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Perspectives on a collaborative Canada-China research program on diagnostic biomarkers for pre-dementia stages of Alzheimer’s disease

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Journal of Translational Neuroscience 2017年第3期2卷 1-6页

作者： Serge Gauthier Jianping Jia Sylvie Belleville Simon Cloutier Dessa Sadovnick Colleen Guimond Laura Robb Mario Masellis Guy A Rouleau Liyong Wu pedro Rosa-neto McGill Center for Studies in Aging Douglas Mental Health Research Institute Montreal H4H IR3 Canada Innovation Center for Neurological Disorders Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China Beijing Key Laboratory of Geriatric Cognitive Disorders Beijing 100053 China Clinical Center for Neurodegenerative Disease and Memory Impairment Capital Medical University Beijing 100053 China Center of Alzheimer's Disease Beijing Institute for Brain Disorders Beijing 100053 China Key Laboratory of Neurodegenerative Diseases Ministry of Education Beijing 100053 China National Clinical Research Center for Geriatric Disorders Beijing 100053 China Institut Universitaire de Gériatrie de Montréal Montréal H3W IW5 Canada Department of Medical Genetics University of British Columbia Vancouver V6T IZ4 Canada Division of Neurology Department of Medical Genetics University of British Columbia Vancouver V6T IZ4 Canada Division of Neurology/Department of Medicine Sunnybrook Health Sciences Centre University of Toronto Toronto M5S 3H7 Canada Hurvitz Brain Sciences Research Program Sunnybrook Research Institute Toronto M4N 3M5 Canada Montreal Neurological Institute Montréal H3A 2B4 Canada Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China

As biomarkers are important in the early diagnosis ofAlzheimer’s disease （AD）, the frst collab-orative work of recruiting early-onset familial AD （EO-FAD） families in Canada and China was initiated in 2012. The registration networks have collected hundreds of pedigrees, for which genetic screening, neuropsycholog-ical tests and amyloid and tau imaging was used to study diagnostic biomarkers for preclinical and mild cognitive impairment （MCI） stages of AD. Besides identifying ped-igrees with novel mutations in presenilins （PSENs）/amy-loid precursor protein （APP）, the program has benefted training of Chinese research fellows, AD clinical trials forprevention,the ethical concernsfor clinical fndings, and other collaborative projects with Chinese investiga-tors. Further research of the collaborative program may facilitate the testing and clinical use of novel treatments for EOFAD and late onset AD and contribute to dementia prevention strategies in Canada and China.

关键词： registration network early-onset fa-milial Alzheimer’s disease (EOFAD) mutation neuro-psychological testing

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Comparative Study of the Complications of Pedicular Screw Fixation Techniques in the Thoracolumbar Spine: A Systematic Review

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Open Journal of Orthopedics 2023年第8期13卷 343-353页

作者： Vanessa Cavazana Takata João Vitor Lois Balestrieri pedro Bastos neto Rodrigo Eduardo Souza Garcia Idiberto José Zotarelli Filho Luis Fernando Ricci Boer Fabiano Morais Nogueira FAMERP-Faculty of Medicine of Sã o José do Rio Preto Orthopedics and Traumatology at Hospital de Base S&atildeo José do Rio Preto S&atildeo Paulo Brazil ABRAN-Brazilian Association of Nutrology Catanduva Sao Paulo Brazil Clinical Research and Biostatistical Department College of Palliative Medicine of Sri Lanka Colombo Sri Lanka

Introduction: The use of pedicle screws increases postoperative stability and consolidation of arthrodesis. Pedicle arthrodesis is currently the standard treatment for the thoracolumbar spine, presenting the best fusion and stiffness rates, and among its main indications is the possibility of better correction of spine deformities in the thoracic and lumbar region. However, due to different definitions and the lack of a control group, many of these studies have limited comparative analysis, resulting in the scarcity of comparative studies with standardized methodology. Objective: It was to analyze, through a systematic review, the safety and efficacy of instrumentation with pedicle screws in the spine which have been questioned, despite its wide use for stabilization of the spine, comparing the complications present in the insertion techniques of pedicle screws. Methods: The rules of the Systematic Review-PRISMA were followed. The literary search process was carried out from January to March 2023. A bibliographic search was carried out in MEDLINE, PubMed, and Scielo for articles produced between 2001 and 2023. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. The Cohen test (Funnel Plot) and The Heterogeneity Test (Chi-Square Test – X2) were performed, with p Results and Conclusion: A total of 134 articles were found. A total of 67 articles were evaluated in full and 12 were selected to compose the results of this systematic review. According to the GRADE instrument, most studies (X2 = 90.2% > 50%) followed a controlled clinical study model and had a good methodological design, with p < 0.05. It was shown that poor positioning of pedicle screws is the most common cause of complications. The surgeon’s skills and the length and diameter of the pedicle screw can also affect the different modes of placement. Robotic computer assistance has the potential to reduce th

