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Relations of Budd-Chiari syndrome to prothrombin gene mutation

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 214-218页

作者： Guo-Ling Lin, pei-qin xu, Hua Qi, Jian-Hua Lian, Hong Zheng and xiao-wei dang zhengzhou, chinadepartment of general surgery, first Affiliated hospi- tal of zhengzhou university the Faculty of Cytobiology and Medical Genetics, Medical School, zhengzhou Univer- sity , zhengzhou 450052, china department of general surgery First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China.

BACKGROUND: Budd-Chiari syndrome (BCS) is a type of disease characterized by portal hypertension and/or hy- pertension of the inferior vena cava (IVC) due to the ob- struction of the hepatic veins (HV) and/or intrahepatic IVC outlet. Being etiologically complicated and obscure, BCS can be acquired or idiopathic and several gene muta- tions may be contributable. This study was to explore whether prothrombin gene mutation (F G20210A) takes part in the pathogenesis of BCS and to investigate their cor- relativity. METHODS: In 38 proven BCS patients and 70 controls, polymerase chain reaction-restriction fragment length poly- morphism (PCR-RFLP) was used to find F G20210A mutation. To detect whether there are any mutations, four steps were taken: purification of genome DNA from whole blood, amplification of special fragment by polymerase chain reaction, digestion of the fragment via restriction en- donuclease, and analysis of results by polyacrylamide gel electrophoresis. RESULTS: F G20210A mutation was not detected in all patients and controls. CONCLUSIONS: No F G20210A mutation exists in Chi- nese patients with BCS, nor correlativity between the oc- currence of BCS and F G20210A mutation. The etiology of BCS in the Chinese needs further investigation.

关键词： hepatic vein thrombosis etiology F G20210A gene mutation

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in china:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou wei-Hong Jiang Yan Jiang Jing-Wu Sun qin-Tai Yang xue-Zhong Li Ya-Nan Sun Li Shi Min Wang Xi-Cheng Song Fu-Quan Chen xiao-Shu Zhang Hong-Quan wei Shao-qing Yu Dong-Dong Zhu Luo Ba Zhi-wei Cao xu-Ping xiao Xin wei Zhi-Hong Lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-qing Zhao Zhen-Lin Wang Hua-Bin Li Feng Liu xiao-Bo Cui Sheng-Nan Ye Zheng Liu Yu xu xiao Cai wei Huang Ru-Xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping Lu Yang Shen Yu-Tong Zhao Jia-Hong pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate School of Beijing university of Chinese Medicine BeijingChina department of Otorhinolaryngology Head and Neck surgery China-Japan Friendship HospitalBeijingChina department of Otorhinolaryngology Head and Neck surgery The First People's Hospital of YinchuanYinchuanChina department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina department of Otorhinolaryngology Head and Neck surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina department of Otorhinolaryngology Head and Neck surgery Xiangya Hospital Central South UniversityChangshaChina department of Otorhinolaryngology Head and Neck surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina department of Otorhinolaryngology Head and Neck surgery The First Affiliated Hospital of USTCHefeiChina department of Otorhinolaryngology Head and Neck surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina department of Otorhinolaryngology Head and Neck surgery Qilu Hospital of Shandong UniversityJinanChina department of Otorhinolaryngology Head and Neck surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina department of Otorhinolaryngology Head and Neck surgery Peking University People's HospitalBeijingChina department of Otorhinolaryngology Head and Neck surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina department of Otorhinolaryngology Head and Neck surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina department of Otorhinolaryngology Head and Neck surgery The First Affiliated Hospital of China Medical UniversityShenyangChina department of Otorhinolaryngology Head and Neck surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

重症布-加综合征外科治疗174例的临床分析

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临床和实验医学杂志 2006年第9期5卷 1303-1305页

作者：常青党晓卫许培钦高东宸首都医科大学附属北京友谊医院普外科北京100050 郑州大学第一附属医院普外科河南郑州450000

目的探讨目前重症布-加综合征合理的治疗方案.方法对我院收治的重症布-加综合征174例患者的临床资料做一回顾性分析.放射介入治疗12例,均行经皮肝穿肝静脉球囊导管扩张成形术,成形后内支架置入5例;手术治疗148例,其中肠-腔分流术 93例... 详细信息

