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History and progress of hypotheses and clinical trials for Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2019年第1期4卷 412-433页

作者： pei-pei liu Yi Xie Xiao-Yan Meng Jian-Sheng Kang Clinical Systems Biology Laboratories The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052 HenanChina

Alzheimer’s disease(AD)is a neurodegenerative disease characterized by progressive memory loss along with neuropsychiatric symptoms and a decline in activities of daily *** main pathological features are cerebral atrophy,amyloid plaques,and neurofibrillary tangles in the brains of *** are various descriptive hypotheses regarding the causes of AD,including the cholinergic hypothesis,amyloid hypothesis,tau propagation hypothesis,mitochondrial cascade hypothesis,calcium homeostasis hypothesis,neurovascular hypothesis,inflammatory hypothesis,metal ion hypothesis,and lymphatic system ***,the ultimate etiology of AD remains *** this review,we discuss the main hypotheses of AD and related clinical *** puzzles and lessons have made it possible to develop explanatory theories and identify potential strategies for therapeutic interventions for *** combination of hypometabolism and autophagy deficiency is likely to be a causative factor for *** further propose that fluoxetine,a selective serotonin reuptake inhibitor,has the potential to treat AD.

关键词： Alzheimer metabolism clinical

Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system

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Journal of Molecular Cell Biology 2020年第5期12卷 327-336页

作者： Ya-Jie Xu pei-pei liu Shyh-Chang Ng Zhao-Qian Teng Chang-Mei liu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

High-throughput sequencing has facilitated the identification of many types of non-coding RNAs(ncRNAs)involved in diverse cellular *** as epigenetic mediators play key roles in neuronal development,maintenance,and dysfunction by controlling gene expression at multiple *** may not only target specific DNA or RNA for gene silence but may also directly interact with chromatin-modifying proteins like Polycomb group(PcG)proteins to drive orchestrated transcriptional *** significant progress has been made in characterizing ncRNAs and PcG proteins involved in transcriptional,post-transcriptional,and epigenetic *** importantly,dysregulation of ncRNAs,PcG proteins,and interplay among them is closely associated with the pathogenesis of central nervous system(CNS)*** this review,we focus on the interplay between ncRNAs and PcG proteins in the CNS and highlight the functional roles of the partnership during neural development and diseases.

关键词： epigenetics Polycomb complexes non-coding RNAs central nervous system neurological diseases

Continuity of Solutions for Parametric Set Optimization Problems via Scalarization Methods

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Journal of the Operations Research Society of China 2021年第1期9卷 79-97页

作者： pei-pei liu Hong-Zhi Wei Chun-Rong Chen Sheng-Jie Li College of Mathematics and Statistics Chongqing UniversityChongqing 401331China

The aim of this paper is to investigate the continuity of solution mappings for para-metric set optimization problems with upper and lower set less order relations by scalarization ***,we recall some linear and nonlinear scalarization prop-erties used to characterize the set order ***,we introduce new monotonicity concepts of the set-valued mapping by linear and nonlinear scalarization ***,we obtain the semicontinuity and closedness of solution mappings for parametric set optimization problems(both convex and nonconvex cases)under the monotonicity assumption and other suitable *** results achieved do not impose the continuity of the set-valued objective mapping,which are obviously different from the related ones in the literature.

关键词： Upper semicontinuity Lowersemicontinuity Parametricset optimization problems Scalarization Monotonicity

Development and Application of a Mitochondrial Genetically Encoded Voltage Indicator in Narcosis

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Neuroscience Bulletin 2024年第10期40卷 1529-1544页

作者： Run-Zhou Yang Dian-Dian Wang Sen-Miao Li pei-pei liu Jian-Sheng Kang Clinical Systems Biology Laboratories The First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China The Academy of Medical Sciences Zhengzhou UniversityZhengzhou 450052China

