检索结果-南通市图书馆

Effect of cholesterol metabolism on hepatolithiasis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-yu Ye jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

北方沥青混凝土路面冬季低温施工技术

建筑技术开发 2017年第3期44卷 48-49页

作者：裴玉军中铁十九局集团第三工程有限公司沈阳110136

低温环境下的沥青路面施工在路面性能控制与工艺技术应用等环节均存在一定难度,对我国北方地区冬季施工质量把控造成一定影响。沥青混凝土路面冬季低温施工主要涉及混合料制备、混合料运输及路面摊铺碾压等环节,针对上述施工要点进行详... 详细信息

低温环境下的沥青路面施工在路面性能控制与工艺技术应用等环节均存在一定难度,对我国北方地区冬季施工质量把控造成一定影响。沥青混凝土路面冬季低温施工主要涉及混合料制备、混合料运输及路面摊铺碾压等环节,针对上述施工要点进行详细的分析阐述,并提出相应质量控制措施,旨在提供一定参考与借鉴。

关键词：北方冬季低温沥青路面施工

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen yu Han jun Wang Shibo Xi yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

神经前体细胞表达下调因子8类泛素修饰抑制因子MLN4924对单核巨噬细胞白血病细胞增殖和凋亡的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2015年第3期29卷 424-429页

作者：裴钰君朱宁郭银汉王庆阳北京中医药大学中药学院北京100029 军事医学科学院基础医学研究所免疫学研究室北京100850

目的观察神经前体细胞表达下调因子8（NEDD8）类泛素修饰抑制因子MLN4924对单核巨噬细胞白血病细胞增殖的影响,并探讨其作用机制。方法 MLN4924 0.25~4.0μmol·L-1与U937细胞、THP-1细胞、Mo7e细胞和RAW264.7细胞作用24 h,采用MTT法检... 详细信息

目的观察神经前体细胞表达下调因子8（NEDD8）类泛素修饰抑制因子MLN4924对单核巨噬细胞白血病细胞增殖的影响,并探讨其作用机制。方法 MLN4924 0.25~4.0μmol·L-1与U937细胞、THP-1细胞、Mo7e细胞和RAW264.7细胞作用24 h,采用MTT法检测细胞存活。MLN4924 0.25~8.0μmol·L-1与RAW264.7细胞作用24 h,用Western蛋白质印迹法检测NEDD8类泛素化修饰的主要底物cullin蛋白表达水平。MLN4924 0.5μmol·L-1作用于RAW264.7细胞24 h,用流式细胞仪检测细胞周期和细胞凋亡率。结果 MLN4924 0.25~4.0μmol·L-1作用24 h对RAW264.7细胞、U937细胞、THP-1细胞和Mo7e细胞增殖具有抑制作用,IC50分别为0.52,3.11,2.89和0.76μmol·L-1;对正常小鼠骨髓巨噬细胞增殖无明显影响。MLN4924 0.25~8.0μmol·L-1作用24 h,NEDD8类泛素化修饰的cullin蛋白表达减少（P〈0.01）,表明RAW264.7细胞NEDD8修饰逐渐减少。MLN4924 0.5,1.0和2.0μmol·L-1作用于RAW264.7细胞24 h,G0/G1期细胞百分率由正常对照组的（61.3±1.3）%分别升高到（64.5±1.5）%（P〈0.05）,（69.5±2.3）%（P〈0.01）和（72.8±1.7）%（P〈0.01）,细胞凋亡率由正常对照组的（1.5±0.3）%分别升高到（2.3±0.5）%,（4.3±0.9）%（P〈0.05）和（7.5±0.8）%（P〈0.01）。结论 MLN4924能够明显抑制单核巨噬细胞白血病细胞增殖,并诱导其细胞周期阻滞和细胞凋亡。

关键词： MLN4924 神经前体细胞表达下调因子8 单核细胞白血病细胞增殖细胞凋亡

基于μCOS系统的嵌入式动态加载技术实现与改进

在线全文

学校读者我要写书评

暂无评论

软件导刊 2017年第11期16卷 149-152页

作者：裴俊宇刘子龙上海理工大学光电信息与工程学院上海20093

针对嵌入式操作系统不支持外部程序动态加载技术,限制其灵活性和可扩展性的弊端,基于STM32F103μc/OS-III平台,运用ELF文件重定位原理,对原系统功能进行拓展,对编译合适的ELF文件、ELF加载器实现等作深入分析。测试表明,系统支持对软件... 详细信息

