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GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines

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World Journal of Stem Cells 2024年第5期16卷 538-550页

作者： Yang-Zhou Jiang Lan-Yue Hu Mao-Shan Chen Xiao-Jie Wang Cheng-ning Tan pei-pei Xue Teng Yu Xiao-Yan He Li-Xin Xiang Yan-Ni Xiao Xiao-Liang Li Qian Ran Zhong-Jun Li Li Chen Laboratory of Radiation Biology Department of Blood TransfusionLaboratory Medicine CenterThe Second Affiliated HospitalThird Military Medical UniversityChongqing 400037China Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center Ministry of Education of the People’s Republic of ChinaChongqing 400037China

BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ***,the positive regulators of ANKRD26 are still *** To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 *** Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family *** to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activi

关键词： Ankyrin repeat domain containing 26 GATA binding protein 2 Thrombocytopenia 2 Transcriptional regulation Myeloid-derived cell lines

Disease and Economic Burden of Kashin-Beck Disease—China,2021

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China CDC weekly 2024年第2期6卷 40-44页

作者： Silu Cui Wenjun Que Zhe Jiao Qing Deng Xufeng Zhang Yanhong Cao ning Liu Ailin Li Alphonse Sowanou Zhe Li Tuo Wang Yang Li Jun Yu Junrui pei NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Key Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Kashin-Beck Disease ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Heilongjiang Provincial Key Laboratory of Trace Elements and Human HealthKey Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Endemic Fluorosis ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Kashin-Beck disease(KBD)is a chronic and degenerative osteoarthropathy characterized by cartilage *** is an endemic disease that is highly prevalent among the Chinese population and poses a significant health *** is added by this report?This is the first national report on the economic burden of KBD in *** to the data from 2021,KBD has caused significant disease and economic *** most substantial reduction in healthy life expectancy was observed among patients with degree II severity and those aged 60 years and older,resulting in a total indirect economic burden of 112.74 million Chinese Yuan(CNY).What are the implications for public health practice?The results of this study will contribute to informing the development of tailored prevention and control strategies by the *** strategies will include targeted policies and recommendations for appropriate healthcare and financial subsidies,which will be based on the demographic characteristics of the endemic areas.

关键词： prevention degeneration burden

高钛渣制备TiN/β′-Sialon复相导电陶瓷及其性能

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中国有色金属学报 2011年第11期21卷 2863-2868页

作者：姜涛薛向欣李江段培宁东北大学材料与冶金学院沈阳110819

以高钛渣合成出的TiN/β′-Sialon粉体作为原料,常压烧结制备了TiN/β′-Sialon复相导电陶瓷。利用X射线衍射仪和扫描电镜对材料相组成和显微结构进行了表征分析,研究了材料的致密化行为、力学性能及常温导电性能。结果表明:烧结产物主... 详细信息

以高钛渣合成出的TiN/β′-Sialon粉体作为原料,常压烧结制备了TiN/β′-Sialon复相导电陶瓷。利用X射线衍射仪和扫描电镜对材料相组成和显微结构进行了表征分析,研究了材料的致密化行为、力学性能及常温导电性能。结果表明:烧结产物主晶相为β′-Sialon和TiN。其中β′-Sialon多呈板条状,TiN为细小粒状,粒度多小于0.5μm。烧结温度为1 530℃、初始原料中TiO2加入量为35%(质量分数)时,材料的体积密度为3.01 g/cm3,硬度为9.62 GPa,抗弯强度为120.07 MPa。30%TiO2加入量是决定材料能否形成TiN导电网络的最低TiO2加入量,此时材料的电阻率为1.3×10-2·cm。

关键词：高钛渣 TiN/β′-Sialon 复相导电陶瓷性能

TiO_2/O-′Sialon界面反应过程

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中国有色金属学报 2005年第8期15卷 1236-1242页

作者：刘欣薛向欣杨建段培宁东北大学材料与冶金学院沈阳110004

以反应烧结的O-′Sialon和金红石型TiO2为研究对象,设计制备了TiO2/O-′Sialon扩散偶,采用X射线衍射(XRD)、扫描电镜(SEM)及电子探针微区分析(EPMA)等方法,对扩散偶的扩散界面及垂直于界面的断面进行了物相分析、形貌观察及元素面分布分... 详细信息