目的探讨目前重症布-加综合征合理的治疗方案.方法对我院收治的重症布-加综合征174例患者的临床资料做一回顾性分析.放射介入治疗12例,均行经皮肝穿肝静脉球囊导管扩张成形术,成形后内支架置入5例;手术治疗148例,其中肠-腔分流术 93例,脾-腔分流术 5例,脾-颈内静脉转流术48例,肠-颈内静脉转流术2例;介入加分流联合手术治疗14例,均采用Seldinger技术行下腔静脉球囊导管扩张成形和内支架置入后再行肠-腔分流术.结果围手术期死亡9例(死亡率5.17%),随访160例(随访率96 .97%),随访时间3月～8年,有效例数156例(有效率96.88%),远期死亡2例(死亡率1.25%).结论重症布-加综合征治疗方式的选择应根据病变类型进行.

关键词：布-加综合征外科疗法

Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)

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Military Medical Research 2022年第5期9卷 515-533页

作者： Xian-Tao Zeng Ying-Hui Jin Tong-Zu Liu Fang-Ming Chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing Huang Zhi Hou Wan-Li Hu Xin-Li Kang Gong-Hui Li Jian-Xing Li pei-Jun Li Chao-Zhao Liang Xiu-Heng Liu Zhi-Yu Liu Chun-xiao Liu Jiu-Min Liu Guang-Heng Luo Yi Luo wei-Jun qin Jian-Hong Qiu Jian-Xin Qiu xue-Jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian Feng Wang Feng Wang Yin-Huai Wang Yu-Jie Wang Zhi-Ping Wang Zhong Wang Qiang wei Min-Hui xiao Wan-Hai xu Fa-Xian Yi Chao-Yang Zhu Qian-Yuan Zhuang Li-Qun Zhou xiao-Feng Zou Nian-Zeng Xing Da-Lin He Xing-Huan Wang 无 department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China department of Urology Tianjin Third Central Hospital Affiliated To Nankai UniversityTianjin300170China department of Urology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China department of Urology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China department of Urology China-Japan Union Hospital of Jilin UniversityChangchun130033China department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China department of Urology Qinghai University Affiliated HospitalXi’ning810012China department of Urology People’s Hospital of Hainan ProvinceHainan Affiliated Hospital of Hainan Medical University HaikouHaikou570311China department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China department of Urology General Hospital of Ningxia Medical UniversityYinchuan750003China department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China department of Urology The Second Hospital of Dalian Medical UniversityDalian116023LiaoningChina department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou510282China department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China department of Urology surgery Guizhou Province People’s HospitalGuiyang550002China department of Urology Xijing Hospital of Air Force Military Medical UniversityXi’an710032China department of Urology The 980St Hospital of the PLA Joint Logistics Support Force(Bethune International Peace Hospital of PLA)Shijiazhuang050082China department of Urology

Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different

关键词： Transurethral plasmakinetic resection of prostate Benign prostatic hyperplasia Recommendation Treatment Guideline

