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Large area^(3)He tube array detector with modular design for multi‑physics instrument at CSNS

Nuclear Science and Techniques 2023年第1期34卷 1-12页

作者： Lin Zhu Jian‑Rong Zhou Yuan‑Guang Xia Liang Xiao Hong Luo Xiao‑Juan Zhou Wen‑Qin Yang Bei‑Ju Guan Xing‑Fen Jiang Yan‑Feng Wang Hong Xu Hai‑Yun Teng Li‑Xin Zeng Jia‑Jie Li Lei Hu Ke Zhou Yong‑Xiang Qiu pei‑xun shen Jun Xu Li‑Jiang Liao Xiao‑Zhuang Wang Gui‑An Yang Huai‑Chan Chen Ju‑Ping Xu Zhi‑Duo Li Song‑Lin Wang Jian Zhuang Yu‑Bin Zhao Jun‑Rong Zhang Wen Yin Zhi‑Jia Sun Yuan‑Bo Chen Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China

The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering *** imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum *** satisfy these demands,a large-area array of 3He-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 *** uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 *** detector works in air,which is separated from the vacuum environment to facilitate installation and *** characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental *** results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam *** detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event *** of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully.

关键词： Neutron detector LPSD Position resolution Counting rate capacity

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Development of 3He-filled linear position-sensitive detector for neutron scattering instruments at CSNS

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Radiation Detection Technology and Methods 2023年第1期7卷 100-106页

作者： Lin Zhu Jian-rong Zhou Xin-feng Jiang Xiao-juan Zhou Wen-qin Yang Yuan-Guang Xia Liang Xiao Hong Luo Bei-ju Guan Yan-feng Wang Hong Xu pei-xun shen Hai-yun Teng Jia-jie Li Gui-an Yang Ju-ping Xu Huai-can Chen Song-lin Wang Jian Zhuang Jun-rong Zhang Wen Yin Zhi-jia Sun Yuan-bo Chen Tianjiao Liang Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Spallation Neutron Source Science Center Dongguan523803GuangdongChina University of Chinese Academy of Sciences Beijing100049China

Background Helium-3-filled linear position-sensitive detectors(LPSDs)have been widely applied to neutron scattering instruments in recent decades owing to the high detection efficiency,the excellent neutron/gamma discrimination,and the ability to construct the detector with large area *** than 65%of neutron instruments at the China Spallation Neutron Source(CSNS)require ^(3)He LPSDs for the building of the detector *** detector of a neutron scattering instrument is normally an array detector composed of a large number of ^(3)He ***,no appropriate substitute detector is available for the ^(3)He LPSD for operation over a short period,and its specifications need to be customized to satisfy the requirements of different *** necessitates the development of ^(3)He LPSDs with different specifications for building and upgrading the detectors of neutron scattering instruments at *** To meet the general requirements specified by the neutron instruments at CSNS,a ^(3)He LPSD was developed and its performances were investigated by using the neutron *** The neutron beam experiments for this ^(3)He LPSD,including measurements of counting rate plateau curve,position calibration,and position resolution along the tube path,were carried out at the beamline-20 of *** evaluate its performance in the instrument operation,a detector module made of this ^(3)He LPSD has been installed in the multi-physics instrument(MPI),and the comparison test with the commercial ^(3)He LPSD has been conducted at neutron scattering *** and conclusion The experimental measurements for this ^(3)He LPSD based on the neutron beam showed that it satisfies the requirements for use in neutron scattering *** reaches a plateau slope of 2.6%/100 V with a plateau range from 1750 to 1950 V and attained a minimal position resolution of 5.3 mm(FWHM),superior to the one achieved by the commercial ^(3)He *** addition,this ^(3)He

关键词： Counting rate CSNS LPSD Plateau curve Position resolution

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A survey on online learning and optimization for spark advance control of SI engines

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Science China(Information Sciences) 2018年第7期61卷 6-26页

作者： Yahui ZHANG xun shen Tielong shen Department of Engineering and Applied Sciences Sophia University

One of the most important factors affecting fuel efficiency and emissions of automotive engines is combustion quality that is usually controlled by managing spark advance(SA) in spark ignition(SI) *** increasing sensing capabilities and enhancements in on-board computation capability, online learning and optimization techniques have been the subject of significant research interest. This article surveys the literature of learning and optimization algorithms with applications to combustion quality optimization and control of SI engines. In particular, this paper reviews extremum seeking control algorithms for iterative solution of online optimization problems, stochastic threshold control algorithms for iterative solution of probability control of stochastic knock event, as well as feedforward learning algorithms for iterative solution of operating-point-dependent feedforward adaptation problems. Finally, two experimental case studies including knock probabilistic constrained optimal combustion control and on-board map learning-based combustion control are carried out on an SI gasoline engine.

