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Pharmaceutical resource discovery from traditional medicinal plants:Pharmacophylogeny and pharmacophylogenomics

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Chinese Herbal Medicines 2020年第2期12卷 104-117页

作者： Da-cheng Hao pei-gen xiao Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

The worldwide botanical and medicinal culture diversity are astonishing and constitute a Pierian spring for innovative drug R&***,the latest awareness and the perspectives of pharmacophylogeny and pharmacophylogenomics,as well as their expanding utility in botanical drug R&D,are systematically summarized and *** is based on the fact that closely related plants contain the same or similar chemical ***,it is better to combine morphological characters,DNA markers and chemical markers in the inference of medicinal plant *** plants within the same phylogenetic groups may have the same or similar therapeutic effects,thus forming the core of *** we systematically review and comment on the versatile applications of pharmacophylogeny in(1)looking for domestic resources of imported drugs,(2)expanding medicinal plant resources,(3)quality control,identification and expansion of herbal medicines,(4)predicting the chemical constituents or active ingredients of herbal medicine and assisting in the identification and determination of chemical constituents,(5)the search for new drugs sorting out,and(6)summarizing and improving herbal medicine experiences,*** studies should be enhanced within the context of deeper investigations of molecular biology and genomics of traditional medicinal plants,phytometabolites and metabolomics,and ethnomedicine-based pharmacological activity,thus enabling the sustainable conservation and utilization of traditional medicinal resources.

关键词： pharmaceutical resource discovery pharmacophylogenomics pharmacophylogeny traditional medicinal plants

A new triterpenoid saponin from Clematis ganpiniana

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Chinese Chemical Letters 2007年第9期18卷 1078-1080页

作者： Feng Sun Qing He pei gen xiao Yi Yu Cheng Pharmaceutical Informatics Institute College of Pharmaceutical Sciences Zhejiang University Hangzhou 310027 China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Beijing 100094 China

A new triterpenoid saponin, named clematiganoside A (1), was isolated from the whole plant of Clematis ganpiniana. Its structure was elucidated on the basis of 1D, 2D NMR, TOF-MS and ESI-MS techniques, and physicochem... 详细信息

关键词： Clematis ganpiniana Triterpenoid saponin Clematiganoside A

The Crystalline Changes of Starch from Rhizoma Dioscorea by Acid Hydrolysis

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Chinese Chemical Letters 2006年第9期17卷 1255-1258页

作者： Shu Jun WANG Wen Yuan GAO Jing Lin YU pei gen xiao College of Pharmaceuticals and Biotechnology Tianjin University Tianjin 300072 School of Science Tianjin University Tianjin 300072 Institute of Medicinal Plant Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100094

The changes in crystalline properties of starch from Rhizoma Dioscorea by acid hydrolysis was characterized by X-Ray diffractometry （XRD）. The results revealed that the crystalline type of Rhizoma Dioscorea starch changed from C-type to A-type after 16 days of the acid hydrolysis. This phenomenon was different from that of other starches subjected to the acid hydrolysis. The results revealed that the B-polymorphs of C-type starch constituted the amorphous regions while the crystalline areas were mainly composed of A-polymorphs. The degree of crystallinity of the acid-thinned starch increased gradually with the time of acid hydrolysis.

关键词： Rhizoma Dioscorea starch crystalline acid hydrolysis X-ray diffraction.

Distribution patterns and industry planning of commonly used traditional Chinese medicinal plants in China

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Plant Diversity 2022年第3期44卷 255-261页

作者： Zhang-Jian Shan Jian-Fei Ye Da-Cheng Hao pei-gen xiao Zhi-Duan Chen An-Ming Lu State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China China National Botanical Garden Beijing 100093China Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

