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Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi sun department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

Hierarchically Crosslinked Gels Containing Hydrophobic Ionic Liquids towards Reliable Sensing Applications

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Chinese Journal of Polymer Science 2020年第4期38卷 332-341,I0005页

作者： Xia-Chao Chen pei-Ru sun Hong-Liang Liu Laboratory of Bio-inspired Smart Interface Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Bio-inspired Smart Interfadal Science and Technology of Ministry of Education and Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 100191China School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing 401331China

Human skin can function steadily regardless of surrounding circumstarices(dry or wet),while it is still a challenge for artificial ionic skins,which tend to release solvents in dry air and leach electrolytes in wetted ***,a series of hierarchically crosslinked ionogels containing hydrophobic ionic liquids(ILs)is fabricated by combining a crystalline fluorinated copolymer with hydrophobic *** a reasonable combination of nonvolatility,transparency,stretchablility,and sensitivity,such ionogels can work as reliable sensors for real-time monitoring huma n motions and operate steadily in complex environments as human skin does,which can contribute to the developme nt of durable sen sing devices with a simple design.

关键词： Ionogels Conductivity Hydrophobicity Strain sensors

Chi Phase after Short-term Aging and Corrosion Behavior in 2205 Duplex Stainless Steel

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Journal of Iron and Steel Research International 2016年第10期23卷 1071-1079页

作者： Qi sun Jian WANG Hua-bing LI Yue LI Ya-di HU Jin-gang BAI pei-de HAN College of Materials Science and Engineering Taiyuan University of Technology Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of Technology School of Metallurgy Northeastern University Technology Center of Taiyuan Iron and Steel(Group)Co. Ltd.

Correlation between pitting corrosion behavior and chi（ χ ）phase formed after a short-term aging（5,10 and 15 min）at 850 ℃ of 2205 duplex stainless steel（DSS）was investigated using potentiodynamic polarization tests,optical microscopy,and scanning electron microscopy equipped with energy-dispersive spectrum *** showed that after aging for 5min,the χ phase initially precipitated at ferrite grain boundaries,developed and then became linked with prolonging aging *** χ phase was rich in Cr and Mo,resulting in formation of depleted zones *** χ phase could reduce corrosion resistance of DSS and slightly influence its stability,but the specimens still displayed the capacity for *** lines of evidence showed that stable pitting corrosion initiated at the boundaries of *** χ phase was selectively corroded during the first stage of corrosion and then the depleted zones nearby were *** addition,the grain size and volume of precipitates also affected pit nucleation and progress,and suitable size and distribution of χ phase could aggravate pit initiation at precipitate *** χ phase with considerably low volume fraction and small size was not sensitive position for pit initiation.

关键词： duplex stainless steel short-term aging χ phase pitting corrosion selective corrosion grain size

determining burn degree of fire-damaged concrete constructions by thermoluminescence

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Chinese Science Bulletin 1997年第21期42卷 1829-1833页

作者： pei, JX Han, Y sun, XH Chinese Acad Sci Inst Geol Beijing 100029 Peoples R China

NOWADAYS there are many skyscrapers in cities. If fire-damaged, the only way to lessen

关键词： determining of thermolominescence concrete constructions.

Nanoimprint lithography-assisted block copolymer self-assembly for hyperfine fabrication of magnetic patterns based on L10-FePt nanoparticles

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Science China Chemistry 2025年

作者： Jie Zhang Yi Chen Guijun Li Zelin sun Zhengong Meng Wai-Yeung Wong department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic University The Hong Kong Polytechnic University Shenzhen Research Institute Division of Integrative Systems and design and Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology School of Flexible Electronics (Future Technology) and Institute of Advanced Materials (IAM) Nanjing Tech University

L10-FePt-type bit-patterned media has provided a promising alternative for ultrahigh-density magnetic recording systems in the current digital era, but rapid fabrication of magnetic patterns with hyperfine bit islands is still challenging, especially with the target for miniaturization and scalable production simultaneously. Herein, Fe,Pt-containing block copolymers were utilized as single-source precursors for solution-processable patterning and subsequent generation of the demanding magnetic FePt dots by in situ pyrolysis. High-throughput nanoimprint lithography was initially employed to fabricate the predefined bit cells precisely,and then the intrinsic self-assembly of phase-separated block copolymers further drove the formation of accurate bit *** from the synergistic effect of top-down lithographic approach and bottom-up self-assembly, the customizable patterns could be achieved for large-scale mass production in targeted areas, but high-density isolated dots could also be accurately aligned along the patterned features after subsequent self-assembly. This reliable strategy would provide a good avenue to precisely construct ultrahigh-density magnetic data storage devices.