针对嵌入式操作系统不支持外部程序动态加载技术,限制其灵活性和可扩展性的弊端,基于STM32F103μc/OS-III平台,运用ELF文件重定位原理,对原系统功能进行拓展,对编译合适的ELF文件、ELF加载器实现等作深入分析。测试表明,系统支持对软件模块的动态加载功能,并实现外部任务之间的通讯。最后针对内存开销大的问题作出改进,使该项技术具备更高的实用价值。

关键词：动态加载 μC/OS 单地址空间 ELF文件

脂质体平衡透析与液质联用技术筛选脊痛宁片物质基础研究

在线全文

学校读者我要写书评

暂无评论

中草药 2017年第4期48卷 668-672页

作者：高迪王保军裴玉白雪何毅宋兆辉中国药科大学天然药物活性组分与药效国家重点实验室江苏南京210009 天士力控股集团有限公司研究院现代中药开发中心天津300410 天士力制药集团股份有限公司创新中药关键技术国家重点实验室天津300410

目的研究脊痛宁片有效成分与模拟生物膜的相互作用,预测药物在体内的吸收情况。方法将脂质体作为模拟生物膜,采用脂质体平衡透析与液质联用技术筛选脊痛宁片中与脂质体有相互作用的成分,并考察脂质体质量浓度和缓冲液p H值对脊痛宁片与... 详细信息

目的研究脊痛宁片有效成分与模拟生物膜的相互作用,预测药物在体内的吸收情况。方法将脂质体作为模拟生物膜,采用脂质体平衡透析与液质联用技术筛选脊痛宁片中与脂质体有相互作用的成分,并考察脂质体质量浓度和缓冲液p H值对脊痛宁片与脂质体互相作用的影响。结果脊痛宁片中共有11个成分与脂质体作用明显,包括4个黄酮类成分,2个萜类成分,4个香豆素类成分,1个苯丙酸类成分。脂质体的质量浓度和缓冲液p H值都对脊痛宁片与脂质体互相作用有一定的影响。结论脂质体平衡透析与液质联用可预测脊痛宁片潜在的活性成分在体内的吸收情况,为其药效物质基础的进一步研究提供依据。

关键词：脊痛宁片模拟生物膜脂质体平衡透析液质联用活性成分

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu yu Wang Hanlin Huang jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long Zhou Wei-Jin Jiang Ji yu Mao-jun Yao yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

潍坊北部超采区地下水化学成分演变特征分析

中国农村水利水电 2017年第3期 85-89,95页

作者：曹滨唐培军焦裕飞郭亚萍林洪孝王刚山东农业大学水利土木工程学院山东泰安271018 潍坊市水文局山东潍坊261031

以潍坊市北部超采区漏斗演变过程中浅层地下水水化学要素为依据,综合运用Radial plot图、Box-whisker图、Piper三线图解分析了超采区浅层地下水化学成分的演变情况,阐述了硬度、TDS的时空变化规律,揭示了近年来地下水超采影响下该区地... 详细信息

以潍坊市北部超采区漏斗演变过程中浅层地下水水化学要素为依据,综合运用Radial plot图、Box-whisker图、Piper三线图解分析了超采区浅层地下水化学成分的演变情况,阐述了硬度、TDS的时空变化规律,揭示了近年来地下水超采影响下该区地下水水质变化规律。结果表明:(1)超采区水化学类型发生改变,2000年研究区浅层地下水水化学类型以Na+-K+-HCO-3、Ca2+-Mg2+-HCO-3型为主,转变为以Na+-K+-HCO-3-Cl-和Ca2+-Mg2+-HCO-3-Cl-型为主;(2)地下水超采地下水改变了地下水的流场,增大了入渗补给,加剧水污染,导致总硬度和TDS浓度的增加;(3)从地下水化学成分的年际变化来看:Na+、K+、Cl-、HCO-3含量变化与地下水位波动基本一致,离子浓度随地下水位的变化发生改变。Ca2+、Mg2+、SO2-4的含量随着地下水位的降低而升高:地下水超采导致含钙镁矿物和石膏等矿物的溶解增多,入渗量增大,离子浓度升高。

关键词：水化学特征超采地下水