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Management of Ectopic Pregnancy at the Brazzaville Hospital and University Centre

Open Journal of Obstetrics and Gynecology 2019年第7期9卷 1050-1057页

作者： Jean Alfred Mbongo peggy mawandza Gickelle Bitsene Mpika Clotaire Itoua Léon Herve Iloki Service de Gynécologie Obstétrique CHU Brazzaville Brazzaville Congo Service de Réanimation Polyvalente CHU Brazzaville Brazzaville Congo

Objective: To evaluate the current management of ectopic pregnancies (EPG) at the University Hospital Centre (UHC) in Brazzaville because the practice was usually limited to total salpingectomy by laparotomy. Patients and methods: This was a descriptive study, with retrospective data collection, conducted from July 30, 2015 to January 30, 2016. It included patient records admitted to the Obstetrical Gynecology Department of the Brazzaville University Hospital for an EP, a diagnosis made before visualization on ultrasound of an active embryo outside the uterine cavity or per laparoscopy, but often by exploratory laparotomy. Sociodemographic and clinical data, as well as the therapeutic modalities of the patients, were analyzed. Cases of women operated for EP in other health facilities and referred to the UHC for complication management and cases that were unusable were excluded. Results: We noted 39 EPs out of 4490 deliveries, representing a frequency of 0.86%. The average age of the patients was 28.9 years (extreme 18 - 46 years). The transfusion of labile blood products concerned 84.6% of patients. There was no therapeutic abstention;medical treatment was performed in 3 patients (7.7% of cases). Diagnostic and therapeutic laparoscopy was performed in 9 patients (23.1%) and laparotomy was used in 26 patients (66.7% of cases) in which 35 Salpingectomies (89.7% of cases) were performed. The immediate postoperative period was marked by anaemia (32 cases or 82.1%), surgical site infection (1 case or 2.6%) and parietal suppuration (1 case or 2.6%). Conclusion: The dissemination of therapeutic advances in the management of EP is also possible in African settings.

关键词： EP Frequency Therapeutic Modalities Brazzaville

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The Fate of Newborns Delivered through Cesarian Section at Brazzaville University Hospital

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Open Journal of Obstetrics and Gynecology 2019年第7期9卷 1073-1082页

作者： Jean Alfred Mbongo Gickelle Bitsene Mpika peggy mawandza Delvie Ardèche Bitsangou Gaston Ekouya Bowassa Clotaire Itoua Leon Herve Iloki Obstetrical Gynecology Department Brazzaville University Hospital Brazzaville Congo Polyvalent Resuscitation Department Brazzaville University Hospital Brazzaville Congo Neonatology Department Brazzaville University Hospital Brazzaville Congo

Objectives: To assess the fate of newborns born by emergency Cesarean section during the early neonatal period at the University Hospital Centre (UHC) in Brazzaville, with a view to improving neonatal prognosis. Patients and methods: This was a descriptive and cross-sectional analytical study of exposed and unexposed type, which took place from 24 March 2018 to 24 May 2018. All cases of newborns born by Cesarean section were included. Children born by extreme emergency and urgent Cesarean section were considered as exposed, and the others not exposed. The variables studied were the epidemiological characteristics of the mothers, the history of pregnancy and its management, anthropometric data on the newborn, the state of the child at birth and monitoring up to the seventh day. The test for comparing the proportions of target groups related to the child’s condition was used. Results: The mothers were aged 20 to 29 years (extreme 16 to 44 years);32 of them (22.5%) had a scarred uterus;29 pregnant women (20.4%) had a pathology associated with pregnancy. The distance travelled to consult was between 5 and 10 Km (63 cases or 44.3%). Emergency Caesarean sections were performed in 110 patients (77.5%) and scheduled Caesarean sections in 32 pregnant women (22.5%). Localoregional anaesthesia by spinal anaesthesia predominated (78.9%), by the association Bipivancaine + Fentanyl (69 cases or 48.6%) whose practitioner was often the nurse anaesthetist (131 cases or 92.3%). No accidents have occurred intraoperatively. At birth we noticed: 4.2% stillbirth, 19.7% bad, requiring resuscitation of at least 5 minutes for 16 newborns (57.1%). 26 newborns (18.3%) required care in the Neonatology Department. Early neonatal morbidity was dominated by respiratory distress (10 cases or 38.5%), early neonatal infection (5 cases or 19.1%) and a lethality rate of 19.2%. Conclusion: The future of the newborn, born by emergency Cesarean section is mixed;emergency control can improve the situation

