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Insights into the effects of pulsed antimicrobials on the chicken resistome and microbiota from fecal metagenomes

Journal of Integrative Agriculture 2023年第6期22卷 1857-1869页

作者： ZHAO Ruo-nan CHEN si-yuan TONG Cui-hong HAO Jie LI pei-si XIE Long-fei XIAO Dan-yu ZENG Zhen-ling XIONG Wen-guang Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642P.R.China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642P.R.China National Laboratory of Safety Evaluation(Environmental Assessment)of Veterinary Drugs College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642P.R.China

Antimicrobial resistance has become a global problem that poses great threats to human health. Antimicrobials are widely used in broiler chicken production and consequently affect their gut microbiota and resistome. To better understand how continuous antimicrobial use in farm animals alters their microbial ecology, we used a metagenomic approach to investigate the effects of pulsed antimicrobial administration on the bacterial community, antibiotic resistance genes(ARGs) and ARG bacterial hosts in the feces of broiler chickens. Chickens received three 5-day courses of individual or combined antimicrobials, including amoxicillin, chlortetracycline and florfenicol. The florfenicol administration significantly increased the abundance of mcr-1 gene accompanied by floR gene, while amoxicillin significantly increased the abundance of genes encoding the AcrAB-tolC multidrug efflux pump(marA, soxS, sdiA, rob, evgS and phoP).These three antimicrobials all led to an increase in Proteobacteria. The increase in ARG host, Escherichia, was mainly attributed to the β-lactam, chloramphenicol and tetracycline resistance genes harbored by Escherichia under the pulsed antimicrobial treatments. These results indicated that pulsed antimicrobial administration with amoxicillin,chlortetracycline, florfenicol or their combinations significantly increased the abundance of Proteobacteria and enhanced the abundance of particular ARGs. The ARG types were occupied by the multidrug resistance genes and had significant correlations with the total ARGs in the antimicrobial-treated groups. The results of this study provide comprehensive insight into pulsed antimicrobial-mediated alteration of chicken fecal microbiota and resistome.

关键词： metagenomic chicken antimicrobials resistome microbial community

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The Impact of Entrepreneurial Self-efficacy on Entrepreneurial Intention ——The Moderating Role of Fear of Failure

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环球市场信息导报 2018年第29期 94-96页

作者： WANG Zi LI pei-si School of Management University of South China Hengyang 421001

*** prerequisite for entrepreneurial behavior is entrepreneurial intention,and not everybody has the *** Studies indicated that individual entrepreneurial intention is affected by many factors. External influencing factors such as material basis,policy environment and ethnic family[1-2],and the internal influencing factors such as risk orientation,personality traits,cognitive process,entrepreneurial self-efficacy, etc.[3-4].

关键词：人才创业群体规模人力资源管理人才培养

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Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A single-Center, Double-Blind, Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2023年第2期29卷 99-107页

作者： LIU si-pei ZHOU Jian-guan JIN Yan GUO Yan ZHOU Shi-wei LIN Mei-lan ZHANG Jun WANG Xiao-nv GUAN Xia-fei WANG Lei Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjing 210008China Department of Rehabilitation College of Acupuncture and Moxibustion and Massage Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China Division of Cardiovascular Rehabilitation Ruian Hospital of Traditional Chinese MedicineRuianZhejiang Province 325299China Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing 100091China

Objective:To evaluate the therapeutic efficacy of Shexiang Baoxin Pill combined with exercise in heart failure patients with preserved ejection fraction(HFpEF).Methods:sixty patients with HFpEF were randomly divided into group A(n=20),receiving Shexiang Baoxin Pill combined with home-based exercise training based on conventional drugs for 12 weeks;group B(n=20),receiving conventional drugs combined with home-based exercise training for 12 weeks;and group C(n=20),receiving conventional drug treatment *** oxygen uptake(peakVO2),anaerobic threshold(AT),6-min walking test(6MWT),Pittsburgh Sleep Quality Index(PSQI),and SF-36 questionnaire(SF-36)results before and after treatment were compared among ***:After the 12-week intervention,patients in group C showed significant declines in peakVO2,AT,6MWT,PSQI,and SF-36 compared with pre-treatment(Psignificant improvements in peakVO2,AT,6MWT,PSQI,and SF-36 results compared with pre-treatment(Psignificant improvements in peakVO2,AT,6MWT,PSQI,and SF-36(Psignificant improvements in physical function,role-physical,vitality,and mental health scores on the SF-36 questionnaire,and PSQI scores than those in group B(Psions:Exercise training improved exercise tolerance,sleep quality and quality of life(QoL)in patients with ***,Shexiang Baoxin Pill played an active role in sleep quality and QoL of patients with HFpEF.

