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Effect of pre-ischemia on hypoxia-inducible factor expression in the brain tissue of rats with cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2007年第10期2卷 595-598页

作者： pei rong zhou Shi sen Zhang Department of Neurology People＇s Hospital of Ningjin County Ningjin 253400Shandong ProvinceChina

Hypoxia-inducible factor 1 （HIF-1） can lead to the adaptative reaction of body for hypoxia and ischemia. HIF-1 plays an important role in the response of ischemia-hypoxia. At present, there has been no overall report on the significance for the expression of HIF-1 following experimental cerebral ischemia. OBJECTIVE： To observe the expression of HIF-1 after middle cerebral artery occlusion （MCAO） by immunohistochemical method. DESIGN： Completely randomly grouped controlled animal experiment. SETTING： Second Hospital, Xi＇an Jiaotong University. MATERIALS： Thirty-six Sprague-Dawley healthy male rats, with body mass of 250 - 330 g, were used in this study. Thirty-six rats were randomized into 3 groups： preischemia group, sham-operation group and control group, with 12 rats in each. METHODS： This study was carried out in the clinical laboratory, People＇s Hospital of Ningjin County of Shandong Province from March 2006 to January 2007. Rats in the pre-ischemia group were created into preischemia models by two embolisms twice. Three days after ischemic preconditioning, middle cerebral artery （MCA） was occluded for 2 hours with the same method. After being perfused for 22 hours, the rats were euthanized. In the sham-operation group, rats were not given the treatment of preischemia. In the first operation, only common carotid artery （CCA） and its crotch were exposed in the first operation, and MCA was not blocked by inserting embolism. At postoperative 3 days, rats were euthanized after being subjected to MCAO for 2 hours and reperfusion 22 hours by the same procedure as that in the preischemia group. As for each rat in the control group, only CCA and its crotch were exposed, and no any other treatment was carried out on them. MAIN OUTCOME MEASURES： Brain tissue of each rat was performed immunohistochemical staining at reperfusion 22 hours after preischemia, HIF-1 expression and brain infarct volume were detected. RESULTS： Thirty-six Sprague-Dawley rats were involved in the e

关键词： ischemic preconditioning ischemic tolerance cerebral ischemia HIF-1α

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Inherited CHEK2 p.H371Y mutation in solitary rectal ulcer syndrome among familial patients:A case report

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World Journal of Gastroenterology 2023年第31期29卷 4809-4814页

作者： Cheng-Cheng He Shan-Ping Wang pei-rong zhou Zhi-Jun Li Na Li Ming-Song Li Department of Gastroenterology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150Guangdong ProvinceChina

BACKGROUND Solitary rectal ulcer syndrome(SRUS)is a rare rectal disease with unknown *** on the genetic background in SRUS is *** SUMMARY Here,we report the first case of SRUS in a mother-son *** sequencing was conducted on the whole family,which revealed an inherited CHEK2 p.H371Y *** experiment preliminarily revealed that the CHEK2 mutation did not affect the expression of CHEK2 protein,but affected the function of CHEK2,resulting in the expression level changes of downstream genes such as *** SRUS is a genetic susceptibility disease where CHEK2 p.H371Y mutation may play a crucial role in the development and prognosis of SRUS.

关键词： Solitary rectal ulcer syndrome CHEK2 mutation CDC25A Genetic background Gene sequencing Case report

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Biān stone hot compress combined with acupuncture at cervical Jiājǐ acupoint for axial pain after cervical LIF operation: A randomized controlled trial

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World Journal of Acupuncture-Moxibustion 2019年第4期29卷 264-268页

作者： De-sheng Zhang pei-rong zhou Shui-chun Liu Shao-qiu Sun The Second Affiliated Hospital Hunan University of Traditional Chinese MedicineChangsha 410005China Hunan University of Traditional Chinese Medicine Changsha 410208China

