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Quality of life in adult intermittent exotropia and the risk factors

International Journal of Ophthalmology(English edition) 2021年第3期14卷 442-447页

作者： Bo-Wen Zhao Jing Fu Jing-Hui Wang Hai-Xia Bai pei-pei liu Ya-Nan Guo Rong-Han Zhang Han Su Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China Eye Center Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina

AIM: To study the quality of life of adult patients with intermittent exotropia(IXT) in China and analyze the factors affecting the quality of life in IXT ***: Total y 109 cases of normal eye(control group), 77 cases of IXT(IXT group) and 115 cases of strabismus control group(except IXT) were collected. The quality of life of the patients was assessed by Chinese version of adult strabismus patient’s quality of life scale(CAS-20). The differences of general characteristics, visual function and quality of life were analyzed, and the effects of individual factors and visual function on quality of life of patients with IXT were ***: The IXT group had a high proportion of patients with family history, low proportion of patients with amblyopia compared with strabismus control group. The proportion with normal near and far stereopsis of IXT group were lower than that of normal control group. The best corrected visual acuity of IXT group was higher than that of strabismus control group, but lower than the control group. In addition, the median strabismus degree in IXT group was higher than that in other strabismus control group. The median psychosocial scores and median visual function scores of the IXT group was lower than that of the normal control group, but not different from strabismus control group. Occupation status, course of disease, far stereopsis and near stereopsis significantly affected the quality of life in IXT ***: Adult IXT patients in China have a certain proportion of family history and lower quality of life, The main factors affecting the quality of life of IXT patients is stereopsis, course of disease and occupation status.

关键词： intermittent exotropia quality of life scale binocular function

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Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children

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Current Medical Science 2018年第4期38卷 640-647页

作者： Yu-xia TAN Hui WANG Hua LV pei-pei liu Shun-gang XIA Yu WANG Gao-yan WANG Ya GUO Ye-dan liu Cheng-qing YANG Li-ping CHEN Zong-bo CHEN Department of Pediatrics the Affiliated Hospital of Qingdao University Qingdao 266000 China Department of Pediatrics Zibo Maternal and Child Health Hospital Zibo 255029 China Department of Clinical Laboratory the Affiliated Hospital of Qingdao University Qingdao 266003 China

This study aimed to assess the relationship of OAS2 rs739901 5＇-flanking C/A polymorphisms with the susceptibility to Enterovirus-71 （EV71） infection. We investigated 294 hand-foot-mouth disease （HFMD） Chinese children with EV71 infection （165 mild cases and 129 encephalitis cases）. The improved multiplex ligation detection reaction （iMLDR） technique was used to test the genotypes. In EV71-infected patients, the CA genotype distribution （P=0.007）, A allele frequency （OR 1.32, 95% CI 1.0-1.7, P=0.034） and CA＋AA carriage frequency （P=0.003） of OAS2 rs739901 5＇-flanking were obviously elevated as compared with controls, but there were no statistically significant differences between mild cases and encephalitis cases. In EV71-infected patients, the counts of white blood cells （P=0.034） and blood glucose concentrations （P=0.042） were raised in A carriers （CA＋AA）. Among different genotypes of encephalitis cases, the contents of cerebrospinal fluid （CSF） showed no significant differences. IFN-7 levels in EV71-infected patients were higher than those in controls （mild group vs. control group, P〈0.01; encephalitis group vs. control group, P〈0.001）. In encephalitis cases, IFN-7 levels were reduced （P〈0.05） in A carriers compared to CC genotype, however, there were no significant differences between genotypes CA and AA （ P=0.226）. These findings suggest that OAS2 rs739901 5＇-flanking C/A genetic polymorphisms involve the susceptibility to EV71 infection, and A allele might be a risk factor of the susceptibility to EV-71 infection.

关键词： enterovirus-71 infection OAS2 rs739901 C/A polymorphism

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Centrosome and vascular microenvironmental homeostasis

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Microenvironment & Microecology Research 2021年第1期3卷 12-16页

作者： Yang Yang pei-pei liu Ming-Li Li Shu-Ang Li Yi Luan Department of Translational Medicine Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

The homeostasis of vascular microenvironment is essential to maintain the normal vascular structure and function,while its disorder leads to vascular dysfunction,and cardiovascular and cerebrovascular *** is an important organelle existing in mammalian cells as well as the microtubule organizing center,playing an important role in maintaining vascular structure and *** study reviewed the role of centrosome in the regulation of vascular microenvironmental *** proteins intricately regulate microtubule dynamics and stabilization,and diverse microtubule-relatived cellular activities,including the division,polarization and directional migration of vascular endothelial cells,smooth muscle cells and other types of *** addition,primary cilia formed by centrosome are essential in vascular *** endothelial cells usually acquire excess centrosomes,and excess centrosomes are regulated by several angiogenic ***,uncovering the detailed molecular mechanisms underlying centrosome affecting vascular microenvironmental homeostasis are needed for the treatment of cardiovascular and cerebrovascular diseases.

