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Use of subsequent PET/CT in diffuse large B-cell lymphoma patients in complete remission following primary therapy

Chinese Journal of Cancer 2015年第2期34卷 70-78页

作者： Xu Zhang Wei Fan Zhong-Jun Xia Ying-Ying Hu Xiao-Ping Lin Ya-Rui Zhang Zhi-Ming Li pei-yan liang Yuan-Hua Li Collaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China Department of Nuclear Medicine Sun Yat sen University Cancer Center Department of Hematological Oncology Sun Yat sen University Cancer Center Department of Medical Oncology Sun Yat sen University Cancer Center

Interim 18F-fluorodeoxyglucose(FDG) positron emission tomography/computed tomography(I-PET/CT) is a powerful tool for monitoring the response to therapy in diffuse large B-cell lymphoma(DLBCL). This retrospective study aimed to determine when and how to use I-PET/CT in DLBCL. A total of 197 patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone(R-CHOP) were enrolled between October 2005 and July 2011; PET/CT was performed at the time of diagnosis(PET/CT0), after 2 and 4 cycles of chemotherapy(PET/CT2 and PET/CT4, respectively), and at the end of treatment(F-PET/CT). According to the International Harmonization Project for Response Criteria in Lymphoma, 110 patients had negative PET/CT2 scans, and 87 had positive PET/CT2 scans. The PET/CT2-negative patients had significantly higher 3-year progression-free survival rate(75.8% vs. 38.2%) and 3-year overall survival rate(93.5% vs. 55.6%) than PET/CT2-positive patients. All PET/CT2-negative patients remained negative at PET/CT4, but 3 were positive at F-PET/CT. Among the 87 PET/CT2-positive patients, 57 remained positive at F-PET/CT, and 32 progressed during chemotherapy(15 at PET/CT4 and 17 at F-PET/CT). Comparing PET/CT4 with PET/CT0, 7 patients exhibited progression, and 8 achieved partial remission. Comparing F-PET/CT with PET/CT0, 10 patients exhibited progression, and 7 achieved partial remission. In conclusion, our results indicate that I-PET/CT should be performed after 2 rather than 4 cycles of immunochemotherapy in DLBCL patients. There is a limited role for subsequent PET/CT in the detection of relapse in PET/CT2-negative patients, but repeat PET/CT is required if the PET/CT2 findings are positive.

关键词： B细胞淋巴瘤 PET CT2 弥漫性患者治疗计算机断层扫描正电子发射断层扫描

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Qualitative visual trichotomous assessment improves the value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in predicting the prognosis of diffuse large B-cell lymphoma

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Chinese Journal of Cancer 2015年第6期34卷 21-28页

作者： Xu Zhang Wei Fan Ying-Ying Hu Zhi-Ming Li Zhong-Jun Xia Xiao-Ping Lin Ya-Rui Zhang pei-yan liang Yuan-Hua Li Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Nuclear Medicine Sun Yat-sen University Cancer Center Department of Medical Oncology Sun Yat-sen University Cancer Center Department of Hematological Oncology Sun Yat-sen University Cancer Center

Introduction:Fluorine-18 fluorodeoxyglucose(18F-FDG)positron emission tomography/computed tomography(PET/CT)is a powerful tool for monitoring the response of diffuse large B-cell lymphoma(DLBCL)to therapy,but the criteria to interpret PET/CT results remain under *** investigated the value of post-treatment PET/CT in predicting the prognosis of DLBCL patients when interpreted according to qualitative visual trichotomous assessment(QVTA)criteria compared with the Deauvil e ***:In this retrospective study,final PET/CT scans of DLBCL patients treated with rituximab-based regimens between October 2005 and November 2010 were interpreted using the Deauvil e and QVTA *** curves were estimated using Kaplan-Meier analysis and compared using the log-rank ***:A total of 253 patients were enrol *** interpretation according to the Deauvil e criteria revealed that 181patients had negative PET/CT scan results and 72 had positive *** 3 year overal survival(OS)rate was significantly higher in patients with negative scan results than in those with positive results(91.6%vs.57.5%,P<0.001).The72 patients with positive scan results according to the Deauville criteria were divided into two groups by the interpretation according to the QVTA criteria:29 had indeterminate results,and 43 had positive *** 3 year OS rate was significantly higher in patients with indeterminate scan results than in those with positive results(91.2%vs.33.5%,P<0.001)but was similar between patients with negative and indeterminate scan results(91.6%vs.91.2%,P=0.921).Conclusions:Compared with the Deauvil e criteria,using the QVTA criteria for interpreting post-treatment PET/CT scans of DLBCL patients is likely to reduce the number of false positive *** QVTA criteria are feasible for therapeutic outcome evaluation and can be used to guide risk-adapted therapy.

