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Diagnostic Accuracy of Computerized Bowel Sound Analysis with Non-Invasive Devices for Irritable Bowel Syndrome:A Systematic Review and Meta-Analysis

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Chinese Medical Sciences Journal 2024年第2期39卷 122-130页

作者： Xia-Xiao Yan Yue-Lun zhang Yu-pei zhang Ying-Yun Yang Dong Wu Department of Gastroenterology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Eight-Year Medical Doctor Program Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To assess the diagnostic accuracy of bowel sound analysis for irritable bowel syndrome(IBS)with a systematic review and *** We searched MEDLINE,Embase,the Cochrane Library,Web of Science,and IEEE Xplore databases until September ***-sectional and case-control studies on diagnostic accuracy of bowel sound analysis for IBS were *** estimated the pooled sensitivity,specificity,positive likelihood ratio,negative likeli-hood ratio,and diagnostic odds ratio with a 95% confidence interval(CI),and plotted a summary receiver operat-ing characteristic curve and evaluated the area under the *** Four studies were *** pooled diagnostic sensitivity,specificity,positive likelihood ratio,nega-tive likelihood ratio,and diagnostic odds ratio were 0.94(95%CI,0.87‒0.97),0.89(95%CI,0.81‒0.94),8.43(95%CI,4.81‒14.78),0.07(95%CI,0.03‒0.15),and 118.86(95%CI,44.18‒319.75),respectively,with an area under the curve of 0.97(95%CI,0.95‒0.98).Conclusions Computerized bowel sound analysis is a promising tool for ***,limited high-quality data make the results'validity and applicability *** is a need for more diagnostic test accuracy studies and better wearable devices for monitoring and analysis of IBS.

关键词： irritable bowel syndrome bowel sound analysis diagnostic accuracy systematic review meta-analysis

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Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis

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World Journal of Stem Cells 2024年第7期16卷 739-741页

作者： Hang pei Yi zhang Chao Wang Bang-Jian He The First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Orthopaedics Anji County Hospital of Chinese MedicineAnji 313300Zhejiang ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

Recently,we read an article published by the Yang et *** results of this study indicated that engineered exosomes loaded with microRNA-29a(miR-29a)alleviate knee inflammation and maintain extracellular matrix stability in Sprague Dawley *** study’s results provide useful information for treating knee osteoarthritis(KOA).This letter,shares our perspectives on treating KOA using engineered exosomes for miR-29a.

关键词： Exosomes Intra-articular injection Mesenchymal stem cells MicroRNA-29a Osteoarthritis

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Analytical Method for the Wave Diffraction of Asymmetrically Arranged Breakwaters

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China Ocean Engineering 2024年第05期38卷 797-808页

作者： ZHOU pei-xin zhang Hong-sheng College of Ocean Science and Engineering Shanghai Maritime University Bureau of Transport of Beilun District of Ningbo

The layout forms of several breakwater structures can be generalized as asymmetrical arrangements in actual engineering. However, the problem of wave diffraction around asymmetrically arranged breakwaters has not been adequately investigated. In this study, we propose an analytical method of wave diffraction for regular waves passing through asymmetrically arranged breakwaters, and we use the Nystr?m method to obtain the analytical solution numerically. We compared the results of this method with those of previous analytical solutions and with numerical results to demonstrate the validity of our approach. We also provided diffraction coefficient diagrams of breakwaters with different layout forms. Moreover, we described the analytical expression for the problem of diffraction through long-wave incident breakwaters and presented an analysis of the relationship between the diffraction coefficients and the widths of breakwater gates. The analytical method presented in this study contributes to the limited literature on the theory of wave diffraction through asymmetrically arranged breakwaters.

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Decreased Nrf2 protein level and low sperm quality in intractable spermatocystitis

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Asian Journal of Andrology 2024年第2期26卷 189-194页

作者： Shi-Ze Wang Jian-Nan Liu fen-Fang Zhou Ye-Jin-Peng Wang Peng zhang Song-Tao Cheng Department of Urology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Health Management and Clinical Medicine School of Medicine and HealthWuhan PolytechnicUniversityWuhan 430071China

