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Journal of Iron and Steel Research(International) 2022年第1期29卷 3-16页

作者： Wan-lin Wang Cheng Lu Le-jun Zhou Pei-sheng Lyu School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina National Center for International Research of Clean Metallurgy Central South UniversityChangsha 410083HunanChina

Interfacial heat transfer behavior between the molten steel and twin-rolls is a key issue in the strip casting process,and it has already attracted wide attention from industrial and academic communities of steel.The research methods and influencing factors on the interfacial heat transfer were summarized.Numerical simulation models,semi-industrial scale,and laboratory equipment have been developed in this field,and these methods were also improved by worldwide researchers based on the development of computer,automatic,and visual technologies.Coating properties,naturally deposited film,and casting parameters are the main factors which affect the heat transfer significantly.Although lots of research has been carried out,the internal relations among these influencing factors,interfacial heat transfer,and the quality of the strip are still worth to be further explored.Keywords Strip casting Interfacial heat transfer Simulation method Coating property Naturally deposited film Casting parameter.

关键词： Strip casting Interfacial heat transfer Simulation method Coating property Naturally deposited film Casting parameter

A Nomogram Model for Predicting Type-2 Myocardial Infarction Induced by Acute Upper Gastrointestinal Bleeding

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Current Medical Science 2022年第2期42卷 317-326页

作者： Gui-jun JIANG Ru-kai GAO Min WANG Tu-xiu XIE Li-ying ZHAN Jie WEI sheng-nan SUN pei-yu JI Ding-yu TAN Jing-jun lyu Emergency Department Renmin Hospital of Wuhan UniversityWuhan430060China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan430060China Wuhan Britain-China School Wuhan430022China Medical College of Wuhan University of Science and Technology Wuhan430065China Department of General Practice Renmin Hospital of Wuhan UniversityWuhan430060China Emergency Department Qilu Hospital of Shandong University(Qingdao)Qingdao266000China Emergency Department Clinical Medical College of Yangzhou UniversityNorthern Jiangsu People’s HospitalYangzhou225001China

Objective To examine the independent risk factors of type-2 myocardial infarction(T2MI)elicited by acute upper gastrointestinal bleeding(AUGIB),and to establish a nomogram model for the prediction of AUGIB-induced T2MI.Methods A nomogram model was established on the basis of a retrospective study that involved 533 patients who suffered from AUGIB in the Department of Critical Care Medicine(CCM)or Emergency Intensive Care Unit(EICU)of Renmin Hospital of Wuhan University,Wuhan,China,from January 2017 to December 2020.The predictive accuracy and discriminative power of the nomogram were initially evaluated by internal validation,which involved drawing the receiver operating characteristic(ROC)curve,calculating the area under the curve(AUC),plotting the calibration curve derived from 1000 resampled bootstrap data sets,and computing the root mean square error(RMSE).The predictive ability of the nomogram was further validated through the prospective and multicenter study conducted by the investigators,which enrolled 240 AUGIB patients[including 88 cases from Renmin Hospital of Wuhan University,73 cases from Qilu Hospital of Shandong University(Qingdao),and 79 cases from Northern Jiangsu People’s Hospital)],who were admitted to the Department of CCM or EICU,from February 2021 to July 2021.Results Among the 533 patients in the training cohort,78(14.6%)patients were assigned to the T2MI group and 455(85.4%)patients were assigned to the non-T2MI group.The multivariate analysis revealed that age>65,hemorrhagic shock,cerebral stroke,heart failure,chronic kidney disease,increased blood urea nitrogen,decreased hematocrit,and elevated D-Dimer were independent risk factors for AUGIB-induced T2MI.All these factors were incorporated into the nomogram model.The AUC for the nomogram for predicting T2MI was 0.829(95%CI,0.783-0.875)in the internal validation cohort and 0.848(95%CI,0.794-0.902)in the external validation cohort.The calibration curve for the risk of T2MI exhibited good consistency between the prediction by the nomogram a

关键词： acute upper gastrointestinal bleeding type-2 myocardial infarction nomogram prediction risk factors prognosis

Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca^(2+)-dependent AMPK/mTOR pathway