关键词：正电子发射断层扫描计算机断层扫描 B细胞淋巴瘤脱氧葡萄糖定性视觉预后预测评估

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Inverse Gaussian-beam common-reflection-point-stack imaging in crosswell seismic tomography

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Applied Geophysics 2019年第3期16卷 349-357,396,397页

作者： Wei Zheng Rong yang Fei-Long Liu Bao-Hua pei yan-liang College of the Geological Engineering and Geomatics Chang'an UniversityXi'an710065 China College of the Geoscience and Engineering Xi'an Shiyou University Xi'an710064 China National Deep See Center Qingdao266273China The First Institute of Oceanography SOAQingdao266061 China

To solve problems in small-scale and complex structural traps,the inverse Gaussian-beam stack-imaging method is commonly used to process crosswell seismic wave reflection *** to limited coverage,the imaging quality of conventional ray-based crosswell seismic stack imaging is poor in complex areas;moreover,the imaging range is small and with sever interference because of the arc phenomenon in seismic ***,we propose the inverse Gaussian-beam stack imaging,in which Gaussian weight functions of rays contributing to the geophones energy are calculated and used to decompose the seismic *** effectively enlarges the coverage of the reflection points and improves the transverse *** with the traditional VSP–CDP stack imaging,the proposed methods extends the imaging range,yields higher horizontal resolution,and is more adaptable to complex geological *** method is applied to model a complex structure in the *** results suggest that the wave group of the target layer is clearer,the resolution is higher,and the main frequency of the crosswell seismic section is higher than that in surface seismic exploration The effectiveness and robustness of the method are verified by theoretical model and practical data.

关键词： crosswell seismic Gaussian weight function inverse beam common reflection stack imaging

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Establishing a new testing protocol of the electrochemical stability window for electric double-layer capacitors

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Science China Chemistry 2025年第1期68卷 217-225页

作者： Ruilin Hou Xiaoxi Zhao Tingting liang Qingyun Dou Shan Xu Xingbin yan School of Materials Science and Engineering Sun Yat-sen University Laboratory of Clean Energy Chemistry and Materials Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Engineering and Applied Sciences Nanjing University Center of Industrial Analysis and Testing Guangdong Academy of Science

The electrochemical stability window(ESW) is crucial for determining the energy density of electric double-layer capacitors(EDLCs). However, current ESW testing protocols of EDLCs are strongly affected by artificial factors, thereby leading to unreliable result. To solve this problem, we first identify the key shortcomings of the traditional protocols by analyzing their test principles. Subsequently, taking an aqueous carbon-based EDLC as an example, we design a side reaction descriptor to represent the response difference in the charging capacitance to side reactions between the cyclic voltammetry and galvanostatic chargedischarge methods. With the aid of this descriptor, we propose a new ESW testing protocol, which is not only able to completely avoid the adverse influence of subjective factors but also fully consider the operating condition limitations. The protocol can be extended from the single electrode to the full device. This work proposes a more rigorous definition of ESW and provides a reliable protocol for evaluating the ESW of EDLCs.

关键词： electric double-layer capacitors electrochemical stability window testing protocol side reaction descriptor operating limitation

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Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 498-503页

作者： liang Chu Haoyu Shen Hudie Wei Hongyu Chen Guoqiang Ma Wensheng yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

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“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： yan Zhao Qiang Yuan Liting yang Guisheng liang Yifeng Cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

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Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期68卷 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng yan Yong liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

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深拖多道高分辨率地震探测技术综述

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地球物理学进展 2020年第3期35卷 1191-1198页

作者：魏峥嵘裴彦良刘保华长安大学地质工程与测绘学院西安710054 自然资源部第一海洋研究所自然资源部海洋地质与成矿作用重点实验室青岛266061 国家深海基地管理中心青岛266237 青岛海洋科学与技术国家实验室海洋地质过程与环境功能实验室青岛266061