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遗传性耳聋基因治疗临床指南

实用医院临床杂志 2024年第2期21卷 39-44页

作者：齐洁玉谈方志张李燕陆玲王洪阳李文妍刘闻闻付小龙贺祖宏丁小琼孙珊方巧军董耀东朱学伟童步升曹现宝郭敏范欣淼汪芹马璐张天虹于亚峰李永新樊建刚崔勇吴佩娜张宏征唐杰郭维维查定军叶放蕾何双八曹卫杨见明钱晓云赵宇孙敬武陈晓巍孙宇夏明王秋菊袁慧军冯永孔维佳杨仕明王海波高下李华伟徐磊柴人杰东南大学数字医学工程全国重点实验室附属中大医院耳鼻咽喉头颈外科生命科学与技术学院生命与健康高等研究院江苏省生物医学高新技术研究重点实验室江苏南京210096 南通大学神经再生联合创新中心江苏南通226001 北京理工大学航天中心医院神经内科生命学院北京10081 南京大学医学院附属鼓楼医院耳鼻喉头颈外科江苏省医学重点学科(实验室)江苏南京210008 中国人民解放军总医院耳鼻咽喉头颈外科医学部北京100853 听觉与平衡觉全国重点实验室北京100853 国家耳鼻咽喉疾病临床医学研究中心北京100853 聋病教育部重点实验室北京100853 聋病防治北京市重点实验室北京100853 复旦大学附属眼耳鼻喉科医院医学神经生物学国家重点实验室教育部脑科学前沿研究中心上海200031 复旦大学生物医学研究所上海200032 国家卫健委听觉医学重点实验室上海200031 复旦大学脑科学研究院和脑科学协同创新中心上海200032 山东大学山东省耳鼻喉医院耳鼻咽喉头颈外科山东济南250022 山东省耳鼻喉研究所山东济南250022 山东第一医科大学/山东省医学科学院医学科技创新中心山东济南250000 武汉大学中南医院耳鼻咽喉头颈外科湖北武汉430071 东南大学附属中大医院耳鼻咽喉头颈外科江苏南京210009 复旦大学附属眼耳鼻喉科医院耳鼻喉科上海200032 安徽医科大学第二附属医院耳鼻咽喉头颈外科安徽合肥230601 中国医科大学附属盛京医院耳鼻咽喉头颈外科辽宁沈阳110004 吉林大学中日联谊医院耳鼻咽喉头颈外科吉林长春130033 安徽医科大学第一附属医院耳鼻咽喉头颈外科安徽合肥230022 云南省第一人民医院耳鼻喉科云南昆明650032 昆明医科大学第一附属医院耳鼻喉科云南昆明650032 中国医学科学院北京协和医学院北京协和医院耳鼻咽喉科北京100730 中南大学湘雅二医院耳鼻咽喉头颈外科湖南长沙410008 南华大学衡阳医学院基础医学院细胞生物学与遗传学教研室细胞应激生物学衡阳市重点实验室湖南衡阳421001 哈尔滨医科大学附属第一医院黑龙江哈尔滨150001 苏州大学附属第一医院耳鼻咽喉科江苏苏州215006 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科北京100730 四川省医学科学院·四川省人民医院/电子科技大学附属医院耳鼻咽喉头颈外科四川成都610072 广东省人民医院耳鼻咽喉头颈外科/广东省医学科学院/南方医科大学广东广州510080 南方医科大学珠江医院耳鼻咽喉头颈外科广东广州510282 空军军医大学西京医院耳鼻咽喉-头颈外科陕西西安710032 郑州大学第一附属医院耳科河南郑州450000 东南大学医学院附属南京同仁医院耳鼻咽喉头颈外科江苏南京211102 四川大学华西医院耳鼻咽喉头颈外科四川成都610041 中国科学技术大学附属第一医院耳鼻咽喉头颈外科安徽合肥230001 华中科技大学同济医学院附属协和医院耳鼻咽喉头颈外科湖北武汉430022 山东第一医科大学附属山东省立医院耳鼻咽喉科山东济南250021 山东省医学科学院医学科技创新中心山东济南250021 山东大学附属山东省立医院耳鼻咽喉科山东济南250021 国家卫生健康委耳鼻咽喉重点实验室山东济南250021 四川大学华西医院罕见病研究院四川成都6010041 南华大学衡阳医学院南华大学附属妇幼保健院湖南长沙410008 中南大学湘雅医院耳鼻咽喉头颈外科湖南长沙410008 上海人工耳蜗工程技术研究中心上海200031 东南大学深圳研究院广东深圳518063

遗传性耳聋是一种常见的遗传性疾病,新生儿的发病率为1‰~3‰。患者终身携带致病突变,导致不可逆性耳聋,至今尚无临床可用的治疗药物。在部分遗传性耳聋动物模型中,基因治疗已被证实为潜在有效的治疗方法。国内外已开展了多项遗传性耳... 详细信息

遗传性耳聋是一种常见的遗传性疾病,新生儿的发病率为1‰~3‰。患者终身携带致病突变,导致不可逆性耳聋,至今尚无临床可用的治疗药物。在部分遗传性耳聋动物模型中,基因治疗已被证实为潜在有效的治疗方法。国内外已开展了多项遗传性耳聋基因治疗的临床试验。其中,由东南大学附属中大医院牵头,联合国内多家医院成功开展的遗传性耳聋基因治疗临床试验,取得了显著的疗效,并积累了丰富的经验。为规范遗传性耳聋基因治疗并提供临床研究指导,全国多家医院的耳科专家讨论制定了遗传性耳聋基因治疗临床指南,内容涵盖了伦理审查、遗传性耳聋的诊断和入组标准、临床前准备、药物、疗效与安全性评估标准、术后言语康复等。本指南将为耳聋基因治疗的临床诊疗提供规范的理论和技术指导。

关键词：遗传性耳聋基因治疗临床指南

The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma

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Cancer Communications 2021年第11期41卷 1195-1227页

