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Elevated nitric oxide and 3',5' cyclic guanosine monophosphate levels in patients with alcoholic cirrhosis

World Journal of Gastroenterology 2008年第2期14卷 236-242页

作者： Cíntia Siqueira Miguel Carneiro de Moura Ana Júlia pedro Paula Rocha Center of Gastroenterology Institute of Molecular Medicine School of Medicine University of Lisbon Portugal Department of Medicine Ⅱ University Hospital of Santa MariaLisbonPortugal

AIM: To evaluate whether serum levels of nitric oxide (NO ·) and plasma levels of cyclic guanosine monophosphate (cGMP) and total glutathione (GSH) are altered in patients with alcoholic cirrhosis and to examine their correlation with the severity of liver ***: Twenty-six patients with alcoholic liver cirrhosis were studied. Serum levels of NO · and plasma levels of cGMP and GSH were measured in 7 patients with compensated alcoholic cirrhosis (Child-Pugh A) and 19 patients with advanced cirrhosis (Child-Pugh B and C). The model for end-stage liver disease (MElD) score was evaluated. Sixteen healthy volunteers served as controls. liver enzymes and creatinine levels were also ***: NO · and cGMP levels were higher in patients with Child-Pugh B and C cirrhosis than in Child-Pugh A cirrhosis or controls (NO ·: 21.70 ± 8.07 vs 11.70 ± 2.74; 21.70 ± 8.07 vs 7.26 ± 2.47 μmol/l, respectively; P l/l, respectively; P l glutathione levels were lower in patients with Child-Pugh B and C cirrhosis than in patients with Child-Pugh A cirrhosis or controls (16.04 ± 6.06 vs 23.01 ± 4.38 or 16.04 ± 6.06 vs 66.57 ± 26.23 μmol/l, respectively; P lation between NO · and cGMP levels in all patients with alcoholic cirrhosis. A significant negative correlation between reduced glutathione/glutathione disulfide and the MElD score was found in all cirrhotic ***: Our results suggest a role for oxidative stress in alcoholic liver cirrhosis, which is more significant in decompensated patients with higher levels of NO ·and cGMP and lower GSH levels than in compensated and control patients. Altered mediator levels in decompensated patients may influence the hemodynamic changes in and progression of liver disease.

关键词： Oxidative stress Nitric oxide Alcoholic cirrhosis Fibrosis Model for end-stage liver disease

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Phosphorus fractions and sorption dynamics in the sediments of two Ca-SO4 water reservoirs in the central Argentine Andes

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International Journal of Sediment Research 2017年第3期32卷 442-451页

作者： José Gabriel león Fernando luis pedrozo pedro Félix Temporetti Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA)CCT Mendoza Departamento General de Irrigación Gobierno de Mendoza Espaa y Barcala Instituto de Investigaciones en Biodiversidad y Medio Ambiente (INIBIOMA) CONICET-Universidad Nacional del Comahue

Phosphorus（P） fractionation and sorption behavior were studied in the sediments of two calcium-sulfate(Ca-SO4: Ca2+170 mg l-1; SO42-400 mg l-1) water reservoirs in the southern central Argentine Andes-El Carrizal Reservoir（ECR）,which stratifies in summer and El Nihuil Reservoir（ENR）,which is vertically mixed throughout the year. Sediment size classes reflected the lithology of both basins and the reservoirs relative location: ECR（downstream from a valley adjacent to a mountain environment） had higher clay proportions while the sand fraction was more important in ENR（just next to a mountain environment）.In both reservoirs, the chemical composition revealed low alteration and calcium enrichment. Total P content was relatively high(1.1-1.6 mg P kg-1dry weight) as expected from the contribution of marine formations. P fractionation was dominated by Ca-P（ECR, 69% and ENR, 63%） followed by organic-P（23%）in summer-anoxic ECR and by iron/aluminum（Fe/Al）-P（27%） in oxic ENR. Batch experiments showed that sorption behavior in ECR had a typical langmuir isotherm plot while in ENR that model fitted only at low dissolved P values(l-1) and co-precipitation evidence was observed at higher P concentrations. It is proposed that lower Fe/Al-P content in anoxic（ECR） vs. oxic（ENR） sediments results from the P released from iron-bound phosphorus due to sulfate reduction-ferrous sulfide formation in an anoxic environment. This condition should enable ECR sediments to adsorb P into fresh oxidized iron,and ENR sediments to co-precipitate P with calcium due to Fe/Al-P saturation, as observed in batch experiments. This paper constitutes the first description of phosphorus content and dynamics in reservoir sediments in arid central western Argentina, where water sulfate concentrations are naturally high due to basin lithology.