关键词： heart failure preserved ejection fraction exercise training Shexiang Baoxin Pill

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Determination of Elements of Groups Ⅲ A and ⅣA Using Microwave Plasma Torch Atomic Emission Spectrometry

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Chemical Research in Chinese Universities 1997年第2期13卷 34-40页

作者： ZHANG Han qi YUAN Xiang lin LIANG Feng LIU si pei ZHAO Li wei JIN Qin han Department of Chemistry Jilin UniversityChangchun130023

The determination of the elements of groups ⅢA and ⅣA by means of microwave plasma torch atomic emission spectrometry(MPT AES) was studied systematically. Sample solutions were introduced into the plasma with a pneumatic nebulizer in continuous sampling mode and flow injection (FI) mode. The emission characteristics of these elements were investigated in details, and the basic data obtained are very important to the development of MPT AES. The analytical performances were examined. For most elements, the detection limits obtained by this method were principally the same as those obtained by inductively coupled plasma atomic emission spectrometry (ICP AES).

关键词： Atomic emission spectromery Microwave plasma torch Groups ⅢA and ⅣA

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The signal pathway of siRT1 underlying the neuroprotection in NMDA-induced excitotoxicity

The signal pathway of SIRT1 underlying the neuroprotection i...

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中国神经科学学会第十届全国学术会议

作者： Xue-Fei SUN pei-pei si Yu ZHANG Xiao-Rong YANG Ce ZHANG Department of Physiology Shanxi Medical University

Objective The silent information regulator the factor 2 enzyme 1(silent information regulator 2 homolog 1,siRT1) is one of the members of the sirtuin family,widely presents in mammalian *** recent years,people have paid more and more attention on the neuroprotective effect of *** researches have suggested that many factors can regulate siRT1 ***,specific intracellular signaling mechanism does not *** The study was divided into three *** NMDA-induced Excitotoxicity cell model,apphed to Gene silencing technology,Genetic mutations,Western blotting(WB),Real Time PCR,immunoprecipitation(IP),the enzyme activity detection experiments and so on to observe(1) the effects of HuR phosphorylation to siRT1 in NMDA-induced Excitotoxicity,(2) the effects of PKC kinase activity to HuR in NMDA-induced Excitotoxicity,(3) the effects of influx of Ca to PKC kinase activity in NMDA-induced *** In NMDA-induced excitotoxicity cell model,NMDA induces extracellular Ca influx,intracellular increased Ca activates PKC,activation of PKC phosphorylates HuR,the phosphorylated HuR with siRT1 mRNA combines reduces,so that siRT1 mRNA decreases stability,siTR1downregulates,causing cell damages and even to *** Ca-PKC-HuR-siRTl pathway may be the access to regulating siRT1 function in neurons.

关键词： NMDA excitatory neurotoxicity siRT1 neuroprotection signaling pathways

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The neuroprotective effects of siRT1 on NMDA-induced excitotoxicity

The neuroprotective effects of SIRT1 on NMDA-induced excitot...

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中国神经科学学会第十届全国学术会议

作者： pei-pei si Xue-Fei SUN Xin ZHAO Xiao-Rong YANG Ce ZHANG Department of Neurobiology Shanxi Medical University

Objective siRT1 is a NAD-dependent *** study observed the neuroprotective effects of siRT1 on NMDA-induced excitotoxicity by overexpression of siRT1 *** In NMDA-induced excitotoxicity model,overexpress siRT1 with Lipofectamine ***,use CCK-8 assay,LDH test,Calcein-AM/PI staining to detect cell survival,use Real Time PCR,Western-blot to detect siRT1 expression level and use siRT1 deacetylase activity assay to detect siRT1 *** In NMDA-induced excitotoxicity,(1) NMDA reduced the expression of siRT1.(2) siRT1 overexpression promoted cell survival and increased siRT1 deacetylase activity.(3) BAPTA-AM inhibited neuronal *** siRT1 overexpression promotes cell survival to antagonize NMDA insults by increasing siRT1 deacetylase activity.

关键词： NMDA excitotoxicity siRT1 neuroprotection

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脂质质谱成像揭示三氯生促进三维肝癌肿瘤细胞球增长的相关机理

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质谱学报 2023年第2期44卷 213-222页

作者：陈静谢佩斯蔡宗苇福州大学化学学院福建福州350108 香港浸会大学环境与生物分析国家重点实验室中国香港999077

三氯生(triclosan,TCS)作为一种广谱抗菌剂被广泛应用于多种日常消费品中。当前研究表明,TCS暴露可以促进肝癌肿瘤增长,但涉及的相关脂质代谢机理尚不完全清楚。基于此,本研究建立了TCS暴露的肝癌肿瘤细胞球模型,利用质谱成像技术分析... 详细信息

