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Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility and Aging(SOMMA)

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Journal of Sport and Health Science 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Terri L.Blackwell peggy M.Cawthon Paul M.Coen Steven R.Cummings Giovanna Distefano Samaneh Farsijani Daniel E.Forman Bret H.Goodpaster Stephen B.Kritchevsky Theresa Mau Frederico G.S.Toledo Anne B.Newman Nancy W.Glynn Department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA Department of Medicine(Geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of Endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported PA or structured exercise ***,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(SB)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle ***:As part of the Study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOS))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn ActiGraph GT9X over 7 ***-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for Seniors(CHAMPS)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary *** a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle ***:Every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOS and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(p<0.05).Light activity was not associated with maxOXPHOS or ATP_(max).Meanwhile,every 30 min/day spent in ActiGraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOS and0.

关键词： Aging Exercise Mitochondria

Efficacy and tolerability of chitin-glucan combined with simethicone(GASTRAP^(■)DIRECT)in irritable bowel syndrome:A prospective,open-label,multicenter study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 10-22页

作者： Nathalie Talbodec Pauline Le Roy peggy Fournier Benoit Lesage Elodie Lepoutre François Castex Jean Michel Godchaux Lionel Vandeville Benjamin Bismuth Xavier Lesage Pauline Bayart Michael Genin Christel Rousseaux Veronique Maquet Salvatore Modica Pierre Desreumaux Caroline Valibouze Department of Gastroenterology Hôpital privéLe BoisLille 59000France Department of Gastroenterology Hôpital privéde Villeneuve d’AscqVilleneuve d’Ascq 59650France Univ.Lille CHU LilleULR 2694–METRICSÉvaluation des Technologies de Santéet des Pratiques MédicalesLille 59000France Development of Intestinal Biotech 1 Avenue Oscar LambretLille 59045France KitoZyme SA Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium BiOkuris A Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium Department of Hepato-Gastroenterology Lille University HospitalLille 59000France U1286-INFINITE Institute for Translational Research in InflammationUniv.LilleInsermCHU LilleLille 59000France Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel ***-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic ***^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of *** To evaluate the efficacy,tolerability,and safety of 4-week GASTRAP^(■)DIRECT treatment in patients with *** In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of GASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 *** primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)*** analysis was performed using the per-protocol *** symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were *** Overall,100 patients were *** W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,P<0.0001).Similar improvements were observed for bloating[8.0±1.7 vs 4.7±2.9,P<0.0001;60%(95%CI:50-70)responders],abdominal distension[7.2±2.1 vs 4.4±3.1,P<0.0001;53%(95%CI:43-63)responders],and impact of global symptoms on daily life[7.1±2.0 vs 4.6±2.9,P<0.0001;54%(95%CI:44-64)responders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by *** severe adverse event occurred,and tolerabil

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Flatulence Defecatory disorders Stool consistency Natural non-pharmacological treatment

développement vert dans la nourelle ère

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今日中国（法文版） 2022年第11期60卷 35-37页

作者： peggy CANTAVE FUYET I'lnstitut de recherche sur Ihistoire et la littérature du Parti communiste chinois.

Composting of Disposal Organic Wastes: Resource Recovery for Agricultural Sustainability

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过程工程学报 2006年第4期6卷 585-591页

作者： Mohammad H.Golabi peggy Denney Clancy Iyekar College of Natural and Applied Sciences University of Guam Mangilao Guam-USA

One of the major problems of agricultural soils in the tropical regions of the Pacific is the low organic matter *** of the hot and humid environment,the soil organic matter(SOM)is minimal due to rapid *** organic material is being applied on agricultural fields as an amendment to provide nutrients and enhance the organic matter content for improving the physical and chemical properties of the cultivated *** addition land application of composted material as a fertilizer source effectively disposes of wastes that otherwise are buried in *** our soil program at the University of guam,we are evaluating the use of organic material as an alternative to synthetic *** goal is to develop management strategies and use available resources for improving crop production while conserving resources and preserving environmental *** case study project is designed to improve soil fertility status by using composted organic wastes and assessing how the nitrogen and other essential nutrients contribute to long-term soil fertility and crop productivity without application of synthetic *** our pilot project,compost is produced from wood chips,grinded typhoon debris mixed with animal manure,fish feed,shredded paper and other organic *** compost is then applied on the field at the rates of 0,5,10 and 20 t/ha as a soil amendment on the eroded cobbly soils of southern *** is planted and monitored for growth performance and *** effect of land application of composted material on the SOM content and overall soil quality indices are being evaluated in this pilot study.