随着我国主要海域的天然气水合物勘探逐步进入详查和开采阶段,对深海天然气水合物矿体空间分布的探查精度要求显著提高,而海洋常规多道地震探测系统分辨率不足,难以满足现阶段深海天然气水合物资源详查、勘探和开发的需要.本文详细阐述... 详细信息

随着我国主要海域的天然气水合物勘探逐步进入详查和开采阶段,对深海天然气水合物矿体空间分布的探查精度要求显著提高,而海洋常规多道地震探测系统分辨率不足,难以满足现阶段深海天然气水合物资源详查、勘探和开发的需要.本文详细阐述了深拖多道高分辨率地震探测技术探测方式及其特点,分析对比了深拖多道地震技术与常规海洋多道地震技术、短排列小道距地震技术及OBC地震技术相比的优越性;总结了国外深拖多道高分辨率地震探测装备以及在精细识别BSR、海底冷泉及海底麻坑等的应用效果.因为深拖多道高分辨率地震探测技术是将震源与采集缆拖曳与近海底(约100 m)且震源具有高主频、宽频带的特点,从而降低了勘探海洋噪声对地震信号的影响,缩短了与被探测目标的距离,降低了地震信号在传播过程中海水的吸收衰减,并且能够克服海面拖曳地震勘探中多次波、气泡效应的影响,所以其具有很高的纵向分辨率和横向分辨率以及高信噪比特点,将在天然气水合物勘探以及海洋工程领域具有极大的应用价值.

关键词：深拖地震纵向分辨率横向分辨率高分辨率天然气水合物

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海底热流探测技术综述

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地球物理学进展 2005年第3期20卷 611-619页

作者：李官保裴彦良刘保华国家海洋局第一海洋研究所青岛266061

热流探测是一项重要的基础地球物理调查项目,使用探针式热流计测量海底热流是常用的方法.自二十世纪中期以来,先后出现的三种主要的热流计:Bullard型、Ewing型和Lister型,使热流探测的精度和效率有了很大的提高.文中比较详细地介绍了这... 详细信息

热流探测是一项重要的基础地球物理调查项目,使用探针式热流计测量海底热流是常用的方法.自二十世纪中期以来,先后出现的三种主要的热流计:Bullard型、Ewing型和Lister型,使热流探测的精度和效率有了很大的提高.文中比较详细地介绍了这三种热流计的主要技术特点,分析了我国海底热流探测的现状与不足,并对热流探测技术未来的发展进行了展望.

关键词：热流探针地温梯度热导率

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海底缆线的磁力探测方法与实践

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地球物理学进展 2012年第5期27卷 2226-2232页

作者：裴彦良梁瑞才郑彦鹏韩国忠李正光国家海洋局第一海洋研究所青岛266061 海洋沉积与环境地质国家海洋局重点实验室青岛266061

在路由调查过程中,为保证海底光缆工程新建过程中已敷设的缆线安全,必须准确测得新建光缆的路由以及与它们交叉点的位置,进而采取一些必要的保护措施.本文回顾了海底缆线磁法探测的历史,介绍了探测原理和测线布设方法,通常海底缆线磁力... 详细信息

在路由调查过程中,为保证海底光缆工程新建过程中已敷设的缆线安全,必须准确测得新建光缆的路由以及与它们交叉点的位置,进而采取一些必要的保护措施.本文回顾了海底缆线磁法探测的历史,介绍了探测原理和测线布设方法,通常海底缆线磁力探测测线,一般垂直于已敷设缆线布设,并以路由交汇点为中心布设3～5条测线,测线长度1km,测线间距200m.文中给出了探测中需要使用的磁力仪、定位仪、测深仪等仪器设备的技术要求和推荐配置.另外,通过采取适当降低船速和在磁力传感器附件适当配重等手段,提高测量精度.在此基础上,结合亚美光缆中国段路由磁力调查的工程实例,对应用磁力仪探测海缆的探测过程、磁测资料处理和解释方法进行了分析和总结,绘制了AAG路由与某海底光缆交汇点的磁力探测成果图件.最后,给出了几次典型工程实践的探测成功率统计.多次工程实践表明,磁力探测方法对于海底缆线的探测具有很好的效果.磁力探测是海底缆线探测不可或缺的方法手段之一.

关键词：海底缆线磁力探测方法实践

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