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Determination of terbinafine and its main metabolite in rat plasma by UPLC-MS/MS:application to a pharmacokinetic study

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Determination of terbinafine and its main metabolite in rat ...

徐州市三级综合医院2007-2013年肺癌患者住院费用分析

中华医学会临床药学分会2014年全国学术会议

作者：王双户 Yun-fang Zhou Ting Ding pei-pei pan Guo-xin Hu Xiang-hong Lu The Laboratory of Clinical Pharmacy People's Hospital of Lishui City Department of Pharmacology Wenzhou Medical University

Aims An accurate and validated liquid chromatography method with triple quadrupole mass spectrometer has been developed for detecting terbinafine and N-Desmethylterbinafine in rat *** A reversed-phase BEH C18 column kept at 30℃was *** initial mobile phase was consisted of acetonitrile and water(0.01%formic acid and 0.05%ammonia water)(70:30,V A/)at a flow rate of 0.2 mL/min with the injection

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中华肿瘤防治杂志 2017年第17期24卷 1183-1189页

作者：石春雷娄培安董宗美陈培培张盼赵春艳乔程李婷徐州医科大学公共卫生学院江苏徐州221004 徐州市疾病预防控制中心慢病科江苏徐州221006

目的随着经济的快速发展、生活方式以及人口结构的变化,肺癌因其高发病率及高死亡率已成为影响人们生命健康的主要公共问题。本研究分析2007-2013年徐州地区三级综合医院肺癌患者的住院费用,为下一步肺癌防控及卫生决策提供参考依据。... 详细信息

目的随着经济的快速发展、生活方式以及人口结构的变化,肺癌因其高发病率及高死亡率已成为影响人们生命健康的主要公共问题。本研究分析2007-2013年徐州地区三级综合医院肺癌患者的住院费用,为下一步肺癌防控及卫生决策提供参考依据。方法随机抽取徐州市3家三级综合医院,并摘录其2007-2013年收治的肺癌患者病例资料,采用我国医疗保健消费价格指数将费用数据贴现,再采用时间序列分析中的线性模型及年均增长率等方法估算次均住院费用、日均住院费用以及各自构成的趋势变化情况。结果 3家医院累计摘录肺癌患者病例资料17 235人次,最终获取有效病例资料15 868人次,有效率92.07%(15 868/17 235)。患者平均年龄为(63.30±11.31)岁。肺癌患者次均住院费用自2007年的14 587.93元上升至2013年的21 103.92元,年均增长率为6.35%(F=39.255,b1=1 292.681,P<0.05);费用构成中,以药品费用所占比重最高,范围在41.00%~52.00%,但构成比的上升速度以其他费用最快,年均增长率为27.51%;各项目费用中,以其他费用的增长速度最快,自2007年的621.36元上升到2013年的3 556.10元,年均增长率为33.10%(F=28.967,b1=541.334,P<0.05)。肺癌患者日均住院费用自2007年的778.05元上升至2013年的1 475.69元,年均增长率为11.26%(F=263.614,b1=118.149,P<0.05);各项费用中以其他费用的日均费用上升速度最快,年均增长率为31.07%(F=33.310,b1=16.164,P<0.05)。结论徐州市肺癌患者的次均住院费用呈日益上升趋势;药品费用仍占有最高构成比,且与蛋白质、化验和其他费用数值呈不同程度增长,但因其增长速度慢,在总费用的占比呈下降趋势;单纯通过减少住院天数并不能降低肺癌患者住院费用。

关键词：肺癌住院费用趋势分析线性模型年均增长率

Assisted reproductive technologies induce changes in the expression of INSIG-SCAP-SREBP and cardiometabolic dysfunction in aged mice

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Assisted reproductive technologies induce changes in the exp...

