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Mediated protective effect of electroacupuncture pretreatment by miR-214 on myocardial ischemia/reperfusion injury

Journal of Geriatric Cardiology 2014年第4期11卷 303-310页

作者： pei-yu liu Yi TIAN Shi-yuan XU Department of Anesthesiology ZhuJiang Hospital of Southern Medicine University Guangzhou 510282 Guangdong Province China Department of Anesthesiology Hainan Provincial Corps Hospital of Chinese People's Armed Police Forces Haikou 570203 Hainan Province China Department of Anesthesiology Haikou People's Hospital Haikou 570203 Hainan Province China

Background Electroacupuncture pretreatment plays a protective role in myocardial ischemia/reperfusion （I/R） injury and microRNAs （miRNAs） could act on various facets of cardiac function. However, the role of miRNAs in the cardioprotection by electroacupuncture pre-treatment on myocardial I/R injury remains unknown. The purpose of the study was to examine whether miR-214 was involved in cardio-protection by electroacupuncture. Methods Using rat myocardial I/R model, we examined the role of electroacupuncture pretreatment in myocardial I/R injury and analyzed the changes in the expression of miR-214. In addition, I/R was simulated in vitro by performing oxy-gen-glucose deprivation （OGD） on H9c2 cell cultures, and the effect of electroacupuncture pretreatment on I/R injury as well as expressional level of miR-214 were examined in vitro. Furthermore, the miR-214 mimic was transfected into OGD-treated H9c2 cells, we analyzed the cell apoptosis, lactate dehydrogenase （LDH） and creatine kinase （CK） activities, intracellular free Ca2＋concentration （[Ca2＋]i） as well as the relative protein levels of sodium/calcium exchanger 1（NCX1）, BCL2-like 11 （BIM）, calmodulin-dependent protein kinase IIδ（CaMKIIδ） and Cyclophilin D （CypD）. Results The in vivo results revealed that compared with the I/R group, the electroacupuncture pretreatment group showed significant decreased myocardial infarct size, as well as the increased indices of the cardiac function, including heart rate, mean arterial pressure, left ventricular systolic pressure and maximal rate for left ventricular pressure rising and declining （±dp/dt max）. In addition, electroacupuncture pretreatment could inhibit the elevation of LDH and CK activities induced by I/R injury. The quantitative PCR （qPCR） results demonstrated electroacupuncture pretreatment could provide cardioprotection against myocardial I/R injury in rats with miR-214 up-regulation. In the meanwhile, in vitro, electroacupuncture pretreatment protected H9c2 c

关键词： I/R injury miR-214 Electroacupuncture Protective effect

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Effect of process parameters on steel tube roundness in straightening process

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Journal of Iron and Steel Research International 2020年第11期27卷 1270-1283页

作者： Li-dong Ma yu-kang Du Zhi-juan Meng Li-feng Ma Zi-jian liu pei-yu liu Coordinative Innovation Center of Taiyuan Heavy Machinery Equipment Taiyuan University of Science and TechnologyTaiyuan 030024ShanxiChina School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024ShanxiChina School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024ShanxiChina School of Applied Science Taiyuan University of Science and TechnologyTaiyuan 030024ShanxiChina

The inclined six-roll tube straightener is an important equipment for the finishing *** can not only straighten the steel pipe,but also finish the ovality of the cross *** the actual straightening process,the cross section of the tube is prone to deform,that is,the round ness is not *** flatteni ng displacement is an import a nt parameter to control cross-section forming of *** to the established mechanical model,the analytical calculation equations of the flattening force and the flattening displacement were derived using the energy *** on the finite element simulation data,the ratios of the finite element results of the什attening force to the analytical ones were *** correlation coefficient after fitting is greater than 99%,and the fitting effect is *** flattening experiment was carried out on tubes of different materials and different specifications,and the setting method of the optimal flattening displacement during straightening process was *** the actual straightening process,using this flattening displacement,the ovality of straightened steel tube is less than 0.3%.Therefore,the proposed method can provide a reference for the flattening displacement in the actual straightening process.

