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浙江电力 2011年第5期30卷 33-35页

作者：夏克宁胡斌李汝萍张晋波党培神华浙江国华浙能发电有限公司浙江宁海315612 浙江省电力试验研究院杭州310014 华能铜川电厂陕西铜川727100

从锅炉运行的角度分析了宁海发电厂3号机组再热汽温偏低的主要影响因素,提出了运行调整对策,对于提高再热汽温及降低波动具有一定的指导意义。

关键词： 600MW机组再热汽温偏低调整

合成扩散加权成像评估脑胶质瘤分级的应用研究

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磁共振成像 2022年第7期13卷 12-16页

作者：吕瑞瑞党佩葛鑫李敏黄雪莹王明磊杨旭宏雍鹏王晓东宁夏医科大学临床医学院银川750004 宁夏医科大学总医院放射科银川750004 通用电气医疗(中国)磁共振部北京100176

目的探讨合成扩散加权成像(synthetic DWI,sDWI)在高低级别胶质瘤评估中的应用价值。材料与方法回顾性分析术前一周行颅脑MRI(GE Signa Architect 3.0 T)检查的脑胶质瘤患者,根据纳入排除标准纳入72例患者病例(低级别胶质瘤30例,高级别... 详细信息

目的探讨合成扩散加权成像(synthetic DWI,sDWI)在高低级别胶质瘤评估中的应用价值。材料与方法回顾性分析术前一周行颅脑MRI(GE Signa Architect 3.0 T)检查的脑胶质瘤患者,根据纳入排除标准纳入72例患者病例(低级别胶质瘤30例,高级别胶质瘤42例),两名神经影像诊断医师采用双盲法在sDWI上对图像进行评估勾画病灶感兴趣区,对不同b值对应DWI图像信号强度进行分析并与最终病理结果进行对照。两组间比较使用独立样本t检验,使用logistic回归和受试者工作特征曲线下面积(area under the curve,AUC)分析评估高低级别胶质瘤诊断效能。结果在鉴别高低级别胶质瘤方面,sDWI b值为500、800、1000、1200、1500、1800、2000、2200、2500 s/mm^(2)对应的信号强度值,差异均有统计学意义(P<0.001),b值为2500 s/mm^(2)时鉴别高低级别胶质瘤的诊断效能最高,AUC为0.935,敏感度为98%,特异度为87%。结论sDWI单次扫描可获得0~2500 s/mm^(2)任意b值对应的信号强度值,b值越高对胶质瘤分级的诊断效能越高。

关键词：胶质瘤磁共振成像合成扩散加权成像分级诊断

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基于隧道视野的洪水VR场景优化方法

地理信息世界 2020年第6期27卷 93-97页

作者：路井涛朱军付林李维炼党沛韩啸西南交通大学地球科学与环境工程学院四川成都611756

在虚拟现实(Virtual Reality,VR)中进行洪水灾害探索分析可有效地提高用户对灾情信息的认知效率,但现有洪水场景存在绘制效率低、眩晕感严重的问题。针对上述问题,提出一种基于隧道视野的洪水VR场景优化方法,重点研究顾及人眼视觉特性... 详细信息

在虚拟现实(Virtual Reality,VR)中进行洪水灾害探索分析可有效地提高用户对灾情信息的认知效率,但现有洪水场景存在绘制效率低、眩晕感严重的问题。针对上述问题,提出一种基于隧道视野的洪水VR场景优化方法,重点研究顾及人眼视觉特性的洪水VR场景感兴趣区域计算、基于高斯滤波的隧道视野简化等关键技术,研发原型系统并选择案例区域开展实验分析。实验结果表明,提出的方法可在保证细节损失较小的前提下约减少30%〜50%的场景绘制数据,显著提升了帧速率,降低了用户在VR场景中探索分析中的眩晕感。

关键词：洪水灾害虚拟现实隧道视野高斯滤波场景优化

集成磁共振成像在轻微型肝性脑病临床应用中的初探

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磁共振成像 2022年第5期13卷 6-10,16页

作者：刘文潇党佩杨旭宏王明磊赵建国葛鑫吕瑞瑞雍鹏王晓东宁夏医科大学临床医学院银川750001 宁夏医科大学总医院放射科银川750001 宁夏医科大学颅脑疾病重点实验室银川750001

目的探究集成磁共振成像(synthetic magnetic resonance imaging,SyMRI)技术对轻微型肝性脑病(minimal hepatic encephalopathy,MHE)患者脑实质内特定区域弛豫值、质子密度(proton density,PD)值定量检测的价值。材料与方法前瞻性纳入2020年8月至2021年11月在宁夏医科大学总医院感染疾病科经临床诊断为肝硬化的住院患者并根据神经精神量表筛选出MHE患者23名为MHE组。同期招募年龄、性别及受教育程度等相匹配的健康志愿者20名为健康对照(healthy control,HC)组。所有受试者均在3.0 T MRI扫描仪上行SyMRI扫描,选取双侧尾状核、壳核、苍白球、背侧丘脑及额叶白质为感兴趣区(region of interest,ROI),并分别测量T1、T2及PD值。采用组内相关系数(intraclass correlation coefficient,ICC)评价观察者间数据测量的一致性,采用Mann-Whitney U秩和检验对MHE组及HC组T1、T2及PD值进行比较并统计其在两组间的差异及诊断效能。结果两名医师对脑实质各ROI的T1、T2及PD值测量的一致性较好,ICC值分别为0.863、0.822、0.816。除双侧额叶白质外,MHE组较HC组部分亚区T1、T2及PD值降低,差异具有统计学意义(P<0.05)。T1值中双侧壳核、右侧苍白球在MHE组及HC组间差异具有统计学意义;T2值中右侧尾状核、双侧壳核及左侧苍白球在MHE组及HC组间差异具有统计学意义;PD值中右侧壳核在MHE组及HC组间差异具有统计学意义。与HC组相比,MHE组双侧额叶T1值及PD值升高,差异具有统计学意义(P<0.05)。右侧额叶的PD值诊断效能最高,受试者工作特征曲线下面积为0.901。结论SyMRI对MHE患者各脑区弛豫值具有较好的定量能力,其T1、T2及PD值在检出MHE患者中有一定的潜在价值。

关键词：轻微型肝性脑病集成磁共振成像质子密度弛豫值诊断效能

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TJ1508的合成及晶型研究

现代药物与临床 2017年第2期32卷 165-169页

作者：赵胜贤厉昆付凌燕任党培金龙浙江普洛得邦制药有限公司浙江东阳322118

目的研发一种新型唑烷酮类抗生素((3R,3a S)-7-(6-((S)3-甲基-2-唑烷酮-5-基)吡啶-3-基)-1-氧-1,3,3a,4-四氢苯并[b]唑[3,4-d][1,4]嗪-3-基)甲基)磷酸单酯(TJ1508)的合成工艺,并研究其晶型。方法以磷酸二苄酯中间体为原料,通过酸催化脱... 详细信息

目的研发一种新型唑烷酮类抗生素((3R,3a S)-7-(6-((S)3-甲基-2-唑烷酮-5-基)吡啶-3-基)-1-氧-1,3,3a,4-四氢苯并[b]唑[3,4-d][1,4]嗪-3-基)甲基)磷酸单酯(TJ1508)的合成工艺,并研究其晶型。方法以磷酸二苄酯中间体为原料,通过酸催化脱苄基得到TJ1508,在不同的溶剂体系中析晶得到不同晶型,采用粉末X射线衍射分析(PXRD)和差示扫描量热分析(DSC)对其进行表征,并对其进行加速稳定性试验和溶剂残留检测。结果目标化合物的收率最高为89%,得到3种不同的晶型A、B和C,稳定性、溶剂残留和钯残留均优于化合物专利无定型产品。结论设计了一种TJ1508的简易合成路线,得到3种稳定的晶型,其中晶型C最为稳定。

关键词： TJ1508 唑烷酮磷酸二苄酯抗生素晶型

彩色硅胶罐联合运动疗法治疗卒中后偏侧忽略临床研究

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上海针灸杂志 2020年第8期39卷 983-987页

作者：姬鹏博忤志强贾党培王霖舒媛媛南阳市第九人民医院南阳473000

目的观察彩色硅胶罐联合运动疗法治疗卒中后偏侧忽略的临床疗效。方法选取卒中后偏侧忽略患者60例,采用随机数字表法将患者分为两组,每组30例,治疗组采用彩色硅胶罐联合运动疗法治疗,对照组采用单独运动疗法治疗,统计分析两组患者的单... 详细信息

目的观察彩色硅胶罐联合运动疗法治疗卒中后偏侧忽略的临床疗效。方法选取卒中后偏侧忽略患者60例,采用随机数字表法将患者分为两组,每组30例,治疗组采用彩色硅胶罐联合运动疗法治疗,对照组采用单独运动疗法治疗,统计分析两组患者的单侧空间忽略各项参数、凯瑟琳-伯哥量表(CBS)评分、简易智能精神状态检查量表(MMSE)评分、Fugl-Meyer(FMA)运动功能评定量表评分、改良Barthel指数(MBI)评分、满意度。结果两组治疗前平面图形临摹试验、画钟试验、线段划销试验、直线二等分试验评分比较差异无统计学意义(P>0.05);两组治疗后平面图形临摹试验、画钟试验、线段划销试验、直线二等分试验评分均显著低于治疗前(P0.05);两组治疗后的CBS评分均显著低于治疗前(P0.05)。结论彩色硅胶罐联合运动疗法治疗卒中后偏侧忽略的临床效果较单独运动疗法好。

关键词：拔罐彩色硅胶罐运动疗法中风后遗症卒中偏侧忽略

Distribution of glycerol dialkyl glycerol tetraethers in surface soils along an altitudinal transect at cold and humid Mountain Changbai:Implications for the reconstruction of paleoaltimetry and paleoclimate

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Science China Earth Sciences 2018年第7期61卷 925-939页

作者： Yue LI Shijin ZHAO Hongye pei Shi QIAN Jingiie ZANG Xinyue dang Huan YANG School of Earth Sciences China University of GeosciencesWuhan 430074China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China

Glycerol Dialkyl Glycerol Tetraethers(GDGTs)serve as important tools for the quantitative reconstruction of paleoclimate and paleoecology in both continental and marine *** studies of GDGTs in the terrestrial environments focused primarily on the soils from the relatively warm-humid or cold-dry ***,it is still unclear how GDGTs respond to environmental variables in the cold-humid ***,we collected soils along an altitudinal transect of Mountain(Mt.)Changbai,which has a typical cold-humid climate,to investigate the distribution of GDGTs and the response of GDGT-based proxies to changes in climate along the *** shift in the distribution of archaeal isoprenoidal GDGTs(iso GDGTs)revealed that the archaeal community varied significantly along the transect,which can affect the relationship between TEX_(86)and mean annual air temperature(MAT).In addition,the increased temperature seasonality at higher altitudes exerted a significant impact on TEX_(86).We proposed a global calibration of TEX_(86)for the growing season temperature reconstruction in the soil environments:T=85.19×TEX_(86)-46.30(R^2=0.84,p<0.001).The methylation indices for 5-methyl branched GDGTs(br GDGTs)including MBT′_(5me)and MBT_(5/6),showed correlation with soil water content but no relationship with MAT,indicating that MBT′_(5me)and MBT_(5/6)from cold-humid environments may be not suitable for temperature and altitude *** contrast,the recently developed p H proxies,including MBT′_(6me)(the methylation index for 6-methyl br GDGTs),CBT(Cyclisation index of Branched Tetraethers),IR_(IIa’)(Isomer ratio of IIa′)and IR_(IIIa′)(Isomer ratio of IIIa′)exhibited significant correlations with soil p H,suggesting these proxies can still be used for soil p H reconstruction in the coldhumid *** combination of MBT′_(5me)and MBT′_(6me)was strongly related to different types of climate(cold-dry,warmhumid,cold-humid,and warm-dry).For example,MBT′_(5me)<0

关键词： Cold-humid climate GDGTs Temperature Soil pH Soil water content

单节段固定关节突峡部融合治疗年轻人轻度峡部裂腰椎滑脱的临床观察

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现代生物医学进展 2017年第32期17卷 6287-6290页

作者：王彦东赵燕党培业张伟马琼李耀章陕西省榆林市星元医院(榆林市第四医院)骨2科陕西榆林719000 济南市疾病预防控制中心山东济南250000 第四军医大学唐都医院全军骨科中心陕西西安710038

目的:介绍和分析单节段固定关节突峡部融合治疗年轻人轻度峡部裂腰椎滑脱的临床应用。方法:对2010.01-2016.01来我院就诊,诊断为峡部裂伴轻度腰椎滑脱的共计46例青年患者(<30岁),采用单节段固定结合关节突峡部融合的方法进行治疗。分析... 详细信息

目的:介绍和分析单节段固定关节突峡部融合治疗年轻人轻度峡部裂腰椎滑脱的临床应用。方法:对2010.01-2016.01来我院就诊,诊断为峡部裂伴轻度腰椎滑脱的共计46例青年患者(<30岁),采用单节段固定结合关节突峡部融合的方法进行治疗。分析包括患者术前与术后3月、6月及12月VAS(Visual Analogue Scale)疼痛评分,Lehmann腰椎功能评分等功能恢复指标的比较及融合率、并发症等临床观察指标的总结。结果:所有患者均至少接受12个月的术后随访,患者在术后(3,6,12月)的VAS评分及Macnab评分较术前均有显著改善和提高(P<0.05)。影像资料显示:未出现不融合现象。1例患者出现皮肤浅层感染,处理后好转,余无明显并发症出现。结论:对于年轻人的轻度峡部裂伴腰椎滑脱患者,使用单节段固定结合关节突峡部融合的方法具有较好的疗效,且对后期影响较小。

关键词：滑脱峡部裂融合临床疗效

Theoretical investigations on the thiol–thioester exchange steps of different thioesters

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Chinese Chemical Letters 2015年第10期26卷 1259-1264页

作者： Xiao-Hui Sun Hai-Zhu Yu Shu-Qi pei Zhi-Min dang Department of Polymer Science and Engineering University of Science and Technology Beijing Department of Chemistry and Centre for Atomic Engineering of Advanced Materials Anhui University

As the rate-determining step in native chemical ligation reactions, the thiol–thioester exchange step is important in determining the efficiency of the ligations of peptides. In the present study, systematic theoretical calculations were carried out on the relationships between the structure of different thioesters and the free energy barriers of the thiol–thioester exchange step. According to the calculation results, the thiol–thioester exchange step is disfavored by the steric hindrance around the carbonyl center, while the electronic effect（i.e. conjugation and hyper-conjugation effects） becomes important when the steric hindrance is insignificant.

关键词： Native chemical ligation Thiol–thioester exchange Density functional theory

Radical resection of pathological membrane for Budd-Chiari syndrome

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Hepatobiliary & Pancreatic Diseases International 2007年第2期6卷 157-160页

作者： dang, Xiao-Wei Xu, pei-Qin Ma, Xiu-Xian Zhengzhou Univ Dept Gen Surg First Affiliated Hosp Zhengzhou 450052 Peoples R China

BACKGROUND: Budd-Chiari syndrome (BCS) refers to posthepatic portal vein hypertension and/or inferior vena cava hypertension syndrome caused by obstruction of the blood flow at the portal cardinal hepatic vein and/or posterior hepatic inferior vena cava. The main surgical treatments of BCS include operations on pathological lesioned membrane, shunt, and combined operations. There are more than ten treatments available and reports on their therapeutic effects vary. As to operations on lesioned membrane, there are Kimura's finger rupture, balloon dilatation and membrane removal. With reference to our experience, the clinical value of membrane resection at normal temperature and under direct vision is discussed. METHODS: A total of 292 patients with BCS undergoing membrane resection at normal temperature and under direct vision from June 1996 to June 2005 were retrospectively analyzed. RESULTS: The short-term therapeutic effect in 256 patients was satisfactory and the effective rate was 87.7% (256/292). Within a week, ascitic fluid disappeared, the liver shrank and edema of the lower extremities was greatly relieved or even disappeared. Perioperative death occurred in 14 patients (4.8%). Of these, 3 had acute heart failure (one during the operation, one after 6 hours and one 7 days later). Six patients had thoracic cavity bleeding within 12 hours after the operation, 3 had acute respiratory distress syndrome (ARDS), 2 had disseminated intravascular coagulation (DIC), and I had pulmonary embolism. 158 patients were followed up for 6 months to 12 years, and 12 (7.6%) had recurrences. CONCLUSIONS: After membrane resection at normal temperature and under direct vision, hemodynamics was found to be close to normal, damage was slight, effectiveness was evident and the recurrence rate low. So this method is effective in treating BCS.

关键词： hepatic vein thrombosis pathological membrane