以反应烧结的O-′Sialon和金红石型TiO2为研究对象,设计制备了TiO2/O-′Sialon扩散偶,采用X射线衍射(XRD)、扫描电镜(SEM)及电子探针微区分析(EPMA)等方法,对扩散偶的扩散界面及垂直于界面的断面进行了物相分析、形貌观察及元素面分布分析,并在此基础上探讨了TiO2/O-′Sialon界面反应过程。XRD结果表明:TiO2与O-′Sialon在界面处发生反应生成TiN和SiO2,但在1200℃时扩散反应程度微弱,界面处存在Sm2O3偏析,并且与SiO2生成Sm2Si2O7;SEM照片显示TiO2/O-′Sialon界面处存在不规则硅酸盐熔融层;EP-MA元素面分布分析表明Ti、Si等元素富集于硅酸盐熔融层内,只有微量元素扩散至基体内。综合分析结果得出,TiO2/O-′Sialon界面反应过程可分为三个阶段:物理接触阶段、熔融层形成及元素富集阶段、熔融层增长阶段。

关键词： TiO2/O′-Sialon 扩散偶界面反应电子探针

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科学教学中的建模活动：若干概念与研究主题

全球教育展望 2009年第2期38卷 82-86页

作者：何美裴新宁华东师范大学课程与教学研究所

模型是科学研究共同体对物理系统和自然现象进行表征、探究和解释的主要手段,也是科学家对研究对象进行预测、控制和施加秩序的基本途径,是自然科学和人类认知研究的重要内容。科学学习与教学研究以科学哲学与认知科学对模型以及思维模... 详细信息

模型是科学研究共同体对物理系统和自然现象进行表征、探究和解释的主要手段,也是科学家对研究对象进行预测、控制和施加秩序的基本途径,是自然科学和人类认知研究的重要内容。科学学习与教学研究以科学哲学与认知科学对模型以及思维模型与概念转变之间的关联所作的探究为基础,将基于模型的推理和建模活动引入科学教学过程及学习环境的构建。本文梳理了科学教育研究在该领域中的核心概念及四大研究主题。

关键词：模型建模活动基于模型的推理科学教学

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水热处理对神华煤液化性能的影响

燃料化学学报 2007年第6期35卷 655-659页

作者：水恒福裴占宁王知彩安徽工业大学化学与化工学院安徽省高校重点实验室安徽马鞍山243002

基于水热处理煤的镜质组反射率测定和热重分析,研究了水热处理对神华煤结构及液化性能的影响,并通过TG/DTA和IR对比考察了原煤和水处理煤液化产物前沥青烯结构变化。结果表明,水热处理提高了煤的镜质组反射率,水处理温度越高处理煤的镜... 详细信息

基于水热处理煤的镜质组反射率测定和热重分析,研究了水热处理对神华煤结构及液化性能的影响,并通过TG/DTA和IR对比考察了原煤和水处理煤液化产物前沥青烯结构变化。结果表明,水热处理提高了煤的镜质组反射率,水处理温度越高处理煤的镜质组反射率越大;250℃水热处理煤的最大反射率为0.774,其失重率显著高于其他水处理煤。水热处理对煤液化性能的影响与处理煤的镜质组反射率及热重性能变化一致。一定温度下水处理能够促进煤分子中脂肪侧链的裂解和环化,提高了处理煤镜质组反射率和煤基体的供氢能力,改善煤的液化性能。此外,水热处理也明显提高了液化产物前沥青烯的热稳定性。

关键词：水热处理煤液化反射率热重分析

两层无线传感器网络中安全Skyline查询协议

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计算机工程与设计 2015年第12期36卷 3183-3187,3193页

作者：宋玲武佩宁广西大学计算机与电子信息学院广西南宁530004

针对目前在两层无线传感器网络中极少有关于Skyline安全协议的情况,提出一种基于Z-O编码的阈值预筛选技术、能保证查询的安全性Skyline协议SSLine。通过阈值预筛选技术提高查询效率,采用Z-O编码技术,保证存储节点安全,完成查询操作。理... 详细信息

针对目前在两层无线传感器网络中极少有关于Skyline安全协议的情况,提出一种基于Z-O编码的阈值预筛选技术、能保证查询的安全性Skyline协议SSLine。通过阈值预筛选技术提高查询效率,采用Z-O编码技术,保证存储节点安全,完成查询操作。理论分析结果表明,两层无线传感器网络中的SSLine在保证数据安全方面表现优越;仿真结果表明,相比没有安全策略的Skyline查询协议,SSLine能耗的增加在可接受范围内。

