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Chinese Chemical Letters 2024年第3期35卷 384-388页

作者： Yi-Jing Li Lingze Zhang Ming-Hao Pang pei-pei yang Lu-Ming Guo Kuo Zhang Da-Yong Hou Lei Wang Hao Wang Hui Cao State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Peptide drugs are known for their high biological ***,compared with small molecule drugs,peptide drugs are easily oxidized and hydrolyzed as well as short in ***,inspired by the long circulation of albumin in blood,we screened albumin binding peptides(ABPs)from a one-bead one-compound(OBOC)peptide library to increase the half-life of peptide *** displaying random peptides were screened using fluorescent labeled human serum *** beads with specific binding to albumin were isolated for *** selected ABPs can effectively bind to albumin,thus possessing the long circulation of *** dissociation constant(K_(D))of ABPs to albumin is up to 1×10^(-8)mol/*** one of ABPs(ABP2)was coupled to triptorelin,the circulation half-life of triptorelin in mice was significantly prolonged to 263.50 h much longer than that of triptorelin alone(179.07 h).In addition,the combination therapy using ABP-conjugated triptorelin and doxorubicin(DOX)can effectively inhibit the proliferation of tumor cells in *** OBOC screening strategy and resulting ABPs showed great potential for enhancing the delivery efficiency of peptide drugs.

关键词： One-bead one-compound Combinatorial library Albumin binding Drug delivery Triptorelin

Recent advances of transformable nanoparticles for theranostics

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Chinese Chemical Letters 2017年第9期28卷 1808-1816页

作者： Kuo Zhang pei-pei yang Jing-Ping Zhang Lei Wang Hao Wang School of Chemistry Northeast Normal University Changchun 130024 China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biological Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190 China

In recent years,various transformable nanoparticles（NPs）were successfully prepared and widely utilized for biomedical *** sizes,surface charges or morphologies of transformable NPs would affect their behavior in physiological/pathological conditions including circulation,penetration,accumulation and retention *** other way round,the NPs could be precisely modulated in the specific physiological/pathological condition for precision theranostics of ***,we summarized recent advances of transformable NPs for disease diagnostics and *** this review,the transformation of NPs was divided into three groups including changes in size,surface charge and morphology,which was induced by internal stimuli,such as p H,enzyme,receptor or external stimuli,such as light,temperature ***,we focused on the characterization of structural transformation in vivo,as well as the transformation-induced biological effects for theranostics of disease.

关键词： Transformable Nanoparticles Tumor Imaging Therapy

Terminal attitude selection method of missile attack aircraft

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Chinese Journal of Aeronautics 2024年第2期37卷 385-400页

作者： Peng HOU yang pei Yuxue GE Mengjie ZHU School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Research Department Shanghai Electro-Mechanical Engineering InstituteShanghai 201108China

The appropriate terminal attitude of missile is important to improve the damage effectiveness of fragmentation warhead against aircraft *** this paper,three missile terminal attitude selection methods are proposed to solve the problem of terminal attitude selection in different situations according to their respective evaluation *** MVE-based method uses the damage probability of each detonation point around the aircraft at a given attitude of missile to calculate the Mean Volume of Effectiveness(MVE)at the corresponding attitude,and then uses the MVE for different attitudes to select the terminal strike *** detonation position-based method addresses the case where the missile detonation position can be assessed in *** the effects of missile guidance errors and fuze activation position errors,Monte Carlo simulations are used to calculate the damage probability of aircraft with different strike attitudes,from which the terminal strike attitude is *** BP-ANN model-based method uses the constructed Back Propagation Artificial Neural Network(BP-ANN)model instead of simulation to calculate the evaluation indexes in the corresponding cases of MVE-based method and Detonation position-based method,which can improve the efficiency of attitude *** are conducted for different scenarios to verify the feasibility and effectiveness of the proposed method.

关键词： Aircraft vulnerability Attitude selection BP-ANN Damage probability Damage effectiveness

Disparity estimation for multi-scale multi-sensor fusion

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Journal of Systems Engineering and Electronics 2024年第2期35卷 259-274页

作者： SUN Guoliang pei Shanshan LONG Qian ZHENG Sifa yang Rui Suzhou Automotive Research Institute Tsinghua UniversitySuzhou 215000China Beijing Smarter Eye Technology Co. Ltd.Beijing 100023China College of Artifical Intelligence Tianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Department of Precision Instrument Tsinghua UniversityBeijing 100084China

The perception module of advanced driver assistance systems plays a vital *** schemes often use a single sensor for data processing and environmental perception or adopt the information processing results of various sensors for the fusion of the detection *** paper proposes a multi-scale and multi-sensor data fusion strategy in the front end of perception and accomplishes a multi-sensor function disparity map generation scheme.A binocular stereo vision sensor composed of two cameras and a light deterction and ranging(LiDAR)sensor is used to jointly perceive the environment,and a multi-scale fusion scheme is employed to improve the accuracy of the disparity *** solution not only has the advantages of dense perception of binocular stereo vision sensors but also considers the perception accuracy of LiDAR *** demonstrate that the multi-scale multi-sensor scheme proposed in this paper significantly improves disparity map estimation.