关键词： Straightening Tube Energy method Flattening force Flattening displacement Finite element method

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A self-management application“painhousekeeper”to control cancer pain:a randomized controlled trial study protocol

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Frontiers of Nursing 2020年第3期7卷 257-267页

作者： Qian liu Xiao-Man Zhang pei-yu liu Ya-Ling Wang yu-Qin Wang School of Nursing Xuzhou Medical UniversityXuzhouJiangsu 221000China Department of General Surgery Affiliated HospitalXuzhou Medical UniversityXuzhouJiangsu 221000China

Objective:Pain is a prevalent and distressing symptom in patients with cancer which has a significant impact on patients’physical health,psychological well-being,and quality of life(QOL).Deficiency of pain care,inadequate pain communication,and reluctance toward pain medication contribute to the difficulties in improving the situation of patients with cancer ***,the integration of self-management and professional healthcare provides new opportunities for patients with cancer ***:A two-arm randomized controlled trial will be conducted to assess the effectiveness of self-management application compared with routine care among patients with cancer *** on Orem’s self-care theory and Naylor’s transitional care theory,cancer pain self-management application“Pain-housekeeper”was developed with dual client:patient client and medical client.A total of 120 patients with cancer pain are recruited from two university-affiliated tertiary public hospitals in *** are randomly assigned to the control group and the intervention *** patients in the control group get routine care while the patients in the intervention group get routine care and Pain-housekeeper *** intervention is delivered by registered doctors,nurses,and postgraduate nursing students specialized in pain *** measurements for both groups are carried out with questionnaires at baseline(T0),after 4 weeks(T1)and after 12 weeks(T2).The primary outcomes include pain condition,self-efficacy,and *** secondary outcomes include pain medication adherence,satisfaction,anxiety,and *** of data submission,economic evaluation,usage,and clinical data are also considered in the *** for the evaluation are gathered continuously during the study ***:This article provides insight into the effectiveness of a theory-based self-management mobile application intervention delivered to patients with uncontrolled cancer *** results are used to he

关键词： cancer pain self-management application pain condition quality of life self-efficacy•randomized controlled trial

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A case-control study on the relationship between salt intake and salty taste and risk of gastric cancer

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World Journal of Gastroenterology 2011年第15期17卷 2049-2053页

作者： Wan-Guang Yang Chuan-Bo Chen Zhi-Xin Wang yu-pei liu Xiao-yuan Wen Shan-Feng Zhang Tong-Wen Sun Department of Emergency The First Affiliated Hospital Zhengzhou University Zhengzhou 450052 Henan Province China School of Nursing Henan University Kaifeng 475001 Henan Province China School of Basic Medicine Zhengzhou University Zhengzhou 450052 Henan Province China Department of Sports Medicine Chengdu Sports University Chengdu 610041 Sichuang Province China

AIM: To investigate the relationship between salt intake and salty taste and risk of gastric cancer. METHODS: A 1:2 matched hospital based case-control study including 300 patients with gastric cancer and 600 cancer-free subjects as controls. Subjects were interviewed with a structured questionnaire containing 80 items, which elicited information on dietary, lifestyle habits, smoking and drinking histories. Subjects were tested for salt taste sensitivity threshold (STST) usingconcentrated saline solutions (0.22-58.4 g/L). Conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CI). RESULTS: Alcohol and tobacco consumption increased the risk of gastric cancer [OR (95% CI) was 2.27 (1.27-4.04) for alcohol and 2.41 (1.51-3.87) for tobacco]. A protective effect was observed in frequent consumption of fresh vegetable and fruit [OR (95% CI) was 0.92 (0.58-0.98) for fresh vegetable and 0.87 (0.67-0.93) for fruit]. Strong association was found between STST ≥ 5 and gastric cancer [OR = 5.71 (3.18-6.72)]. Increased STST score was significantly associated with salted food intake and salty taste preference (P < 0.05). CONCLUSION: A high STST score is strongly associated with gastric cancer risk. STST can be used to evaluate an inherited characteristic of salt preference, and it is a simple index to verify the salt intake in clinic.