In vitro fertilization alters growth and expression of Igf2/H19 and their epigenetic mechanisms in the liver and skeletal muscle of newborn and elder mice

2014浙江省计划生育与生殖医学学术年会暨“第七届生殖安全转化医学研讨会”

作者： Fang Le Ning Wang Le-Jun Li Hang-Ying Lou pei-pei pan Yi-Yun Lou Fan Zhang Yu-Qing Luo Shu-yuan Liu Xiang-Rong Xu Fan Jin Center of Reproductive Medicine Women's HospitalSchool of MedicineZhejiang University Key Laboratory of Reproductive Genetics Ministry of Education

Objective:Abnormal embryo environments can produce cardiometabolic dysfunction later in life,and the use of assisted reproductive technology(ART)is still a matter of *** explanation of such outcome is epigenetic regul...

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In vitro fertilization alters growth and expression of Igf2/...

Alterations in the frequency of trinucleotide repeat dynamic mutations in offspring conceived through assisted reproductive technology

第七次全国妇科内分泌学术会议

作者： Fang Le pei-pei pan Ning Wang Li-ya Wang Le-jun Li Ying-ming Zheng Hang-ying Lou Cheng-xia Hu Shu-yuan Liu Xiao-zhen Liu Xiang-rong Xu He-feng Huang Fan Jin Center of Reproductive Medicine Women’s HospitalSchool of MedicineZhejiang University

Objective Epidemiological studies have reported a higher incidence of growth disorders among newborns conceived by in vitro fertilization(IVF),suggesting that IVF may be disruptive to the process of embryonic and feta...

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Alterations in the frequency of trinucleotide repeat dynamic...

Bullous pemphigoid associated with acquired hemophilia A: A case report

2013浙江省医学遗传学学术年会

作者： Ying-Ming Zheng Li Li pei-pei pan Fang Le Yi-Yun Lou Kai Yan Le-Jun Li Li-Ya Wang Shu-Yuan Liu Xin-Yun Yang Min-Hao Hu Song-Chang Chen Chen-Ming Xu Fan Jin Department of Reproductive Endocrinology Women's HospitalZhejiang University School of Medicine Key Laboratory of Reproductive Genetics National Ministry of Education(Zhejiang University)Women's Reproductive Healthy Laboratory of Zhejiang Province

Background:This study investigates possible changes in the frequency of trinucleotide repeat dynamic mutations in offspring conceived through assisted reproductive technology(ART) in comparison with matched controls from spontaneous pregnancies. Methods:A prospective clinical observational study was performed on two hundred and forty-six families recruited from the in vitro fertilisation centre at a tertiary -care,university -affiliated,teaching hospital. Parental,peripheral and umbilical cord blood samples were collected and the trinucleotide repeat dynamic mutation genes of ATNl,AR,ATXNl,ATXN3,Huntington,DMPK and FMR-1 were investigated between *** frequencies and sizes of the mutational repeats of intergenerational instability were measured. Results:A total of 2,466 transmissions were identified in ART offspring,with 2.11%(n=52/2,466) of alleles being unstable upon *** the control group,the frequency of dynamic mutation was 0.77% (n=10/l,300).Statistical significance was found between the ART group and the control group(P pansion or the rates of contraction among the three groups(P>0.05).The repeat copy numbers of examined genes in all parents and their babies were found to be within the normal ranges. Conclusions:Our results illustrated that more significant alterations in the frequency of trinucleotide repeat dynamic mutations in offspring conceived through *** studies determining the factors that influence instability of genome in ART procedure are urgently needed.

