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Periprostatic fat thickness measured on MRI correlates with lower urinary tract symptoms,erectile function,and benign prostatic hyperplasia progression

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Asian Journal of Andrology 2021年第1期23卷 80-84页

作者： Bo Zhang Xiang Chen Yu-Hang liu Yu Gan pei-hua liu Zhi Chen Wei-Ping Xia Guo-Yu Dai Feng Ru Ze-Xiang Jiang Yao He Department of Urology Xiangya HospitalCentral South UniversityChangsha 410008China

This study investigated the correlation between periprostatic fat thickness(PPFT)measured on magnetic resonance imaging and lower urinary tract symptoms,erectile function,and benign prostatic hyperplasia(BPH)progression.A total of 286 treatment-naive men diagnosed with BPH in our department between March 2017 and February 2019 were *** were divided into two groups according to the median value of PPFT:high(PPFT>4.35 mm)PPFT group and low(PPFT<4.35 mm)PPFT *** the initial evaluation,all patients received a combination drug treatment of tamsulosin and finasteride for 12 *** the 286 enrolled patients,244 completed the drug treatment *** with high PPFT had larger prostate volume(PV;P=0.013),higher International Prostate Symptom Score(IPSS;P-0.008),and lower five-item version of the International Index of Erectile Function(IIEF-5)score(P=0.002)than those with low *** high and low PPFT groups showed significant improvements in PV,maximum flow rate,IPSS,and quality of life score and a decrease of IIEF-5 score after the combination drug *** decrease of IIEF-5 score was more obvious in the high PPFT group than that in the low PPFT *** addition,more patients in the high PPFT group underwent prostate surgery than those in the low PPFT ***,Pearson’s correlation coefficient analysis indicated that PPFT was positively correlated with age,PV,and IPSS and negatively correlated with IIEF-5 score;however,body mass index was only negatively correlated with IIEF-5 score.

关键词： benign prostatic hyperplasia clinical progression erectile function lower urinary tract symptoms periprostatic fat thickness

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Free peroneal perforator-based sural neurofasciocutaneous flaps for reconstruction of hand and forearm

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Chinese Medical Journal 2009年第14期122卷 1621-1624页

作者： CAI pei-hua liu Sheng-he CHAI Yi-min WANG Hai-ming RUAN Hong-jiang FAN Cun-yi Department of Orthopedic Surgery Sixth People's Hospital Shanghai Jiao Tong University Shanghai 200233 China

Background Sural neurofasciocutaneous flap has been popularly used as an excellent option for the coverage of soft tissue defects in the lower third of leg, ankle and foot, but its free transplantation has been rarely reported. The objective of our work was to investigate the operative technique and clinical results of repairing the soft tissue defects of hand and forearm with free peroneal perforator-based sural neurofasciocutaneous flap. Methods Between May 2006 and March 2007, 10 patients including 7 men and 3 women were treated. Their ages ranged from 22 to 51 years. They presented to emergency with large soft tissue defects of 16 cm × 7 cm to 24 cm × 10 cm in size in hand and forearm after injured by motor vehicle accidents （2 cases） or crushed by machine （8 cases）. Thorough debridements and primary treatments to associated tendon ruptures or bone fractures were performed on emergency. And free peroneal perforator-based sural neurofasciocutaneous flaps were transplanted when the wound areas were stable at 5 to 7 days after emergency treatment. The flaps were designed along the axis of the sural nerve according to the shape and size of the soft tissue defects, with the peroneal perforator above the lateral malleolus as the pedicle and along with a part of the peroneal artery for vascular anastomosis. Then the flaps were harvested to repair the recipient sites with the peroneal artery anastomosed to the radial （or ulnar） artery and the peroneal veins to one of the radial （or ulnar） veins and the cephalic vein respectively. The flap sizes ranged from 18 cm × 8 cm to 25 cm × 12 cm. The donor areas were closed by skin grafts. Results All of the 10 flaps survived after surgeries. Marginal necrosis occurred in only 2 cases. The skin grafts survived entirely in the donor sites, and no obvious influence on the donor legs was observed. All of the transplanted flaps presented favourable contours and good functions at 9 to 12 months＇ follow-up. Conclusions Peroneal perfora

关键词： free transplantation peroneal perforator sural neurofasciocutaneous flap soft tissue defect

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RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen pei-Yao Wang Bang liu Yang-Pu Jia Zhao-Xiong Zhang Xin liu Dao-Han Wang Yong-Jia Yan Wei-hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

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Channel Arrangement for optical communication subsystems with 12 parallel channels

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Optoelectronics Letters 2006年第4期2卷 296-298页

作者： CHEN Xiong-bin JIA Jiu-chun ZHOU Yi TANG Jun pei Wei-hua liu Bo CHEN Hong-da State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of sciences Beijing 100083 China

This paper devoted to report the design and the achievement of an optical communication subsystem with 12 parallel channels in one *** system is capable of transmitting 10 Gbps bidirectional date over hundreds of *** can provide error detection and correction by using 8B/10B encoding and Cyclical Redundancy Checking (CRC) encoding when only single-channel *** design scheme has already passed the simulation in *** technique is useful to enhance the capability and the reliability of the very short reach (VSR) transmission systems.