关键词： Gastric cancer Salt taste sensitivity threshold Salt taste preference

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融合均匀变异与高斯变异的蝙蝠优化算法

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控制与决策 2017年第10期32卷 1775-1781页

作者：李煜裴宇航刘景森河南大学管理科学与工程研究所河南开封475004 河南大学计算机与信息工程学院河南开封475004 河南大学智能网络系统研究所河南开封475004

为提高蝙蝠算法的寻优精度和收敛速度,提出一种融合均匀变异和高斯变异的蝙蝠优化算法.算法引入变异开关函数,该函数使所有蝙蝠个体在任何时期都有概率发生变异,使种群保持较高的多样性和活跃性.同时在算法整个寻优过程中融入均匀变异... 详细信息

为提高蝙蝠算法的寻优精度和收敛速度,提出一种融合均匀变异和高斯变异的蝙蝠优化算法.算法引入变异开关函数,该函数使所有蝙蝠个体在任何时期都有概率发生变异,使种群保持较高的多样性和活跃性.同时在算法整个寻优过程中融入均匀变异和高斯变异,两种变异机制共同协作使算法首先快速定位到全局最优解区域,随后完成局部精确搜索.仿真结果表明,改进后的算法寻优性能显著提高,具有较快的收敛速度和较高的收敛精度.

关键词：蝙蝠算法均匀变异高斯变异变异开关函数

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The effect of control measures on COVID-19 transmission in Italy:Comparison with Guangdong province in China

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Infectious Diseases of Poverty 2020年第5期9卷 116-116页

作者： pei-yu liu Sha He Li-Bin Rong San-Yi Tang School of Mathematics and Information Science Shaanxi Normal University710119 Xi’anPR China 不详

Background:COVID-19 has spread all around the *** is one of the worst affected countries in *** there is a trend of relief,the epidemic situation hasn’t stabilized *** study aims to investigate the dynamics of the disease spread in Italy and provide some suggestions on containing the ***:We compared Italy’s status at the outbreak stage and control measures with Guangdong Province in China by data observation and analysis.A modified autonomous SEIR model was used to study the COVID-19 epidemic and transmission potential during the early stage of the outbreak in *** also utilized a time-dependent dynamic model to study the future disease dynamics in *** impact of various non-pharmaceutical control measures on epidemic was investigated through uncertainty and sensitivity ***:The comparison of specific measures implemented in the two places and the time when the measures were initiated shows that the initial prevention and control actions in Italy were not sufficiently timely and *** estimated parameter values based on available cumulative data and calculated the basic reproduction number to be 4.32 before the national lockdown in *** on the estimated parameter values,we performed numerical simulations to predict the epidemic trend and evaluate the impact of contact limitation,detection and diagnosis,and individual behavior change due to media coverage on the ***:Italy was in a severe epidemic status and the control measures were not sufficiently timely and effective in the ***-pharmaceutical interventions,including contact restrictions and improvement of case recognition,play an important role in containing the COVID-19 *** effect of individual behavior changes due to media update of the outbreak cannot be *** policy-makers,early and strict blockade measures,fast detection and improving media publicity are key to containing the epidemic.

关键词： COVID-19 Cumulative cases Control measures Model prediction

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人工智能在青光眼诊疗中的应用

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国际眼科杂志 2022年第5期22卷 706-710页

作者：刘沛雨张旭南昌大学附属眼科医院南昌大学眼视光学院中国江西省南昌市330006

青光眼是世界首位不可逆致盲眼病,由于其隐匿性与渐进性,临床上早期诊断及监测青光眼进展是一项十分重要的工作。人工智能(AI)在医学领域发展迅速,AI及其子集机器学习(ML)、深度学习(DL)在青光眼中的研究与应用日臻成熟,促进了人们对青... 详细信息

青光眼是世界首位不可逆致盲眼病,由于其隐匿性与渐进性,临床上早期诊断及监测青光眼进展是一项十分重要的工作。人工智能(AI)在医学领域发展迅速,AI及其子集机器学习(ML)、深度学习(DL)在青光眼中的研究与应用日臻成熟,促进了人们对青光眼的理解,极大地提高了青光眼筛查与诊断的准确性与效率,大大降低了检查成本。利用AI技术对青光眼患者进行早期筛查与诊断能降低患者视功能损伤的风险,其次可以对青光眼进展进行预测,设计个性化治疗方案,从而达到改善患者预后的目的。本文总结了AI在青光眼筛查、诊断、预后中的最新进展,以及在临床上的困难与挑战,并展望了AI在青光眼中的优势与未来发展趋势。