Mitochondrial membrane potential(MMP)plays a crucial role in the function of cells and organelles,involving various cellular physiological processes,including energy production,formation of reactive oxygen species(ROS),unfolded protein stress,and cell ***,there is a lack of genetically encoded fluorescence indicators(GEVIs)for *** our screening of various GEVIs for their potential monitoring MMP,the Accelerated Sensor of Action Potentials(ASAP)demonstrated optimal performance in targeting mitochondria and sensitivity to depolarization in multiple cell ***,mitochondrial ASAPs also displayed sensitivity to ROS in ***,two ASAP mutants resistant to ROS were generated.A double mutant ASAP3-ST exhibited the highest voltage sensitivity but weaker ***,four GEVIs capable of targeting mitochondria were obtained and named mitochondrial potential indicators 1-4(MPI-1-4).In vivo,fiber photometry experiments utilizing MPI-2 revealed a mitochondrial depolarization during isoflurane-induced narcosis in the M2 cortex.

关键词： M2 cortex Mitochondria Genetically encoded voltage indicators Membrane potential ROS sensitivity Fiber photometry Isoflurane-induced narcosis

The effect of selective serotonin reuptake inhibitors on cognitive function in patients with Alzheimer’s disease and vascular dementia: focusing on fluoxetine with long follow-up periods

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Signal Transduction and Targeted Therapy 2019年第1期4卷 386-388页

作者： Yi Xie pei-pei liu Ya-Jun Lian Hong-Bo liu Jian-Sheng Kang Clinical Systems Biology Laboratories The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052 HenanChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052 HenanChina

Dear Editors,Alzheimer’s disease(AD)and vascular dementia(VaD)are two of the most common forms of dementia,resulting in increased disability and mortality,impaired quality of life,and serious burdens on society and ***,the presently available drugs can only alleviate symptoms for a short time without delaying the progression of the cognitive *** 2003,no new drugs have been approved by the US Food and Drug Administration for the treatment of *** 2019,phase III clinical trials of crenezumab and aducanumab,two anti-amyloid beta monoclonal antibodies,were *** scant progress in clinical trials urges efforts towards an alternative therapeutic strategy for dementia.

关键词： drugs Alzheimer impaired

A cytotoxic pyrrolidinoindoline diketopiperazine dimer from the algal fungus Eurotium herbariorum HT-2

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Chinese Chemical Letters 2013年第12期24卷 1049-1052页

作者： Ye Li Kun-Lai Sun Yi Wang Peng Fu pei-pei liu Chen Wang Wei-Ming Zhu Key Laboratory of Marine Drugs Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of China

A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey＇s amino acid analysis. Cristatumin E （1） showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC50 and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.

关键词： Cristatumin E Pyrrolidinoindoline diketopiperazine dimer Eurotium herbariorum Algal fungus Cytotoxicity Enteromorpha prolifera Marine algae

Flexible Electrochromic Poly(thiophene-furan) Film via Electrodeposition with High Stability

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Chinese Journal of Polymer Science 2021年第3期39卷 344-354,I0007页

作者： Wen-Qian Yao pei-pei liu Wei-Qiang Zhou Xue-Min Duan Jing-Kun Xu Jia-Ji Yang Shou-Li Ming Meng Li Feng-Xing Jiang Flexible Electronics Innovation Institute Jiangxi Science and Technology Normal UniversityNanchang 330013China

