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PRELIMINARY NOTES ON THE COMPOSITION AND STRUCTURE OF THE FIRST SPECIMEN OF METEORIC STONE RECEIVED BY THE GEOLOGICAL SURVEY OF CHINA.

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地质学报 1923年第Z2期 95-97+123页

作者： C.Y.hsieh.

In spite of the immense records of meteoric fall kept in many ofthe Chinese books, specimens of real meteorite were very seldom *** the first found of iron meteorite was from Inner Mongolia described

关键词： PRELIMINARY NOTES ON THE COMPOSITION AND STRUCTURE OF THE FIRST SPECIMEN OF METEORIC STONE RECEIVED BY THE GEOLOGICAL SURVEY OF CHINA very

CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis

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World Journal of Gastroenterology 2005年第38期11卷 6043-6048页

作者： Hsin-Hung Huang Tsai-Yuan hsieh Division of Gastroenterology

AIM: To investigate the relationship between genetic polymorphism of the CD14 promoter and the occurrence of alcoholic cirrhosis and alcoholic pancreatitis, and to challenge the conclusion made earlier that the patients with acute alcoholic pancreatitis and patients with alcoholic cirrhosis of liver are two different ***: Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, we determined the polymorphism of CD14 gene and aldehyde dehydrogenase gene 2 (ALDH 2) in 335 alcoholic patients with different organ complications i.e., cirrhosis of liver (n = 100), acute pancreatitis (n = 100), esophageal cancer (n = 82) and avascular necrosis of hip joint (AVN) (n = 53)and 194 non-alcoholic controls in a Chinese ***: The results showed that the carriage of T allele was not different among alcoholic patients with cirrhosis of liver, alcoholic patients with other complication and non-alcoholic controls. On the other hand, the carriage of the C allele was significantly more prevalent for alcoholic pancreatitis than for esophageal cancer (0.79 vs 0.60,P＜0.001), alcoholic AVN (0.79 vs 0.65, P＜0.025) and nonalcoholic controls (0.79 vs 0.68, P＜0.025). Furthermore,when only subjects with ALDH2 1-1 genotype were examined, the C allele frequency was significantly more prevalent for alcoholic pancreatitis than for alcoholic liver cirrhosis (0.82 vs 0.69, P＜0.025), esophageal cancer (0.82 vs 0.61, P＜0.01), alcoholic AVN (0.82 vs 0.64,P＜0.01) and non-alcoholic controls (0.82 vs 0.69, P＜0.05).CONCLUSION: The C allele may be associated with some mechanism, which is important in the pathogenesis of alcoholic pancreatitis, and that alcoholic patients with acute pancreatitis and cirrhosis of liver are probably two different subpopulations.

关键词： CD14 基因多态性中国酒精肝肝硬化急性胰腺炎

PULMONARY TUBERCULOSIS IN DIABETES MELLITUS

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中华医学杂志(英文版) 1936年第7期 885-890+1013-1014页

作者： C. K. hsieh M.D. Department of Radiology Peiping Union Medical College Peiping

Of 316 in-patients with the diagnosis of diabetes mellitus 143 hadroentgenologic examination of the chest. 40 cases showed signs ofparenchymal lesions characteristic of pulmonary tuberculosis. Old,minimal, apical fibrotic lesions were seen in 4 cases (10 percent);minimal or moderate, infra-clavicular, fibro-exudative lesions in 6 cases(15 percent) and advanced, exudative and, caseous lesions with smallor large cavities in 30 cases (75 percent). In general, the roentgenologicappearance of the pulmonary lesions was not different from thatobserved in non-diabetic patients. In 8 cases the changes simulatedthose in unsensitized subjects as described by Sosman. The mostsignificant finding in this study is the high incidence (75 percent) ofextensive, caseous or cavernous lesions for which the diabetes is pro-bably responsible in some way. The exact relationship betweenpulmonary tuberculosis and diabetes is not known, but it seems rea- sonable to believe that diabetes changes the tissue resistance, makingit more favorable for the development of tuberculosis. Once tuberculosishas. reached an advanced stage, even when the diabetes is controlled,the prognosis is poor. It is, therefore, important to have early andfrequent roentgenologic examinations of the chest of all diabetic patientso as to detect and treat the pulmonary lesions at the earliest stage.