关键词： Newborns Emergency Caesarean Sections Congo

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Rare Neonatal Digestive Surgical Emergencies at the Brazzaville University Hospital Center

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Open Journal of Pediatrics 2020年第3期10卷 463-473页

作者： Lucienne Irène Patricia Ondima Caryne Mboutol-Mandavo Moïse Service Yanguedet Didace Massamba Miabaou Jean-Claude Mieret Cardinale Princilia Okiemy Niendet Gracia Christelle Ossete peggy Dahlia Gallou mawandza Neli Yvette Ngakengni Gaston Ekouya Bowassa Department of Pediatric Surgery University Hospital Center Brazzaville Republic of Congo Department of Visceral Surgery University Hospital Center Brazzaville Republic of Congo Department of Intensive care and Anesthesia University Hospital Center Brazzaville Republic of Congo Department of Neonatology University Hospital Center Brazzaville Republic of Congo

The purpose of our study was to evaluate the morbidity-morality of rare neonatal digestive emergencies in order to improve their management. Observations: 7 newborns ranging in age from 6 hours to 3 weeks were treated for rare digestive pathologies between January 2013 and July 2017 (a period of 3 years and 6 months) in the Department of Pediatric surgery of Brazzaville University Center, Congo. Males were predominant (5 versus 2 females). Pathologies listed were: 1 antenatal volvulus of the small intestine, 1 annular pancreas and 5 gastric perforations. The average time of care in the operating room was 12 hours. The newborns were hospitalized in the pediatric surgery department in 28.6% of cases (n = 2), and 71.4% (n = 5) in the neonatology department. The antenatal volvulus of the intestine and annulus pancreas were integrated into a nosologic entity named neonatal occlusion (NNO). The postoperative outcomes were simple for 4 patients (57.14%) while 3 patients died immediately after surgery (42.86%). Conclusion:

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Isolated Caeco-Vesical Fistula: A Case Report

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Open Journal of Urology 2020年第12期10卷 309-314页

作者： Lucienne Irène Patricia Ondima Melvin Ondongo Atipo Steve Aristide Ondziel Opara Didace Massamba-Miabaou Régis Moyikoua peggy Dalhia Galou mawandza Moï se Yanguedet Service Caryne Mboutol-Mandavo Pierre Aymar Oko Jean-Claude Mieret Cardinale Princilia Okiemy Niendet Gracia Christelle Ossete Erica Nuptia Akobande Anani Wenceslas Séverin Odzébé Prosper Bouya Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Pediatric Surgery Department University Hospital Center Brazzaville Republic of Congo Urology and Andrology Department University Hospital Center Brazzaville Republic of Congo Visceral Surgery Department University Hospital Center Brazzaville Republic of Congo Medical Imaging Department University Hospital Center Brazzaville Republic of Congo Multipurpose Resuscitation Department University Hospital Center Brazzaville Republic of Congo Pediatric Intensive Care Unit University Hospital Center Brazzaville Republic of Congo

Congenital uro or genito-digestive fistulas are frequently found in the context of caudal pole malformations. Isolated congenital forms without associated anorectal malformation have not been reported until now. We report the first case we know a 9 year old female child received in a pediatric surgery consultation for fecaluria evolving since birth with a permeable anus. She presented a good general condition, a good staturo-ponderal and psychomotor development, a vulva soiled by stool and a permeable anus with a tonic sphincter. A retrograde urethrocystography revealed a caeco-vesical fistula. Surgery consisted of ligation-section of the caeco-vesical septum. A follow-up urethrocystography at three months post-surgery no longer visualized the fistula. Our post-operative follow-up is 4 years. Isolated congenital caeco-vesical fistula is an unknown pathology whose late diagnosis can have serious repercussions.