Medicinal plants are the primary material basis for disease prevention and treatment in traditional Chinese medicine(TCM).The conservation and sustainable utilization of these medicinal plants is critical for the development of the TCM ***,wild medicinal plant resources have sharply declined in recent *** ameliorate the shortage of medicinal plant resources,it is essential to explore the development potential of the TCM industry in different geographical *** this purpose,we examined the spatial distribution of commonly used medicinal plants in China,the number of Chinese medicinal material markets,and the number of TCM decoction piece ***,multispecies superimposition analysis and Thiessen polygons were used to reveal the optimal range for planting bulk medicinal plants and the ideal regions for building Chinese medicinal material markets,***,we quantitatively analyzed mismatches between the spatial distribution of commonly used medicinal plant richness,Chinese medicinal material markets,and TCM decoction piece *** found that the areas suitable for growing commonly used medicinal plants in China were mainly distributed in Hengduan Mountain,Nanling Mountain,Wuling Mountain,and Daba Mountain *** Thiessen polygon network based on Chinese medicinal material market localities showed there are currently fewer markets in southwestern,northwestern,and northeastern China than in central and southern *** decoction piece enterprises are concentrated in a few provinces,such as Hebei and *** found that the distribution of commonly used medicinal plants,Chinese medicinal material markets and TCM decoction piece enterprises are mismatched in Henan,Shaanxi,Hunan,Hubei,Zhejiang,Fujian,Chongqing,and *** recommend strengthening development of the TCM industry in Henan,Hunan,Zhejiang,Shaanxi,Hubei,Chongqing,Fujian,and Xizang;building more Chinese medicinal material markets in southw

关键词： Medicinal plant Distribution pattern Traditional Chinese medicine industry Thiessen polygon

A Novel Flavonoid Glucoside from Anoectochilus roxburghii （Wall,） Lindl.

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Journal of Integrative Plant Biology 2006年第3期48卷 359-363页

作者： Chun-Nian He Chun-Lan Wang Shun-Xing Guo Jun-Shan Yang pei-gen xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100094 China

Eight compounds were isolated from the ethyl acetate- and n-butanol-soluble fractions of the ethanollc extract of the whole plant of Anoectochllus roxburghll（Wali.） Lindi. （Orchidaceee）. On the basis of spectroscopic methods, the structures of these compounds were elucidated as quercetin-7-O-β-D-[6＂-O-（trans-feruloyi）]- giucopyranosids （compound 1）, 8-C-p-HydroxybenzyiquerceUn （compound 2）, isorhamnetin-7-O-β-D- giucopyranoside （compound 3）, isorhamnetin-3-O-β-D-giucopyranoside （compound 4）, kaempferoi-3-O-β-D- giucopyranoside （compound 5）, kaempferoi-7-O-β-D-giucopyranoside （compound 6）, 5-hydroxy-3＇,4＇,7- trimethoxyfiavonoi-3-O-β-D-rutinoside （compound 7）, and isorhamnetin-3-O-β-D-rutinoside （compound 8）. Of the compounds isoisted, compound 1 was a new flavonoid giucoside and exhibited strong scavenging activity against the 1,1-diphenyi-2-picryihydrazyi free radical, whereas the ethanolic extract showed weak activity. Compounds 2-8 were obtained from this family for the first time.

关键词： Anoectochilus roxburghii quercetin-7-O-β-D-[6"-O-(trans-feruloyl)]-glucopyranoside radical-scavenging activity.

A Cytotoxic Neolignan from Schisandra propinqua （Wall.） Baill.

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Journal of Integrative Plant Biology 2006年第12期48卷 1493-1497页

作者： Li-Jia Xu Feng Huang Si-Bao Chen Lian-Niang Li Shi-Lin Chen pei-gen xiao Institute of Medicinal Plant Development Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100094 China State Key Laboratory of Chinese Medicine and Molecular Pharmacology Shenzhen 518057 China Department of Appfied Biology and Chemical Technology Hong Kong Polytechnic University Hong Kong SAR China Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 China

In the course of our study of bioactive natural products from Schisandra plants, we isolated a neolignan from an EtOAc extract of the stems of Schisandra propinqua （Wall.） Baill. The structure of the new com- pound was determined to be 4, 4-di （4-hydroxy-3-methoxyphenly）-2, 3-dimethylbutanol （compound 1） on the basis of 1H- and 13C-NMR spectra and 2D NMR methods. Eight known compounds, compounds 2-9, were also isolated and identified, of which compounds 3, 4, 6 and 9 were isolated for the first time from this plant. In addition, compounds 1-4 were evaluated for cytotoxicity by an 3-（4,5-dimethyl-2 thiazoyl）-2,5-diphenyl-2H- tetrazolium bromide （MTT） assay. Compound 1 showed significant potential cytotoxic ability in the bioassay.