关键词：光学通信子系统并行通道误差检测循环冗余检测

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基于预置动压的高超声速飞行器上升段轨迹设计

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飞行力学 2017年第5期35卷 57-61页

作者：孙佩华刘燕斌陈柏屹南京航空航天大学航天学院江苏南京210016

针对高超声速飞行器燃料最省上升轨迹的研究问题,为实现高超声速飞行器的燃料最省上升轨迹快速求解,对定动压情况下高超声速飞行器上升段轨迹特性进行了研究分析,给出了定动压情况下高超声速飞行器燃料最省上升轨迹的快速反解方法,总结... 详细信息

针对高超声速飞行器燃料最省上升轨迹的研究问题,为实现高超声速飞行器的燃料最省上升轨迹快速求解,对定动压情况下高超声速飞行器上升段轨迹特性进行了研究分析,给出了定动压情况下高超声速飞行器燃料最省上升轨迹的快速反解方法,总结分析了不同定动压下的上升轨迹特性,并在此研究的基础上提出了基于预置动压的高超声速飞行器上升段轨迹设计方法。该方法可以通过设计燃料最省的动压曲线,反解出该预置动压下的上升轨迹参数,得到一条近似燃料最省最优解的轨迹。仿真结果表明,经过解算得到的上升轨迹结果与高斯伪谱法得到的最优上升轨迹结果基本相似。

关键词：预置动压高超声速飞行器上升段轨迹设计定动压

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广东省高新技术产业竞争力动态综合评价

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特区经济 2009年第5期244卷 36-37页

作者：赵佩华刘照德梅琴华南理工大学工商管理学院广东广州510640 广东商学院经济学院广东广州510320

本文在国内外研究基础上,根据我国高新技术产业的特点,深入分析了影响我国高新技术产业竞争力的主要因素,利用我国广东等11个有代表性的省市2006年相关数据建立了符合我国高新技术产业发展特征的产业竞争力评价指标体系和评价指数模型,... 详细信息

本文在国内外研究基础上,根据我国高新技术产业的特点,深入分析了影响我国高新技术产业竞争力的主要因素,利用我国广东等11个有代表性的省市2006年相关数据建立了符合我国高新技术产业发展特征的产业竞争力评价指标体系和评价指数模型,同时利用该指标体系和评价指数模型对广东省高新技术产业竞争力进行了动态综合评价,并对存在的问题提出了相应的对策建议。

关键词：高新技术产业竞争力指标体系动态评价

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Clinical effects of phospholipase D2 in attenuating acute pancreatitis

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei Niu Guo-Chao Zhang Wu Ning Hai-Bin liu hua Yang Chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

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皖南尖吻蝮蛇毒I型金属蛋白酶Acutolysin A的表达、重折叠及其生物学活性

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生物化学与生物物理学报 2002年第5期34卷 675-679页

作者：向开军余红秀邹春森袁培华刘兢中国科学技术大学生命科学学院中国科学技术大学生命科学学院合肥230027

将皖南尖吻蝮蛇毒I型金属蛋白酶acutolysinA基因克隆进原核表达载体pBAD/gIIIA后得到重组表达质粒 pDS。在 0 .0 2 %的L (+) 阿拉伯糖的诱导下 ,质粒pDS在E .coliTOP1 0中表达了重组acutolysinA。与其天然形式相比 ,重组蛋白质在N端和C... 详细信息

将皖南尖吻蝮蛇毒I型金属蛋白酶acutolysinA基因克隆进原核表达载体pBAD/gIIIA后得到重组表达质粒 pDS。在 0 .0 2 %的L (+) 阿拉伯糖的诱导下 ,质粒pDS在E .coliTOP1 0中表达了重组acutolysinA。与其天然形式相比 ,重组蛋白质在N端和C端各增加了 2 2个和 8个氨基酸残基 (均源于载体序列 ) ,并以包含体的形式存在于胞质中 ,表达量约占菌体总蛋白质的 5 %～ 1 0 %。在经 8mol/L尿素或 6mol/L盐酸胍变性及体外复性后 ,重组蛋白质获得了良好的免疫学及生物学活性。Western印迹及ELISA实验表明 ,天然金属蛋白酶acutolysinA与重组蛋白质具有良好的免疫反应相关性。动物实验表明 ,复性的重组蛋白质能明显引起皮下出血 ,其最低出血剂量约为 2 0 μg左右。1mmol/LEDTA、1mmol/LEGTA及 3mmol/L咪唑均能不同程度的抑制天然及重组金属蛋白酶的出血活性。PMSF没有明显的抑制效果。并对出血毒金属蛋白酶的出血机制进行了探讨

关键词：蛇毒金属蛋白酶表达重折叠出血活性

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin Meng Li Weibin Chen pei liu Tao huang Zhencheng huang Yuying liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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微合金钢连铸表面横裂纹形成机理与控制技术研究现状

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钢铁研究学报 2017年第1期29卷 1-12页

作者：兰鹏杜辰伟陈培莉刘华松邱东升张家泉北京科技大学冶金与生态工程学院北京100083

表面和角部横裂纹是高强度微合金钢连铸及热轧工艺中最为突出的质量问题,也是国内钢铁企业多年来仍未彻底突破的技术难点。在回顾前人对微合金钢连铸表面横裂纹问题研究的基础上,全面概述了其形成原因、影响因素以及解决措施,重点分析... 详细信息

表面和角部横裂纹是高强度微合金钢连铸及热轧工艺中最为突出的质量问题,也是国内钢铁企业多年来仍未彻底突破的技术难点。在回顾前人对微合金钢连铸表面横裂纹问题研究的基础上,全面概述了其形成原因、影响因素以及解决措施,重点分析了基体粗大奥氏体晶粒对连铸表面裂纹倾向的影响,揭示了表层组织控制技术的机理及相关参数的制定准则,提出了解决表面横裂纹问题的可行研究方向。

关键词：微合金钢表面横裂纹粗大奥氏体晶粒表层组织控制技术

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