关键词： online learning stochastic optimization iterative solution combustion control spark ignition engine

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Logical control scheme with real-time statistical learning for residual gas fraction in IC engines

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Science China(Information Sciences) 2018年第1期61卷 45-57页

作者： xun shen Yuhu WU Tielong shen Department of Engineering and Applied Sciences Sophia University School of Control Science and Engineering Dalian University of Technology

In this paper, an optimal control scheme for reducing the fluctuation of residual gas fraction(RGF) under variational operating condition is developed by combining stochastic logical system approach with statistical learning method. The method estimating RGF from measured in-cylinder pressure is introduced firstly. Then, the stochastic properties of the RGF are analyzed according to statistical data captured by conducting experiments on a test bench equipped with a L4 internal combustion engine. The influences to the probability distribution of the RGF from both control input and environment parameters are also analyzed. Based on the statistical analysis, a stochastic logical transient model is adopted for describing cyclic behavior of the RGF. Optimal control policy maps for different fixed operating conditions are calculated then. Besides, a statistical learning-based method is applied to learn the probability density function(PDF)of RGF in the real-time which is used to adjust the control MAP based on logical optimization. The whole optimal control policy map is obtained based on Gaussian process regression with consideration of statistical information of RGF. Finally, the performance of the proposed method is experimentally validated.

关键词： combustion engine statistical learning residual gas fraction variable valve timing logical control

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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru shen Zheng Song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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NUMERICAL SIMULATION OF 3-D TURBULENT FLOW IN THE MULTI-INTAKES SUMP OF THE PUMP STATION

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Journal of Hydrodynamics 2007年第1期19卷 42-47页

作者： CHEN Hong-xun shen Xin-rong Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China

In this article, a numerical model forthree-dimensional turbulent flow in the sump of the pumpstation was presented. A reasonable boundary condition for the flow in the sump with several water intakes at different flowrates was proposed. The finite volume method was employed tosolve the governing equations with the body fitted gridgenerated by the multi-block grid technique. By using theFluent software, the fluid flow in a model sump of the pumpstation was calculated. Compared with the experimental result,the numerical result of the example is fairly good.

关键词： pumping station sump suction pipe turbulentmodel numerical simulation

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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li shen Du Ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

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Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing shen Qiu-Wan Wei Yi-Ren Tian Yun-Zhi Ling Min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen Gu Hua Yan Dingding shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Cooperative Secrecy to Resist Authentication Error in Two-Hop Wireless Networks

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Chinese Journal of Electronics 2016年第4期25卷 746-752页

作者： shen Yulong pei Qingqi MA Jianfeng School of Computer Science and Technology Xidian University The State Key Laboratory of Integrated Services Networks School of Telecommunications Engineering Xidian University

The authentication error in two-hop wireless networks is considered without knowledge of eavesdropper channels and *** wireless informationtheoretic security has attracted considerable attention recently.A prerequisite for available works is the precise distinction between legitimate nodes and *** it is unrealistic in the wireless *** is always existing in the node authentication *** of our knowledge,there are no works focus on solving this problem in the information-theoretic *** paper presents a eavesdropper model with authentication error and two eavesdropping ***,the number of eavesdroppers can be tolerated is analyzed while the desired secrecy is achieved with high probability in the limit of a large number of relay ***,we draw two conclusions for authentication error:1) The impersonate nodes are chosen as relay is the dominant factor of the transmitted message leakage,and the impersonation attack does seriously decrease the number of eavesdroppers can be tolerated.2) The error authentication to legitimate nodes is almost no effect on the number of eavesdroppers can be tolerated.

关键词： Wireless networks Information-theoretic security Cooperative secrecy Authentication error

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