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Intermolecular reductive coupling of aliphatic ketones with alkynes and alkenes by BCN photocatalysts

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Science China Chemistry 2025年第1期 181-185页

作者： Yanping Xia Luyang sun Jiajia Cheng Sibo Wang Meifang Zheng Xinchen Wang State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

A photocatalytic process was developed for intermolecular reductive coupling of aliphatic ketones with alkynes/alkenes to furnish tertiary alcohols. Mechanistic studies support that boron carbonitrides(BCN) promote the single electron reduction of unactivated aliphatic ketones to generate ketyl radicals with visible light irradiation, which then react with alkynes and alkenes to afford the allylic and aliphatic alcohols, respectively. The heterogeneous photocatalytic system is compatible with diverse substrates including pharmaceutical-related molecules(43 examples) with reusability and scale-up experiments, verifying the complementary synthetic utility of this method to the homogeneous catalysts.

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Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering

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Chinese Journal of Polymer Science 2018年第6期36卷 712-719页

作者： Xu-Dong Shi pei-Jian sun Zhi-Hua Gan Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China The GAS Key Laboratory of Engineering Plastics Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China State Key Laboratory of Organic-inorganic Composites College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China

In this study, porous polylactide（PLA） microspheres with different structures were prepared through the multiple emulsion solvent evaporation method. By changing organic solvents（ethyl acetate and chloroform） and adding effervescent salt NH4 HCO3 in the inner water phase, microspheres with porous capsular, matrix, microcapsular and multivesicular structures were prepared. The protein encapsulation and release, and the cell growth behavior of porous microspheres were further explored. Under the same inner water phase, microspheres prepared with chloroform had higher protein encapsulation efficiency and less protein release rate as compared with those prepared with ethyl acetate. Cell experiments showed that the relatively rough surface of microspheres prepared with chloroform was more favorable for the cell growth in comparison with the smooth surface of microspheres prepared with ethyl acetate. This study shows a simple and effective method to control the protein release and cell growth behaviors of polymer microspheres by tuning their porous structure.

关键词： Polylactide Porous microspheres Drug release Cell Tissue engineering

Changes in ecological stoichiometry and nutrient resorption in Castanopsis hystrix plantations along an urbanization gradient in the lower subtropics

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Journal of Forestry Research 2021年第6期32卷 2323-2331页

作者： Feifan Li Bing sun Zhaowan Shi Nancai pei Research Institute of Tropical Forestry Chinese Academy of ForestryGuangzhou510520People’s Republic of China

The stoichiometry of carbon,nitrogen and phosphorous in plants can reflect the interactions between plants and their *** interplay between plant nutrients,climatic factors,and soil properties and the underlying regulatory mechanisms are pillars of ecology but remain *** this study of plant C-N-P stoichiometry and nutrient resorption in Castanopsis hystrix groves in three cities(Guangzhou,Zhongshan,and Lechang)that represent an urban-rural gradient in Guangdong Province,South China,we explored potential relationships among NO_(2) concentrations,diameter at breast height(DBH),and resident human *** annual temperature,mean annual precipitation,insolation duration per year,and the human resident population differed significantly among the three *** C-N-P was always highest in suburban Lechang,and the concentration of NO_(2) was highest in urban Guanghzou(55.33±0.67μg m^(-3))and positively correlated with the resident population and leaf N:*** findings suggest that C-N-P stoichiometry of *** was better explained by NO_(2)than by soil C-N-P stoichiometry and that nutrient resorption was better explained by leaf nutrients and DBH than by NO_(2) and soil *** study supports the hypothesis that rapid urbanization influences NO_(2) concentrations and microclimate,which may jointly change the stoichiometry of plant nutrients in the forest ecosystems.

关键词： Ecological stoichiometry Nutrient cycling Plant-environment interaction Subtropical forest Urban–rural gradient

Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion