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New anthraquinone derivatives from the roots of Berchemia floribunda

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Chinese Chemical Letters 2007年第4期18卷 412-414页

作者： Xin Wei Jian Shuang Jiang Zi Ming Feng pei cheng zhang Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine （Ministry of Education） Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beifing 100050 China

A new naphthoquinone-anthraquinone dimer named floribundiquinone E （1） and a new anthraquinone 2-acetylphyscion （2） were isolated from the roots of Berchemia floribunda Brongn. Their structures were elucidated on ... 详细信息

关键词： Berchemia floribunda Anthraquinone Floribundiquinone E 2-Acetylphyscion

Two New Compounds from Goniothalamus Cheliensis Hu

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Chinese Chemical Letters 2001年第9期12卷 787-790页

作者： Si WANG pei cheng zhang Ruo Yun CHEN De Quan YU Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050

Two new compounds, gonioquinone (1) and goniofufurone acetonide (2), have been isolated from the roots of Goniothalamus cheliensis Hu. Their structures were determined on the basis of spectral and chemical evidence.

关键词： Goniothalamus cheliensis Hu gonioquinone goniofufurone acetonide

Five Novel Pterocarpan Derivatives from Sophora flavescens

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Chinese Journal of Chemistry 2021年第10期39卷 2763-2768页

作者： Kai-Zhou Lu Zi-Ming Feng Xiang Yuan Ya-Nan Yang Jian-Shuang Jiang Xu zhang pei-cheng zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050 China

Main observation and conclusion Five novel pterocarpan derivatives(1—5)and three known pterocarpans were isolated from the roots of Sophora flavescens *** structures were elucidated based on extensive spectroscopic data(UV,IR,1D and 2D NMR,and HR-ESI-MS).Notably,compounds 1—5 were the first reported natural products,which possess unique pterocarpan-glucose-long chain aliphatic acid *** kinds of aliphatic acids were determined by comparison with authentic aliphatic acids using HPLC-ELSD analysis after acid *** absolute configurations of 1—5 were confirmed by analysis of their ECD *** compounds were evaluated against lipopolysaccharide(LPS)-induced TNF-αproduction in RAW264.7 cells,and compound 1 showed significant inhibitory activity with inhibition rate of 86.22%,IC_(50)=0.79μmol/L(dexamethasone as positive control,inhibition rate of 71.38%).

关键词： Sophora flavescens Pterocarpan derivatives Natural products Structure elucidation Biological activity

Sesquiterpenoid and C14-polyacetylene glycosides from the rhizomes of Atractylodes lancea

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Chinese Chemical Letters 2017年第3期28卷 597-601页

作者： Kuo Xu Zi-Ming Feng Jian-Shuang Jiang Ya-Nan Yang pei-cheng zhang State Key Laboratory of Bioactive Substance and Function of Natural Medidnes Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sdences BeUing 100050 China

Four new glycosides including a eudesmane-type sesquiterpenoid（1）, a guaiane-type sesquiterpenoid（2）, and two C_（14）-polyacetylenes（3, 4） were isolated from the rhizomes of Atractylodes lancea. Their structures were elucidated by means of spectroscopic and spectrometric analyses（UV, IR, 1D and 2D NMR, and HR-ESIMS）. The absolute configurations of their aglycones were established based on the experimental and calculated electronic circular dichroism（ECD）, whereas those of monosaccharide moieties were determined by the GC method after chiral derivatization. Compound 4 showed weak anti-inflammatory effects on the LPS-induced NO production in microglia BV2 cells at a concentration of10μmmolL^（-1）.

关键词： Atractylodes lancea Eudesmane-type sesquiterpenoid Guaiane-type sesquiterpenoid C_(14)-Polyacetylene Anti-inflammatory effect

A New Isoprenylated flavonol from the Leaves of Broussonetia kazinoki

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Chinese Chemical Letters 2001年第2期12卷 141-142页

作者： pei cheng zhang Si WANG Ying Hong WANG Ruo Yun CHEN De Quan YU Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050

A new isoprenylated flavonol, named broussonol A (1) was isolated from the leaves of Broussonetia kazinoki Sieb. The structure of broussonol A was characterized by chemical and spectral methods.

