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World Journal of Gastrointestinal Surgery 2023年第3期15卷 480-487页

作者： Xiang-Cheng Hu Chen-Xiao Gan Hui-Min zheng Xue-Ping Wu Wen-sheng pan Department of Gastroenterology Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastroenterology Zhejiang Provincial People’s hospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Peutz-Jeghers syndrome(PJS)is a rare autosomal dominant disorder,and female patients may develop gynecologic *** prognosis for such patients is poor and the specific pathogenesis remains ***,there are currently no uniform treatment *** SUMMARY Herein,we introduce the case of a 45-year-old female who was diagnosed with PJS for 45 years and cervical cancer for 3 *** pathological examination showed metastases in the right external iliac lymph *** patient was initially treated with a combination of doxorubicin and carboplatin chemotherapy and pelvic magnetic resonance showed that the metastases had ***,we performed whole exome sequencing in this patient and identified the relevant causative *** addition to the chemotherapy regimen,sindilizumab was administered and the patient was followed *** 4 cycles of treatment,the metastases were substantially reduced and were not enlarged after six months of *** case report suggests that patients with PJS combined with cervical cancer may have a sustained response to immunecombination chemotherapy *** Clinicians should be aware of the importance of immunotherapy in patients with PJS combined with advanced cervical cancer.

关键词： Peutz-Jeghers syndrome Cervical cancer Programmed cell death protein 1 Chemotherapy Case report

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MIMO多用户系统中的有限反馈研究

电子科技大学学报 2012年第4期41卷 507-511页

作者：潘沛生宋荣方郑宝玉曹士坷南京邮电大学通信与信息工程学院江苏210003

在MIMO下链路通信系统中,如果每个用户将它们的信道状态信息反馈回基站,则基站可以根据用户信道状态信息,调度信道条件好的用户传输数据,从而获得很高的系统容量。该文针对当系统中用户个数显著增加,大量的反馈信息导致反馈信道溢出的状... 详细信息

在MIMO下链路通信系统中,如果每个用户将它们的信道状态信息反馈回基站,则基站可以根据用户信道状态信息,调度信道条件好的用户传输数据,从而获得很高的系统容量。该文针对当系统中用户个数显著增加,大量的反馈信息导致反馈信道溢出的状况,提出一种基于用户分级的减少反馈信息总量的策略,该策略要求只有当用户的信扰噪比高于某个门限,用户才反馈其信道方向信息和用户级别信息;否则不反馈任何信息。理论分析和计算机仿真结果证明了该策略能有效地减少反馈的信息总量并且可获得复用增益和多用户分集增益。

关键词：有限反馈 MIMO信道多用户分集用户级别波束成形

Quadrupole Moment of the h_(11/2) Quasineutron Band in ^(129)Ce

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Chinese Physics Letters 1998年第8期15卷 564-565页

作者： LI Guang-sheng DAI zheng-yu LIU Xiang-an ZHANG Lan-kuan WEN Shu-xian WU Xiao-guang yuAN Guan-jun WENG pei-kun LI sheng-gang YANG Chun-xiang China Institute of Atomic Energy Beijing 102413

Mean lifetimes of the h_(11/2) quasineutron band in 129Ce were measured by using the Doppler shift attenuation method in connection with the reaction ^(116)Sn(^(l6)O,3n)^(129)Ce at a bombarding energy of *** data indicate that transition quadrupole moment of ^(129)Ce is smaller than that of *** reduction in collectivity caused by the addition of an h_(11/2) neutron can be interpreted as due to triaxiality induced byγdriving effect.

关键词： effect. addition

Collective Behavior of Negative Parity States in ^(126)Ba at High Spin

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Chinese Physics Letters 1998年第3期15卷 168-169页

作者： LI Guang-sheng DAI zheng-yu LIU Xiang-an ZHANG Lan-kuan WEN Shu-xian WU Xiao-guang yuAN Guan-jun WENG pei-kun LI sheng-gang YANG Chun-xiang China Institute of Atomic Energy Beijing 102413

Lifetimes of the high spin states in the negative parity band of ^(126)Ba were measured by using the Doppler shift attenuation method in conjunction with the reaction ^(116)Sn(^(16)O,2p4n)^(126) Ba at a beam energy of 73 *** band shows a typically collective behavior and possesses a near-axial prolate shape with a deformation parameter β_(2)=0.27±0.01 and triaxiality γ~-5°.