关键词： composting resource recovery management soil improvement waste disposal agricultural sustainability

Upscaling human mesenchymal stromal cell production in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and cargo profile

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生物活性材料(英文) 2023年第7期25卷 732-747页

作者： Richard Jeske Chang Liu Leanne Duke Maria L.Canonicco Castro Laureana Muok peggy Arthur Mandip Singh Sunghoon Jung Li Sun Yan Li Department of Chemical and Biomedical Engineering FAMU-FSU College of EngineeringFlorida State UniversityTallahasseeFLUSA Department of Biomedical Sciences College of MedicineFlorida State UniversityTallahasseeFLUSA College of Pharmacy and Pharmaceutical Sciences Florida A&M UniversityTallahasseeFLUSA 阿

Human mesenchymal stromal cells(hMSCs)are mechanically sensitive undergoing phenotypic alterations when subjected to shear stress,cell aggregation,and substrate changes encountered in 3D dynamic bioreactor ***,little is known about how bioreactor microenvironment affects the secretion and cargo profiles of hMSC-derived extracellular vesicles(EVs)including the subset,“exosomes”,which contain therapeutic proteins,nucleic acids,and lipids from the parent *** this study,bone marrow-derived hMSCs were expanded on 3D Synthemax II microcarriers in the PBS mini 0.1L Vertical-Wheel bioreactor system under variable shear stress levels at 25,40,and 64 RPM(0.1-0.3 dyn/cm^(2)).The bioreactor system promotes EV secretion from hMSCs by 2.5-fold and upregulates the expression of EV biogenesis markers and glycolysis genes compared to the static 2D *** microRNA cargo was also altered in the EVs from bioreactor culture including the upregulation of miR-10,19a,19b,21,132,and *** protein cargo was characterized by proteomics analysis,showing upregulation of metabolic,autophagy and ROS-related proteins comparing with 2D cultured *** addition,the scalability of the Vertical-Wheel bioreactor system was demonstrated in a 0.5L bioreactor,showing similar or better hMSC-EV secretion and cargo content compared to the 0.1L *** study advances our understanding of bio-manufacturing of stem cell-derived EVs for applications in cell-free therapy towards treating neurological disorders such as ischemic stroke,Alzheimer’s disease,and multiple sclerosis.

关键词： Human mesenchymal stromal cells Extracellular vesicles Cargo profile 3D microcarriers Shear stress Vertical-Wheel bioreactor

Need of integrated dietary therapy for persons with diabetes mellitus and “unhealthy” body constitution presentations

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Journal of Integrative Medicine 2016年第4期14卷 255-268页

作者： Yee Chi peggy Wong Dietetic Department Tuen Mun Hospital

From a perspective of Chinese medicine （CM）, persons with unregulated ＂unhealthy＂ body constitution （BC） will further develop chronic diseases, such as diabetes mellitus （DM）. Conventional dietary therapy with nutrition component has its limitations in the regulation of ＂unhealthy＂ BC. However, empirical evidence supports that ＂unhealthy＂ BC can be regulated with food natures and flavors from a perspective of CM. Presentations of ＂unhealthy＂ BC types, such as Yin-deficiency, Yang-deficiency and Yin-Yangdeficiency were found in persons with DM. It would be necessary to regulate the ＂unhealthy＂ BC presentations with integration of conventional dietary therapy and Chinese food therapy. The ultimate goal is to either stabilize glycaemic control or prevent the development of other chronic diseases leading to reduction of disease burden, such as disease-related poor quality of life, stress of healthcare professionals and the rising of healthcare cost.

关键词： body constitution diabetes mellitus Yin deficiency Yang deficiency dietary therapy

Potential Application of a Wine Extract in Skin Care: How to Benefit from the Antibacterial, Antioxidant and Elastase Inhibiting Properties

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第2期13卷 136-155页

作者： Lisa-Marie Sittek Thomas Michael Schmidts peggy Schlupp Novigo GmbH Grünberg Germany

Since plant polyphenols have many beneficial properties on health, the aim of this study was to evaluate the potential use of a phenolic wine extract, a by-product of wine production, for skin care on HaCaT cells. In these studies, a significant reduction of reactive oxygen species formation in HaCaT cells and severe elastase inhibition was observed. In contrast, the wine extract caused a major increase in lipase activity. The extract showed no influence on cell proliferation, but an immunomodulatory effect on the release of the interleukins IL-6 and IL-8 was found. The phenolic wine extract demonstrated a strong activity against gram-positive and gram-negative pathogens, yeasts, and fungi. Overall, our results show that the investigated phenolic wine extract is a promising ingredient for anti-aging skin care, could contribute to the improvement of skin appearance and health, and may positively affect cellulite.