关键词： Broussonetia kazinoki moraceae isoprenyl flavonol broussonol A

Effective assignment of positional isomers in dimeric shikonin and its analogs by ^(1)H NMR spectroscopy

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Chinese Chemical Letters 2024年第5期35卷 223-226页

作者： Ling-Hao Zhao Hai-Wei Yan Jian-Shuang Jiang Xu zhang Xiang Yuan Ya-Nan Yang pei-cheng zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and ***,the ^(1)H(proton)nuclear magnetic resonance(NMR)pattern of phenolic hydroxyl protons was developed as a“diagnosis signal”to ascertain the relative location of each side chain in DMSO-d_(6) at sample concentrations of 0.022-0.034 mol/*** chemical shift differences of 0.6ppm between OH-5' and OH-1 and between OH-8'and OH-4 are assigned to Type A and Type B,*** reported ambiguous structures were corrected by this ***,the steric structures of isolated compounds were elucidated by quantum chemical calculations of electronic circular dichroism(ECD)spectra.

关键词： Arnebia euchroma Dimeric hydroxyl naphthoquinones Positional isomers ^(1)H NMR spectroscopy Chemical shift difference

Indole Alkaloids from the Roots of Ervatamia hainanensis

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Chinese Chemical Letters 2006年第6期17卷 779-782页

作者： Jian Peng HUANG Zi Ming FENG Chong Fei ZHENG pei cheng zhang Yang Min MA Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 College of Life Science Northwest A-F University Yangling Shaanxi 712100

Two new indole alkaloids, named ibogamine-18-carboxylic acid, 3, 4-didehydro-7, 8-dioxo-methyl ester 1, ibogamine-18-carboxylic acid, 16, 17-didehydro-9, 17-dihydro-9-hydroxy （2-oxopropyl）-methyl ester 2, were isola... 详细信息

关键词： Ervatamia hainanensis indole alkaloid ibogamine-18-carboxylic acid 3 4-didehydro-7 8-dioxo-methyl ester ibogamine- 18-carboxylic acid 16 17-didehydro-9 17-dihydro-9-hydroxy-(2-oxopropyl)-methyl ester.

Conformational Study of 8-C-glucosyl-prunetin by Dynamic NMR Spectroscopy

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Chinese Chemical Letters 2002年第7期13卷 645-648页

作者： pei cheng zhang Ying Hong WANG Xin LIU Xiang YI Ruo Yun CHEN De Quan YU Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

By means of variable temperature NMR spectra, conformation of 8-C-glucosyl prunetin, isolated from the leaves of Dalbergia hainanensis (Leguminosae), was studied. The restricted rotation around the C (sp3)-C (sp2) bond in the C-glucosides isoflavonoid results in two main conformers (syn and anti). With the help of MM calculation, the preferred conformation A has H-1 gauche to the 7-OCH3. The barrier to rotation was 18.1 kcal/mol. This result agrees with the calculated value 16.2 kcal/mol of free energy of activation for the interconversion between the conformers.

关键词： C-Glucosyl prunetin dynamic NMR MM calculation conformation.

Arnequinol A and arnequinone A, two unique meroterpenoids from Arnebia euchroma

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Chinese Chemical Letters 2022年第5期33卷 2555-2558页

作者： Hai-Wei Yan Rong-Rong Du Xu zhang Ya-Nan Yang Xiang Yuan Zi-Ming Feng Jian-Shuang Jiang pei-cheng zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Arnequinol A(1),featuring an unprecedented 6/6/3 tricyclic carbon skeleton fused with a heptatomic oxo-bridge,together with arnequinone A(2)bearing a highly conjugated methyl-shifting benzogeijerene skeleton,were isolated from Arnebia *** structures were elucidated by extensive spectro-scopic methods and quantum chemical calculations of the 13 C nuclear magnetic resonance(NMR)data and electronic circular dichroism(ECD)*** plausible biosynthetic pathways for 1 and 2 were *** in vitro test,compound 2 showed potent neuroprotective activity against serum-deprivation induced PC12 cell damage at a concentration of 10μmol/L.

关键词： Arnebia euchroma Meroterpenoids Arnequinol A and arnequinone A Cytotoxicity Neuroprotective activity