检索结果-南通市图书馆

维普期刊数据库

The roles of macrophage migration inhibitory factor in retinal diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第2期19卷 309-315页

作者： Hongbing Zhang Xianjiao Zhang Hongsong Li Bing Wang pei chen Jiamin Meng Shaanxi Institute of Ophthalmology Xi’anShaanxi ProvinceChina Department of Ophthalmology First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Department of Pathology First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina

Macrophage migration inhibitory factor(MIF),a multifunctional cytokine,is secreted by various cells and participates in inflammatory reactions,including innate and adaptive *** are some evidences that MIF is involved in many vitreoretinal *** example,MIF can exacerbate many types of uveitis;measurements of MIF levels can be used to monitor the effectiveness of uveitis *** also alleviates trauma-induced and glaucoma-induced optic nerve ***,MIF is critical for retinal/choroidal neovascularization,especially complex *** exacerbates retinal degeneration;thus,anti-MIF therapy may help to mitigate retinal *** protects uveal melanoma from attacks by natural killer *** mechanism underlying the effects of MIF in these diseases has been demonstrated:it binds to cluster of differentiation 74,inhibits the c-Jun N-terminal kinase pathway,and triggers mitogen-activated protein kinases,extracellular signal-regulated kinase-1/2,and the phosphoinositide-3-kinase/Akt *** also upregulates Toll-like receptor 4 and activates the nuclear factor kappa-B signaling *** review focuses on the structure and function of MIF and its receptors,including the effects of MIF on uveal inflammation,retinal degeneration,optic neuropathy,retinal/choroidal neovascularization,and uveal melanoma.

关键词： diabetic retinopathy glaucoma macrophage migration inhibitory factor migration inhibitory factor receptor optic neuropathy retinal degeneration retinal neovascular uveal melanoma uveitis

维普期刊数据库

Machine learning-based prediction of pregnancy outcomes in couples with non-obstructive azoospermia using micro-TESE for ICSI: a retrospective cohort study

在线全文

学校读者我要写书评

暂无评论

生殖与发育医学(英文) 2024年第1期08卷 24-31页

作者： Jia Lei chen pei-Gen chen Li-Na Fang Cong Zhang Jing chen Pan-Yu Reproductive Medicine Center The Sixth Affiliated Hospital 3. Sun Yat-sen University 4. Guangzhou 510275 5. China

Objective: To develop a clinically applicable tool for predicting clinical pregnancy, providing individualized patient counseling, and helping couples with non-obstructive azoospermia (NOA) decide whether to use fresh or cryopreserved spermatozoa for oocyte insemination before microdissection testicular sperm extraction (mTESE).Methods: A total of 240 couples with NOA who underwent mTESE-ICSI were divided into two groups based on the type of spermatozoa used for intracytoplasmic sperm injection (ICSI): the fresh and cryopreserved groups. After evaluating several machine learning algorithms, logistic regression was selected. Using LASSO regression and 10-fold cross-validation, the factors associated with clinical pregnancy were ***: The area under the curves (AUCs) for the fresh and cryopreserved groups in the Logistic Regression-based prediction model were 0.977 and 0.759, respectively. Compared with various modeling algorithms, Logistic Regression outperformed machine learning in both groups, with an AUC of 0.945 for the fresh group and 0.788 for the cryopreserved ***: The model accurately predicted clinical pregnancies in NOA couples.

关键词： Cryopreserved spermatozoa Fresh spermatozoa Logistic regression Microdissection testicular sperm extraction

Clinical application of the endometrial microbiota test combined with personalized treatment in patients with repeated implantation failure

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

生殖与发育医学(英文) 2024年第1期08卷 18-23页

作者： chen Rou-Zhu Wang Yan-Fang chen pei-Gen Fang Cong Li Ting-Ting Reproductive Medicine Center The Sixth Affiliated Hospital 3. Sun Yat-sen University 4. Guangzhou 510655 5. China

Objective: The objective of this study was to investigate the clinical value of the endometrial microbiota test (EMT) combined with personalized treatment in patients with repeated implantation failure (RIF).Methods: From March 2019 to August 2022, the clinical data of patients with RIF at the Reproductive Medicine Research Center of the Sixth Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed. A total of 356 patients underwent the EMT using 16S rRNA sequencing and were included in the EMT group. The SPSS statistical software propensity score was set at 1:1 to match the age, anti-Müllerian hormone (AMH), antral follicle count (AFC), years of infertility, and body mass index (BMI) of the women who had not undergone the EMT; subsequently, 354 patients were classified in the non-EMT group. We compared the clinical characteristics of the two groups and analyzed the clinical pregnancy outcomes after personalized ***: The clinical pregnancy rate (CPR) of the EMT group was significantly higher than that of the non-EMT group (47.81%vs. 13.38%,P <0.05). Among 356 patients who underwent the EMT, 55 patients (15.45%) in group A with normal endometrial microbiota composition did not test positive for the pathogenic bacteria causing chronic endometritis, 34 patients (9.55%) in group B with abnormal endometrial microbiota composition did not test positive for the pathogenic bacteria causing chronic endometritis, 35 patients (9.83%) in group C with normal endometrial microbiota composition tested positive for the pathogenic bacteria causing chronic endometritis, and 232 patients (65.17%) in group D with abnormal endometrial microbiota composition tested positive for the pathogenic bacteria causing chronic endometritis. After administration of probiotics or antibiotic plus probiotics treatment, the pregnancy rates of groups C and D were higher than those of group A (44.00%vs. 20.00% and 55.03%vs. 20.00%, respectively; bothP <0.05).Conclusion:

