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Artificial intelligence empowers the second-observer strategy for colonoscopy:a randomized clinical trial

Gastroenterology Report 2023年第1期11卷 216-223页

作者： Pu Wang xiao-Gang liu Min Kang Xue Peng Mei-Ling Shu Guan-Yu Zhou pei-xi liu Fei xiong Ming-Ming Deng Hong-Fen xia Jian-Jun Li xiao-Qi Long Yan Song Liang-Ping Li Department of Gastroenterology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanP.R.China Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuanP.R.China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqingP.R.China Department of Gastroenterology Suining Central HospitalSuiningSichuanP.R.China

Background:In colonoscopy screening for colorectal cancer,human vision limitationsmay lead to highermiss rate of lesions;artificial intelligence(AI)assistance has been demonstrated to improve polyp ***,there still lacks direct evidence to demonstrate whether AI is superior to trainees or experienced nurses as a second observer to increase adenoma detection during *** this study,we aimed to compare the effectiveness of assistance fromAI and human observer during ***:A prospective multicenter randomized study was conducted from 2 September 2019 to 29 May 2020 at four endoscopy centers in *** patients were randomized to either computer-aided detection(CADe)-assisted group or observer-assisted *** primary outcome was adenoma per colonoscopy(APC).Secondary outcomes included polyp per colonoscopy(PPC),adenoma detection rate(ADR),and polyp detection rate(PDR).We compared continuous variables and categorical variables by using R studio(version 3.4.4).Results:A total of 1,261(636 in the CADe-assisted group and 625 in the observer-assisted group)eligible patients were ***(0.42 vs 0.35,P=0.034),PPC(1.13 vs 0.81,P<0.001),PDR(47.5%vs 37.4%,P<0.001),ADR(25.8%vs 24.0%,P=0.464),the number of detected sessile polyps(683 vs 464,P<0.001),and sessile adenomas(244 vs 182,P=0.005)were significantly higher in the CADe-assisted group than in the observer-assisted *** detections of the CADe system were lower than those of the human observer(122 vs 191,P<0.001).Conclusions:Compared with the human observer,the CADe system may improve the clinical outcome of colonoscopy and reduce disturbance to routine practice(*** No.:ChiCTR1900025235).

关键词： artificial intelligence colon cancer screening adenoma early detection computer-aided detection

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制备工艺对(Ba0.85Ca0.15)(Ti0.9Zr0.1)O3无铅压电陶瓷结构与性能的影响

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无机材料学报 2017年第3期32卷 299-304页

作者：龙佩青刘希涛易志国中国科学院福建物质结构研究所中国科学院光电材料化学与物理重点实验室福州350002

采用液相混合与固相烧结相结合的方法制备了(Ba_(0.85)Ca_(0.15))(Ti_(0.9)Zr_(0.1))O_3(BCTZ)无铅压电陶瓷,系统研究了烧结保温时间对其相结构、介电、压电和铁电性能的影响以及电学性能随温度的变化。研究结果表明:制备的陶瓷样品具... 详细信息

采用液相混合与固相烧结相结合的方法制备了(Ba_(0.85)Ca_(0.15))(Ti_(0.9)Zr_(0.1))O_3(BCTZ)无铅压电陶瓷,系统研究了烧结保温时间对其相结构、介电、压电和铁电性能的影响以及电学性能随温度的变化。研究结果表明:制备的陶瓷样品具有单一的四方钙钛矿结构。当烧结温度为1540℃时,随着保温时间的延长,样品晶粒尺寸变大,居里温度(Tc)升高,压电性能提高,电致伸缩性能下降。当保温时间为24 h时,BCTZ陶瓷综合性能最为优异:Tc^90℃,tanδ<0.05,kp^0.46,d33~540 p C/N,Ps^17μC/cm^2。陶瓷电学性能随温度变化测试结果又表明,BCTZ陶瓷的电学性能具有很强的温度依赖性,随着温度的升高其电学性能逐渐下降。