关键词： collective typically

The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4614-4627页

作者： Qiaonan Shan Lu Yin Qifan Zhan Jiongjie yu sheng pan Jianyong Zhuo Wei Zhou Jiaqi bao Lincheng Zhang Jiachen Hong Jianan Xiang Qingyang Que Kangchen Chen shengjun Xu Jingrui Wang Yangbo Zhu Bin He Jingbang Wu Haiyang Xie Shusen zheng Tingting Feng Sunbin Ling Xiao Xu Department of Hepatobiliary and pancreatic Surgery NHC Key Laboratory of Combined Multi-organ TransplantationThe First Affiliated HospitalZhejiang University School of MedicineHangzhou310058China Department of Hepatobiliary and pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhou310006China Department of Hepatobiliary and pancreatic Surgery and Minimally Invasive Surgery Zhejiang Provincial People’s Hospital(Affiliated People’s Hospital)School of Clinical MedicineHangzhou Medical CollegeHangzhou314408China Institute of Translational Medicine Zhejiang UniversityHangzhou310009China Zhejiang Cancer Hospital Hangzhou310022China

Lenvatinib is a targeted drug used for first-line treatment of hepatocellular carcinoma(HCC).A deeper insight into the resistance mechanism of HCC against lenvatinib is urgently *** this study,we aimed to dissect the underlying mechanism of lenvatinib resistance(LR)and provide effective treatment *** established an HCC model of acquired *** counting,migration,self-renewal ability,chemoresistance and expression of stemness genes were used to detect the stemness of HCC *** and biochemical strategies such as RNA-sequencing,immunoprecipitation,mass spectrometry and ubiquitination assays were used to explore the underlying ***-derived HCC models and HCC samples from patients were used to demonstrate clinical *** identified that increased cancer stemness driven by the hypoxia-inducible factor-1α(HIF-1α)pathway activation is responsible for acquired LR in *** non-muscle myosin heavy chain 9(MYH9)at Ser1943,p-MYH9(Ser1943),could recruit ubiquitin-specific protease 22(USP22)to deubiquitinate and stabilize HIF-1αin lenvatinib-resistant ***,p-MYH9(Ser1943)expression was upregulated in HCC samples,which predicted poor prognosis and LR.A casein kinase-2(CK2)inhibitor and a USP22 inhibitor effectively reversed LR in vivo and in ***,the p-MYH9(Ser1943)/USP22/HIF-1αaxis is critical for LR and cancer *** the diagnosis and treatment of LR in HCC,p-MYH9(Ser1943),USP22,and HIF-1αmight be valuable as novel biomarkers and targets.

关键词： USP22 hepatocellular diagnosis

Schisandrae Fructus oil-induced elevation in serum triglyceride and lipoprotein concentrations associated with physiologic hepatomegaly in mice

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Asian Pacific Journal of Tropical Biomedicine 2022年第2期12卷 59-68页

作者： Si-yuan pan Xue-Lan Song Zhao-Heng Lin Qing yu Yi Zhang Hai-Chuan Tai Gan Luo Xiao-Yan Wang pei-Li Zhu Nan Sun Zhu-sheng Chu Zhi-Ling yu Yi Zhang Kam-Ming Ko School of Traditional Dai-Thai Medicine West Yunnan University of Applied SciencesJinghongYunnanChina School of Chinese Materia Medica Beijing University of Chinese MedicineBeijingChina Department of Biology Hong Kong Baptist UniversityHong KongChina School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Division of Life Science Hong Kong University of Science&TechnologyHong KongChina