To investigate the molecular etiology of low sperm quality in patients with intractable spermatocystitis,spermatozoa samples from patients with persistent hematospermia undergoing transurethral seminal vesiculoscopy and healthy volunteers were *** samples were collected from the seminal vesicles through transurethral seminal vesiculoscopy or by masturbation *** quality was analyzed by a WLJY-9000 color semen analysis *** of tumor necrosis factor alpha(TNFa)and interleukin-6(IL-6)in the seminal plasma was performed using enzyme-linked immunosorbent assay(ELISA).Measurement of H_(2)O_(2)in the seminal plasma was performed with a hydrogen peroxide *** protein levels of nuclear factor erythroid 2-related factor 2(Nrf2)and phosphorylated-Nrf2(p-Nrf2)were measured by western blot analysis and immunofluorescence *** sperm quality parameters and increased levels of inflammatory cytokines(TNFa,IL-6,and H_(2)O_(2))in the seminal plasma were detected among the semen samples from the patients with persistent ***2 and p-Nrf2 were strongly expressed in the nucleus and periphery of human sperm cells,according to the results of the immunofluorescence *** protein levels of Nrf2 and p-Nrf2 were significantly lower in the spermatozoa samples from patients with persistent hematospermia than in those from healthy volunteers with normal sperm *** results suggested that Nrf2 signaling might play a role in the low sperm quality of patients with intractable spermatocystitis.

关键词： H_(2)O_(2) Nrf2 sperm quality spermatocystitis

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Structural transformation from Waugh-type to Keggin-type polyoxomolybdate-based crystalline material for photo/electrocatalysis

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Rare Metals 2024年第5期43卷 2241-2250页

作者： pei-Sen Wang Zi-Tong Wang Ya-Ya Tan Peng Chen Xue-Cheng zhang Lu-Nan zhang Yong-Ge Wei Lu-Bin Ni School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing100191China

An inorganicDorganic hybrid crystalline material(SiMo_(12)O_(40))[Cu(2,2'-bipy)_(2)]_(2)·2H_(2)O(Complex 1,2,2'-bipy=2,2'-bipyridine)was synthesized for the first time by using 2,2'-bipy and transition metal copper to convert Waugh-type polyoxometalate[MnMo_(9)O_(3)_(2)]_(6-)into a Keggin polyoxometalate structure[SiMo_(12)O_(40)]^(4-)under hydrothermal conditions in glass *** crystal tests and a series of characterizations were carried out on Complex *** structure of Complex 1 is composed of[SiMo_(12)O_(40)]^(4-)and[Cu^(Ⅱ)(2,2'-bipy)_(2)]^(2+).The five-coordinated Cu is connected to two 2,2'-bipy through CuDN bonds,forming an approximately square ***,Complex 1 exhibited good photocatalytic performance for methylene blue degradation and electrocatalytic nitrite reduction properties simultaneously.

关键词： Polyoxometalates Inorganic-organic hybrid materials Photocatalytic Electrocatalytic

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Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis:A Multi-center,Double-Blinded and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第7期30卷 579-587页

作者： zhang Shao-yan QIU Lei zhang Shun-xian XIAO He-ping CHU Nai-hui zhang Xia zhang Hui-qiang ZHENG pei-yong zhang Hui-yong LU Zhen-hui Institute of Respiratory Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Clinical Research Center Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Tuberculosis Shanghai Pulmonary HospitalTongji UniversityShanghai200433China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing101100China Department of Tuberculosis the Second Hospital of NanjingNanjing210003China Department of Tuberculosis the First Hospital Affiliated to Xinxiang Medical CollegeXinxiangHenan Province453100China

Objective: To assess the efficacy and safety of Bufei Jiedu(BFJD) Granules as adjuvant therapy for patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB). Methods: A large-scale, multi-center, double-blinded, and randomized controlled trial was conducted in 18 sentinel hospitals in China from December 2012 to December 2016. A total of 312 MDR-PTB patients were randomly assigned to BFJD Granules or placebo groups(1:1) using a stratified randomization method, which both received the long-course chemotherapy regimen for 18 months(6 Am-Lfx-P-Z-Pto, 12 Lfx-P-Z-Pto). Meanwhile, patients in both groups also received BFJD Granules or placebo twice a day for a total of 18 months, respectively. The primary outcome was cure rate. The secondary outcomes included time to sputum-culture conversion, changes in lung cavities and quality of life(QoL) of patients. Adverse reactions were monitored during and after the trial. Results: A total of 216 cases completed the trial, 111 in the BFJD Granules group and 105 in the placebo group. BFJD Granules, as adjuvant treatment, increased the cure rate by 13.6% at the end of treatment, compared with the placebo(58.4% vs. 44.8%, P=0.02), and accelerated the median time to sputum-culture conversion(5 months vs. 11 months). The cavity closure rate of the BFJD Granules group(50.6%, 43/85) was higher than that of the placebo group(32.1%, 26/81;P=0.02) in patients who completed the treatment. At the end of the intensive treatment, according to the 36-item Short Form, the BFJD Granules significantly improved physical functioning, general health, and vitality of patients relative to the placebo group(all P<0.01). Overall, the death rates in the two groups were not significantly different;5.1%(8/156) in the BFJD Granules group and 2.6%(4/156) in the placebo group. Conclusions: Supplementing BFJD Granules with the long-course chemotherapy regimen significantly increased the cure rate and cavity closure rate, and rapidly improved QoL of pati