关键词： BCTZ 无铅压电陶瓷制备工艺热稳定性

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu xiaoling liu Biao Meng Tao Chen Yu Han Jun Wang Shibo xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li xi liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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大剂量阿莫西林/埃索美拉唑二联方案根除幽门螺杆菌

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世界华人消化杂志 2018年第6期26卷 353-359页

作者：高采平肖迅刘培曦周洲李良平韩盛玺电子科技大学医学院附属四川省人民医院消化科四川省成都市610072

目的评估大剂量阿莫西林/埃索美拉唑二联方案在幽门螺杆菌(Helicobacter pylori,***)感染初次治疗患者中的疗效及安全性.方法 142例***感染的初次治疗患者随机进入大剂量阿莫西林/埃索美拉唑二联方案(EA)组(埃索美拉唑20 mg qid+阿莫西... 详细信息

目的评估大剂量阿莫西林/埃索美拉唑二联方案在幽门螺杆菌(Helicobacter pylori,***)感染初次治疗患者中的疗效及安全性.方法 142例***感染的初次治疗患者随机进入大剂量阿莫西林/埃索美拉唑二联方案(EA)组(埃索美拉唑20 mg qid+阿莫西林0.75g qid,疗程14d)和铋剂四联方案(EBAC)组(埃索美拉唑20mg bid+枸橼酸铋钾220 mg bid+阿莫西林1.0g bid+克拉霉素0.5g bid,疗程14d),治疗结束后6wk复查尿素呼气试验,判断***根除疗效.结果共131例患者完成研究,EA组按意向治疗(intentionto-treat,ITT)与按方案(per-protocol,PP)分析***根除率分别为82.9%和89.2%,EBAC组分别为86.1%和93.9%,两组根除率的ITT、PP分析差异均无统计学意义(P>0.05).按PP分析,EBAC组不良反应发生率明显高于EA组(15.2%vs 3.1%,P<0.05).结论大剂量阿莫西林/埃索美拉唑二联方案可作为安全、有效的***感染初次治疗方案.

关键词：幽门螺杆菌治疗阿莫西林临床研究二联方案

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao Lei xi Zhen Yuan Ping Wang Bin liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin Meng Li Weibin Chen pei liu Tao Huang Zhencheng Huang Yuying liu Jiaojiao Deng Shenghua Ye Xuming Yang xiangzhong Ren xiaoping Ouyang Jianhong liu Biwei xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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窄带成像国际结直肠内镜分型在结直肠病变诊治中的价值

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中国内镜杂志 2018年第5期24卷 1-6页

作者：杨雪刘培曦肖迅王璞李娟四川省医学科学院.四川省人民医院消化内科四川成都610072 四川省医学科学院.四川省人民医院病理科四川成都610072

目的评价非放大内镜下窄带成像(NBI)国际结直肠内镜分型(NICE)实时预判结直肠病变性质并指导治疗的价值。方法对结直肠隆起或扁平隆起性的黏膜病变采用NICE分型进行实时预判分类和处置建议,依据活检、内镜或外科手术后的病理结果评价NIC... 详细信息

目的评价非放大内镜下窄带成像(NBI)国际结直肠内镜分型(NICE)实时预判结直肠病变性质并指导治疗的价值。方法对结直肠隆起或扁平隆起性的黏膜病变采用NICE分型进行实时预判分类和处置建议,依据活检、内镜或外科手术后的病理结果评价NICE分型的敏感性、特异性、准确性、阳性预测值和阴性预测值。进行观察一致性检验。结果共计241例患者307处病变被纳入分析。其中非肿瘤性病变12.07%、腺瘤性病变82.07%、癌5.86%,病变直径0.1~6.0 cm。NICE分型预判肿瘤性及非肿瘤性病变的敏感性、特异性、准确性、阳性预测值、阴性预测值分别为97.04%、89.19%、96.09%、98.50%和80.49%。一致性检验,判断肿瘤性病变和非肿瘤性病变的Kappa值为0.795,判断黏膜下深层病变和黏膜下浅层以上病变的Kappa值为0.875,总的Kappa值为0.814。结论 NICE分型能较准确地实时预判结直肠病变的性质并指导治疗,有利于推广仅将肿瘤性病变纳入内镜下切除或外科手术的适度治疗模式。