Objective:To investigate hypertriglyceridemia and hepatomegaly caused by Schisandrae Sphenantherae Fructus(FSS)and Schisandra chinensis Fructus(FSC)oils in ***:Mice were orally administered a single dose of ***(TG),triglyceridetransferprotein(TTP),apolipoproteinB48(Apo B48),very-low-densitylipoprotein(VLDL),hepatocytegrowth factor(HGF),alanine aminotransfease(ALT)and liver index were measured at 6-120 h ***:FSS and FSC oil caused time and dose-dependent increases in serum and hepatic TG levels,with maximum increases in the liver(by 297%and 340%)at 12 h post-dosing and serum(244%and 439%)at 24-h post-dosing,*** Fructus oil treatments also elevated the levels of serum TTP by 51%and63%,Apo B48 by 152%and 425%,and VLDL by 67%and 38%in mice,*** and FSC oil treatments also increased liver mass by 53%and 55%and HGF by 106%and 174%,but lowered serum ALT activity by 38%and 22%,*** pre/co-treatment attenuated the FSS and FSC oil-induced elevation in serum TG levels by 41%and 49%at 48 h post-dosing,respectively,but increased hepatic TG contents(by 38%and 33%,respectively)at 12 h ***:Our findings provide evidence to support the establishment of a novel mouse model of hypertriglyceridemia by oral administration of FSS oil(mainly increasing endogenous TG)and FSC oil(mainly elevating exogenous TG).

关键词： Schisandrae Fructus oils Triglyceride Alanine aminotransferase Hepatomegaly Mouse model Hypertriglyceridemia

Temperature and current sensitivity extraction of optical superconducting transition-edge sensors based on a two-fluid model

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Chinese Physics B 2021年第9期30卷 594-598页

作者： yue Geng pei-Zhan Li Jia-Qiang Zhong Wen Zhang zheng Wang Wei Miao yuan Ren sheng-Cai Shi Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Science and Technology of China Hefei 230026China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210023China

Optical superconducting transition-edge sensor(TES)has been widely used in quantum information,biological imaging,and fluorescence microscopy owing to its high quantum efficiency,low dark count,and photon number resolving *** temperature sensitivity(α_(I))and current sensitivity(β_(I))are important parameters for optical TESs,which are generally extracted from the complex *** we present a method to extractα_(I)andβ_(I)based on a two-fluid model and compare the calculated current-voltage curves,pulse response,and theoretical energy resolution with the measured *** method shows qualitative agreement that is suitable for further optimization of optical TESs.

关键词： transition-edge sensor single-photon detector two-fluid model

Research of detonation products of RDX/Al from the perspective of composition

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Defence Technology（防务技术） 2023年第6期24卷 31-45页

作者： Xing-han Li Zhi-cong Yi Qi-jun Liu Fu-sheng Liu Ze-teng Zhang Shen-yuan Hou Xian-xu zheng Xu Zhang Hong-bo pei School of Physical Science and Technology Southwest Jiaotong UniversityChengdu610031China National Key Laboratory for Shock Wave and Detonation Physics Mianyang621900China

Aluminized explosives exhibit excellent performance because the oxidation of aluminum(Al)powders enhances the pressure and temperature of detonation ***,the equation of state(EOS)of detonation products has not been understood *** the present study,we conducted long-time tests(approximately 1 ms)of a metal rod driven by detonation products of RDX,RDX/Li F,and RDX/*** addition,we used laser velocimetry(PDV)to measure the freesurface velocity of the *** code DLCHEQ was successfully applied to the hydrodynamic program SSS to perform the roddriven test,and a novel method was established to study the EOS of detonation products from the perspective of *** reliability of DLCEHQ was validated by a small deviation(<10%)between the experimental rod free-surface velocity of RDX and the calculated results;the deviation was considerably less than that from the results obtained using the JWL EOS and ideal-gas *** endothermic process and the reaction of Al powders(Al+H_(2)O+NO+CO_(2)→CO+H_(2)+N_(2)+Al_(2)O_(3))were analyzed by calculating the rod free-surface velocity of RDX/Li F and RDX/Al,*** results of the present study demonstrated that the thermodynamic state of Al powders has notable influence on the EOS of aluminized detonation products,and the findings were compared with those of previous ***,the temperature equilibrium between Al powders and CHNO products is not always achieved,and the disequilibrium is more obvious when the reaction of Al powders is ***,the reaction rate of Al powders depends on pressure and Al ***,the endothermic process of Al powders has a high contribution to the decrease in the work ability of RDX/Al instead of the gasconsumption mechanism of the Al *** than half of the reaction heat of Al powders is used to heat itself,whereas the gas consumption during the reaction is negligible.