关键词： Vascular microenvironment Homeostasis Centrosome Microtubule Cardiovascular and cerebrovascular diseases

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Rosacea-Like Dermatitis Caused by Icotinib Hydrochloride: A Case Report

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International Journal of Dermatology and Venereology 2019年第2期2卷 122-124页

作者： pei-pei liu Yu-Yang Yue Yu-Ting Li Cai-Xia Hu Yi Cheng Guo-Qiang Zhang Department of Dermatology The Fourth Affiliated Hospital of Hebei Medical University Shijiazhuang Hebei 050011 China

IntroductionIn recent years,drugs that have been reported to be associated with dermatitis include glucocorticoid,tacrolimus pimecrolimus,1 epidermal growth factor receptor inhibitors (EGFRIs) such as erlotinib2 and cetuximab,vitamin B6,3 rarely the oral antidiabetic drug metformin,parabens,calcium channel blockers,and selective phosphodiesterase ***,few reports have described drug-induced rosacea-like dermatitis.

关键词： Rosacea-Like Dermatitis Case Report cetuximab

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一种新的应用于文本特征子集优化的GATS算法

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计算机工程与应用 2009年第30期45卷 121-122,149页

作者：姜沛佩刘培玉山东师范大学信息科学与工程学院济南250014

针对文本分类中特征子集优化问题,将禁忌搜索算法引入到遗传算法中对遗传算法的核心算子———交叉算子进行改进形成禁忌交叉算子,改进后的算法称为GATS(遗传禁忌搜索算法),并将其应用在文本分类中来实现空间降维。实验证明,应用此方法... 详细信息

针对文本分类中特征子集优化问题,将禁忌搜索算法引入到遗传算法中对遗传算法的核心算子———交叉算子进行改进形成禁忌交叉算子,改进后的算法称为GATS(遗传禁忌搜索算法),并将其应用在文本分类中来实现空间降维。实验证明,应用此方法进行文本特征项的选取不仅能够保持GA和TS算法本身的优点,还能在一定程度上提高文本分类的准确率。

关键词：遗传算法禁忌搜索遗传禁忌搜索算法禁忌交叉算子

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin Meng Li Weibin Chen pei liu Tao Huang Zhencheng Huang Yuying liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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Author Correction: History and progress of hypotheses and clinical trials for Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2019年第1期4卷 326-326页

作者： pei-pei liu Yi Xie Xiao-Yan Meng Jian-Sheng Kang Clinical Systems Biology Laboratories The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052 HenanChina

Correction to:Signal Transduction and Targeted Therapy https://***/10.1038/s41392-019-0063-8,published online 23 August 2019 Since the publication of this Review Article,we noticed several mistakes in Table 2 and the Perspective section that need to be corrected *** Table 2,the status of AAB-003 Phase I trial is *** addition,the status of GV-971 Phase III trial is completed in *** correct portion of Table 2 is displayed as *** the perspective section,the sigma-1 receptor activator Anavex 2-73 has entered a phase III clinical trial but it was not granted fast-track status by the ***,the texts should be corrected to“In addition,fluoxetine can bind to the endoplasmic reticulum protein sigma-1 receptor.418 Sigma-1 receptor ligands can enhance acetylcholine secretion.

关键词： clinical Alzheimer corrected

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Coordination polymers with ditetrazole ligands of different length

Coordination polymers with ditetrazole ligands of different ...

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中国化学会第五届全国结构化学学术会议

作者： pei-pei liu En-Qing Gao Department of Chemistry,East China Normal University,Shanghai Key Laboratory of Green Chemistry and Chemical Processes,Shanghai 200062

＜正＞The crystal engineering and structural chemistry of coordination polymers have received considerable attention in recent *** rigid organic bridging ligands usually have fixed coordination orientation,ligands with aliphatic spacers may adopt flexible coordination mode, contributing to the structural diversity of coordination ***,we report different

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An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

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Polycomb protein family member CBX7 Regulates Axon Growth and Regeneration

Polycomb protein family member CBX7 Regulates Axon Growth an...

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中国神经科学学会第十二届全国学术会议

作者： Run-Shan Duan Gang-Bin Tang Hong-Zhen Du Yi-Wen Hu pei-pei liu Ya-Jie Xu Yu-Qiang Zeng Shuang-Feng Zhang Rui-Ying Wang Zhao-Qian Teng Chang-Mei liu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of Sciences Department of Orthopaedic Surgery Affiliated Hospital of Guilin Medical University University of Chinese Academy of Sciences School of Life Sciences University of Science and Technology of China

Objective Neurons in the central nervous system（CNS） lose their intrinsic ability and fail to regenerate, but the underlying mechanisms are largely unknown. Polycomb group（Pc G） proteins, which include PRC1 and PRC2 complexes, function as gene repressors and are involved in the regulation of many biological processes. However, we still don’t know which and how Cbx subunits contribute to neuronal functions in postmitotic neurons, especially in regulation of axon regeneration. Method Cbx family members, si RNA, sh RNA or overexpression plasmid together with EGFP were electroporated into E15 cortical neurons or adult dorsal root ganglion neurons to evaluate whether they can regulate axon growth or regeneration. Results（1） Cbx4, cbx6 and cbx7 gradually increase their expressions in the cortical tissues during development, respond differently after axon injury.（2） Cbx2, cbx7 and cbx8 are key regulators of axon regeneration.（3）Cbx7 modulates axon regeneration by repressing SOX11 and GATA4,and downregulation of SOX11 and GATA4 can rescue the axon regeneration ability of neurons lacking CBX7. Conclusion Cbx family members have different functions in axon growth and regeneration and Cbx7 is a novel regulator of axon growth and regeneration.

关键词： Axon CBXs Regeneration

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