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Ferroptosis inhibition attenuates inflammatory response in mice with acute hypertriglyceridemic pancreatitis

World Journal of Gastroenterology 2023年第15期29卷 2294-2309页

作者： Yi-Teng Meng Yi Zhou pei-yu han Hong-Bo Ren Department of Gastroenterology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina Wuxi School of Medicine Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Department of Gastroenterology Qilu HospitalJinan 250012Shandong ProvinceChina

BACKGROUND Ferroptosis is involved in developing inflammatory diseases;yet,its role in acute hypertriglyceridemic pancreatitis(HTGP)remains *** To explore whether ferroptosis is involved in the process of HTGP and elucidate its potential *** An HTGP mouse model was induced using intraperitoneal injection of P-407 and caerulein(CAE).Then,pancreatic tissues from the model animals were subjected to proteome sequencing *** pathological changes and scores of the pancreas,lung,and kidney were determined using hematoxylin-eosin *** levels of serum amylase(AMY),triglyceride,and total cholesterol were measured with an automatic blood cell ***,the serum levels of tumor necrosis factor(TNF)-α,interleukin(IL)-6,and IL-1βwere determined by enzyme linked immunosorbent ***(MDA),glutathione(GSH),and Fe^(2+)were detected in the ***,immunohistochemistry was performed to assess the expression of ferroptosis-related *** Proteome sequencing revealed that ferroptosis was involved in the process of HTGP and that NADPH oxidase(NOX)2 may participate in ferroptosis ***,the levels of serum AMY,TNF-α,IL-6,and IL-1βwere significantly increased,MDA and Fe^(2+)were upregulated,GSH and ferroptosis-related proteins were reduced,and the injury of the pancreas,lung,and kidney were aggravated in the P407+CAE group compared to CAE and wild type groups(all P<0.05).Notably,the inhibition of ferroptosis and NOX2 attenuated the pathological damage and the release of TNF-α,IL-6,and IL-1βin the serum of the *** Ferroptosis was found to have an important role in HTGP and may be considered a potential target for clinical treatment.

关键词： Ferroptosis Acute hypertriglyceridemic pancreatitis NADPH oxidase 2 Ferrostatin-1 Vas2870

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Identification of a fatty acid synthase gene(FAS1)from Laodelphax striatellus planthoppers contributing to fecundity

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Insect Science 2023年第3期30卷 599-610页

作者： Jia-Yan Cheng pei-han yu Xue Xia Ru Zhang Li-Hua Wang Ji-Chao Fang Ary AHoffmann Guang-Hua Luo Cllege of Plant Protection Nanjing Agricultural UniversityNanjingChina Institute of Plant Protection Jiangsu Academy of Agricultural SciencesJiangsu Key Laboratory for Food and Safety-State Key Laboratory Cultivation Base of Ministry of Science and TechnologyNanjingChina School of BioSciences Bio21 InstituteUniversity of MelbourneParkvilleVictoriaAustralia

Fatty acid synthase (FAS) is a multifunctional enzyme that plays an important role in the formation of fatty acids. The fatty acids take part in many processes, such as cell signaling and energy metabolism, and in insects they are important in both cuticular hydrocarbon (CHC) formation and reproduction. Here we characterized the sequence structure and function of an FAS from the small brown planthopper (SBPH), Laodelphax striatellus. The full-length open reading frame (ORF) sequence of LsFAS1 was 7122 bp, encoding a predicted protein of 2373 amino acid residues. There were 7 functional domains in the LsFAS1 protein sequence. Gene expression screening by real-time quantitative polymerase chain reaction (RT-qPCR) showed that LsFAS1 was expressed in all developmental stages. Relative expression was highest at the 4th-instar and female adult stages. Among different tissues, the expression level of LsFAS1 in the ovary was the highest. Phylogenetic analysis showed that LsFAS1 clustered in a clade with 2 FASs from Nilaparvata lugens. Furthermore, these 3 FASs are related to cockroach BgFAS and locust LmFAS. After RNA interference-mediated knock-down, most treated insects died at eclosion. In addition, the lifespan of dsFAS1-treated female adults was shorter than that of the dsGFP-injected control, and offspring production decreased. Also, the expression of vitellogenin (Vg) and vitellogenin receptor (VgR) genes decreased. Virgin females dissected at days 2 and 4 post-eclosion showed many matured oocytes in planthoppers treated with dsGFP but not with dsFAS1. These data highlight the importance of LsFAS1 in SBPH, including a role in reproduction.

关键词： fatty acid synthase fecundity Laodelphax striatellus RNA interference sequence analysis

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Catalytic Performance of Carbon Smoke over Ag-LSCF Composite Catalysts

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 30-34页

作者： GUO Guanlun han Ming LU Shaomin yu Jing JU Hongling 无 Hubei Key Laboratory of Advanced Technology for Automotive Components&Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China College of Mechanical and Transportation Southwest Forestry UniversityKunming 650000China

To improve the catalytic performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF *** conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO_(3) group,LaFeO_(3) group,and catalyst-free *** results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9℃at 10%,50%,and 90%carbon soot conversion,*** values are 24.8,20.2,and 23.1℃lower than those of the LSCF *** also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion *** characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.