关键词： stereo vision light deterction and ranging(LiDAR) multi-sensor fusion multi-scale fusion disparity map

Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

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International Journal of Extreme Manufacturing 2024年第1期6卷 296-311页

作者： Cijun Shuai Xiaoxin Shi Feng yang Haifeng Tian pei Feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083People’s Republic of China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013People’s Republic of China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017People’s Republic of China

Bacterial infection is a major issue after artificial bone transplantation due to the absence of antibacterial function of bone scaffold,which seriously causes the transplant failure and even amputation in severe *** this study,oxygen vacancy(OV)defects Fe-doped Ti O2(OV-FeTiO2)nanoparticles were synthesized by nano TiO2and Fe3O4via high-energy ball milling,which was then incorporated into polycaprolactone/polyglycolic acid(PCLGA)biodegradable polymer matrix to construct composite bone scaffold with good antibacterial activities by selective laser *** results indicated that OV defects were introduced into the core/shell-structured OV-FeTiO2nanoparticles through multiple welding and breaking during the high-energy ball milling,which facilitated the adsorption of hydrogen peroxide(H2O2)in the bacterial infection microenvironment at the bone transplant *** accumulated H2O2could amplify the Fenton reaction efficiency to induce more hydroxyl radicals(·OH),thereby resulting in more bacterial deaths through·OH-mediated oxidative *** antibacterial strategy had more effective broad-spectrum antibacterial properties against Gram-negative Escherichia coli(***)and Gram-positive Staphylococcus aureus(***).In addition,the PCLGA/OV-FeTiO2scaffold possessed mechanical properties that match those of human cancellous bone and good biocompatibility including cell attachment,proliferation and osteogenic differentiation.

关键词： bacterial infection bone scaffold selective laser sintering Fenton reaction antibacterial properties

Permanent lining castable with low bulk density and thermal conductivity:bauxite castable for tundish obtained by adding pearlescent sand

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Journal of Iron and Steel Research International 2024年第3期31卷 634-646页

作者： Yi Wang Jian yang Bao Wang Hai-jun Zhang Juan Han pei-yan pei Wen-long Lv Jian-an Zhou The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina Wuhan Research Institute of Metallurgical Construction MCCWuhan 430081HubeiChina

The low thermal conductivity and light mass of castables for tundish permanent linings are crucial for minimizing the heat loss of molten *** consideration of the low bulk density and thermal conductivity of pearlescent sand,the thermal insulation performance of castables was attempted to be improved by adding pearlescent *** sand was modified to prevent the strength of its porous structure from *** modification mechanism of pearlescent sand and the effect of pearlescent sand on the performance of bauxite castables were *** results suggested that the addition of the modified pearlescent sand significantly raised the apparent porosity and decreased the bulk density of bauxite *** 1000℃,the bulk density of more than 60%of the modified pearlescent sand-bauxite castable was only 2.03 g/cm^(3).The mechanical properties and thermal shock resistance of the modified pearlescent sand-bauxite castable were inferior to those of conventional bauxite castable but were adequate to meet the use conditions of casta-bles for tundish permanent *** high temperatures of 200-800℃,the thermal conductivity of more than 60%of the modified pearlescent sand-bauxite castable was smaller than that of conventional bauxite *** addition of the modified pearlescent sand can greatly reduce the thermal conductivity and bulk density of bauxite castable.

关键词： Pearlescent sand-Hydrophobic modification Bauxite castable Thermal insulation performance Mechanical property

Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration

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Chinese Chemical Letters 2024年第6期35卷 358-364页

作者： Xin Zhang Junyu Chen Xiang pei Linxin yang Liang Wang Luona Chen Guangmei yang Xibo pei Qianbing Wan Jian Wang State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesChengdu 610041China Department of Prosthodontics West China Hospital of StomatologySichuan UniversityChengdu 610041China

Surface modification of microporous bone scaffolds using nanoparticles has been broadly studied in bone tissue *** at improving vascularized bone regeneration(VBR),zeolitic imidazolate framework-8(ZIF-8)was encapsulated with dimethyloxallyl glycine(DMOG)and the drug-carrying nanoparticles(D@Z)could be uniformly coated onto the surface of the bone *** osteogenic and angiogenic actions of D@Z are closely correlated with the amount of slowly released DMOG,and in general,exhibited a favorable ***,the D7.5@Z group,which showed the greatest capacity to induce in vitro osteogenesis-angiogenesis coupling,was utilized for surface modification of the bone *** processes including phosphate-containing compound metabolic process,cell differentiation,cell proliferation and cell motility might contribute to enhanced ability to induce VBR by the coated scaffold and signaling pathways such as Rap1,Ras,phosphatidylinositol 3-kinase/protein kinase B(PI3K-AKT)and vascular endothelial growth factor(VEGF)signaling pathways participated in these ***,as depicted by in vitro real time-polymerase chain reaction(RT-PCR),Western blot(WB)and in vivo cranial bone defect model,the microporous scaffold coated with nano-D7.5@Z greatly promoted *** conclude,nano-D@Z has significant promise for practical application in modification of microporous bone scaffolds to enhance VBR,and DMOG loading quantity has a beneficial influence on D@Z to improve osteogenesis-angiogenesis coupling.