关键词： Fistula Congenital Isolated Caecum Bladder Child Surgery

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Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility and Aging(SOMMA)

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Journal of Sport and Health Science 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Terri L.Blackwell peggy M.Cawthon Paul M.Coen Steven R.Cummings Giovanna Distefano Samaneh Farsijani Daniel E.Forman Bret H.Goodpaster Stephen B.Kritchevsky Theresa Mau Frederico G.S.Toledo Anne B.Newman Nancy W.Glynn Department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA Department of Medicine(Geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of Endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported PA or structured exercise ***,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(SB)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle ***:As part of the Study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOS))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn ActiGraph GT9X over 7 ***-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for Seniors(CHAMPS)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary *** a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle ***:Every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOS and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(p<0.05).Light activity was not associated with maxOXPHOS or ATP_(max).Meanwhile,every 30 min/day spent in ActiGraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOS and0.

关键词： Aging Exercise Mitochondria

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Efficacy and tolerability of chitin-glucan combined with simethicone(GASTRAP^(■)DIRECT)in irritable bowel syndrome:A prospective,open-label,multicenter study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 10-22页

作者： Nathalie Talbodec Pauline Le Roy peggy Fournier Benoit Lesage Elodie Lepoutre François Castex Jean Michel Godchaux Lionel Vandeville Benjamin Bismuth Xavier Lesage Pauline Bayart Michael Genin Christel Rousseaux Veronique Maquet Salvatore Modica Pierre Desreumaux Caroline Valibouze Department of Gastroenterology Hôpital privéLe BoisLille 59000France Department of Gastroenterology Hôpital privéde Villeneuve d’AscqVilleneuve d’Ascq 59650France Univ.Lille CHU LilleULR 2694–METRICSÉvaluation des Technologies de Santéet des Pratiques MédicalesLille 59000France Development of Intestinal Biotech 1 Avenue Oscar LambretLille 59045France KitoZyme SA Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium BiOkuris A Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium Department of Hepato-Gastroenterology Lille University HospitalLille 59000France U1286-INFINITE Institute for Translational Research in InflammationUniv.LilleInsermCHU LilleLille 59000France Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel ***-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic ***^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of *** To evaluate the efficacy,tolerability,and safety of 4-week GASTRAP^(■)DIRECT treatment in patients with *** In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of GASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 *** primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)*** analysis was performed using the per-protocol *** symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were *** Overall,100 patients were *** W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,P<0.0001).Similar improvements were observed for bloating[8.0±1.7 vs 4.7±2.9,P<0.0001;60%(95%CI:50-70)responders],abdominal distension[7.2±2.1 vs 4.4±3.1,P<0.0001;53%(95%CI:43-63)responders],and impact of global symptoms on daily life[7.1±2.0 vs 4.6±2.9,P<0.0001;54%(95%CI:44-64)responders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by *** severe adverse event occurred,and tolerabil

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Flatulence Defecatory disorders Stool consistency Natural non-pharmacological treatment

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développement vert dans la nourelle ère

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今日中国（法文版） 2022年第11期60卷 35-37页

作者： peggy CANTAVE FUYET I'lnstitut de recherche sur Ihistoire et la littérature du Parti communiste chinois.

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Composting of Disposal Organic Wastes: Resource Recovery for Agricultural Sustainability

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过程工程学报 2006年第4期6卷 585-591页

作者： Mohammad H.Golabi peggy Denney Clancy Iyekar College of Natural and Applied Sciences University of Guam Mangilao Guam-USA

One of the major problems of agricultural soils in the tropical regions of the Pacific is the low organic matter *** of the hot and humid environment,the soil organic matter(SOM)is minimal due to rapid *** organic material is being applied on agricultural fields as an amendment to provide nutrients and enhance the organic matter content for improving the physical and chemical properties of the cultivated *** addition land application of composted material as a fertilizer source effectively disposes of wastes that otherwise are buried in *** our soil program at the University of Guam,we are evaluating the use of organic material as an alternative to synthetic *** goal is to develop management strategies and use available resources for improving crop production while conserving resources and preserving environmental *** case study project is designed to improve soil fertility status by using composted organic wastes and assessing how the nitrogen and other essential nutrients contribute to long-term soil fertility and crop productivity without application of synthetic *** our pilot project,compost is produced from wood chips,grinded typhoon debris mixed with animal manure,fish feed,shredded paper and other organic *** compost is then applied on the field at the rates of 0,5,10 and 20 t/ha as a soil amendment on the eroded cobbly soils of southern *** is planted and monitored for growth performance and *** effect of land application of composted material on the SOM content and overall soil quality indices are being evaluated in this pilot study.