关键词： Pedicular Arthrodesis Complications Spinal Instrumentation

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Spacing between Soybean Rows

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American Journal of Plant Sciences 2018年第4期9卷 711-721页

作者： Luiz Claudio Garcia Ivo Frare Thiago Inagaki pedro Henrique Weirich neto Marcos Martins Maghnom Henrique Melo Leandro Nadolny Marcos Kruppa Rogenski Newton Seifert Filho Ezequiel Barbosa de Oliveira Department of Soil Science and Agricultural Engineering State University of Ponta Grossa Ponta Grossa Brazil

The soybean crop has great economical importance in Brazil and in the world. In order to make the crop production profitable, several factors must be considered. The objective of this study was to evaluate the impact of spacing between soybean crop rows (Glycine max). The experiment was installed in the Mutuca farm (Arapoti—PR, southern Brazil), in the crop seasons of 2012/2013 (four seeding seasons) and 2013/2014 (two seeding seasons), in a completely randomized blocks design. We used four treatments and six replicates. The treatments were the spacing between rows as follow: 0.25, 0.50, 0.75 and 1.00 m. The variables evaluated were: initial and final plant population, plant height, number of internodes, viable internodes, pods per plant, grains per pod, mass of thousand grains and crop productivity. We concluded that the reduction of the spacing between rows significantly increased, in most part of the crop seasons, the number of pods per plants and the crop productivity.

关键词： Productivity Components Glycine max No-Till System

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核医学中的机器学习:第二部分——神经网络与临床

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中华核医学与分子影像杂志 2021年第8期41卷 507-512页

作者：谢宗能(译) 颜建华(审校) 上海理工大学医疗器械与食品学院 200093 上海健康医学院、上海市分子影像学重点实验室 201318

第一部分概述了机器学习(ML)在核医学中的应用,第二部分重点介绍神经网络。该文先用一个例子说明神经网络是如何工作的,并讨论其潜在的应用。重点关注ML在图像重建、低剂量PET、疾病检测以及诊断和预后预测的最新进展。目前在核医学中... 详细信息

第一部分概述了机器学习(ML)在核医学中的应用,第二部分重点介绍神经网络。该文先用一个例子说明神经网络是如何工作的,并讨论其潜在的应用。重点关注ML在图像重建、低剂量PET、疾病检测以及诊断和预后预测的最新进展。目前在核医学中应用的ML算法呈现多样化,迫切需要对算法设计和结果指标解读进行规范,该文给出了一个规范清单以供业界参考和遵循。

关键词：机器学习核医学神经网络

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核医学中的机器学习:第一部分——引言

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中华核医学与分子影像杂志 2021年第8期41卷 501-506页

作者：陈文坤(译) 李雪娜李亚明(审校) 中国医科大学附属第一医院核医学科沈阳110001

该系列文章介绍了核医学背景下的机器学习(ML)。第一部分讨论了ML的历史,描述了常见的算法并举例说明ML何时可用于核医学。第二部分聚焦于ML在当下对核医学领域的贡献,讨论了未来对ML的预期和局限性,并对ML能做什么和不能做什么进行非... 详细信息

该系列文章介绍了核医学背景下的机器学习(ML)。第一部分讨论了ML的历史,描述了常见的算法并举例说明ML何时可用于核医学。第二部分聚焦于ML在当下对核医学领域的贡献,讨论了未来对ML的预期和局限性,并对ML能做什么和不能做什么进行非常严谨的评估。

关键词：机器学习人工智能核医学算法

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Altitude as environmental filtering influencing phylogenetic diversity and species richness of plants in tropical mountains

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Journal of Mountain Science 2023年第2期20卷 285-298页

作者： GALVÁN-CISNEROS Carlos M. VILLA pedro M. COELHO Alex J.P. CAMPOS Prímula V. MEIRA-neto João A.A. Laboratory of Ecology and Evolution of Plants Departamento de Biologia VegetalUniversidade Federal de ViçosaViçosaMG36570-900Brazil Botany Gradute Program Universidade Federal de ViçosaViçosaMG36570-900Brazil