关键词： alternative medicine Chinese herbal formula Bufei Jiedu Granules multidrug-resistant tuberculosis long-course chemotherapy regimen randomized controlled trial

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Evaluation of laboratory and environmental exposure systems for protein modification upon gas pollutants and environmental factors

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Journal of Environmental Sciences 2024年第9期143卷 213-223页

作者： Zhiwei Pan ShiyiWu Qiaoze Zhu Fobang Liu Yongjian Liang Chenglei pei Haoyu Jiang Yingyi zhang Senchao Lai The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationSchool of Environment and EnergySouth China University of TechnologyGuangzhou 510006China Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China Guangzhou Sub-branch of Guangdong Ecological and Environmental Monitoring Center Guangzhou 510006China State Key Laboratory of Organic Geochemistry Guangdong Key Laboratory of Environmental Protection and Resources Utilizationand Joint Laboratory of the Guangdong-Hong Kong-Macao Greater Bay Area for the EnvironmentGuangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China School of Marine Sciences Sun Yat-sen UniversityZhuhai 519082China

Chemical modifications of proteins induced by ambient ozone(O_(3))and nitrogen oxides(NOx)are of public health concerns due to their potential to trigger respiratory *** laboratory and environmental exposure systems have been widely used to investigate their relevant mechanism in the *** bovine serum albumin(BSA)as a model protein,we evaluated the two systems and aimed to reduce the uncertainties of both the reactants and products in the corresponding kinetic *** the laboratory simulation system,the generated gaseous pollutants showed negligible *** layers of BSA were coated on the flow tube with protein extraction recovery of 87.4%.For environmental exposure experiment,quartz fiber filter was selected as the upper filter with low gaseous O_(3)(8.0%)and NO_(2)(1.7%)losses,and cellulose acetate filter was appropriate for the lower filter with protein extraction efficiency of 95.2%.The protein degradation process was observed without the exposure to atmospheric oxidants and contributed to the loss of protein monomer mass fractions,while environmental factors(e.g.,molecular oxygen and ultraviolet)may cause greater protein monomer *** on the evaluation,the study exemplarily applied the two systems to protein modification and both showed that O_(3) promotes the protein oligomerization and nitration,while increased temperature can accelerate the oligomerization and increased relative humidity can inhibit the nitration in the environmental exposure *** developed laboratory and environmental systems are suitable for studying protein modifications formed under different atmospheric conditions.A combination of the two will further reveal the actual mechanism of protein modifications.

关键词： Protein modification Laboratory simulation Environmental exposure Oligomerization Nitration

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Effective assignment of positional isomers in dimeric shikonin and its analogs by ^(1)H NMR spectroscopy

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Chinese Chemical Letters 2024年第5期35卷 223-226页

作者： Ling-Hao Zhao Hai-Wei Yan Jian-Shuang Jiang Xu zhang Xiang Yuan Ya-Nan Yang pei-Cheng zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and ***,the ^(1)H(proton)nuclear magnetic resonance(NMR)pattern of phenolic hydroxyl protons was developed as a“diagnosis signal”to ascertain the relative location of each side chain in DMSO-d_(6) at sample concentrations of 0.022-0.034 mol/*** chemical shift differences of 0.6ppm between OH-5' and OH-1 and between OH-8'and OH-4 are assigned to Type A and Type B,*** reported ambiguous structures were corrected by this ***,the steric structures of isolated compounds were elucidated by quantum chemical calculations of electronic circular dichroism(ECD)spectra.