关键词： Phenolic Wine Extract Skin Care HaCaT Cells Elastase Lipase IL-6 IL-8 Cell Proliferation Reactive Oxygen Species Antimicrobial Antimycotic

Vestibular migraine in low-and lower-middle-income countries:A scoping review

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Journal of Otology 2023年第3期18卷 173-184页

作者： Eric K.Kim Amina Seguya May Htoo Thaw peggy Tahir Eric J.Formeister Christopher J.Waterworth Ali F.Jaffer The Global Otolaryngology-Head and Neck Surgery Initiative USA Department of Otolaryngology-Head and Neck Surgery University of CaliforniaSan FranciscoSan FranciscoCAUSA Ear Nose and Throat SurgeonMulago National Referral HospitalKampalaUganda Eye ORL-HNS HospitalMandalayMyanmar UCSF Library University of CaliforniaSan FranciscoCAUSA Department of Otolaryngology-Head and Neck Surgery Duke UniversityDurhamNCUSA Department of Audiology and Speech Pathology The University of MelbourneVictoriaAustralia Nossal Institute for Global Health University of MelbourneVictoriaAustralia HearWell Audiology Clinic Dar es SalaamTanzania

Background:Vestibular migraine(VM)is a common cause of dizziness that is underrecognized,underdiagnosed,and challenging to effectively *** prevalence,appropriate diagnostic workup,and therapies for VM in low-and lower-middle-income countries(LLMICs)remain *** objective of this scoping review is to evaluate the current state of VM research in ***:PubMed,Embase,and Web of Science databases were searched to execute a scoping review of ***“vestibular diseases”and“vertigo”were used in combination with terms referring to LLMICs as defined by the World *** and abstract screening,full-text review,and data collection were conducted by two authors ***:Twenty-six studies were included in the scoping *** studies were cross-sectional(57.7%)or case studies/series(23.1%)and were conducted in urban settings only(92.3%).Geographic distribution of studies was skewed,with 65.4%of articles originating from *** prevalence of VM among clinic patients ranged from 0.3%to 33.3%.VM most frequently presented as headache,nausea and vomiting,and *** imaging,audiometry,and electronystagmography/videonystagmography were the three most commonly utilized diagnostic modalities in the dizziness *** most studied pharmacotherapies included calcium channel blockers,followed by beta-blockers and *** studies and series discussed less common VM pharmacotherapies,such as ayurvedic ***:There is a need for more VM research in LLMICs,including innovative diagnostic approaches and therapies that can improve VM care *** partnerships between LLMIC and highincome country researchers must expand vestibular research capacity and productivity in LLMICs.

关键词： Vestibular migraine Migraine Global Otolaryngology Scoping review

Therapeutic Route of Patients with Cirrhosis in Bangui

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Open Journal of Gastroenterology 2020年第4期10卷 88-96页

作者： Serges Magloire Camengo Police peggy gué rendo Georges Service Benoî t Elowa Gaé tan Adouaka Eveline Mofini Armelo Thibaut Yangba Kalebanga Nathalie Philomè ne Boua-Akelelo Bernard Bessanguem Joseph Rogevr Molowa Kobendo Department of Hepato-Gastroenterology and Internal Medicine of “Amitié Sino-Centrafraine” University Hospital Center Bangui Central African Republic Department Venerology Dermatology National University Hospital Center Bangui Central African Republic Department of Internal Medicine “Maman Elisabeth Domitien” University Hospital Center Bimbo Central African Republic

Introduction: Cirrhosis is the final stage in the development of any chronic liver disease. The objective of our study was to determine the therapeutic route of patients with cirrhosis. Patients and Methods: This was a one-year cross-sectional study of consenting patients of both sexes with cirrhosis who were hospitalized for the first time. The study took place from October 1, 2013 to September 30, 2014. The diagnosis of cirrhosis was based on clinical, biological and morphological arguments. Results: In total, 1028 patients were hospitalized, including 202 for cirrhosis (19.6%). One hundred and four patients (10.1%) met our inclusion criteria. These were 70 men (67.3%) and 34 women (32.7%). The sex ratio was 2.05. The average age was 43.74 ± 13.74 years. In 68 cases (65.4%), cirrhosis was considered a supernatural disease and in 36 cases (34.6%) was a natural disease. At the first signs, 88 patients (84.6%) had consulted (traditional healer in 34 cases, pastor in 25 cases, marabout in 16 cases and general practitioner in 13 cases). The pastor prayed to 25 patients (24%). The traditional healer made the patients ingest herbal preparations (n = 18), associated or not with scarification (n = 4) and/or enema (n = 28). The marabout recited Quranic verses written on a board, then washed and ingested in 16 cases (15.4%). The general practitioner prescribed treatment to the 13 patients (12.5%). The various treatments received had led to hepatic encephalopathy (21 cases), digestive hemorrhage (15 cases), abdominal pain (3 cases), jaundice (3 cases), increased abdominal bloating (21 cases). The patients had consulted the specialist within an average of 74 ± 15.3 days. The average time to hospital was 21 days ± 13. Conclusion: Cirrhosis is diagnosed at the complication stage due to inappropriate treatment by pastors, marabouts and the general practitioner. The population must be made aware of the early use of health care facilities.

关键词： Therapeutic Route Cirrhosis Bangui