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On the Age of the Hsiwan Coal Series

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地质学报 1940年第1期 33-36页

作者： C.Y.hsieh Formerly Professor and Dean Geological Department National University of Peking at present General Manager Kiang Hua Mining Administration

The geology of the Hsiwan coal field has been studied by Dr. Yoh of theGeological Survey of Kwangtung and Kwangsi and Messrs. Meng and Chang ofthe Geological Institute of the Academia Sinica. All these authors assigne... 详细信息

关键词： In On the Age of the Hsiwan Coal Series

PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer

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中国肺癌杂志 2015年第6期18卷 345-350页

作者： Yang WANG Zhidong XU Jian-Hua MAO David.hsieh Alfred AU David M. JABLONS Hui LI Liang YOU Thoracic Surgery Department Beijing Chao-Yang Hospital Capital University of Medical Science Thoracic Oncology Laboratory Department of Surgery Comprehensive Cancer Center University of California Life Sciences Division Lawrence Berkeley National Laboratory University of California Division of Diagnostic Pathology Comprehensive Cancer Center University of California

Background and objective Maintenance of genomic integrity is essential to ensure normal organismal development and to prevent diseases such as ***-Set7(also known as Set8)is a cell cycle regulated enzyme that catalyses monomethylation of histone 4 at Lys20(H4K20me1)to promote chromosome condensation and prevent DNA *** studies show that CRL4CDT2-mediated ubiquitylation of PR-Set7 leads to its degradation during S phase and after DNA *** might occur to ensure appropriate changes in chromosome structure during the cell cycle or to preserve genome integrity after DNA *** We developed a new model of lung tumor development in mice harboring a conditionally expressed allele of *** have therefore used a mouse model to demonstrate for the first time that Cul4A is oncogenic in *** this model,staining of PR-Set7 in the preneoplastic and tumor lesions in Adeno Cre-induced mouse lungs was *** we identified higher protein level changes ofγ-tubulin and pericentrin by *** The level of PR-Set7 down-regulated in the preneoplastic and adenocarcinomous lesions following over-expression of *** also identified higher levels of the proteins pericentrin andγ-tubulin in Cul4A mouse lungs induced by Adeno *** PR-Set7 is a direct target of Cul4A for degradation and involved in the formation of lung tumors in the conditional Cul4A transgenic mouse model.

关键词：临床诊断医学肺疾病

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On some examples of River Capture

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地理学报 1935年第3期 152-153页

作者： C.Y.hsieh National Geological Survey of China

In the course of stream development, each stream and its tributaries tend toincrease their length by headward erosion, or in other words to enlarge their catchment area. A shifting of divide and eventually a struggle for existence by which a part or the whole of tne stream will be diverted or captured by the otherwill be resulted. This phenomena is called in physiography, river capture or river piracy.

关键词： On some examples of River Capture

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Routine blood tests to predict liver fibrosis in chronic hepatitis C

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World Journal of Gastroenterology 2012年第8期18卷 746-753页

作者： Yung-Yu hsieh Shui-Yi Tung Cheng-Shyong Wu Kuo- Liang Wei Chien-Heng Shen Te-Sheng Chang Kamfai Lee Yi-Hsiung Lin Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Chiayi 613 Taiwan Chang Gung University College of Medicine Taoyuan 333 Taiwan Chiayi School ChangOung Institute of Technology Chiayi 613 Taiwan Department of Pathology Chang Gung MemorialHospital Chiayi 613 Taiwan Department of Health Care Administration Taiwan Shoufu University Tainan 721 Taiwan

AIM: To verify the usefulness of FibroQ for predicting fi brosis in patients with chronic hepatitis C, compared with other noninvasive tests. METHODS: This retrospective cohort study included 237 consecutive patients with chronic hepatitis C who had undergone percutaneous liver biopsy before treatment. FibroQ, aspartate aminotransferase (AST)/alanine aminotransferase ratio (AAR), AST to platelet ratioindex, cirrhosis discriminant score, age-platelet index (API), Pohl score, FIB-4 index, and Lok's model were calculated and compared. RESULTS: FibroQ, FIB-4, AAR, API and Lok's model results increased significantly as fibrosis advanced (analysis of variance test: P < 0.001). FibroQ trended to be superior in predicting signifi cant fi brosis score in chronic hepatitis C compared with other noninvasive tests. CONCLUSION: FibroQ is a simple and useful test for predicting signifi cant fi brosis in patients with chronic hepatitis C.