Elucidating how multiple factors affect biodiversity and plant community assembly is a central issue in ecology,especially in vulnerable ecosystems such as tropical *** studies are more relevant in global warming scenarios that induce the upward displacement of plant species towards reduced habitats and hostile environments in tropical *** study aimed to analyze how altitude affects taxonomic and phylogenetic diversity in plant communities of tropical ***,we tested if(i)increased altitude works as an environmental filtering promoting decreased species richness,decreased phylogenetic diversity,and increased phylogenetic clustering in these tropical mountains;and if(ii)plant communities of high altitude in tropical mountains are also result of recent diversification with plant species recently split shortening phylogenetic distances between closest related *** tested effects of altitude on species richness and phylogenetic metrics using linear mixed-effects *** Haleakala presented 114 species,Mount Kilimanjaro presented 231 species and Mount Purace presented 280 *** found an environmental filtering effect with increasing altitude causing phylogenetic clustering,decreased phylogenetic diversity and decreased species *** decreasing phylogenetic distances between closest relatives are congruent with neo-endemics,suggesting recent plant diversification in high altitudes of tropical mountains,possibly driven by geographic isolation and environmental *** of global warming should be monitored in tropical mountains focusing on distribution shifts.

关键词： Tropical mountains Global warming Environmental filtering Phylogenetic ecology Assembly rules Conservation Mountaintop vegetation

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Automatic Detection of COVID-19 Infection Using Chest X-Ray Images Through Transfer Learning

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IEEE/CAA Journal of Automatica Sinica 2021年第1期8卷 239-248页

作者： Elene Firmeza Ohata Gabriel Maia Bezerra João Victor Souza das Chagas Aloísio Vieira Lira neto Adriano Bessa Albuquerque Victor Hugo Cde Albuquerque pedro pedrosa Rebouças Filho the Universidade Federal do Ceará FortalezaCE 60455-970and also with the Instituto Federal do CearáFortalezaCE 60040-215Brazil the Instituto Federal do Ceará FortalezaCE 60040-215Brazil the Universidade de Fortaleza FortalezaCE 60811-905Brazil

The new coronavirus(COVID-19),declared by the World Health Organization as a pandemic,has infected more than 1 million people and killed more than 50 *** infection caused by COVID-19 can develop into pneumonia,which can be detected by a chest X-ray exam and should be treated *** this work,we propose an automatic detection method for COVID-19 infection based on chest X-ray *** datasets constructed for this study are composed of194 X-ray images of patients diagnosed with coronavirus and 194 X-ray images of healthy *** few images of patients with COVID-19 are publicly available,we apply the concept of transfer learning for this *** use different architectures of convolutional neural networks(CNNs)trained on Image Net,and adapt them to behave as feature extractors for the X-ray ***,the CNNs are combined with consolidated machine learning methods,such as k-Nearest Neighbor,Bayes,Random Forest,multilayer perceptron(MLP),and support vector machine(SVM).The results show that,for one of the datasets,the extractor-classifier pair with the best performance is the Mobile Net architecture with the SVM classifier using a linear kernel,which achieves an accuracy and an F1-score of 98.5%.For the other dataset,the best pair is Dense Net201 with MLP,achieving an accuracy and an F1-score of 95.6%.Thus,the proposed approach demonstrates efficiency in detecting COVID-19 in X-ray images.

关键词： Convolutional neural networks(CNNs) COVID-19 transfer learning X-ray

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Ecophysiology and multivariate analysis for production of Tachigali vulgaris in Brazil:Influence of rainfall seasonality and fertilization

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Journal of Forestry Research 2023年第5期34卷 1289-1305页

作者： pedro Henrique Oliveira Simoes Candido Ferreira de Oliveira neto Manoel Tavares de Paula Dênmora Gomes de Araújo Rodrigo Silva do Vale Joao Olegário Pereira de Carvalho Universidade Federal de Mato Grosso Campus Universitario de SinopSinop 78550728Mato GrossoBrazil Universidade Federal Rural da Amazonia Campus BelemBelem 66077830ParaBrazil Universidade do Estado do Para Centro de Ciencias Naturais e TecnologiaBelem 66095015ParaBrazil Universidade Federal Rural da Amazonia Campus Capitao-PocoCapitao Poco 68650000ParaBrazil

Studies on fertilization management of species native to the Amazon for energy plantations contribute to the diversity of species use and reduce biological risk due to the excessive use of clones or hybrids of *** study evaluates the effect of precipitation seasonality and phosphorus and potassium fertilization on gas exchange in a Tachigali vulgaris *** levels of P(zero,65.2,130.4 kg ha^(-1))and three of K(zero,100.0,200.0 kg ha^(-1))were applied in a 3×3 factorial randomized block *** exchange measurements were conducted in April and November *** low rainfall,high irradiance period,photo synthetic rates were up to four times higher than in the high rainfall period,reaching 20.3μmol m^(-2)s^(-1)in the treatment with 130.4 g kg^(-1)of P and 100.0 g kg^(-1)of *** analysis and principal component analysis reduced the initial eight gas exchange variables to two and three principal components in periods of high and low rainfall,*** multivariate method used in this study readily identified variations in the variables as a function of rainfall,with high reliability in explaining the data set.