关键词： Aluminized explosive Detonation products EOS Rod-driven test Compositional evolution

The potential application of the traditional Chinese herb Exocarpium Citri grandis in the prevention and treatment of COVID-19

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Traditional Medicine Research 2020年第3期5卷 160-166页

作者： Wei-Wei Su Yong-Gang Wang pei-Bo Li Hao Wu Xuan Zeng Rui Shi yu-Ying zheng pan-Lin Li Wei Peng Guangdong Engineering&Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine Guangdong Provincial Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

Huajuhong(Exocarpium Citri grandis,ECG)is a traditional Chinese herbal medicine and has been used for the treatment of respiratory diseases for hundreds of ***,ECG has been listed in a traditional Chinese medicine formula in the Guidelines for the Diagnosis and Treatment of Coronavirus Disease 2019(sixth edition)in *** date,the effect and mechanism of ECG against respiratory diseases have not been systematically *** this paper,the researchers summarized the effects of ECG and its pharmacologically active compound naringin in functioning as an antitussive and expectorant,improving lung function,alleviating acute lung injury,attenuating pulmonary fibrosis,and enhancing antiviral immune response,so as to provide a reference for its clinical application in the prevention and treatment of multiple respiratory diseases,including coronavirus disease 2019.

关键词： Huajuhong Exocarpium Citri grandis Naringin coronavirus disease 2019 Clinical application

Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation

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Chinese Journal of Natural Medicines 2022年第6期20卷 443-457页

作者： DUAN Fei-Peng LI Yi-sheng HU Tian-Yong pan Xin-Quan MA Fang FENG yue QIU Shu-Qi zheng Yi-Qing Institute of Otolaryngology Institute of Hearing and Speech of Sun Yat-sen UniversitySun Yat-sen Me-morial HospitalSun Yat-sen UniversityGuangzhou 510520China Department of Otolaryngology Longgang E.N.T hospital&Shenzhen Key Laboratory of E.N.TInstitute of E.N.TShenzhen 518172China

Antibiotic exposure-induced dysbiosis of the intestinal flora increases the risk of developing allergic ***,regulating the balance of intestinal flora may be useful for preventing and treating allergic ***,the underlying mechanism is *** nobile(Shihu)exhibits anti-inflammatory and immune ***,in this study,we investigated the mechanism via which Shihu may improve allergic *** models of allergic rhinitis with intestinal flora dysbiosis(Model-D,antibiotics induce intestinal flora dysbiosis with ovalbumin-induced allergy)and normal intestinal flora with allergic rhinitis(Model-N,ovalbumin-induced allergy)were *** effect of Shihu on intestinal flora and inflammation caused during allergic rhinitis were *** symptoms,infiltration of hematoxylin and eosin in the lungs and nose,and the release of various factors[interleukin(IL)-2,IL-4,IFN-y,IL-6,IL-10,and IL-17]in the lungs were *** results indicate that intestinal flora dysbiosis exacerbated lung and nose inflammation in allergic ***,treatment with the Shihu extract effectively reversed these ***,the Shihu extract inhibited the PI3K/AXT/mTOR pathway and increased the level of Forkhead box protein in the ***,the Shihu extract reversed intestinal flora dysbiosis at the phylum and genus levels and improved regulator T cell ***,in the Model-D group,the Shihu extract inhibited the decrease in the diversity and abundance of the intestinal *** was performed to determine which intestinal flora was positively correlated with Treg differentiation using Spearman5 s correlation *** conclusion,we showed that Shihu extract restored the balance in intestinal flora and ameliorated inflammation in the lungs of allergic rhinitis mice and predicted a therapeutic new approach using Traditional Chinese Medicine to improve allergic rhinitis.

关键词： Dendrobium nobile(Shihu) Allergic rhinitis Intestinal flora Regulator T cell Inflammation