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Mediated protective effect of electroacupuncture pretreatment by miR-214 on myocardial ischemia/reperfusion injury

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Journal of Geriatric Cardiology 2014年第4期11卷 303-310页

作者： pei-yu liu Yi TIAN Shi-yuan XU Department of Anesthesiology ZhuJiang Hospital of Southern Medicine University Guangzhou 510282 Guangdong Province China Department of Anesthesiology Hainan Provincial Corps Hospital of Chinese People's Armed Police Forces Haikou 570203 Hainan Province China Department of Anesthesiology Haikou People's Hospital Haikou 570203 Hainan Province China

Background Electroacupuncture pretreatment plays a protective role in myocardial ischemia/reperfusion （I/R） injury and microRNAs （miRNAs） could act on various facets of cardiac function. However, the role of miRNAs in the cardioprotection by electroacupuncture pre-treatment on myocardial I/R injury remains unknown. The purpose of the study was to examine whether miR-214 was involved in cardio-protection by electroacupuncture. Methods Using rat myocardial I/R model, we examined the role of electroacupuncture pretreatment in myocardial I/R injury and analyzed the changes in the expression of miR-214. In addition, I/R was simulated in vitro by performing oxy-gen-glucose deprivation （OGD） on H9c2 cell cultures, and the effect of electroacupuncture pretreatment on I/R injury as well as expressional level of miR-214 were examined in vitro. Furthermore, the miR-214 mimic was transfected into OGD-treated H9c2 cells, we analyzed the cell apoptosis, lactate dehydrogenase （LDH） and creatine kinase （CK） activities, intracellular free Ca2＋concentration （[Ca2＋]i） as well as the relative protein levels of sodium/calcium exchanger 1（NCX1）, BCL2-like 11 （BIM）, calmodulin-dependent protein kinase IIδ（CaMKIIδ） and Cyclophilin D （CypD）. Results The in vivo results revealed that compared with the I/R group, the electroacupuncture pretreatment group showed significant decreased myocardial infarct size, as well as the increased indices of the cardiac function, including heart rate, mean arterial pressure, left ventricular systolic pressure and maximal rate for left ventricular pressure rising and declining （±dp/dt max）. In addition, electroacupuncture pretreatment could inhibit the elevation of LDH and CK activities induced by I/R injury. The quantitative PCR （qPCR） results demonstrated electroacupuncture pretreatment could provide cardioprotection against myocardial I/R injury in rats with miR-214 up-regulation. In the meanwhile, in vitro, electroacupuncture pretreatment protected H9c2 c

关键词： I/R injury miR-214 Electroacupuncture Protective effect

Effect of process parameters on steel tube roundness in straightening process

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Journal of Iron and Steel Research International 2020年第11期27卷 1270-1283页

作者： Li-dong Ma yu-kang Du Zhi-juan Meng Li-feng Ma Zi-jian liu pei-yu liu Coordinative Innovation Center of Taiyuan Heavy Machinery Equipment Taiyuan University of Science and TechnologyTaiyuan 030024ShanxiChina School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024ShanxiChina School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024ShanxiChina School of Applied Science Taiyuan University of Science and TechnologyTaiyuan 030024ShanxiChina

The inclined six-roll tube straightener is an important equipment for the finishing *** can not only straighten the steel pipe,but also finish the ovality of the cross *** the actual straightening process,the cross section of the tube is prone to deform,that is,the round ness is not *** flatteni ng displacement is an import a nt parameter to control cross-section forming of *** to the established mechanical model,the analytical calculation equations of the flattening force and the flattening displacement were derived using the energy *** on the finite element simulation data,the ratios of the finite element results of the什attening force to the analytical ones were *** correlation coefficient after fitting is greater than 99%,and the fitting effect is *** flattening experiment was carried out on tubes of different materials and different specifications,and the setting method of the optimal flattening displacement during straightening process was *** the actual straightening process,using this flattening displacement,the ovality of straightened steel tube is less than 0.3%.Therefore,the proposed method can provide a reference for the flattening displacement in the actual straightening process.

关键词： Straightening Tube Energy method Flattening force Flattening displacement Finite element method

Isogeometric Analysis for the Arbitrary AFG Microbeam with Two-Phase Nonlocal Stress-Driven Model

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Acta Mechanica Solida Sinica 2024年第2期37卷 341-360页

作者： pei-Liang Bian Zhaowei liu Hai Qing Tiantang yu Department of Engineering Mechanics Hohai UniversityNanjing211100China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

Scale effects play critical roles in the mechanical responses of *** isogeometric analysis was developed here to investigate the mechanical responses of an axially functionally graded *** Euler–Bernoulli beam model was utilized,and size effects in the structure were modeled with a stress-driven two-phase local/nonlocal integral *** governing equation of microstructures was given in an equivalent differential form with two additional constitutive boundary *** framework was verified and utilized to analyze the microbeam’s static and dynamic mechanical *** present work showed great potential for modeling various types of functionally graded microstructures.