关键词： Photosynthesis rate Stomatal conductance Principal component analysis Factor analysis Tachigali vulgaris

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Sensor-based physical activity, sedentary time, and reported cell phone screen time: A hierarchy of correlates in youth

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Journal of Sport and Health Science 2021年第1期10卷 55-64页

作者： pedro B.Júdice João P.Magalhães Gil B.Rosa Duarte Henriques-neto Megan Hetherington-Rauth Luís B.Sardinha Exercise and Health Laboratory CIPERFaculty of Human KineticsUniversity of LisbonLisbon 1499-002Portugal Faculty of Physical Education and Sport Lusofona UniversityLisbon 1749-024Portugal

Background:Evidence on correlates relies on subjective metrics and fails to include correlates across all levels of the ecologic *** determined which correlates best predict sensor-based physical activity(PA),sedentary time(ST),and self-reported cell phone screen time(CST)in a large sample of youth,while considering a multiplicity of ***:Using sensor-based accelerometry,we assessed the PA and ST of 2179 youths.A χ^2 automatic interaction detection algorithm was used to hierarchize the correlates associated with too much ST(>50th percentile),insufficient moderate-to-vigorous PA(MVPA)(<60 min/day),and prolonged CST(≥2 h/day).Results:Among youth 10-14 years old,the correlates for being inactive consisted of being a girl,not having sport facilities in the neighborhood,and not perceiving the neighborhood as a safe place,whereas in the youth 15-18 years old,the correlate for being inactive was not performing sports(9.7%chance of being active).The correlates for predicting high ST in the younger group was not performing sports(55.8%chance for high ST),and in the older group,the correlates were not owning a pet,perceiving the neighborhood as safe,and having inactive parents(63.7%chance for high ST).In the younger group,the greatest chances of having high CST were among those who were in the last elementary school years,who were girls,and who did not have friends in the neighborhood(73.1%chance for high CST),whereas in the older group,the greatest chance for having high CST was among those who were girls and had a TV in the bedroom(74.3%chance for high CST).Conclusion:To counteract ST and boost MVPA among youths,a specific focus on girls,the promotion of sport participation and facilities,neighborhood safety,and involvement of family must be prioritized.

关键词： Adolescents Environment Objective Sedentary behavior Socioecologic model

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Plant growth and nutrient use efficiency of two native Fabaceae species for mineland revegetation in the eastern Amazon

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Journal of Forestry Research 2020年第6期31卷 2287-2293页

作者： Silvio J.Ramos Markus Gastauer Simone K.Mitre Cecı´lio F.Caldeira Joyce R.Silva Antonio E.Furtini neto Guilherme Oliveira pedro W.M.Souza Filho Jose´O.Siqueira Instituto Tecnolo´gico Vale Rua Boaventura da Silva955Belem 66055-090Brazil Departamento de Ciencia do Solo Universidade Federal de LavrasLavras 37200-000Brazil

The primary challenge of mineland revegetation is the establishment of species able to cope with low availability of nutrients,especially in steep slopes such as of mine *** evaluated plant growth response and nutrient use efficiency(NUE)of two promising native Fabaceae species(Dioclea apurensis—liana from metalliferous savannas;Bauhinia longipedicellata—tree from Amazon rainforest)from the Caraja´s Mineral Province,eastern *** were grown separately in 2-kg pots filled with mining *** were fertilized with nitrogen,phosphorus,potassium(NPK),lime,and *** results showed increments on growth of both species when nutrients were applied to the mining *** showed increases in leaf area,plant height,stem diameter,and shoot dry mass production when NPK or NPK?micronutrients were applied,while *** was responsive to application of NPK?lime or NPK?lime?***,*** showed higher NUE than ***,especially at the lowest doses of N,P and *** findings may indicate a substantial advantage of *** for mineland revegetation,as this species may require lower nutrient inputs,being,therefore,a more sustainable way to revegetate degraded areas.

关键词： Fertilizer application Mining soil Tropical forest Nutrient use efficiency

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