Objective:To compare the clinical effect differences of biān(砭)stone hot compress combined with acupuncture at cervical Jiājǐ(夹脊EX-B2)acupoint and simple acupuncture at cervical EX-B2 for axial pain after cervical laminectomy with implant fixation(LIF)***:A total of 80 patients with axial pain after cervical LIF operation were randomly assigned into the biān(砭)stone hot compress combined with acupuncture at cervical EX-B2 group(Group A)and the acupuncture at cervical EX-B2 group(Group B),and 40 patients in each *** group A was treated by biān(砭)stone hot compress and acupuncture at cervical EX-B2,while the group B was treated by acupuncture at cervical *** of groups were treated once a day,one course of treatment consisted of 7 days,6-day treatment plus 1-day rest,and there were 3 courses of treatment in *** pain score(Visual analogue scale,VAS),neck dysfunction indices(NDI),and serum creatine phosphokinase(CPK)levels of patients were compared before and after the treatment,and their clinical effects were ***:The VAS score,NDI,and CPK in patients of the two groups after treatment were all lower than those before treatment(all P<0.05),and the indicators in the group A after treatment were all lower than those in the group B after treatment(all P<0.05).The effective rate in the group A was 92.5%,higher than that(77.5%)in the group B,and there was statistically significant difference(P<0.05).Conclusions:The biān(砭)stone hot compress combined with acupuncture at cervical EX-B2 acupoint was better than acupuncture at cervical EX-B2 alone in treatment of axial pain after cervical LIF *** the group A,therapeutic effects were improved by relieving pain,improving neck function,and repairing muscle injury.

关键词： Axial pain Biān(砭)stone Hot compress Acupuncture Cervical Jiājǐacupoint

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持续湿化在喉癌患者气管切开术后护理的要点探讨

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中国卫生标准管理 2017年第4期8卷 182-184页

作者：沈佩周荣江苏省泰兴市人民医院耳鼻咽喉头颈外科江苏泰兴225400

目的探讨分析持续湿化在喉癌患者气管切开术后的临床护理要点。方法抽选我院2013年1月—2016年12月收治的40例喉癌气管切开患者,按照随机法均分为实验组(20例)和对照组(20例),对照组采用间断注射器滴注法,实验组采用氧喷式雾化器持续湿... 详细信息

目的探讨分析持续湿化在喉癌患者气管切开术后的临床护理要点。方法抽选我院2013年1月—2016年12月收治的40例喉癌气管切开患者,按照随机法均分为实验组(20例)和对照组(20例),对照组采用间断注射器滴注法,实验组采用氧喷式雾化器持续湿化法,记录两组生命体征指标数据。结果实验组气管切开术生命体征状况优于对照组,临床不良反应概率相对较低,组间对比,差异存在统计学意义,P<0.05。结论氧喷式雾化器持续湿化法有助于降低各种并发症发生率,提升术后临床护理效果,更加有利于喉癌患者气管切开术后康复治疗。

关键词：持续湿化喉癌气管切开术后护理

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Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： Yingjie Zhao Yicheng Sun Chaoxin pei Xing Yin Xinyi Li Yi Hao Mengru Zhang Meng Yuan Jinglin zhou Yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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Remaining Life Prediction Method for Photovoltaic Modules Based on Two-Stage Wiener Process

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Energy Engineering 2025年第1期122卷 331-347页

作者： Jie Lin Hongchi Shen Tingting pei Yan Wu School of Electrical Engineering and Information Engineering Lanzhou University of TechnologyLanzhou730050China

Photovoltaic (PV) modules, as essential components of solar power generation systems, significantly influence unitpower generation *** service life of these modules directly affects these costs. Over time, the performanceof PV modules gradually declines due to internal degradation and external environmental *** cumulativedegradation impacts the overall reliability of photovoltaic power generation. This study addresses the complexdegradation process of PV modules by developing a two-stage Wiener process model. This approach accountsfor the distinct phases of degradation resulting from module aging and environmental influences. A powerdegradation model based on the two-stage Wiener process is constructed to describe individual differences inmodule degradation processes. To estimate the model parameters, a combination of the Expectation-Maximization(EM) algorithm and the Bayesian method is employed. Furthermore, the Schwarz Information Criterion (SIC) isutilized to identify critical change points in PV module degradation trajectories. To validate the universality andeffectiveness of the proposed method, a comparative analysis is conducted against other established life predictiontechniques for PV modules.