关键词： Reservoir Internal load Phosphorus binding Calcareous watershed Southern Central Andes

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Identification of plant genes putatively involved in the perception of fungal ergosterol-squalene^∞

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Journal of Integrative Plant Biology 2020年第7期62卷 927-947页

作者： laura lindo Rosa E.Cardoza Alicia lorenzana pedro A.Casquero Santiago Gutiérrez Area of Microbiology University of LeónCampus of PonferradaPonferradaSpain University Group of Research in Engineering and Sustainable Agriculture University of LeónLeónSpain

Trichoderma biocontrol strains establish a complex network of interactions with plants,in which diverse fungal molecules are involved in the recognition of these fungi as nonpathogenic *** molecules act as microbial-associated molecular patterns that trigger plant *** studies have reported the im-portance of ergosterol produced by Trichoderma *** the ability of these fungi to induce plant growth and *** addition,squalene,a sterol biosynthetic inter-mediate,seems to play an important role in these ***,we analyzed the effect of different concentrations of ergosterol and squalene on tomato(Solanum lycopersicum)growth and on the transcription level of defense-and growth-related *** used an RNA-seq strategy to identify several tomato genesencoding predicted pattern recognition receptor proteins or WRKY transcription factors,both of which are puta-tively involved in the perception and response to ergo-sterol and ***,an analysis of Arabidopsis thaliana mutants lacking the genes homologous to these tomato candidates led to the identification of a WRKY40 transcription factor that negatively regulates salicylic acid-related genes and positively regulates ethylene-and jasmonate-related genes in the presence of ergosterol and squalene.

关键词： plant perception pattern

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Fluorescence quenching of tryptophan and tryptophanyl dipeptides in solution

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Journal of Biophysical Chemistry 2011年第3期2卷 316-321页

作者： Aaron P.Osysko pedro l.Muino Department of Chemistry Saint Francis UniversityLorettoUSA The Sherwin-Williams Company Paints&Coatings DivisionClevelandUSA

We report measurements of fluorescence quantum yields of tryptophan, tryptophanylaspartate and tryptophanylarginine in several solvents as well as in aqueous solutions over a wide range of pH. We aim to test a computational model developed by Callis and coworkers of fluorescence quantum yield, which postulates that quenching in tryptophan arises from energy loss due to an electron transfer from the aromatic system of tryptophan to one of the amides in the protein backbone. Since the electron transfer state is expected to be high in energy, normally this would not be a possible outcome, but because of its large dipole, such a state should be more accessible in polar solvents. In addition, conditions of low (high) pH, which result in a net positive (negative) charge for the terminal amine (carboxyl) should result in an increase (decrease) of electron transfer rates and low (high) quantum yields. The observed results confirm the predictions of the model.

关键词： Tryptophan Fluorescence Quenching Electron Transfer

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Debaryomyces hansenii supplementation in low fish meal diets promotes growth,modulates microbiota and enhances intestinal condition in juvenile marine fish

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Journal of Animal Science and Biotechnology 2024年第1期15卷 253-276页

作者： Ignasi Sanahuja Alberto Ruiz Joana P.Firmino Felipe E.Reyes-lópez Juan B.Ortiz-Delgado Eva Vallejos-Vidal lluis Tort Dariel Tovar-Ramírez Isabel M.Cerezo Miguel A.Moriñigo Carmen Sarasquete Enric Gisbert Aquaculture Program Institute of Agrifood Research and Technology(IRTA)La Rapita 43540Spain Centro de Biotecnologia Acuicola Universidad de Santiago de ChileSantiagoChile Instituto de Ciencias Marinas de Andalucia(ICMAN-CSIC) Avda.Republica Saharaui no 2Campus Universitario Rio San PedroPuerto RealCadiz 11510Spain Nucleo de Investigaciones Aplicadas en Ciencias Veterinarias y Agronomicas Facultad de Medicina Veterinaria y AgronomiaUniversidad de Las AmericasSantiagoChile Department of Cell Biology Physiologyand ImmunologyUniversitat Autonoma de BarcelonaBarcelonaSpain Centro de Investigaciones Biologicas del Noroeste SC CIBNORLa PazMexico Department of Microbiology Instituto de Biotecnologia Y Desarrollo Azul(IBYDA)Faculty of SciencesUniversity of Malaga29010 MalagaSpain SCBI Bioinformatic UnitUniversity of Malaga29590 MalagaSpain

