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Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-Li Zhang Xi Zhang Wang Hua Zheng-De Xie Han-Min Liu Hai-lin Zhang Bi-quan Chen Yuan Chen Xin Sun Yi Xu Sai-Nan Shu Shun-Ying Zhao Yun-Xiao Shang ling Cao Yan-Hui Jia Luo-Na lin Jiong Li Chuang-Li Hao Xiao-Yan Dong Dao-Jiong lin Hong-Mei Xu De-Yu Zhao Mei Zeng Zhi-Min Chen Li-Su Huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

Rastall gravity:accretion disk image in the context of radiation fields and visual transformations compared to Reissner-Nordström black hole

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Chinese Physics C 2024年第4期48卷 174-182页

作者：黄宇翔郭森梁宇崔宇昊蒋青权林恺 School of Physics and Astronomy China West Normal UniversityNanchong 637000China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Hubei Subsurface Multi-scale Imaging Key Laboratory Institute of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China

In this study,we investigated the astronomical implications of Rastall gravity,particularly its behavior amidst a radiation field compared to Reissner-Nordström(RN)black *** found a crucial correlation between the dynamics of the accretion disk and the parameters Q and Nr,which properly reflect the influence of spacetime metrics on the disk’s *** electric charge Q causes contraction in the disk’s orbit due to enhanced gravitational effects,while higher Nr values lead to outward expansion,influenced by the attributes of the radiation ***,the charged black holes surrounded by radiation fields exhibit distinct visual disparities from RN black *** decreases and expansion occurs within the innermost stable circular orbit of the accretion disk with rising Nr *** study also reveals the process by which the accretion disk transitions from a conventional disk-like structure to a hat-like form at different observation angles,with the redshift effect gradually ***,the results of the considered Rastall gravity radiation field are consistent with the constraints of the gravitational lensing of the host galaxy on Rastall gravity parameters,thereby enhancing the consistency between theoretical predictions and actual observations.

关键词： Rastall theory optical appearance thin accretion disk

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重载交通下分车道管理老路路面改造方案研究

公路 2024年第7期69卷 338-342页

作者：李林程全深圳市交通公用设施建设中心深圳市518040 中交第二公路勘察设计研究院有限公司武汉市430056

以G30连霍高速公路哈密至吐峪沟段改扩建工程为例,通过不同分车道管理后的服务水平和车道数需求进行比较,拟定分车道管理的运营方案,进而明确不同车道的车型分配和轴载作用次数,达到充分利用既有老路的剩余使用寿命目的,避免路面的过度... 详细信息

以G30连霍高速公路哈密至吐峪沟段改扩建工程为例,通过不同分车道管理后的服务水平和车道数需求进行比较,拟定分车道管理的运营方案,进而明确不同车道的车型分配和轴载作用次数,达到充分利用既有老路的剩余使用寿命目的,避免路面的过度利用或改造不彻底情况。

关键词：老路路面改造货车比例大服务水平车道数

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Effect of the traditional Chinese medicine fumigation combined with the meibomian gland squeezer for treatment of dry eye associated with meibomian gland dysfunction

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Integrative Medicine Discovery 2024年第15期8卷 1-5页

作者： Da-Hu Wang lin Mu Xiao-Yu Wu Yin-Jian Zhang Xin-quan Liu Department of Ophthalmology Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200031China

Background:To observe the effect of traditional Chinese medicine fumigation combined with the meibomian gland squeezer for the treatment of dry eye associated with meibomian gland dysfunction(MGD).Methods:This is a randomized,controlled,non-masked,single-center ***-four cases(74 eyes)of dry eye associated with MGD were randomly divided into two ***-seven patients were chosen as the treatment group was treated by the traditional Chinese medicine fumigation 3 times a week combined with the meibomian gland squeezer once a week for one *** other 37 cases were sorted as the control group and only treated with the meibomian gland squeezer once a week for one *** groups received the primary treatment for 1 month,including Tobradex eye ointment once a day and 0.1%sodium hyaluronate eye drops 4-6 times *** were evaluated at baseline and 2-week and 1-month visits for the ocular symptom scores,international ocular surface disease index(OSDI),fluorescein tear break-up time(TBUT),corneal fluorescein staining test(CFS),Schirmer I test,meibum quality and meibum ***:Sixty-seven patients were followed in the study,and the mean age was 57(±12.6)***-three patients(11 males)in the treatment group and 34 patients(8 males)in the control group were followed in the study,and the mean age of the two groups was 45.36±15.02 years and 43.68±13.43 years,*** treatment,there was no significant difference between the two groups in gender,age,ocular symptom scores,OSDI,TBUT,CFS,Schirmer I test,meibum quality,and meibum expressibility(P>0.05).Compared with baseline,the 2 groups had different degrees of improvement in the ocular symptom scores,OSDI,TBUT,CFS,meibum quality,and meibum expressibility at the 2-week and 1-month visits(P<0.05),and the treatment group showed a more significant improvement in the ocular symptom scores,OSDI,TBUT,CFS,meibum quality and meibum expressibility compared with the control group(P