关键词： Isogeometric analysis Size effect Functionally graded material Nonlocal theory Euler-Bernoulli beam

A self-management application“painhousekeeper”to control cancer pain:a randomized controlled trial study protocol

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Frontiers of Nursing 2020年第3期7卷 257-267页

作者： Qian liu Xiao-Man Zhang pei-yu liu Ya-Ling Wang yu-Qin Wang School of Nursing Xuzhou Medical UniversityXuzhouJiangsu 221000China Department of General Surgery Affiliated HospitalXuzhou Medical UniversityXuzhouJiangsu 221000China

Objective:Pain is a prevalent and distressing symptom in patients with cancer which has a significant impact on patients’physical health,psychological well-being,and quality of life(QOL).Deficiency of pain care,inadequate pain communication,and reluctance toward pain medication contribute to the difficulties in improving the situation of patients with cancer ***,the integration of self-management and professional healthcare provides new opportunities for patients with cancer ***:A two-arm randomized controlled trial will be conducted to assess the effectiveness of self-management application compared with routine care among patients with cancer *** on Orem’s self-care theory and Naylor’s transitional care theory,cancer pain self-management application“Pain-housekeeper”was developed with dual client:patient client and medical client.A total of 120 patients with cancer pain are recruited from two university-affiliated tertiary public hospitals in *** are randomly assigned to the control group and the intervention *** patients in the control group get routine care while the patients in the intervention group get routine care and Pain-housekeeper *** intervention is delivered by registered doctors,nurses,and postgraduate nursing students specialized in pain *** measurements for both groups are carried out with questionnaires at baseline(T0),after 4 weeks(T1)and after 12 weeks(T2).The primary outcomes include pain condition,self-efficacy,and *** secondary outcomes include pain medication adherence,satisfaction,anxiety,and *** of data submission,economic evaluation,usage,and clinical data are also considered in the *** for the evaluation are gathered continuously during the study ***:This article provides insight into the effectiveness of a theory-based self-management mobile application intervention delivered to patients with uncontrolled cancer *** results are used to he

关键词： cancer pain self-management application pain condition quality of life self-efficacy•randomized controlled trial

Effects of shore-normal coastal structure on medium-to long-term embayed shoreline evolution

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Acta Oceanologica Sinica 2024年第2期43卷 58-66页

作者： Jitao yu yuanting Ding pei liu Renfu Fan Lin Zhang Hainan Academy of Ocean and Fisheries Sciences Haikou 571126China Yazhou Bay Innovation Institute Hainan Tropical Ocean UniversitySanya 572025China School of Geography and Environmental Sciences Hainan Normal UniversityHaikou 571158China

Based on high-tide shoreline data extracted from 87 Landsat satellite images from 1986 to 2019 as well as using the linear regression rate and performing a Mann-Kendall(M–K)trend test,this study analyzes the linear characteristics and nonlinear behavior of the medium-to long-term shoreline evolution of Jinghai Bay,eastern Guangdong *** particular,shoreline rotation caused by a shore-normal coastal structure is *** results show that the overall shoreline evolution over the past 30 years is characterized by erosion on the southwest beach,with an average erosion rate of 3.1 m/a,and significant accretion on the northeast beach,with an average accretion rate of 5.6 m/*** of the M–K trend test indicate that significant shoreline changes occurred in early 2006,which can be attributed to shore-normal *** to that engineering construction,the shorelines are slightly eroded,where the average erosion rate is 0.7 m/***,after shore-normal engineering is performed,the shoreline is characterized by significant erosion(3.2 m/a)on the southwest beach and significant accretion(8.5 m/a)on the northeast beach,thus indicating that the shore-normal engineering at the updrift headland contributes to clockwise shoreline *** analysis shows that the clockwise shoreline rotation is promoted not only by longshore sediment transport processes from southwest to northeast,but also by cross-shore sediment transport *** findings are crucial for beach erosion risk management,coastal disaster zoning,regional sediment budget assessments,and further observations and predictions of beach morphodynamics.

关键词： shoreline rotation non-linear behavior longshore sediment transport cross-shore sediment transport embayed beach coastal structure

Design of efficient thermoelectric generators

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Science China Materials 2024年第1期67卷 377-378页

作者： Min liu Yanzhong pei Interdisciplinary Materials Research Center School of Materials Science and EngineeringTongji UniversityShanghai 201804China

Thermoelectricity,which enables direct conversion between heat and electricity,undergoes impressive developments in recent decades,and is particularly promising for recovering low-grade heat of<600 K[1,2].Currently,only Bi2Te3-based thermoelectric devices are commercialized[3].However,the scarcity of tellurium(Te)(Fig.1a)is the main *** leads to numerous recent efforts on the development of efficient nonBi2Te3 thermoelectrics as potential alternatives,and successful examples(Fig.1b)include Mg3Sb2-alloys[2,3]and MgAgSb[1,2].