关键词： Photovoltaic modules degradation stochastic processes lifetime prediction

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Recent development in electrode design for wide-temperature supercapacitors

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Science China Chemistry 2025年第1期68卷 96-117页

作者： Jianhong Liu Qiang zhou Yuxiao Lin Xinsheng Zhao Guangmin zhou Xiaoxiao Li School of Physics and Electronic Engineering Jiangsu Normal University Tsinghua-Berkeley Shenzhen Institute & Tsinghua Shenzhen International Graduate School Tsinghua University

An ever-increasing market demand has stimulated the soaring enthusiasm of researchers to develop wide-temperature supercapacitors(SCs). The active electrode is one of the most important parts of SC, which is directly related to the energy density,power transmission and long-term cyclability of the device in the wide-temperature environment. Compared with the SC electrodes aimed for room-temperature application, the SC electrodes for operating at wide-temperature scene often face greater challenges. In this review, the main challenges of SC electrodes under various temperature conditions, including low, high and cross-fade temperatures, are summarized. The relevant performance decay and failure mechanisms of wide-temperature SC electrodes are analyzed. In addition, this review deals with the recent studies and developments in robust wide-temperature SC electrodes with respect to the rational design of electrode structures and the exploitation of advanced active materials. Finally, the future directions for exploring reliable wide-temperature SCs are also proposed.

关键词： supercapacitor wide-temperature electrode design active materials

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不同围术期护理干预模式在中耳炎乳突根治术中的应用

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世界复合医学 2017年第2期3卷 60-62页

作者：沈佩周荣尹海平江苏省泰兴市人民医院头颈外科江苏泰兴225400

目的分析和评估不同围术期护理干预模式在中耳炎乳突根治术中的应用效果。方法选择该院于2013年10月—2016年12月间收治的91例中耳炎乳突根治术患者为研究主体。依据患者的入院顺序,将其划分为A组和B组,分别是47例与44例。A组给予临床... 详细信息

目的分析和评估不同围术期护理干预模式在中耳炎乳突根治术中的应用效果。方法选择该院于2013年10月—2016年12月间收治的91例中耳炎乳突根治术患者为研究主体。依据患者的入院顺序,将其划分为A组和B组,分别是47例与44例。A组给予临床护理路径,B组给予一般护理,对比各项舒适度评分、住院时间、心理状态评分和护理满意度评分。结果 A组的社会环境舒适度评分(26.52±1.81)分,生理舒适度评分(30.25±2.55)分,心理舒适度评分(34.66±3.36)分,均优于B组的(22.37±1.22)分,(26.44±3.12)分,(29.33±1.17)分;住院时间(9.22±0.61)d短于B组(12.67±1.57)d;焦虑评分(4.15±1.11)分与抑郁评分(4.26±1.24)分低于B组的(8.41±1.18)分和(7.21±1.16)分;护理满意度(95.74%)高于B组(79.55%),对比差异有统计学意义(P<0.05)。结论在中耳炎乳突根治术患者围术期实施临床护理路径,可以提高患者的护理舒适度,调整其心理状态,并能获得较佳的护理满意度,值得推广。

关键词：围术期护理干预中耳炎乳突根治术应用效果

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The linear self-attracting diffusion driven by the weighted-fractional Brownian motion II: The parameter estimation

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Science China Mathematics 2025年

作者： Litan Yan Rui Guo Wenyi pei Department of Statistics College of Science Donghua University School of Statistics and Mathematics Zhejiang Gongshang University

Let Ba,bbe a weighted-fractional Brownian motion with Hurst indexes a and b such that a>-1and 0≤b<1∧（1+a）.In this paper,we consider the linear self-attracting diffusion ■ interacting diffusion (see Cranston and Le Jan （1995）).Under the continuous observation,we study asymptotic ■ converges in distribution to the sum of the chi-square random variable with 1 degree of freedom and the random variable Z1a,b.

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Dative B–N bonds weaven toward two-dimensional purely organic materials for single crystals

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Science China Chemistry 2025年第1期68卷 12-14页

作者： Wei-Lei zhou Siwei Wang Yong Chen College of Chemistry and Materials Science Inner Mongolia Key Laboratory of Chemistry for Nature Products and Synthesis for Functional Molecules Innovation Team of Optical Functional Molecular Devices Inner Mongolia Minzu University College of Chemistry Nankai University

Molecular topology is one of the important topics to study and understand the relationship between molecular structure and properties [1]. Particularly, two-dimensional (2D) materials with extremely high surface area and ultra-thin morphology have attracted considerable attention due to their unexpected properties in materials and chemistry [2,3].

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