincosamide-Streptogramin B resistance(MLSB) to co-occur with ABGs. Bacillus and Clostridium of Firmicutes are the dominant host bacteria carrying both ABGs and ARGs in paddy soils. This study would extend our understanding on the co-selection between genes for antibiotics and metals, also unveil the hidden environmental effects of combined pollution.

关键词： Arsenic Arsenic biotransformation genes Antibiotic resistance genes Co-occurrence Host bacteria

Detection of Saponins and Oligosaccharides in Herbs Using Direct Analysis in Real-time Mass Spectrometry

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Chemical Research in Chinese Universities 2017年第2期33卷 172-178页

作者： HE Yangfang LIU Wenlong su Rui XIU Yang pei Jin School of Pharmaceutial Sciences Jilin University Changchun 130021 P R. China Jilin Ginseng Academy Changchun University of Chinese Medicine Changchun 130117 P. R. China The Second Hospital of Jilin University Changchunl 30041 P. R. China

The use of direct analysis m real-time（DART） mass spectrometry（MS） for direct detection of saponins andoligosaccharides is difficult mainly because of the strong polarity of these molecules, which results in challenges re-garding desorption and ionization of the compounds. Structure derivatization, such as methylation, is essential forimproving the volatility and the proton affinity of saponin and oligosaccharides. In this study, solid-phase methylationof saponins and oligosaccharides was accomplished in a stainless steel methylation column, and the methylatedproducts of astragaloside, salidroside, icariin, ginsenosides（Rbl, Rb2, Rb3, Rd, Re, Rf and Rgl）, maltose, isomaltose,sucrose and maltotriose were analyzed using DART-MS. Fragmentations occurred during ionization and tandem massspectrometry, and most fragments corresponded to the glycosidic bond, cross-ring cleavages, and the neutral loss ofCH3OH ions, but the aglycone cleavage fragment was not detected. Furthermore, the method was successfully used inthe rapid and simultaneous analysis of saponins and oligosaccharides in a ginseng extract; quantitative analysis ofginsenoside Rbl was also carried out, and consistent content results were obtained in DART-MS andhigh-performance liquid chromatography（HPLC）.

关键词： Saponin Oligosaccharide Direct analysis in real-time(DART) Methylation

A New Nor-neolignan from Cremanthodium ellisii

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Chinese Chemical Letters 1999年第2期10卷 129-130页

作者： su, BN zhu, QX Jia, ZJ Lanzhou Univ Dept Chem Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China

A new nor-neolignan, named ellisinin A (1), has been isolated from the traditional Tibetan medicinal plants of Cremanthodium ellisii. Its structure has been determined on the basis of spectroscopic evidence, especiall... 详细信息

关键词： Cremanthodium ellisii compositae nor-neolignan ellisinin A

Universal Theory and Basic Rules of Strain-Dependent Doping Behaviors in Semiconductors

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Chinese Physics Letters 2021年第8期38卷 90-95页

作者： Xiaolan Yan pei Li su-Huai Wei Bing Huang Beijing Computational Science Research Center Beijing 100193China Department of Physics Beijing Normal UniversityBeijing 100875China

Enhancing the dopability of semiconductors via strain engineering is critical to improving their functionalities,which is,however,largely hindered by the lack of basic *** this study,for the first time,we develop a universal theory to understand the total energy changes of point defects(or dopants)with different charge states under strains,which can exhibit either parabolic or superlinear behaviors,determined by the size of defect-induced local volume change(ΔV).In general,ΔV increases(decreases)when an electron is added(removed)to(from)the defect ***,in terms of this universal theory,three basic rules can be obtained to further understand or predict the diverse strain-dependent doping behaviors,i.e.,defect formation energies,charge-state transition levels,and Fermi pinning levels,in *** three basic rules could be generally applied to improve the doping performance or overcome the doping bottlenecks in various semiconductors.

关键词： doping defect semiconductors