关键词：丙型肝炎肝纤维化慢性预测血液检查天冬氨酸转氨酶谷丙转氨酶纤维蛋白原

Reactive wetting behaviors of Sn/Cu systems: A molecular dynamics study

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Nano-Micro Letters 2010年第2期2卷 60-67页

作者： J.Y.hsieh J.L.Chen C.Chen H.C.Lin S.S.Yang C.C.Hwang Department of Mechanical Engineering Ming Hsin University of Science and Technology Institute of Precision Mechatronic Engineering Ming Hsin University of Science and Technology Department of Mechanical Engineering Wu Feng Institute of Technology Department of Information Management Meiho Institute of Technology Department of Engineering Science National Cheng Kung University

Influences of temperature and Sn-Cu droplet's composition on reactive wettings of Cu(100), Cu(110), and Cu(111) surfaces were analyzed, by using molecular dynamics(MD) calculations. As a result, the spreading on Cu(110)(Cu(100)) has the fastest(slowest) wetting kinetics. A higher temperature or a diluter Cu content in the Sn-Cu alloy droplet results in a higher wettability. Moreover, this work has addressed a theory for positioning the interface separating the liquidus and solidus alloys in the spreading film to confirm the hypothesis that the reactive wetting will come to the end when the interface saturates with the temperature-dependent solidus weight fraction of Cu.

关键词： Wetting Surface alloying Molecular dynamics Droplet

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Robust Transcriptional Activation in Plants Using Multiplexed CRISPR-Act2.0 and mTALE-Act Systems

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Molecular Plant 2018年第2期11卷 245-256页

作者： Levi G. Lowder Jianping Zhou Yingxiao Zhang Aimee Malzahn Zhaohui Zhong Tzung-Fu hsieh Daniel F. Voytas Yong Zhang Yiping Qi Department of Biology East Carolina University Greenville NC 27858 USA Department of Biotechnology School of Life Science and Technology Center for informational Biology University of Electronic Science and Technology of ChinaChengdu 610054 China Department of Plant Science and Landscape Architecture University of Maryland College Park MD 20742 USA Department of Plant and Microbial Biology and Plants for Human Health Institute North Carolina State University North Carolina Research Campus KannapolisNC 28O81 USA Department of Genetics Ceil Biology and Development Center for Genome Engineering University of Minnesota Minneapolis MN 55455 USA Institute for Bioscience and Biotechnology Research University of Maryland Rockville MD 20850 USA

User-friendly tools for robust transcriptional activation of endogenous genes are highly demanded in plants. We previously showed that a dCas9-VP64 system consisting of the deactivated CRISPR- associated protein 9 （dCasg） fused with four tandem repeats of the transcriptional activator VP16 0/1=64） could be used for transcriptional activation of endogenous genes in plants. In this study, we developed a second generation of vector systems for enhanced transcriptional activation in plants. We tested multiple strategies for dCasg-based transcriptional activation, and found that simultaneous recruitment of VP64 by dCas9 and a modified guide RNA scaffold gRNA2.0 （designated CRISPR-Act2.0） yielded stronger transcrip- tional activation than the dCas9-VP64 system. Moreover, we developed a multiplex transcription activator- likeeffector activation （mTALE-Act） system for simultaneous activation of up to four genes in plants. Our results suggest that mTALE-Act is even more effective than CRISPR-Act2.0 in most cases tested. In addition, we explored tissue-specific gene activation using positive feedback loops. Interestingly, our study revealed that certain endogenous genes are more amenable than others to transcriptional activation, and tightly regulated genes may cause target gene silencing when perturbed by activation probes. Hence, these new tools could be used to investigate gene regulatory networks and their control mechanisms. Assembly of multiplex CRISPR-Act2.0 and mTALE-Act systems are both based on streamlined and PCR-independent Golden Gate and Gateway cloning strategies, which will facilitate transcriptional activation applications in both dicots and monocots.

关键词： CRISPR gRNA2.0 MS2-VP64 TALE-VP64 multiplex transcriptional activation