Background The development of a sustainable business model with social acceptance,makes necessary to develop new strategies to guarantee the growth,health,and well-being of farmed *** hansenii is a yeast species that can be used as a probiotic in aquaculture due to its capacity to i)promote cell proliferation and differen-tiation,ii)have immunostimulatory effects,iii)modulate gut microbiota,and/or iv)enhance the digestive *** provide inside into the effects of *** on juveniles of gilthead seabream(Sparus aurata)condition,we inte-grated the evaluation of the main key performance indicators coupled with the integrative analysis of the intestine condition,through histological and microbiota state,and its transcriptomic *** After 70 days of a nutritional trial in which a diet with low levels of fishmeal(7%)was supplemented with 1.1%of ***(17.2×10^(5) CFU),an increase of ca.12%in somatic growth was observed together with an improve-ment in feed conversion in fish fed a yeast-supplemented *** terms of intestinal condition,this probiotic modu-lated gut microbiota without affecting the intestine cell organization,whereas an increase in the staining intensity of mucins rich in carboxylated and weakly sulphated glycoconjugates coupled with changes in the affinity for certain lectins were noted in goblet *** in microbiota were characterized by the reduction in abundance of several groups of Proteobacteria,especially those characterized as opportunistic *** microarrays-based transcrip-tomic analysis found 232 differential expressed genes in the anterior-mid intestine of ***,that were mostly related to metabolic,antioxidant,immune,and symbiotic *** Dietary administration of *** enhanced somatic growth and improved feed efficiency param-eters,results that were coupled to an improvement of intestinal condition as histochemical and transcriptomic tools *** probiotic ye

关键词： Debaryomyces hansenii Intestine condition low fish meal diet Microbiota Transcriptomics Yeast probiotic

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Internet of things:Conceptual network structure,main challenges and future directions

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Digital Communications and Networks 2023年第3期9卷 677-687页

作者： leonardo B.Furstenau Yan Pablo Reckziegel Rodrigues Michele Kremer Sott pedro leivas Michael S.Dohan José Ricardo lópez-Robles Manuel J.Cobo Nicola luigi Bragazzi Kim-Kwang Raymond Choo Department of Industrial Engineering Federal University of Rio Grande do SulPorto Alegre 90035-190Brazil University of Santa Cruz do Sul Av.Independencia2293Santa Cruz do SulRSBrazil Business School Unisinos UniversityAv.Dr.Nilo Peçanha 160091330-002Porto AlegreBrazil lakehead University Thunder BayONP7B 5E1Canada Academic Unit of Accounting and Management Autonomous University of ZacatecasCalle Comercio y Administracion S/NFracc.ProgresoC.P.98066ZacatecasZacatecasMexico Department of Computer Science and Artificial Intelligence University of Granada18071 GranadaSpain York University ONM3J 1P3Canada Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Internet of Things(IoT)is a key technology trend that supports our digitalized society in applications such as smart countries and smart *** this study,we investigate the existing strategic themes,thematic evolution structure,key challenges,and potential research opportunities associated with the *** this study,we conduct a Bibliometric Performance and Network Analysis(BPNA),supplemented by an exhaustive Systematic literature Review(SlR).Specifically,in BPNA,the software SciMAT is used to analyze 14,385 documents and 30,381 keywords in the Web of Science(WoS)database,which was released between 2002 and *** results reveal that 31 clusters are classified according to their importance and development,and the conceptual structures of key clusters are presented,along with their performance analysis and the relationship with other *** thematic evolution structure describes the important cluster(s)over *** the SlR,23 documents are *** SlR reveals key challenges and limitations associated with the *** expect the results will form the basis of future research and guide decision-making in the IoT and other supporting industries.