三氯生(triclosan,TCS)作为一种广谱抗菌剂被广泛应用于多种日常消费品中。当前研究表明,TCS暴露可以促进肝癌肿瘤增长,但涉及的相关脂质代谢机理尚不完全清楚。基于此,本研究建立了TCS暴露的肝癌肿瘤细胞球模型,利用质谱成像技术分析对照组和暴露组间脂质小分子在肿瘤细胞球内丰度和分布的差异。结果表明,6μmol/L TCS暴露可以显著促进肝癌肿瘤细胞球的增长,并引起脂质代谢的变化。27种脂质代谢小分子(含19种甘油磷脂、3种甘油酯和5种鞘脂)的丰度在对照组和暴露组的肿瘤细胞球内发生了显著性的变化。在暴露组的19种甘油磷脂中,16种在肿瘤细胞球外围增殖区发生了显著性上调;在3种甘油酯中,1种在外围增殖区发生了显著性上调,2种在内部凋亡区发生了显著性下调;5种鞘脂在肿瘤细胞球内部凋亡区均发生了显著性下调。可见,TCS可能是通过促进肿瘤细胞球外围细胞的增殖以及抑制内层细胞的凋亡来促进三维肿瘤细胞球的增长。该结果可为进一步探讨环境污染物对肿瘤发展影响的分子机制提供参考。

关键词：质谱成像(Msi) 肿瘤细胞球三氯生(TCS) 脂质代谢细胞增殖

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The emerging role of fasting-mimicking diets in cancer treatment

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Journal of Nutritional Oncology 2023年第2期8卷 66-70页

作者： Yu-Jia Zhai pei-Yao si Ming-Li Liu Lan Huang Translational Medicine Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450018HenanChina Department of Microbiology Biochemistry&ImmunologyMorehouse School of MedicineAtlanta 30310Georgia StateUSA

Cancer is one of the most common causes of morbidity and mortality *** high demand for specific nutrients and the sensitivity to nutritional deficiencies are newly recognized features of cancer *** interventions can suppress tumor demand for particular nutrients and alter certain nutrients to target a tumor's metabolic *** fasting or fasting-mimicking diets(FMDs)are popular approaches that can reduce nutrient intake over a specific *** evidence suggests that FMDs attenuate tumor growth by altering the energy metabolism of cancer ***,FMDs potentiate the sensitivity of tumors to conventional cancer treatments and limit adverse *** findings also highlight the potential value of FMDs in boosting antitumor immune ***,clinical trials regarding the impact of FMDs on cancer patients remain limited and ***,we provide the latest information on the effects of FMDs on cancer progression and treatment,focusing on future clinical applications.

关键词： Cancer Cancer treatment Fasting Fasting-mimicking diets

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深中通道智慧梁场建设及运营研究

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世界桥梁 2023年第S1期51卷 26-33页

作者：刘佩斯中铁大桥局集团有限公司湖北武汉430050

深中通道项目桥梁工程全长17 km,其上部结构的791片混凝土箱梁全部由中山预制梁场制造。为实现预制梁场的协同远程控制管理,以混凝土箱梁的预制及移运为背景建设深中通道智慧梁场。深中通道智慧梁场基于BIM技术,集成钢筋加工管理系统实... 详细信息

深中通道项目桥梁工程全长17 km,其上部结构的791片混凝土箱梁全部由中山预制梁场制造。为实现预制梁场的协同远程控制管理,以混凝土箱梁的预制及移运为背景建设深中通道智慧梁场。深中通道智慧梁场基于BIM技术,集成钢筋加工管理系统实现了钢筋的自动化加工;使用全自动液压整体式模板优化了箱梁模板安拆方法;配套智能化混凝土输送中心改变了传统混凝土生产的格局;建立智慧梁场协同管理平台集成多种智能生产系统,实现生产过程信息的自动采集、数据共享。智慧梁场的建设及运营,是将智能制造技术与梁场管理流程相融合,大幅提升箱梁生产流程的自动化程度,完善各工序管理流程,降低施工成本和安全风险,提高成品质量和效益。

关键词：跨海桥梁混凝土箱梁智慧梁场 BIM 自动化智能化信息化综合管理

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一种基于CEMD和融合的多视点图像编码方法

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电子与信息学报 2011年第4期33卷 1007-1011页

作者：孙季丰何沛思华南理工大学电子与信息学院广州510640

该文提出了一种新的基于相邻视点融合的多视点图像编码方法,通过融合与拆分对非同源图像同时进行编码。编码时,原始图像经过CEMD(Complex Empirical Mode Decomposition)同步分解成2维的固有模态函数和余量图像并分别融合,再对融合图像... 详细信息

该文提出了一种新的基于相邻视点融合的多视点图像编码方法,通过融合与拆分对非同源图像同时进行编码。编码时,原始图像经过CEMD(Complex Empirical Mode Decomposition)同步分解成2维的固有模态函数和余量图像并分别融合,再对融合图像进行基于EMD的压缩编码。解码时,将融合图像拆分,重构出原始图像。实验结果表明,该方法具有失真度小和压缩比高的优势,具有实践意义。

关键词：多视点图像编码复数经验模态分解(CEMD) 融合拆分压缩

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