关键词： meibomian gland squeezer traditional Chinese medicine dry eye disease meibomian gland dysfunction

基于优化RDD分区的Spark并行K-means大尺度遥感图像分割

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控制与决策 2024年第5期39卷 1612-1619页

作者：李玉崔书琳赵泉华辽宁工程技术大学测绘与地理科学学院辽宁阜新123000

大尺度遥感图像分割对单机处理方式而言是巨大挑战. Spark平台为在单机上构建用于大数据处理的分布式计算环境提供了可能.当Spark平台内置的K-means算法用于数字图像处理时,其中的Spark Shuffle弹性分布式数据集(RDD)分区一般采用缺省设... 详细信息

大尺度遥感图像分割对单机处理方式而言是巨大挑战. Spark平台为在单机上构建用于大数据处理的分布式计算环境提供了可能.当Spark平台内置的K-means算法用于数字图像处理时,其中的Spark Shuffle弹性分布式数据集(RDD)分区一般采用缺省设置,尽管这种RDD设置简单便捷,但对大尺度图像分割任务容易造成“多分区、小数据”现象,极大影响图像分割速度.为此,采用覆盖部分上海市区的WorldView-3遥感图像为测试数据,在K-means算法初始化聚类中心阶段自定义影响RDD分区的参数***,在迭代计算阶段调用coalesce()算子减少分区数;与串行K-means算法对比验证单机处理大数据的可行性与有效性,与优化前的Spark并行K-means算法对比实现了大尺度遥感图像快速分割.实验结果表明,在K-means算法初始化聚类中心和迭代计算阶段,将RDD分区数设置在CPU核数的1~10倍,总用时由优化前的145 s缩减到97 s,尤其在初始化聚类中心阶段的时间效率上,优化后是优化前的500~1 000倍.

关键词： Spark平台单机大数据处理大尺度遥感图像 RDD优化图像分割并行K-means算法

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

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Frontiers of Medicine 2024年第2期18卷 375-393页

作者： Fu’an Xie Yujia Niu Lanlan Lian Yue Wang Aobo Zhuang Guangting Yan Yantao Ren Xiaobing Chen Mengmeng Xiao Xi Li Zhe Xi Gen Zhang Dongmei Qin Kunrong Yang Zhigang Zheng quan Zhang Xiaogang Xia Peng Li lingwei Gu Ting Wu Chenghua Luo Shu-Hai lin Wengang Li Cancer Research Center Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China Xiamen University Research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association Xiamen UniversityXiamen361102China Department of Laboratory Medicine Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing102206China School of Public Health Harvard UniversityBostonMA02115USA Laboratory of Biochemistry and Molecular Biology Research Department of Clinical LaboratoryFujian Medical University Cancer HospitalFuzhou350014China Surgery Department Affiliated Fuzhou First Hospital of Fujian Medical UniversityFuzhou350009China National Institute for Data Science in Health and Medicine Xiamen UniversityXiamen361102China Department of Hepatobiliary Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China

Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for *** proteomic and metabolic profiles of RLPS have remained *** aim of our study was to reveal the metabolic profile of ***,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during *** analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were *** particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor *** study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.

关键词： RLPS proteomics metabolomics lipidomics metabolism

一种新型稳定可结合三维本构的近场动力学方法

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厦门大学学报（自然科学版） 2024年第2期63卷 305-314页

作者：林哲汪磊古泉厦门大学建筑与土木工程学院福建厦门361005 温州大学建筑工程学院浙江温州325035

[目的]针对目前两种近场动力学(PD)理论,键型PD(BPD)无法应用三维材料本构模型,而态型PD在均匀化过程中出现零能模式常导致强非线性问题不稳定的挑战,研究一种新型混合PD(HPD),以增强PD理论在求解复杂强非线性问题时的稳定性和实用性.[... 详细信息