关键词： Internet of things Strategic intelligence Industry 4.0 SciMAT Bibliometric analysis Science mapping

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High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease

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World Journal of Gastroenterology 2010年第36期16卷 4558-4563页

作者： Juan l Mendoza Amparo San-pedro Esther Culebras Raquel Cíes Carlos Taxonera Raquel lana Elena Urcelay Fernando de la Torre Juan J Picazo Manuel Díaz-Rubio Department of Gastroenterology Hospital Clinico San Carlos28040 MadridSpain Department of Clinical Microbiology Hospital Clinico San Carlos28040 MadridSpain Department of Internal Medicine Hospital Clinico San Carlos28040 MadridSpain Department of Immunology Hospital Clinico San Carlos28040 MadridSpain

AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [Crohn's disease(CD) and ulcerative colitis(UC)].METHODS:Thirty patients with CD(15 with at least one NOD2/CARD15 mutation),29 with UC,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood ***:MAP DNA was detected in all original blood samples and 8-wk blood cultures(CD,UC and non-IBD).Positive MAP DNA status was confirmed by dot blot *** 69 cultures were negative by acid-fast Ziehl-Neelsen *** MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 CD patients,one UC patient,and none of the non-IBD *** association was found between positive MAP cultures and use of immunosuppressive drugs or CDassociated single nucleotide ***:MAP is widely present in our area and MAP DNA can be recovered from the blood of CD,UC and non-IBD ***,MAP spheroplasts were only found in CD patients.

关键词： Mycobacterium avium subspecies paratuberculosis Crohn’s disease Ulcerative colitis Inflammatory bowel disease Polymerase chain reaction Genetic susceptibility

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Recombinant streptokinase vs phenylephrine-based suppositories in acute hemorrhoids, randomized, controlled trial(THERESA-3)

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World Journal of Gastroenterology 2014年第6期20卷 1594-1601页

作者： Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-lvarez Roselin Valle-Cabrera Ana Aguilera-Barreto pedro A lópez-Saura Center for Genetic Engineering and Biotechnology "Juan B. Zayas" Hospital National Center for the Coordination of Clinical Trials

AIM: To compare the efficacy and safety of recombinant streptokinase (rSK) and phenylephrine-based suppositories in acute hemorrhoidal disease.

关键词： Streptokinase Suppository Phenylephrine Thrombolysis Hemorrhoids Randomized clinical trial

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SET-VAlUED EXTENSION OF OPERATORS VIA STEINER SElECTIONS (Ⅰ)-THEORETICAl RESUlTS

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Applied Mathematics and Mechanics(English Edition) 2002年第5期23卷 568-579页

作者： Tern, pedro, l  pez_Dían, Miguel (Facultad de Ciencias, Universidad de Oviedo, C/Calvo Sotelo, s/n 33007 Oviedo Spain) (Communicated by ZHANG Shi_sheng) Facultad de Ciencias Universidad de Oviedo C/Calvo Sotelo Oviedo Spain

A way to extend operators in spaces of continuous functions to spaces of continuous set_valued functions is proposed. This extension is developed through the Steiner selections of the set_valued functions. Their properties and characteristics of the convergence of sequences of operators of this class are studied. In Part Ⅱ of this series some applications to approximation theory will be shown.

关键词： set_valued extension steiner selection operator

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Global Optimization of Nonlinear Blend-Scheduling Problems

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Engineering 2017年第2期3卷 188-201页

作者： pedro A.Castillo Castillo pedro M.Castro Vladimir Mahalec Department of Chemical Engineering McMaster UniversityHamiltonON L8S 4L8Canada Center for Mathematics Fundamental Applications and Operations ResearchFaculty of SciencesUniversity of LisbonLisbon 1749-016Portugal

The scheduling of gasoline-blending operations is an important problem in the oil refining industry. Thisproblem not only exhibits the combinatorial nature that is intrinsic to scheduling problems, but alsonon-convex nonlinear behavior, due to the blending of various materials with different quality *** this work, a global optimization algorithm is proposed to solve a previously published continuous-timemixed-integer nonlinear scheduling model for gasoline blending. The model includes blend recipe optimi-zation, the distribution problem, and several important operational features and constraints. The algorithmemploys piecewise McCormick relaxation （PMCR） and normalized multiparametric disaggregation tech-nique （NMDT） to compute estimates of the global optimum. These techniques partition the domain of oneof the variables in a bilinear term and generate convex relaxations for each partition. By increasing the num-ber of partitions and reducing the domain of the variables, the algorithm is able to refine the estimates ofthe global solution. The algorithm is compared to two commercial global solvers and two heuristic methodsby solving four examples from the literature. Results show that the proposed global optimization algorithmperforms on par with commercial solvers but is not as fast as heuristic approaches.

关键词： Global optimization Nonlinear gasoline blending Continuous-time scheduling model Piecewise linear relaxations

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