作者： Ling-Long Tang Yu-pei Chen Chuan-Ben Chen Ming-Yuan Chen Nian-Yong Chen xiao-Zhong Chen xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao Fei Han Xia He Chao-Su Hu De-sheng Hu Guang-Yuan Hu Hao Jiang wei Jiang Feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin xu Liu Qiu-Fang Liu Lin Ma Hai-Qiang Mai Ji-Yong qin Liang-Fang Shen Ying Sun pei-Guo Wang Ren-Sheng Wang Ruo-Zheng Wang xiao-Shen Wang Ying Wang Hui Wu Yun-Fei Xia Shao-Wen xiao Kun-Yu Yang Jun-Lin Yi xiao-Dong Zhu Jun Ma department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China department of Radiation Oncology Fujian Provincial Cancer HospitalFujian Medical University Department of Radiation OncologyTeaching Hospital of Fujian Medical University Provincial Clinical CollegeCancer Hospital of Fujian Medical UniversityFuzhouFujian 350014P.R.China department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Centre for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041P.R.China Cancer hospital of the university of Chinese Academy of Sciences(Zhejiang Cancer hospital)Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of Sciences HangzhouZhejiang 310000P.R.China State Key Laboratory of Oncology in South china Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060P.R.China department of Radiation Oncology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610041P.R.China department of Radiation Oncology Anhui Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui 230001P.R.China department of Clinical Laboratory Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Cancer HospitalJiangsu Institute of Cancer ResearchNanjingJiangsu 210000P.R.China department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China department of Radiotherapy Hubei Cancer HospitalTong

Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North *** develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the *** on the findings of evidencebased medicine in china and abroad,domestic experts have iteratively developed these guidelines to provide proper management of ***,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC.

关键词： Chinese Society of Clinical Oncology CSCO Nasopharyngeal carcinoma Diagnosis Staging Risk Radiotherapy Chemotherapy surgery Immunotherapy

布-加综合征患者不孕不育及反复自然流产的原因分析及治疗

维普期刊数据库评论

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中华普通外科学文献（电子版） 2011年第4期5卷 14-16页

作者：徐大千党晓卫李鹏杨志强许培钦郑州大学第一附属医院肝胆胰外科郑州450052

目的探讨已婚育龄期女性布-加综合征(B-CS)患者不孕及反复自然流产的原因及治疗原则。方法回顾性分析2008年1月至2010年6月我院收治的146例已婚育龄期女性B-CS患者的临床资料。结果根据患者的分型及病情,选取不同的手术方式或药物治疗,... 详细信息

目的探讨已婚育龄期女性布-加综合征(B-CS)患者不孕及反复自然流产的原因及治疗原则。方法回顾性分析2008年1月至2010年6月我院收治的146例已婚育龄期女性B-CS患者的临床资料。结果根据患者的分型及病情,选取不同的手术方式或药物治疗,术后给予0.5～2年的随访:其中有月经异常的56例中有42例恢复正常,有效率为75.0%(42/56);未育的32例中10例成功妊娠或者生育,治疗后怀孕率为31.3%(10/32);治疗后血小板明显升高(P<0.05),其中78例已恢复至正常水平;16例治疗前性激素检查均有不同程度的异常,治疗后均明显好转(P<0.05),其中11例恢复正常。结论布-加综合征是育龄期妇女不孕不育及反复自然流产的高危因素。及早正确的治疗可以纠正此类患者的月经紊乱和提高受孕率及生育率。

关键词：布-加综合征不孕不育反复自然流产

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改良脾-肺固定术对肝纤维化的影响

中华普通外科学文献（电子版） 2013年第2期7卷 31-33页

作者：党晓卫杨志强乔师师徐大千李鹏王兆阳姚振涛许培钦郑州大学第一附属医院普外科 450052

目的探讨门静脉高压症患者行改良脾-肺固定术后血清肝纤维化指标的变化。方法观察2008年6月至2012年12月郑州大学第一附属医院收治的32例行改良脾-肺固定术患者术前及术后6个月血清Ⅲ型胶原(COL-Ⅲ)、Ⅳ型胶原(COL-Ⅳ)、基质金属蛋白酶1... 详细信息