关键词：青光眼人工智能筛查诊断预测

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Rapid screening of Zr-containing particles from Chang’e-5 lunar soil samples for isotope geochronology:Technical roadmap for future study

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Geoscience Frontiers 2022年第3期13卷 68-78页

作者： Jin-Hua Li Qiu-Li Li Liang Zhao Jin-Hai Zhang Xu Tang Li-Xin Gu Qian Guo Hong-Xia Ma Qin Zhou Yan liu pei-yu liu Hao Qiu Gang Li Lin Gu Shun Guo Chun-Lai Li Xian-Hua Li Fu-yuan Wu Yong-Xin Pan Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Lunar and Deep Space Exploration National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100012China Institute of High Energy Physics Chinese Academy of ScienceYuquan Road 19BShijingshan DistrictBeijing 100049China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

New samples returned by China Chang’e-5(CE-5)mission offer an opportunity for studying the lunar geologic longevity,space weathering,and regolith *** age determination of the CE-5 samples was among the first scientific questions to be ***,the precious samples,most in the micrometer size range,challenge many traditional analyses on large single crystals of zircon developed for massive bulk ***,we developed a non-destructive rapid screening of individual zirconium-containing particle for isotope geochronology based on a Micro X-ray fluorescence analysis(μXRF).The selected particles were verified via scanning electron microscopy(SEM),3D X-ray microscopy(XRM),and focused ion beam scanning electron microscopy(FIB-SEM)techniques,which showed that zirconium-bearing minerals with several microns were precisely positioned and readily suitable for site-specific isotopic dating by second ion mass spectrometry(SIMS).Such protocol could be also appli-cable in non-destructively screening other types of particles for different scientific *** there-fore proposed a correlative workflow for comprehensively studying the CE-5 lunar samples from single particles on nanometer to atomic *** various microscopic and spectromicroscopic instru-ments together,this workflow consists of six steps:(1)single-particle selection with non-destructive μXRF technique,(2)2D/3D morphological and structural characterization with a correlative submicron 3D XRM and nanoscale resolution FIB-SEM imaging methods,(3)SEM analysis of the surface morphology and chemistry of the selected particle,(4)a series of microscopic and microbeam analyses(e.g.,SEM,electron probe microanalysis,and SIMS)on the cross-section of the selected particle to obtain structural,mineralogical,chemical,and isotopic features from the micron to nanometer scale,(5)advanced 2D/3D characterization and site-specific sample preparation of thin foil/tip specimens on a microregion of inter-est in

关键词： Chang’e-5 lunar samples Zr-containing particles mXRF Correlative workflow Technical roadmap Extraterrestrial samples

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芳纶纳米纤维增强的碳纳米管复合纤维

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高分子学报 2024年第7期55卷 891-899页

作者：孙虹纪蒋鸿宇刘沛雨杨哲张琨陈培宁彭慧胜聚合物分子工程国家重点实验室复旦大学高分子科学系纤维材料与器件研究院先进材料实验室上海200438

利用浮动催化化学气相沉积法可以将性能优异的碳纳米管(CNT)组装成碳纳米管纤维(CNTF),但如何有效增强碳纳米管纤维内部碳纳米管及其管束之间的相互作用力,以大幅提升其力学和电学性能,是该领域的一个重要难题.本文提出通过溶剂质子化策... 详细信息

利用浮动催化化学气相沉积法可以将性能优异的碳纳米管(CNT)组装成碳纳米管纤维(CNTF),但如何有效增强碳纳米管纤维内部碳纳米管及其管束之间的相互作用力,以大幅提升其力学和电学性能,是该领域的一个重要难题.本文提出通过溶剂质子化策略,将芳纶纳米纤维引入碳纳米管纤维,制备得到了高性能的碳纳米管复合纤维材料,其拉伸强度达到1.23 GPa,杨氏模量达到26.97 GPa,相较于初始的碳纳米管纤维分别提升了92.1%和133.5%.该复合纤维的比强度和比模量分别为28.67和628.67 cN/dtex,与芳纶纤维等高性能纤维相当.此外,该复合纤维兼具良好的柔性与电学性能,可以直接作为纤维电子器件的电极材料,展现出良好的应用潜力.

关键词：碳纳米管纤维芳纶纳米纤维氢键高分子复合纤维

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi yu Faith Teo En Ning Chang liu yu-Chi liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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