Flexible electrochromic(EC) materials have an urgent demand in the current electronic equipment market due to their technological interest and applications. However, at present, few flexible EC devices developed by industry exist due to some problems and challenges still to be solved such as flexibility. In this work, we have successfully synthesized a novel thiophene-furan(TFu) monomer via Stille coupling reaction,and facilely electrochemically polymerized in a neutral Bu_4 NPF_6-CH_2Cl2 electrolyte system to afford the corresponding poly(thiophene-furan)(PTFu) polymer film with good flexibility. The electrochemical and photoelectrochemical analyses of the as-prepared PTFu demonstrate that it has achieved the improved EC performance compared with pure polyfuran and polythiophene polymers, and as a result it possesses favorable EC parameters manifested as a reasonable ΔT(32.1%), faster response(1.38 s), excellent coloration efficiency(CE, 300.9 cm^(2)·C^(-1)), and after a continuous redox process up to 2000 s, its optical stability can be maintained at 96%, and even after 3000 s, it can still be maintained at 80%. In addition, the successful assembly of the electrochromic device of PTFu film can easily realize the reversible conversion of the color from orange to gray. All these systematic studies suggest that the as-prepared flexible PTFu film is a promising candidate for EC materials and has great potential interest for versatile EC applications.

关键词： Organic conjugated polymers Polyfuran derivatives Electrochromism Flexibility Electrochromic devices

Rare earth element-modified MOF materials:synthesis and photocatalytic applications in environmental remediation

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Rare Metals 2024年第4期43卷 1390-1406页

作者： Shu-Kun Le Qi-Jie Jin Jia-Ao Han Hua-Cong Zhou Quan-Sheng liu Fu Yang Jie Miao pei-pei liu Cheng-Zhang Zhu Hai-Tao Xu Inner Mongolia Key Laboratory of High-Value Functional Utilization of Low Rank Carbon Resources Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot010050China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing210009China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212100China Institut National de la Recherche Scientifique-Énergie Matériaux et Télécommunications MontrealQCJ3X 1P7Canada

Metal-organic framework-like materials(MOFs)have been developed in the fields of photocatalysis for their excellent optical properties and physicochemical properties,including environmental remediation,CO_(2)photoreduction,water splitting,and so *** their important roles in various fields,rare earth elements have received growing interests from *** MOFs with rare earth elements for modification allows broadening the absorption spectrum,while the active electrons on their empty 4f orbitals can act as traps to capture photoexcited carriers to inhibit the recombination of electron-hole pairs,thus promoting photocatalytic ***,rare earth elements modified MOFs provide an attractive way to achieve their high value *** this mini-review,the synthesis of rare earth element-modified MOFs photocatalysts and corresponding applications in the removal of antibiotics,CO_(2)reduction,and hydrogen production are constructively summarized and ***,the latest advancements and current difficulties of these materials as well as the application prospects are also provided.

关键词： Rare earth metals MOFs Photocatalytic CO_(2) reduction Environmental remediation Water splitting

[5]Rotaxane, linear polymer and supramolecular organic framework constructed by nor-seco-cucurbit[10]uril-based ternary complexation

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Chinese Chemical Letters 2023年第3期34卷 298-301页

作者： Pan-Qing Zhang Qian Li Ze-Kun Wang Qing-Xuan Tang pei-pei liu Wen-Hao Li Guan-Yu Yang Bo Yang Da Ma Zhan-Ting Li College of Chemistry Zhengzhou UniversityZhengzhou 450001China Department of Chemistry Fudan UniversityShanghai 200438China School of Pharmaceutical and Materials Engineering &Institute for Advanced StudiesTaizhou UniversityJiaojiang 318000China

Here we use nor-seco-cucurbit[10]uril(ns-CB[10]) based ternary complexation to construct [5]rotaxane,linear supramolecular dynamic rotaxane polymers and cubic 3D supramolecular organic framework.A [5]rotaxane is constructed by ns-CB[10], TMe CB[6] and short linear derivatives of 4,4'-bipyridinium(M2). ns-CB[10], CB[7] and long linear derivatives of 4,4'-bipyridinium(M3) self-assemble into a linear supramolecular dynamic rotaxane polymer. ns-CB[10] and tetracationic tetrahedral monomer selfassemble and form a three-dimensional supramolecular organic framework. The above results demonstrate that ns-CB[10]-based ternary complexation is a versatile platform to build various supramolecular systems.

关键词： Rotaxane Linear polymer Supramolecular organic framework nor-seco-Cucurbituril Ternary complexation