关键词： Arnebia euchroma Dimeric hydroxyl naphthoquinones Positional isomers ^(1)H NMR spectroscopy Chemical shift difference

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Transcription factor CabHLH035 promotes cold resistance and homeostasis of reactive oxygen species in pepper

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Horticultural Plant Journal 2024年第3期10卷 823-836页

作者： Huafeng zhang Jiangbai Guo Xiaoqing Chen Yunyun Zhou Yingping pei Lang Chen Saeed ul Haq Mingke zhang Haijun Gong Rugang Chen College of Horticulture Northwest A&F UniversityYanglingShaanxi 712100China Shaanxi Engineering Research Center for Vegetables YanglingShaanxi 712100China Department of Horticulture The University of Agriculture PeshawarPeshawarKhyber Pakhtunkhwa 25130Pakistan

Plant basic helix-loop-helix(bHLH)transcription factors(TFs)play central roles in various abiotic ***,its role in plant cold resistance is largely ***,we characterised CaNAC035 in pepper,which positively regulates tolerance to cold,salt and drought stresses ***,we identified CabHLH035,a CaNAC035-interacting protein in *** explore its functions in cold stress tolerance,we silenced the gene in pepper via virus-induced gene silencing(VIGS)and overexpressed the gene in *** results showed that CabHLH035 expression was induced by cold treatment,and silencing of CabHLH035 decreased cold stress ***,overexpression of CabHLH035 in Arabidopsis increased cold stress *** investigate homologs genes of C-repeat binding factor(CBF)pathway proteins and reactive oxygen species(ROS)marker gene expression blocking by CabHLH035,we performed yeast one-hybrid(Y1H),dual luciferase and electrophoretic mobility shift assay *** results showed that CabHLH035 bound to the region upstream of the CaCBF1A and CaAPX ***,CaCBF1A bound to the CaDHN4 *** together,our results showed that CabHLH035 plays a crucial role in cold stress tolerance and its potential as a target for breeding cold-resistant *** findings provide a basis for studying the functions and regulatory network of cold stress tolerance in pepper.

关键词： Pepper CabHLH035 Silencing Overexpression VIGS Cold tolerance

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Oxidation behavior of FeV_(2)O_(4)and FeCr_(2)O_(4)particles in the air:Nonisothermal kinetic and reaction mechanism

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1839-1848页

作者： Junyi Xiang Xi Lu Luwei Bai Hongru Rao Sheng Liu Qingyun Huang Shengqin zhang Guishang pei Xuewei Lü School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing 401331China Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Rep.of Korea College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

High-temperature oxidation behavior of ferrovanadium(FeV_(2)O_(4))and ferrochrome(FeCr_(2)O_(4))spinels is crucial for the application of spinel as an energy material,as well as for the clean usage of high-chromium vanadium ***,the nonisothermal oxidation behavior of FeV_(2)O_(4)and FeCr_(2)O_(4)prepared by high-temperature solid-state reaction was examined by thermogravimetry and X-ray diffraction(XRD)at heating rates of 5,10,and 15 K/*** apparent activation energy was determined by the Kissinger-Akahira-Sunose(KAS)method,whereas the mechanism function was elucidated by the Malek ***,in-situ XRD was conducted to deduce the phase transformation of the oxidation mechanism for FeV_(2)O_(4)and FeCr_(2)O_(4).The results reveal a gradual increase in the overall apparent activation energies for FeV_(2)O_(4)and FeCr_(2)O_(4)during *** stages of the oxidation process are observed based on the oxidation conversion rate of each *** oxidation mechanisms of FeV_(2)O_(4)and FeCr_(2)O_(4)are complex and have distinct *** particular,the chemical reaction controls the entire oxidation process for FeV_(2)O_(4),whereas that for FeCr_(2)O_(4)transitions from a three-dimensional diffusion model to a chemical reaction *** to the in-situ XRD results,numerous intermediate products are observed during the oxidation process of both compounds,eventually resulting in the final products FeVO_(4)and V2O_(5)for FeV_(2)O_(4)and Fe_(2)O_(3)and Cr_(2)O_(3)for FeCr_(2)O_(4),respectively.

关键词： FeV_(2)O_(4) FeCr_(2)O_(4) oxidation nonisothermal kinetics mechanism

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