关键词： NICE分型窄带成像结直肠病变

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μ-Synthesis control with reference model for aeropropulsion system test facility under dynamic coupling and uncertainty

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Chinese Journal of Aeronautics 2023年第10期36卷 246-261页

作者： Jiashuai liu xi WANG xi liu Meiyin ZHU xitong pei Song ZHANG Zhihong DAN School of Energy and Power Engineering Beihang UniversityBeijing 100191China Zhongfa Aviation Institute Beihang UniversityHangzhou 311115China Research Institute of Aero-Engine Beihang UniversityBeijing 100191China Science and Technology on Altitude Simulation Laboratory AECC(Aero Engine Corporation of China)Sichuan Gas Turbine EstablishmentMianyang 621703China

Due to the dynamic coupling and multi-source uncertainties,it is difficult to accurately control the pressure and temperature of the Aeropropulsion System Test Facility(ASTF)in the presence of rapid command and large *** paper presents the design ofμ-synthesis control to solve the *** incorporating the pressure ratio into the linear equation of the control valve,the modeling error of ASTF in the low frequency range is effectively ***,an uncertain model is established by considering various factors,including parameter variations,modeling error in the low frequency range,unmodeled dynamics,and changes in the working *** address the dynamic coupling,a diagonal reference model with desired performance is incorporated intoμ-***,all weighting functions are designed according to the performance ***,theμ-controller is obtained by using the standardμ-synthesis *** results indicate that theμ-controller decouples the pressure and temperature dynamics of *** with the multivariable PI controller,integral-μcontroller,and double integral-μcontroller,the proposedμ-controller can achieve higher transient accuracy and better disturbance ***,the robustness of theμ-controller is demonstrated by Monte Carlo simulations.

关键词： Aeropropulsion System Test Facility(ASTF) Decoupling Robustness μ-Synthesis Uncertainty

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锥形束CT测量上颌后牙根尖与上颌窦底距离准确性与应用价值研究

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临床军医杂志 2018年第9期46卷 1023-1026页

作者：廖培希刘福祥潘兰兰成都市第六人民医院口腔科四川成都610051 四川大学华西口腔医院种植科四川成都610041 重庆医科大学附属口腔医院牙周科重庆401147

目的探讨锥形束CT(CBCT)测量上颌后牙根尖与上颌窦底距离的准确性与应用价值。方法选取自2016年1月至2018年2月收治的68例接受CBCT检查者为研究对象,总结分析136侧上颌窦、204颗牙齿、952个牙根的CBCT影像资料,观察上颌后牙根尖和上颌... 详细信息

目的探讨锥形束CT(CBCT)测量上颌后牙根尖与上颌窦底距离的准确性与应用价值。方法选取自2016年1月至2018年2月收治的68例接受CBCT检查者为研究对象,总结分析136侧上颌窦、204颗牙齿、952个牙根的CBCT影像资料,观察上颌后牙根尖和上颌窦底的解剖关系,测量上颌后牙根尖和上颌窦底距离。结果上颌后牙各牙根和上颌窦关系分型中A型(59. 6%)最高,第二前磨牙中B型(18. 4%)明显高于E型(8. 1%),差异有统计学意义(P 0. 05)。男性和女性恒牙期CBCT头影测量项目中Ptm-A、Go-Pog、GoCo、Pcd-S、U1-SN、L1-NB、FMIA、L1-MP测量值差异较大(P 0. 05)。结论 CBCT能清晰观察上颌后牙区的解剖特征,准确分析其和上颌窦底间的关系,距离测量数据精确,在评估上颌后牙区生理病理状况、指导治疗方案等方面的应用价值较大。

关键词：锥形束CT 上颌后牙牙根根尖上颌窦底距离应用价值

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