关键词： Endometrial microbiota test Assisted reproductive technology Repeated implantation failure Personalized treatment

Implications of neutron skin measurements on Skyrme equations of state

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第6期48卷 155-161页

作者：管大为裴俊琛蒋崇基 State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

The recent measurements of neutron skins via parity violation in electron scattering have extracted an abnormally thick neutron skin for 208 Pb,which has significant consequences in nuclear equation of state(EoS)and neutron star *** this study,we perform optimizations of extended Skyrme forces in a consistent manner by including neutron skin thicknesses from PREX-Ⅱand CREX experiments and investigate nuclear EoSs and neutron stars in the GW170817 event By varying the fitting weights of neutron skins,several new Skyrme parameterizations are *** results show the competition in the fitting procedure to simultaneously describe neutron skins,other properties of finite nuclei,and neutron star *** prospects of resolving neutron skin issues are also discussed.

关键词： neutron skin equation of state neutron star Skyrme force

维普期刊数据库

Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第5期15卷 958-976页

作者： Hong Xu Li-Bo Zhang Yi-Yi Luo Ling Wang Ye-Pin Zhang pei-Qi chen Xue-Ying Ba Jian Han Heng Luo Department of Ophthalmology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Precision Medicine Center of Chuxiong Yi Autonomous Prefecture The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Endocrinology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Pathology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina

BACKGROUND Synaptotagmins(SYTs)are a family of 17 membrane transporters that function as calcium ion sensors during the release of Ca2+-dependent neurotransmitters and ***,few studies have reported whether members of the SYT family play a role in glucose uptake in diabetic retinopathy(DR)through Ca2+/glucose transporter-1(GLUT1)and the possible regulatory mechanism of *** To elucidate the role of the SYT family in the regulation of glucose transport in retinal pigment epithelial cells and explore its potential as a therapeutic target for the clinical management of *** DR was induced by streptozotocin in C57BL/6J mice and by high glucose medium in human retinal pigment epithelial cells(ARPE-19).Bioinformatics analysis,reverse transcriptase-polymerase chain reaction,Western blot,flow cytometry,ELISA,HE staining,and TUNEL staining were used for *** Six differentially expressed proteins(SYT2,SYT3,SYT4,SYT7,SYT11,and SYT13)were found between the DR and control groups,and SYT4 was highly *** induces SYT4 overexpression,manipulates Ca2+influx to induce GLUT1 fusion with the plasma membrane,promotes abnormal expression of the glucose transporter GLUT1 and excessive glucose uptake,induces ARPE-19 cell apoptosis,and promotes DR *** deficiency inhibits the proteasomal degradation of SYT4 in DR,resulting in SYT4 accumulation and enhanced GLUT1 fusion with the plasma membrane,and these effects were blocked by oe-Parkin ***,dysregulation of the myelin transcription factor 1(Myt1)-induced transcription of SYT4 in DR further activated the SYT4-mediated stimulus-secretion coupling process,and this process was inhibited in the oe-MYT1-treated *** Our study reveals the key role of SYT4 in regulating glucose transport in retinal pigment epithelial cells during the pathogenesis of DR and the underlying mechanism and suggests potential therapeutic targets for clinical DR.

关键词： Diabetic retinopathy Glucose transporter-1 Synaptotagmin 4 Parkin Myelin transcription factor 1

富氮多孔碳纳米片的氮掺杂构型调控及其储锌性能

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

化工进展 2024年第5期43卷 2673-2683页

作者：刘思宇杨卷陈培陈祖田闫斌刘育红邱介山西安交通大学化学工程与技术学院北京化工大学化学工程学院

基于多孔碳正极和锌金属负极构建的水性锌离子电容器（ZICs）具有成本低、环境友好、安全性高和长期耐用等优点，近年来受到广泛关注。本文以具有共价有机框架结构（COF）的富氮聚合物为碳源前体，通过简单的炭化自活化策略，合成了富... 详细信息

基于多孔碳正极和锌金属负极构建的水性锌离子电容器（ZICs）具有成本低、环境友好、安全性高和长期耐用等优点，近年来受到广泛关注。本文以具有共价有机框架结构（COF）的富氮聚合物为碳源前体，通过简单的炭化自活化策略，合成了富氮多孔碳纳米片（NPCN-x）。研究表明，基于聚合物前体丰富的COF结构特点，炭化温度对所制备碳材料的氮含量和氮掺杂构型有显著影响，且碳材料表面的吡咯氮含量与其储锌性能呈现高度线性相关。优化后的NPCN-800其吡咯氮原子分数高达2.15%，作为ZICs的正极材料，在0.5A/g的电流密度下，展现出158mAh/g的高比容量和优异的循环稳定性。结合密度泛函理论计算发现，碳材料表面的吡咯氮构型具有优异的电化学活性，能够显著增强Zn离子的化学吸脱附过程。该研究为高性能ZICs用碳基电极材料的设计构建提供了新思路。