目的探讨门静脉高压症患者行改良脾-肺固定术后血清肝纤维化指标的变化。方法观察2008年6月至2012年12月郑州大学第一附属医院收治的32例行改良脾-肺固定术患者术前及术后6个月血清Ⅲ型胶原(COL-Ⅲ)、Ⅳ型胶原(COL-Ⅳ)、基质金属蛋白酶1(MMP-1)、基质金属蛋白酶组织抑制因子1(TIMP-1)水平,并做统计学比较分析。结果行改良脾-肺固定术后6个月,血清COL-Ⅲ含量由(20.25±3.20)μg/L降至(16.32±2.35)μg/L,COL-Ⅳ由(112.21±23.90)μg/L降至(57.32±18.74)μg/L;血清MMP-1含量由(16.68±8.56)μg/L升至(26.85±8.95)μg/L,TIMP-1由(227.56±76.84)μg/L降至(132.35±62.42)μg/L,各组数据与术前相比均有统计学意义(P<0.01)。结论改良脾-肺固定术可缓解肝脏纤维化进程。

关键词：门静脉高压改良脾-肺固定术肝纤维化

经自然腔道取标本手术(NOSES)治疗胃癌的国际共识(2019)

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Gastroenterology Report 2020年第1期8卷 5-10,I0001页

作者： xu Guan Zheng Liu Amjad Parvaiz Antonio Longo Avanish Saklani Ali AShafik Jian-Chun Cai Charles Ternent Lin Chen Cuneyt Kayaalp Fatih Sumer Fernanda Nogueira Feng Gao Fang-Hai Han qing-Si He Ho-Kyung Chun Chang-Ming Huang Hai-Yang Huang Rui Huang Zhi-wei Jiang Jim S Khan Joaquim Manuel da Costa Pereira JosephWNunoo-Mensah Jung Tack Son Liang Kang Keisuke Uehara Ping Lan Le-Ping Li Han Liang Bing-Rong Liu Juan Liu Dan Ma Ming-Yin Shen Mohammad Rashidul Islam Narimantas Evaldas Samalavicius Kai Pan Petr Tsarkov Xin-Yu qin Ricardo Escalante Sergey Efetov Seung Kyu Jeong Suk-Hwan Lee Dong-Hui Sun Li Sun Tatiana Garmanova Yan-Tao Tian Gui-Yu Wang Guo-Jun Wang Guo-Rong Wang xiao-Qiang Wang William Tzu-Liang Chen Woo Yong Lee Su Yan Zu-Li Yang Gang Yu pei-Wu Yu Dan Zhao Yun-Shi Zhong Jian-Ping Wang Xi-Shan Wang The International Alliance of NOSES department of Colorectal surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Poole hospital NHS Trust PooleUK European Center of Coloproctology and Pelvic Diseases-Multimedica hospital MilanItaly department of GI Surgical Oncology Tata Memorial HospitalMumbaiIndia department of Colorectal surgery Cairo UniversityCairoEgypt department of Gastrointestinal surgery Zhongshan Hospital of Xiamen UniversityXiamenFujianP.R.China Section of Colon and Rectal surgery Creighton University School of MedicineOmahaNEUSA department of general surgery Chinese People’s Liberation Army General HospitalBeijingP.R.China department of Gastrointestinal surgery Inonu UniversityMalatyaTurkey department of surgery Hospital de BragaBragaPortugal department of Colorectal Cancer surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China department of Gastroenterological surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China department of general surgery Shandong University Qilu HospitalJinanShandongP.R.China department of surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea department of Gastric surgery Fujian Medical University Union HospitalFuzhouFujianP.R.China department of general surgery Jiangsu Province Hospital of Traditional Chinese MedicineNanjingJiangsuP.R.China department of Colorectal surgery PortsmouthHospitals NHSTrustQueen Alexandra HospitalPortsmouthUK King’s College hospital LondonUK department of Colorectal surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Division of Surgical Oncology Department of SurgeryNagoya University School of MedicineNagoyaJapan department of Gastrointestinal surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongP.R.China department of Gastric Cancer

At present,natural orifice specimen extraction surgery(NOSES)has attracted more and more attention worldwide,because of its great advantages including minimal cutaneous trauma and post-operative pain,fast post-operative recovery,short hospital stay,and positive psychological ***,NOSES for the treatment of gastric cancer(GC)is still in its infancy,and there is great potential to improve its theoretical system and clinical ***,several key points including oncological outcomes,bacteriological concerns,indication selection,and standardized surgical procedures are raised with this innovative ***,it is necessary to achieve an international consensus to regulate the implementation of GC-NOSES,which is of great significance for healthy and orderly development of NOSES worldwide.

关键词： gastric cancer natural orifice specimen extraction surgery transanal specimen extraction transvaginal specimen extraction transoral specimen extraction consensus