关键词： enable efficient electricity

Temporal assembly patterns of microbial communities in three parallel bioreactors treating low-concentration coking wastewater with differing carbon source concentrations

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Journal of Environmental Sciences 2024年第3期137卷 455-468页

作者： Weijia Li yu Xia Na Li Jie Chang Jing liu pei Wang Xuwen He School of Chemical and Environmental Engineering China University of Mining and Technology-BeijingBeijing 100083China

Carbon source is an important factor of biological treatment systems, the effects of which on their temporal community assembly patterns are not sufficiently understood *** this study, the temporal dynamics and driving mechanisms of the communities in three parallel bioreactors for low-concentration coking wastewater(CWW) treatment with differing carbon source concentrations(S0 with no glucose addition, S1 with 200 mg/L glucose addition and S2 with 400 mg/L glucose addition) were comprehensively studied. Highthroughput sequencing and bioinformatics analyses including network analysis and Infer Community Assembly Mechanisms by Phylogenetic bin-based null model(iCAMP) were used. The communities of three systems showed turnover rates of 0.0029~0.0034 every 15days. Network analysis results showed that the S0 network showed higher positive correlation proportion(71.43%) and clustering coefficient(0.33), suggesting that carbon source shortage in S0 promoted interactions and cooperation of microbes. The neutral community model analysis showed that the immigration rate increased from 0.5247 in S0 to 0.6478in S2. The iCAMP analysis results showed that drift(45.89%) and homogeneous selection(31.68%) dominated in driving the assembly of all the investigated microbial *** contribution of homogeneous selection increased with the increase of carbon source concentrations, from 27.92% in S0 to 36.08% in S2. The OTUs participating in aerobic respiration and tricarboxylic acid(TCA) cycle were abundant among the bins mainly affected by deterministic processes, while those related to the metabolism of refractory organic pollutants in CWW such as alkanes, benzenes and phenols were abundant in the bins dominated by stochastic processes.

关键词： Coking wastewater treatment Temporal dynamics Network analysis Deterministic processes Stochastic processes

A case-control study on the relationship between salt intake and salty taste and risk of gastric cancer

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World Journal of Gastroenterology 2011年第15期17卷 2049-2053页

作者： Wan-Guang Yang Chuan-Bo Chen Zhi-Xin Wang yu-pei liu Xiao-yuan Wen Shan-Feng Zhang Tong-Wen Sun Department of Emergency The First Affiliated Hospital Zhengzhou University Zhengzhou 450052 Henan Province China School of Nursing Henan University Kaifeng 475001 Henan Province China School of Basic Medicine Zhengzhou University Zhengzhou 450052 Henan Province China Department of Sports Medicine Chengdu Sports University Chengdu 610041 Sichuang Province China

AIM: To investigate the relationship between salt intake and salty taste and risk of gastric cancer. METHODS: A 1:2 matched hospital based case-control study including 300 patients with gastric cancer and 600 cancer-free subjects as controls. Subjects were interviewed with a structured questionnaire containing 80 items, which elicited information on dietary, lifestyle habits, smoking and drinking histories. Subjects were tested for salt taste sensitivity threshold (STST) usingconcentrated saline solutions (0.22-58.4 g/L). Conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CI). RESULTS: Alcohol and tobacco consumption increased the risk of gastric cancer [OR (95% CI) was 2.27 (1.27-4.04) for alcohol and 2.41 (1.51-3.87) for tobacco]. A protective effect was observed in frequent consumption of fresh vegetable and fruit [OR (95% CI) was 0.92 (0.58-0.98) for fresh vegetable and 0.87 (0.67-0.93) for fruit]. Strong association was found between STST ≥ 5 and gastric cancer [OR = 5.71 (3.18-6.72)]. Increased STST score was significantly associated with salted food intake and salty taste preference (P < 0.05). CONCLUSION: A high STST score is strongly associated with gastric cancer risk. STST can be used to evaluate an inherited characteristic of salt preference, and it is a simple index to verify the salt intake in clinic.

关键词： Gastric cancer Salt taste sensitivity threshold Salt taste preference

International standard of Traditional Chinese Medicine techniques: the operating specification for Traditional Chinese Medicine enema(2022)

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1035-1043页

作者： yu Miao pei Xiaohua Department of General surgery Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University Department of Chest and Breast Surgery Beijing University of Chinese Medicine Xiamen Hospital

Chinese Medicine Enema is one of the external therapies in Traditional Chinese Medicine(TCM), which has been widely used clinically. The "International Standard of Traditional Chinese Medicine Techniques: The Operating Specifications for Chinese Medicine Enema is drawn up by the Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University and Beijing University of Chinese Medicine Xiamen Hospital in collaboration with domestic TCM universities and hospitals. The specification includes definition, operating process, points for attention and contraindications. It is targeted to provide reference for TCM providers at home and abroad with TCM background in clinical decision-making.

关键词： Chinese Medicine Enema international standard operating specifications traditional Chinese medical technology