关键词：多孔碳纳米片氮掺杂调控锌离子存储电化学优化设计

同方期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

论全国人大常委会法律解释的时间效力

河北法学 2024年第9期42卷 189-200页

作者：陈佩彤中国人民大学纪检监察学院北京100089

根据解释情形的不同,全国人大常委会作出的法律解释可分为解释型、创设型、综合型三种类型。立法解释的不同类型对应了不同的时间效力规则。立法解释的生效时间取决于其解释情形,解释型法律解释应从法律生效之日起生效,创设型法律解释... 详细信息

根据解释情形的不同,全国人大常委会作出的法律解释可分为解释型、创设型、综合型三种类型。立法解释的不同类型对应了不同的时间效力规则。立法解释的生效时间取决于其解释情形,解释型法律解释应从法律生效之日起生效,创设型法律解释应从解释发布之日或规定之日起生效,综合型法律解释生效时间应作分类讨论。立法解释的失效时间取决于解释对象的效力变动情况。立法解释的溯及力应遵循“法不溯及既往”的原则,但解释型法律解释中存在溯及既往的例外情形。立法解释的生效时间、失效时间和溯及力三者相互影响,环环相扣,共同构成了全国人大常委会法律解释的时间效力规则。

关键词：法律解释立法解释时间效力生效时间溯及力

Causal relationships between gut microbiota and dementia:A twosample,bidirectional,Mendelian randomization study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第16期12卷 2780-2788页

作者： Zhao-Lin Ren Hai-Hong Zhou Chu-pei chen Hao He Duo-Lao Wang Zhou Liu Department of Neurology The Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Department of Clinical Medicine Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Department of Clinical Sciences Liverpool School of Tropical MedicineLiverpool L693BXUnited Kingdom

BACKGROUND Existing evidence suggests that gut microbiota represent a significant environmental risk factor for various forms of dementia,including Alzheimer's dementia,vascular dementia,and dementia in other diseases classified ***,the exact causal relationships between gut microbiota and the different forms of dementia or their subtypes remain *** To investigate putative causal relationships between gut microbiota and dementia or its subtypes using Mendelian randomization(MR)*** A bidirectional,two-sample,MR analysis was conducted utilizing publicly available gut microbiota-related genome-wide association study(GWAS)summary data from the MiBioGen consortium alongside GWAS summary statistics for dementia and its subtypes from the FinnGen *** variables were selected according to the fundamental tenets of MR and their strengths were evaluated using the *** MR methods were employed,and the robustness of our findings was *** account for multiple comparisons,we applied the Bonferroni method for P-value *** We identified several gut microbiota taxa exhibiting putative causal relationships with dementia or its subtypes,potentially serving as risk or protective factors for the *** addition,reverse MR analysis indicated that the relative abundance of several gut microbiota taxa might be influenced by dementia or its *** exhaustive sensitivity analysis confirmed the absence of heterogeneity and horizontal *** applying correction for multiple testing,we observed that the order Bacillales(odds ratio:0.830,95%confidence interval:0.740-0.932,P=0.00155,Padjust=0.0311)exhibited a strong association with Alzheimer’s disease-related *** The results suggest that gut microbiota is causally associated with *** findings provide novel insights into the pathophysiology of dementia and have important implications for its treatment and prevention.

关键词： Mendelian randomization FinnGen MiBioGen Gut microbiota Dementia Alzheimer’s disease Vascular dementia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于力矩传递模型的风力机叶片颤振抑制方法

太阳能学报 2024年第4期45卷 159-165页

作者：陈沛刘惠康柴琳周楠武汉科技大学信息科学与工程学院武汉430081

针对永磁直驱水平轴风力机叶片颤振现象,建立叶片-传动轴-电机旋转平面内的振动力矩传递模型,计算叶片侧扰动力矩以及归算到电机侧的扰动力矩,并通过控制电机转矩,在电磁转矩上叠加一个与该侧扰动力矩大小相等、方向相反的控制力矩,使... 详细信息

针对永磁直驱水平轴风力机叶片颤振现象,建立叶片-传动轴-电机旋转平面内的振动力矩传递模型,计算叶片侧扰动力矩以及归算到电机侧的扰动力矩,并通过控制电机转矩,在电磁转矩上叠加一个与该侧扰动力矩大小相等、方向相反的控制力矩,使其通过力矩传递模型抑制叶片颤振,同时对引起轴系谐振的电机转矩成分进行陷波滤波处理,以此抑制轴系谐振。最后通过仿真和实验验证上述方法的有效性。

关键词：风力机叶片颤振谐振力矩电磁转矩

维普期刊数据库博看期刊