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 420-434页

作者： Liu-Hui Huang Jiao lyu sheng Chen Ting-Yi Liang Yu-Qing Rao Ping Fei Jing Li Hai-Ying Jin pei-Quan Zhao Department of Ophthalmology Shanghai Xinhua Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Ophthalmology Shanghai Tenth People’s Hospital Affiliated with Shanghai Tongji University School of MedicineShanghai 200072China Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVictoria 3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVictoria 3002Australia Shenzhen Eye Hospital Shenzhen Key Laboratory of OphthalmologyAffiliated Shenzhen Eye Hospital of Jinan UniversityShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

●AIM:To explore whether autophagy functions as a cellular adaptation mechanism in lens epithelial cells(LECs)under hyperosmotic stress.●METHODS:LECs were treated with hyperosmotic stress at the concentration of 270,300,400,500,or 600 mOsm for 6,12,18,24h in vitro.Polymerase chain reaction(PCR)was employed for the mRNA expression of autophagyrelated genes,while Western blotting detected the targeted protein expression.The transfection of stub-RFP-sens-GFPLC3 autophagy-related double fluorescence lentivirus was conducted to detect the level of autophagy flux.Scanning electron microscopy was used to detect the existence of autolysosome.Short interfering RNA of autophagy-related gene(ATG)7,transient receptor potential vanilloid(TRPV)1 overexpression plasmid,related agonists and inhibitors were employed to their influence on autophagy related pathway.Flow cytometry was employed to test the apoptosis and intracellular Ca^(2+)level.Mitochondrial membrane potential was measured by JC-1 staining.The cell counting kit-8 assay was used to calculate the cellular viability.The wound healing assay was used to evaluate the wound closure rate.GraphPad 6.0 software was utilized to evaluate the data.●RESULTS:The hyperosmotic stress activated autophagy in a pressure-and time-dependent manner in LECs.Beclin 1 protein expression and conversion of LC3B II to LC3B I increased,whereas sequestosome-1(SQSTM1)protein expression decreased.Transient Ca^(2+)influx was stimulated caused by hyperosmotic stress,levels of mammalian target of rapamycin(mTOR)phosphorylation decreased,and the level of AMP-activated protein kinase(AMPK)phosphorylation increased in the early stage.Based on this evidence,autophagy activation through the Ca^(2+)-dependent AMPK/mTOR pathway might represent an adaptation process in LECs under hyperosmotic stress.Hyperosmotic stress decreased cellular viability and accelerated apoptosis in LECs and cellular migration decreased.Inhibition of autophagy by ATG7 knockdown had similar results.TRPV1 overexpression increased auto

关键词： cataract posterior capsular opacification lens epithelial cell hyperosmotic stress autophagy apoptosis transient receptor potential vanilloid 1

Design of Quadrotor's Autonomous Flight Control System Based on BeagleBone Black

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Design of Quadrotor's Autonomous Flight Control System Based...

2015年中国智能自动化学术会议

作者： pei-pei Ni Qiang lyu Guo-sheng Wang Kui-feng Su Feng Guo Department of Control Engineering Academy of Armored Force Engineering

A problem of quadrotor’s autonomous flight control system based on Beagle Bone Black(BBB) high-performance embedded computer is investigated in this paper. BBB is chosen as the main control computer equipped with Wi-Fi receiver, GPS, and camera, while STMS320F28335 is used as the attitude control processer equipped with IMU, optical flow sensor, and infrared range finder. The software system is made up of a cascaded(inner-outer loop) attitude control based on optical flow sensor and ground station control system based on robot operating system(ROS) network. This system enhances quadrotor’s ability of performing complex tasks and enables it autonomy. Indoor hovering tests prove that attitude control algorithm has a stable performance.

关键词： Quadrotor Autonomous flight Beagle Bone black（BBB） Robot operating system ROS

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基于凸包络的交直流混合配电网安全域

电力系统自动化 2021年第18期45卷 45-51页

作者：裴蕾卫志农陈胜孙国强吕思河海大学能源与电气学院江苏省南京市211100

现有配电网安全域研究主要针对交流配电网,文中提出基于凸包络的交直流混合配电网安全域模型。首先,计及电压约束、馈线容量约束和关键设备出力约束,构建交直流配电网非线性安全域模型。其次,基于非线性规划模型求解交直流混合配电网安... 详细信息

现有配电网安全域研究主要针对交流配电网,文中提出基于凸包络的交直流混合配电网安全域模型。首先,计及电压约束、馈线容量约束和关键设备出力约束,构建交直流配电网非线性安全域模型。其次,基于非线性规划模型求解交直流混合配电网安全边界点。最后,采取凸包络拟合的方法生成可观测的安全域空间。算例结果验证了凸包络拟合的合理性和优越性,同时评估了交直流混合配电网中换流器控制方式、换流器无功补偿量和系统电压下限等因素对安全域大小的影响。

关键词：交直流混合配电网凸包络安全域换流器

Novel Affine Power Flow Method for Improving Accuracy of Interval Power Flow Data in Cyber Physical Systems of Active Distribution Networks

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CSEE Journal of Power and Energy Systems 2023年第5期9卷 1881-1892页

作者： Chen lyu Wanxing sheng Keyan Liu Xinzhou Dong Department of Electrical Engineering Tsinghua UniversityBeijing 100084China the China Electric Power Research Institute Beijing 100192China

A large number of load power and power output of distributed generation in an active distribution network(ADN)are uncertain,which causes the classical affine power flow method to encounter problems of interval expansion and low efficiency when applied to an AND.This then leads to errors of interval power flow data sources in the cyber physical system(CPS)of an ADN.In order to improve the accuracy of interval power flow data in the CPS of an ADN,an affine power flow method of an ADN for restraining interval expansion is proposed.Aiming at the expansion of interval results caused by the approximation error of non-affine operations in an affine power flow method,the approximation method of the new noise source coefficient is improved,and it is proved that the improved method is superior to the classical method in restraining interval expansion.To overcome the decrease of computational efficiency caused by new noise sources,a novel merging method of new noise sources in an iterative process is designed.Simulation tests are conducted on an IEEE 33-bus,PG&E 69-bus and an actual 1180-bus system,which proves the validity of the proposed affine power flow method and its advantages in terms of computational efficiency and restraining interval expansion.

关键词： Active distribution network affine power flow interval expansion new noise source uncertainty

A new anterograde trans-synaptic tracer based on Sindbis virus

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Neural Regeneration Research 2022年第12期17卷 2761-2764页

作者： Xiang-Wei Shi Fan Jia pei lyu Fu-Qiang Xu State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior CAS Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease Institute(BCBDI)Translational Research Center for the Nervous System(TRCNS)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhenGuangdong ProvinceChina NMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal Products Key Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese Academy of Sciences BeijingChina Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei ProvinceChina

Mapping neural circuits is critical for understanding the structure and function of the nervous system.Engineered viruses are a valuable tool for tracing neural circuits.However,current tracers do not fully meet the needs for this approach because of various drawbacks,such as toxicity and characteristics that are difficult to modify.Therefore,there is an urgent need to develop a new tracer with low toxicity and that allows for long-term studies.In this study,we constructed an engineered Sindbis virus(SINV)expressing enhanced green fluorescent protein(EGFP)reporter gene(SINV-EGFP)and found that it had no significant difference in biological characterization compared with the wild-type Sindbis virus in BHK-21 cells and neurons in vitro.We injected the virus into the visual circuit of mouse brain and found that the virus infected neurons in the local injected site and anterogradely spread in the neural circuits.Although the efficiency of transmission was limited,the findings demonstrate that SINV can be used as a new anterograde tracer to map neural circuits in mouse brain and that it spreads exclusively in the anterograde direction.Further,use of SINV in mouse brain research will provide longer time windows for circuit tracing than is possible with herpes simplex virus and vesicular stomatitis virus tracers.

关键词： anterograde lateral geniculate nucleus mouse brains neural circuit neurons retina Sindbis virus superior colliculus synapse tracer

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基于地质构造分区的瓦斯地质单元区划方法

煤炭技术 2021年第2期40卷 89-92页

作者：汪佩吕闰生张金陵河南省正龙煤业有限公司城郊煤矿河南永城476600 河南理工大学资环学院河南焦作454000

瓦斯地质单元的合理划分是矿井瓦斯分区分级治理的前提和基础,同时也是正确认识井田瓦斯赋存特征的依据。以瓦斯指标为主的传统瓦斯地质区划往往不能真实反映区域瓦斯的波动,尤其是对复杂地质条件下煤层瓦斯预判结果失真,从而导致瓦斯... 详细信息

瓦斯地质单元的合理划分是矿井瓦斯分区分级治理的前提和基础,同时也是正确认识井田瓦斯赋存特征的依据。以瓦斯指标为主的传统瓦斯地质区划往往不能真实反映区域瓦斯的波动,尤其是对复杂地质条件下煤层瓦斯预判结果失真,从而导致瓦斯事故频发。在分析井田地质构造特征及区域构造演化的基础上,运用构造地质学、瓦斯地质学等理论与方法,以地质构造定量评价为基础,提出以构造等性块段法来划分井田构造分区的方法,采用块段构造指标分别描述不同地质块段构造复杂程度,建立地质构造自然边界和人工边界来区划不同瓦斯地质单元方法。以城郊井田为例,选择断层、褶皱、岩浆侵入3个地质指标对井田构造复杂程度进行评价,并进行了瓦斯区划应用研究。结果显示:运用该方法可以对复杂地质条件下不同瓦斯地质单元进行较准确划分,城郊井田共划分出5个相对独立的瓦斯地质单元,分别研究了5个单元的瓦斯赋存特征。

关键词：瓦斯地质区划地质构造等性块段

Nidogen:A matrix protein with potential roles in musculoskeletal tissue regeneration

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Genes & Diseases 2022年第3期9卷 598-609页

作者： sheng Zhou Song Chen Yixuan Amy pei Ming pei Stem Cell and Tissue Engineering Laboratory Department of OrthopaedicsWest Virginia UniversityMorgantownWV 26506USA Department of Orthopaedics The GeneraLHospital of Western Theater CommandChengduSichuan 610083PR China WVU Cancer Institute Robert C.Byrd Health Sciences CenterWest Virginia UniversityMorgantownWV 26506USA

Basement membrane proteins are known to guide cell structures,differentiation,and tissue repair.Although there is a wealth of knowledge on the functions of laminins,per-lecan,and type IV collagen in maintaining tissue homeostasis,not much is known about nidogen.As a key molecule in the basement membrane,nidogen contributes to the formation of a delicate microenvironment that proves necessary for stem cell lineage-specific differentiation.In this review,the expression of nidogen is delineated at both cellular and tissue levels from embryonic to adult stages of development;the effect of nidogens is also summarized in the context of musculoskeletal development and regeneration,including but not limited to adipogenesis,angiogenesis,chondrogenesis,myogenesis,and neurogenesis.Furthermore,potential mechanisms underlying the role of nidogens in stem cell-based tissue regeneration are also discussed.This concise review is expected to facilitate our existing understanding and utilization of nidogen in tissue engineering and regeneration.

关键词： Adipose Basement membrane Cartilage Differentiation Nerve Nidogens Vessel

Radiofrequency in Facial Rejuvenation

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International Journal of Dermatology and Venereology 2022年第2期5卷 94-100页

作者： Jia-Jie lyu sheng-Xiu Liu Department of Dermatology the First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China.

Rhytides and striae are prominent clinical signs of skin aging.Photoaging,characterized by a thinning epidermis and a decrease in collagens,is the main form of skin aging.Delaying the aging process is a concerning issue for dermatologists.Radiofrequency(RF)is a non-ablative technology used for skin rejuvenation,body contouring,and weight reduction.The selective electro-thermolysis stimulates collagen contraction and neocollagenesis.Compared to traditional cosmetic treatment,it has the advantages of fewer side effects and short patient downtime.This review aims to summarize the efficacy and safety of different RF devices and the limitations during RF treatments.Combinations of RF and other cosmetic technologies are demonstrated.Results have been approving for the various uses of RF,including skin laxity and wrinkles smoothening.However,many studies use subjective ways of evaluation.Further studies are needed to determine the optimization of RF treatments for facial rejuvenation.

关键词： radiofrequency rejuvenation skin tightening noninvasive aging skin