关键词：两层无线传感器网络 Skyline查询阈值能耗数据安全

N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1/RAGE/NF-κB pathway in rats

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 228-238页

作者： Yu-Ze Zhao Xue-ning Zhang Yi Yin pei-Lun Xiao Meng Gao Lu-Ming Zhang Shuan-Hu Zhou Shu-Na Yu Xiao-Li Wang Yan-Song Zhao Department of Ophthalmology Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina School of Medical Imaging Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Anatomy Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Departments of Orthopedic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

AIM:To observe the effects of N-acetylserotonin(NAS)administration on retinal ischemia-reperfusion(RIR)injury in rats and explore the underlying mechanisms involving the high mobility group box 1(HMGB1)/receptor for advanced glycation end-products(RAGE)/nuclear factor-kappa B(NF-κB)signaling ***:A rat model of RIR was developed by increasing the pressure of the anterior chamber of the *** male Sprague Dawley were randomly divided into five groups:sham group(n=8),RIR group(n=28),RIR+NAS group(n=28),RIR+FPS-ZM1 group(n=8)and RIR+NAS+FPS-ZM1 group(n=8).The therapeutic effects of NAS were examined by hematoxylin-eosin(H&E)staining,and retinal ganglion cells(RGCs)*** expression of interleukin 1 beta(IL-1β),HMGB1,RAGE,and nod-like receptor 3(NLRP3)proteins and the phosphorylation of nuclear factorkappa B(p-NF-κB)were analyzed by immunohistochemistry staining and Western blot *** expression of HMGB1 protein was also detected by enzyme-linked immunosorbent assay(ELISA).RESULTS:H&E staining results showed that NAS significantly reduced retinal edema and increased the number of RGCs in RIR *** NAS therapy,the HMGB1 and RAGE expression decreased significantly,and the activation of the NF-κB/NLRP3 pathway was antagonized along with the inhibition of p-NF-κB and NLRP3 protein ***,NAS exhibited an anti-inflammatory effect by reducing IL-1β*** inhibitory of RAGE binding to HMGB1 by RAGE inhibitor FPS-ZM1 led to a significant decrease of p-NF-κB and NLRP3 expression,so as to the IL-1βexpression and retinal edema,accompanied by an increase of RGCs in RIR ***:NAS may exhibit a neuroprotective effect against RIR via the HMGB1/RAGE/NF-κB signaling pathway,which may be a useful therapeutic target for retinal disease.

关键词： retinal diseases retinal ischemia—reperfusion injury N-acetylserotonin high mobility group box 1 receptor for advanced glycation end-products nuclear factor-κB rats

基于单值中智集和云聚类的产品造型设计决策方法

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浙江大学学报（工学版） 2022年第12期56卷 2367-2378页

作者：裴卉宁谭昭芸刘鑫宇田保珍河北工业大学建筑与艺术设计学院天津300401 太原科技大学机械工程学院山西太原030027

为了获得客观、合理的权重分配,综合考虑有限理性心理行为特征和策略操控行为,把决策专家进行科学聚类,提出基于单值中智集(SVNS)和云模型聚类的产品造型设计多属性决策方法.决策专家构造标准属性和备选方案的成对比较比率平方矩阵获得S... 详细信息

为了获得客观、合理的权重分配,综合考虑有限理性心理行为特征和策略操控行为,把决策专家进行科学聚类,提出基于单值中智集(SVNS)和云模型聚类的产品造型设计多属性决策方法.决策专家构造标准属性和备选方案的成对比较比率平方矩阵获得SVNS,映射真、假、不确定3个隶属度值到单值中智立方体(SVNC)中,筛选各标准属性下备选方案的评估结果,获得标准属性的相对权重.利用融合多粒度语言的云模型聚类方法集群决策专家,淘汰存在冲突和非理性的决策专家,获得有效的设计决策专家权重.由标准属性权重和决策专家权重,综合计算各备选方案的总体优先级得分并进行排序.以汽车造型设计方案为例,验证所提方法的可行性和有效性.结果表明,所提方法避免了恶意策略操作,有效地解决了复杂和不确定情况下的汽车造型设计多属性决策问题.

关键词：产品造型设计单值中智集(SVNS) 云模型聚类多属性决策多粒度语言