关键词： Drug-loading nanoparticles Surface coating Microporous bone scaffold Vascularization bone regeneration

Design of efficient thermoelectric generators

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Science China Materials 2024年第1期67卷 377-378页

作者： Min Liu Yanzhong pei Interdisciplinary Materials Research Center School of Materials Science and EngineeringTongji UniversityShanghai 201804China

Thermoelectricity,which enables direct conversion between heat and electricity,undergoes impressive developments in recent decades,and is particularly promising for recovering low-grade heat of<600 K[1,2].Currently,only Bi2Te3-based thermoelectric devices are commercialized[3].However,the scarcity of tellurium(Te)(Fig.1a)is the main *** leads to numerous recent efforts on the development of efficient nonBi2Te3 thermoelectrics as potential alternatives,and successful examples(Fig.1b)include Mg3Sb2-alloys[2,3]and MgAgSb[1,2].

关键词： enable efficient electricity

Role of temperature in tribolayers in fretting wear ofγ-TiAl alloy

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Friction 2024年第5期12卷 939-953页

作者： Yulei yang Hongfei SHANG Huiping pei Jimin XU Yi LIANG Minghui PAN School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing100084China Institute of Tribology Hefei University of TechnologyHefei230009China

The formation of tribolayers may play significant influences on fretting *** elevated temperature,the adhesion among wear debris and the increased diffusion rate facilitate the formation of ***,the intensification of oxidation at elevated temperature and the low diffusion rate in oxides may play an adverse *** present study aims to investigate the role of temperature in tribolayers in fretting wear using aγ-TiAl *** electron microscope,energy dispersive spectrometer,Raman spectrometer,transmission electron microscope and nanoindentation were utilized to investigate the wear debris,tribolayers,and wear *** fretting tests showed that,compared with that at room temperature(RT)and 350℃,significant reduction in wear rate and decrease in the fluctuation of friction coefficient occurred at 550 and 750℃.It was further revealed that when temperature raised from room temperature(RT)to 750℃,the oxidation of the wear debris increased slightly and the diffusion coefficients increased prominently,which facilities the formation of well tribo-sintered *** well tribo-sintered tribolayers presented homogenous structure,nanocrystalline grains with excellent mechanical properties,and resulted in the improvement in the fretting wear resistance of theγ-TiAl alloy at 550 and 750℃.

关键词： tribolayer temperature fretting wear γ-TiAl alloy

Molecular Dynamics Simulation Studies on the Micromorphology and Proton Transport of Nafion/Ti_(3)C_(2)T_(x) Composite Membrane

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Chinese Journal of Polymer Science 2024年第3期42卷 373-387,I0009页

作者： Zhi-Yue Han Su-Peng pei Chun-yang Yu Yong-Feng Zhou School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai 201418China School of Chemistry&Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Key Laboratory of Electrical Insulation and Thermal AgingShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Green and High-end Utilization of Salt Lake Resources Chinese Academy of SciencesXining 810008China

The perfluorosulfonic acid(PFSA) membrane doped with two-dimensional conductive filler Ti_(3)C_(2)T_(x) is a fuel cell proton exchange membrane with high application potential. Experimental studies showed that the proton conductivity of Nafion/Ti_(3)C_(2)T_(x) composite membrane is improved significantly compared with that in pure Nafion. However, the microscopic mechanism of doping on the enhancement of membrane performance is remain unclear now. In this work, molecular dynamics simulation was used to investigate the microscopic morphology and proton transport behaviors of Nafion/Ti_(3)C_(2)T_(x) composite membrane at the molecular level. The results shown that there were significant differences about the diffusion kinetics of water molecules and hydroxium ions in Nafion/Ti_(3)C_(2)T_(x) at low and high hydration levels in the nanoscale *** the increase of water content, Ti_(3)C_(2)T_(x) in membrane was gradually surrounded by ambient water molecules to form a hydration layer, and forming a relatively continuous proton transport channel between Nafion polymer and Ti_(3)C_(2)T_(x) monomer. The continuous proton transport channel could increase the number of binding sites of proton and thus achieving high proton conductivity and high mobility of water molecules at higher hydration level. The current work can provide a theoretical guidance for designing new type of Nafion composite membranes.

关键词： Nafion/Ti_(3)C_(2)T_(x)composite membrane Proton transport Molecular dynamics simulation