[目的]针对目前两种近场动力学(PD)理论,键型PD(BPD)无法应用三维材料本构模型,而态型PD在均匀化过程中出现零能模式常导致强非线性问题不稳定的挑战,研究一种新型混合PD(HPD),以增强PD理论在求解复杂强非线性问题时的稳定性和实用性.[方法] HPD方法结合BPD和SPD的优点参照BPD,将PD点与影响域内其他PD物质点相连形成键,键上的力通过键中点截面上的应力及其法向向量的乘积计算得到,应力可由三维本构关系计算,而应变则使用与SPD类似的方法拟合得到.在HPD中,键力方向与键的方向并不一致.最后通过两个数值算例验证了HPD方法的正确性和稳定性.[结果]在第一个算例中,可以观察到两种影响域半径的HPD和有限元方法(FEM)的结果高度相似.力加载行(M-M)中的最大相对误差仅为4.58%,模型顶行(N-N)中的最大相对误差仅为0.51%.相比之下,由于零能模式的存在,SPD的最大相对误差为382.68%和5.61%.在第二个算例中,选择A点作为代表点,比较了3种方法计算的位移时程.在靠近底座的A点,SPD在位移计算的初始阶段表现出较高的精度.然而,当模型进入强非线性时,误差便会显著增加,达到约65.65%.相比之下,HPD有效地解决了这个问题,在最大位移点实现了仅0.2%的相对误差.[结论] HPD可以消除零能量模式的影响,而且在各种影响域半径下都能产生更准确的结果;即使在强非线性情况下HPD也能解决零能模式问题,同时可确保应力和应变的精确预测,可有效解决强非线性和大变形问题.此外,HPD可以与各种材料模型相结合,是一种实用且有效的计算方法,可用于解决各种复杂问题.

关键词：近场动力学零能模式三维材料本构强非线性

NFIX基因变异导致一对同卵双胞胎Marshall-Smith综合征并文献复习

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中国当代儿科杂志 2024年第7期26卷 750-756页

作者：林雪芹全昱霖贺海兰彭镜中南大学湘雅医院儿科湖南长沙410008 湖南省儿童脑发育障碍性疾病临床医学研究中心湖南长沙410008

该文报道了一对NFIX基因变异导致Marshall-Smith综合征(Marshall-Smith syndrome,MRSHSS)的同卵双胞胎临床及遗传学特点并对相关文献进行复习。2例患儿均表现为全面发育落后、高额头、浅眼眶、漏斗胸。基因检测提示2例患儿均存在NFIX杂... 详细信息

该文报道了一对NFIX基因变异导致Marshall-Smith综合征(Marshall-Smith syndrome,MRSHSS)的同卵双胞胎临床及遗传学特点并对相关文献进行复习。2例患儿均表现为全面发育落后、高额头、浅眼眶、漏斗胸。基因检测提示2例患儿均存在NFIX杂合剪接位点变异c.697+1G>A,父母该位点为野生型,根据美国医学遗传学与基因组学学会指南判定为可能致病性变异,该位点突变既往未见文献报道。复习文献共发现32例MRSHSS患者,突变类型为剪切/移码突变。骨骼成熟加速、中至重度全面发育迟缓/智力障碍是MRSHSS患者最主要的临床表现。基因检测结果是该病重要的诊断依据。

关键词： NFIX基因 Marshall-Smith综合征全面发育迟缓/智力障碍骨骼成熟异常儿童

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浦东新区洪涝预报预警系统构建与应用

中国给水排水 2024年第1期40卷 131-136页

作者：杨森周全黄琳煜宜水环境科技<上海>有限公司上海200235 上海市浦东新区水文水资源管理署上海200129

浦东新区受其地理位置和气候条件的影响,容易遭受风暴潮洪的侵袭。为防范洪涝风险,在前期大量信息化建设的基础上,提出了浦东新区洪涝预报预警系统的构建方法,涵盖系统框架设计、数据集成、平原感潮河网水力模型和强排区雨水管网一二维... 详细信息

浦东新区受其地理位置和气候条件的影响,容易遭受风暴潮洪的侵袭。为防范洪涝风险,在前期大量信息化建设的基础上,提出了浦东新区洪涝预报预警系统的构建方法,涵盖系统框架设计、数据集成、平原感潮河网水力模型和强排区雨水管网一二维耦合模型构建、保障系统稳定运行设置以及系统应用模式设计。该洪涝预报预警系统已在“云雀”“温比亚”“米娜”“利奇马”等台风期间进行了应用实践,可为浦东新区水雨情和汛情形势分析和趋势预测提供量化支撑,辅助防汛管理。

关键词：洪涝预报预警平原感潮河网内嵌河网模型 Delft-FEWS平台 Sobek软件浦东新区