关键词： cytotoxicity lignan Schisandra propinqua Schisandraceae

Two new phenethanol glycosides from Ligustrum robustum

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Chinese Chemical Letters 2011年第3期22卷 326-329页

作者： Li Li Yong Peng Yong Liu Li Jia Xu Na Guo Ren Bing Shi pei gen xiao Institute of Medicinal Plant Development Chinese Academy of Medical Science Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College) Ministry of Education Beijing 100193 China School of Chinese Pharmacy Beijing University of Chinese Medicine Beijing 100102 China Experimental Research Center China Academy of Chinese Medical Sciences Beijing 100700 China

Two new phenethanol glycosides,named ligurobustoside P（1）,ligurobustoside Q（2） have been isolated from the leaves of Ligustrum robustum,together with the known compound angoroside A（3） which was firstly isolated from this *** structures of the two new phenethanol glycosides（1-2） were elucidated by a combination of high-resolution electron ionization mass spectrometry（HR-ESI-MS）,~1H NMR,^（13）C NMR,HMQC,and HMBC spectra for the first time.

关键词： Ligustrum robustum Oleaceae Phenethanol glycosides

Rhizosphere Microbiota and Microbiome of Medicinal Plants: From Molecular Biology to Omics Approaches

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Chinese Herbal Medicines 2017年第3期9卷 199-217页

作者： Da-cheng Hao pei-gen xiao Biotechnology Institute School of Environment and Chemical Engineering Dalian Jiaotong University Institute of Medicinal Plant Development Chinese Academy of Medical Sciences

The rhizosphere is a narrow region of soil that is directly influenced by roots and associated soil microorganisms. Research on rhizosphere microbes of various medicinal plants is essential for microbial ecology, applied microbiology and industrial biotechnology with regard to the sustainable utilization of Chinese medicinal resources. However, the inability of culturing most rhizosphere microorganisms （around 99%） in the laboratory obviates the research progress. In recent years, there is enormous advances in applying non-culturing techniques based on molecular biology and omics to the study of rhizosphere microbial diversity and plant-microbe interactions. DGGE, T-RFLP, ARDRA, DNA cloning and Sanger sequencing are still useful in the rhizosphere studies, while various omics tools, such as FISH, SIP, microarray, next generation sequencing （NGS）, etc., evolve quickly to provide more comprehensive understanding of the rhizosphere microbiota and microbiome. Flexible applications of NGS technologies are here exemplified, e.g., amplicon sequencing, metagenomic sequencing, whole genome sequencing, and transcriptome sequencing, which address the biology and biotechnology potentials of the rhizosphere microbiome of medicinal plants. This review discusses recent findings and future challenges in the study of rhizosphere microbes, highlighting medicinal plant rhizosphere study, evolution of research methods, and innovative combinations of novel high-throughput techniques. The top-down approaches such as metagenomics and bottom-up approaches targeting individual species or strains should be integrated and combined with modeling approaches to afford a wide-ranging understanding of the microbial community as a whole.

关键词： diversity functional potential medicinal plant, molecular biology rhizospheremicrobiota and microbiome omics

Deep in shadows:Epigenetic and epigenomic regulations of medicinal plants

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Chinese Herbal Medicines 2018年第3期10卷 239-248页

作者： Da-Cheng Hao pei-gen xiao Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong University Institute of Medicinal Plant Development Chinese Academy of Medical Sciences

Around 60%of the extant plants have medicinal and health-promoting *** medicinal material(geoherb)is produced in particular geographic regions,that is defined ecological environment and cultivation *** clinical efficacy of a geoherb is superior to that of the same medicinal plant growing in other *** special medicinal features of a plant are determined by its genome,while the proper ecological conditions have major effects on the formation of a geoherb,which is at least partially mediated by the *** epigenetics/epigenomics,researchers uncover the complexities of the influence of the environment on the expression of genes that control medicinal plant growth,development,stress responses,and medicinal phytometabolite yield,and put the other"omics layers"in a meaningful biological *** unique phenotypes of geoherb are closely related to the growth,development,and stress responses of medicinal *** addition to the commonly known genetic control,epigenetic machineries,active at the population level,play an essential role in the formation of *** contribution gives a comprehensive overview of the epigenetic regulation of medicinal plants,and the associated microbes,and the role of DNA methylation,small non-coding RNA,transposable elements,and histone modifications in the gene expression regulation of geoherbs and relevant *** epigenetic and epigenomic mechanisms should be highlighted in the study of specific phenotype and indigenousness of *** the correlation between epigenetics and geoherbs could shed light on the quality assessment,authentication,molecular breeding,and sustainable utilization of medicinal plants and the associated microbes.

关键词： epigenetic regulation epigenomic geoherb medicinal plant microbe