关键词： metallic composites carbon smoke oxidation perovskite catalyst soot

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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang Chao Wang yunhong Zhang Hong Liu yu Zhang Lin han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen yu han Jun Wang Shibo Xi yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Activation energy

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Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： Yingjie Zhao Yicheng Sun Chaoxin pei Xing Yin Xinyi Li Yi Hao Mengru Zhang Meng yuan Jinglin Zhou yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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16Cr奥氏体不锈钢晶间腐蚀的敏感性

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材料保护 2017年第3期50卷 26-28页

作者：毕宗岳严培林余晗汪海涛西安石油大学材料科学与工程学院陕西西安710065 国家石油天然气管材工程技术研究中心陕西宝鸡721008 宝鸡石油钢管有限责任公司陕西宝鸡721008

为了研究1Cr17Mn6Ni5N奥氏体不锈钢(16Cr奥氏体不锈钢)的晶间腐蚀行为,通过光学显微镜(OM)、X射线衍射仪(XRD)和晶间腐蚀试验研究了其在不同敏化温度和冷却方式下,晶间碳化物的析出和耐晶间腐蚀性能的变化。结果表明:16Cr奥氏体不锈钢... 详细信息

为了研究1Cr17Mn6Ni5N奥氏体不锈钢(16Cr奥氏体不锈钢)的晶间腐蚀行为,通过光学显微镜(OM)、X射线衍射仪(XRD)和晶间腐蚀试验研究了其在不同敏化温度和冷却方式下,晶间碳化物的析出和耐晶间腐蚀性能的变化。结果表明:16Cr奥氏体不锈钢在敏化温度区间内加热时,晶界碳化物随加热温度的上升而增加,加热温度为850℃左右时晶界析出碳化物最多,主要为Cr_(23)C_6和Cr_7C_3;在敏化温度区间内相同加热温度时,水冷可显著减少其晶界碳化物的析出;16Cr奥氏体不锈钢对晶间腐蚀不敏感。

关键词：晶间腐蚀 16Cr不锈钢显微组织碳化物析出

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增强型近地警告系统前视预警算法设计与仿真

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系统仿真学报 2009年第20期21卷 6666-6669,6674页

作者：宋东李文娟裴林周宇晗西北工业大学航空学院西安710072

增强型近地警告系统(EGPWS)是重要的航空机载安全系统。针对EGPWS中的重要组成部分——前视预警模块的组成框架、地形库设计、报警算法进行了研究。完成了基于正方形网格建模方法的地形数据库的设计,建立了前视预警的数学模型,重点推演... 详细信息

增强型近地警告系统(EGPWS)是重要的航空机载安全系统。针对EGPWS中的重要组成部分——前视预警模块的组成框架、地形库设计、报警算法进行了研究。完成了基于正方形网格建模方法的地形数据库的设计,建立了前视预警的数学模型,重点推演了直接判断法的预警算法及其基于二次数据缓存技术的改进算法。以高逼真度飞行仿真软件FLSIM为工具,设计并实现了EGPWS仿真系统.仿真试验结果表明,所研究的前视预警算法快速、可靠,能满足增强型近地警告系统的设计需求。

关键词： EGPWS 地形数据库前视地形报警算法飞行仿真

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Day-ahead Electricity Price Prediction Method Based on Similar Day Screening and Combined Deep Learning Modeling

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Dianwang Jishu/Power System Technology 2025年第1期49卷 242-251页

作者： Ai, yu Jia, Yanbing han, Xiaoqing Shanxi Key Laboratory of Power System Operation and Control Taiyuan University of Technology Shanxi Province Taiyuan 030024 China Key Laboratory of Cleaner Intelligent Control on Coal & Electricity Taiyuan University of Technology Ministry of Education Shanxi Province Taiyuan 030024 China

Accurate day-ahead electricity price prediction is the basis for market operation and policy planning, while market disclosure information is essential for electricity price prediction. This paper proposes a combined CNN-GRU deep-learning electricity price prediction model introducing the Self-attention mechanism. Firstly, for the trading process of the Shanxi electricity spot market and the formation mechanism of electricity price before the day, it is proposed to adopt the maximum mutual information coefficient method to extract features from the market disclosed information data such as boundary conditions before the day, to determine the key influencing factors of electricity price and its weight coefficients;and then based on the weighted grey correlation of the history of similar day screening method to generate the historical dataset of electricity price prediction, and to excavate the internal change rule of electricity price and its features;Finally, the CNN-GRU model introducing Self-attention mechanism is used to get the predicted electricity price based on the historical data set. The effectiveness and accuracy of the prediction method proposed in this paper are verified through examples. © 2025 Power System Technology Press. All rights reserved.

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Experimental demonstration of 220-GHz terahertz signals wireless transmission over 4.6 km

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Science China(Information Sciences) 2025年第1期68卷 386-388页

作者： Yi WEI Jianjun yu Mingxu WANG Xiongwei YANG Qiutong ZhanG Jingwen TAN Bing ZhanG Ying WU Yang han Peng TIAN Wen ZHOU Kaihui WANG Feng ZHAO State Key Laboratory of ASIC and System Key Laboratory for Information Science of Electromagnetic Waves (MoE)School of Information Science and Technology Fudan University School of Electronic Engineering Xi'an University of Posts and Telecommunications

The advancement of terahertz (THz) communication technology drives the evolution of wireless communication systems,offering novel pathways and technical means for the development of future 6G communication *** wireless communication systems are often constrained by bandwidth limitations of electronic devices in high frequency ***,THz communication technology leverages the characteristics of electromagnetic waves to transcend these limitations,enabling communication athigher frequencies and wider bandwidths.

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