关键词： assisted reproductive technology offspring dynamic mutation trinucleotide repeat

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia Hao Xu-Ya Chai pei-Sai Li Yang Liu Li-Xia Liu Ying Xu pan-pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

2008-2014年徐州市城乡居民糖尿病死亡趋势分析

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中国慢性病预防与控制 2016年第10期24卷 730-733页

作者：陈培培娄培安张盼乔程李婷董宗美张宁徐州市疾病预防控制中心慢性非传染性疾病防制科江苏省徐州221006

目的分析2008-2014年徐州市城乡居民糖尿病死亡特征及变化趋势,为开展有针对性的干预措施提供依据。方法 2008-2014年所有徐州市户籍居民死亡资料来源于覆盖全市的居民死因登记报告系统。采用U检验、t检验、Spearman等级相关、年估计百... 详细信息

目的分析2008-2014年徐州市城乡居民糖尿病死亡特征及变化趋势,为开展有针对性的干预措施提供依据。方法 2008-2014年所有徐州市户籍居民死亡资料来源于覆盖全市的居民死因登记报告系统。采用U检验、t检验、Spearman等级相关、年估计百分比变化(EAPC)对2008-2014年徐州市城乡居民糖尿病死亡数据进行分析。结果 2008-2014年徐州市居民年均糖尿病死亡率为8.84/10万,其中男性为8.35/10万,女性为9.36/10万,男性年均糖尿病死亡率低于女性,差异有统计学意义(P0.05)。农村年均糖尿病死亡率为7.22/10万,其中男性为6.83/10万,女性为7.63/10万,2012年以前农村男女糖尿病死亡率差异均无统计学意义(P>0.05),2012年及以后,女性糖尿病死亡率高于男性,差异均有统计学意义(P0.05)。徐州市男性平均死亡年龄为(71.1±11.8)岁,女性为(72.4±12.3)岁,城市为(74.6±11.6)岁,农村为(70.6±12.0)岁,男性平均死亡年龄低于女性,城市高于农村,差异均有统计学意义(P<0.05)。城市男性、女性、农村女性居民因糖尿病死亡的平均年龄均呈逐年增长趋势(P<0.01)。结论近年来徐州市糖尿病死亡率呈上升趋势,应全面开展糖尿病的三级预防,并将女性、农村纳入重点干预对象。

关键词：糖尿病死亡趋势年估计百分比变化

Distributed sampling measurement method of network traffic in high-speed IPv6 networks

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Journal of Systems Engineering and Electronics 2007年第4期18卷 835-840页

作者： pan Qiao pei Changxing State Key Lab. of Integrated Services Networks Xidian Univ. Xi'an 710071 P. R. China

With the advent of large-scale and high-speed IPv6 network technology, an effective multi-point traffic sampling is becoming a necessity. A distributed multi-point traffic sampling method that provides an accurate and efficient solution to measure IPv6 traffic is proposed. The proposed method is to sample IPv6 traffic based on the analysis of bit randomness of each byte in the packet header. It offers a way to consistently select the same subset of packets at each measurement point, which satisfies the requirement of the distributed multi-point measurement. Finally, using real IPv6 traffic traces, the conclusion that the sampled traffic data have a good uniformity that satisfies the requirement of sampling randomness and can correctly reflect the packet size distribution of full packet trace is proved.

关键词： network measurement traffic sampling IPv6 distributed measurement Shannon entropy

A novel shape memory alloy actuated soft gripper imitated hand behavior

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Frontiers of Mechanical Engineering 2022年第4期17卷 261-272页

作者： Jie pan Jingjun YU Xu pei School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China

The limited length shrinkage of shape memory alloy(SMA)wire seriously limits the motion range of SMA-based *** this paper,a new soft finger without silicone gel was designed based on pre bent SMA wire,and the finger was back to its original shape by heating SMA wire,rather than relying only on heat exchange with the *** imitating palm movement,a structure with adjustable spacing between fingers was made using SMA spring and rigid *** hook structure design at the fingertip can form self-locking to further improve the load capacity of *** the long thin rod model,the relationship of the initial pre bent angle on the bending angle and output force of the finger was *** stress-strain model of SMA spring was established for the selection of rigid *** grasping modes were proposed to adapt to the weight of the *** the test of the gripper,it was proved that the gripper had large bending amplitude,bending force,and response *** design provides a new idea for the lightweight design and convenient design of soft gripper based on SMA.

关键词： shape memory alloy(SMA) pre bent wire gripper grasping mode lightweight