关键词： composting resource recovery management soil improvement waste disposal agricultural sustainability

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Upscaling human mesenchymal stromal cell production in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and cargo profile

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生物活性材料(英文) 2023年第7期25卷 732-747页

作者： Richard Jeske Chang Liu Leanne Duke Maria L.Canonicco Castro Laureana Muok peggy Arthur Mandip Singh Sunghoon Jung Li Sun Yan Li Department of Chemical and Biomedical Engineering FAMU-FSU College of EngineeringFlorida State UniversityTallahasseeFLUSA Department of Biomedical Sciences College of MedicineFlorida State UniversityTallahasseeFLUSA College of Pharmacy and Pharmaceutical Sciences Florida A&M UniversityTallahasseeFLUSA 阿

Human mesenchymal stromal cells(hMSCs)are mechanically sensitive undergoing phenotypic alterations when subjected to shear stress,cell aggregation,and substrate changes encountered in 3D dynamic bioreactor ***,little is known about how bioreactor microenvironment affects the secretion and cargo profiles of hMSC-derived extracellular vesicles(EVs)including the subset,“exosomes”,which contain therapeutic proteins,nucleic acids,and lipids from the parent *** this study,bone marrow-derived hMSCs were expanded on 3D Synthemax II microcarriers in the PBS mini 0.1L Vertical-Wheel bioreactor system under variable shear stress levels at 25,40,and 64 RPM(0.1-0.3 dyn/cm^(2)).The bioreactor system promotes EV secretion from hMSCs by 2.5-fold and upregulates the expression of EV biogenesis markers and glycolysis genes compared to the static 2D *** microRNA cargo was also altered in the EVs from bioreactor culture including the upregulation of miR-10,19a,19b,21,132,and *** protein cargo was characterized by proteomics analysis,showing upregulation of metabolic,autophagy and ROS-related proteins comparing with 2D cultured *** addition,the scalability of the Vertical-Wheel bioreactor system was demonstrated in a 0.5L bioreactor,showing similar or better hMSC-EV secretion and cargo content compared to the 0.1L *** study advances our understanding of bio-manufacturing of stem cell-derived EVs for applications in cell-free therapy towards treating neurological disorders such as ischemic stroke,Alzheimer’s disease,and multiple sclerosis.

关键词： Human mesenchymal stromal cells Extracellular vesicles Cargo profile 3D microcarriers Shear stress Vertical-Wheel bioreactor

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Need of integrated dietary therapy for persons with diabetes mellitus and “unhealthy” body constitution presentations

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Journal of Integrative Medicine 2016年第4期14卷 255-268页

作者： Yee Chi peggy Wong Dietetic Department Tuen Mun Hospital

From a perspective of Chinese medicine （CM）, persons with unregulated ＂unhealthy＂ body constitution （BC） will further develop chronic diseases, such as diabetes mellitus （DM）. Conventional dietary therapy with nutrition component has its limitations in the regulation of ＂unhealthy＂ BC. However, empirical evidence supports that ＂unhealthy＂ BC can be regulated with food natures and flavors from a perspective of CM. Presentations of ＂unhealthy＂ BC types, such as Yin-deficiency, Yang-deficiency and Yin-Yangdeficiency were found in persons with DM. It would be necessary to regulate the ＂unhealthy＂ BC presentations with integration of conventional dietary therapy and Chinese food therapy. The ultimate goal is to either stabilize glycaemic control or prevent the development of other chronic diseases leading to reduction of disease burden, such as disease-related poor quality of life, stress of healthcare professionals and the rising of healthcare cost.

关键词： body constitution diabetes mellitus Yin deficiency Yang deficiency dietary therapy

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