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m6A-TSHub:Unveiling the Context-specific m^(6)A Methylation and m^(6)A-affecting Mutations in 23 Human Tissues

Genomics, Proteomics & Bioinformatics 2023年第4期21卷 678-694页

作者： Bowen Song Daiyun Huang Yuxin Zhang Zhen Wei Jionglong Su João pedro de Magalhães Daniel J.Rigden Jia Meng Kunqi Chen Key laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhou 350004China Department of Mathematical Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Institute of Systems Molecular and Integrative BiologyUniversity of LiverpoolLiverpool L697ZBUnited Kingdom Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Department of Computer Science University of LiverpoolLiverpool L697ZBUnited Kingdom Institute of Ageing&Chronic Disease University of LiverpoolLiverpool L697ZBUnited Kingdom School of AI and Advanced Computing Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China AI University Research Centre Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs(lncRNAs),N6-methyladenosine(m^(6)A)RNA methylation has been shown to participate in essential biological *** studies have revealed the distinct patterns of m^(6)A methylome across human tissues,and a major challenge remains in elucidating the tissue-specific presence and circuitry of m^(6)A *** present here a comprehensive online platform,m^(6)A-TSHub,for unveiling the context-specific m^(6)A methylation and genetic mutations that potentially regulate m^(6)A epigenetic mark.m^(6)A-TSHub consists of four core components,including(1)m^(6)A-TSDB,a comprehensive database of 184,554 functionally annotated m^(6)A sites derived from 23 human tissues and 499,369 m^(6)A sites from 25 tumor conditions,respectively;(2)m^(6)A-TSFinder,a web server for high-accuracy prediction of m^(6)A methylation sites within a specific tissue from RNA sequences,which was constructed using multi-instance deep neural networks with gated attention;(3)m^(6)ATSVar,a web server for assessing the impact of genetic variants on tissue-specific m^(6)A RNA modifications;and(4)m^(6)A-CAVar,a database of 587,983 The Cancer Genome Atlas(TCGA)cancer mutations(derived from 27 cancer types)that were predicted to affect m^(6)A modifications in the primary tissue of *** database should make a useful resource for studying the m^(6)A methylome and the genetic factors of epitranscriptome disturbance in a specific tissue(or cancer type).m^(6)A-TSHub is accessible at ***/biologicalsciences/m^(6)ats.

关键词： N^(6)-methyladenosine Context-specific analysis Cancer mutation Genome analysis Functional annotation

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liver bioengineering:Current status and future perspectives

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World Journal of Gastroenterology 2012年第47期18卷 6926-6934页

作者： Christopher Booth Tom Soker pedro Baptista Christina l Ross Shay Soker Umar Farooq Robert J Stratta Giuseppe Orlando Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineWinston-SalemNC 27101United States Department of General Surgery Section of TransplantationWake Forest University School of MedicineWinston-SalemNC 27101United States

The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical *** are two general pathways to liver bioengineering and *** first consists of creating a supporting scaffold,either synthetically or by decellularization of human or animal organs,and seeding cells on the scaffold,where they will mature either in bioreactors or in *** strategy seems to offer the quickest route to clinical translation,as demonstrated by the development of liver organoids from rodent livers which were repopulated with organ specific cells of animal and/or human *** bioengineering has potential for transplantation and for toxicity testing during preclinical drug *** second possibility is to induce liver regeneration of dead or resected tissue by manipulating cell *** fact,it is well known that the liver has peculiar regenerative potential which allows hepatocyte hyperplasia after amputation of liver *** of autologous bone marrow cells,which aids in liver regeneration,into patients was shown to be safe and to improve their clinical condition,but the specific cells responsible for liver regeneration have not yet been determined and the underlying mechanisms remain largely unknown.A complete understanding of the cell pathways and dynamics and of the functioning of liver stem cell niche is necessary for the clinical translation of regenerative medicine *** well,it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix,and how this latter supports and drives cell fate.

关键词：肝脏再生生物工程种子细胞器官特异性动物肝脏生物反应器细胞外基质人类起源

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Evaluation of Candidate Predictors for Seasonal Precipitation Forecasting

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Atmospheric and Climate Sciences 2023年第4期13卷 539-564页

作者： pedro M. González-Jardines Maibys Sierra-lorenzo Adrián l. Ferrer-Hernández Arnoldo Bezanilla-Morlot Center for Atmospheric Physics Institute of Meteorology Havana Cuba

This research proposes to carry out a principal component analysis using the maximum covariance method, with the aim of finding the most robust spatio-temporal relationships between several candidate predictors and the accumulated monthly precipitation recorded in Cuba during the period 1980-2020. This process will make it possible to establish quantitative relationships that, together with theoretical considerations, make it possible to reduce the list of predictors to be used for the purpose of obtaining seasonal predictions. The values of the predictors are represented through monthly averages obtained from ERA5 reanalysis, while monthly accumulated precipitation data were obtained from a national-scope grid with 4 km of spatial resolution, used as predictand. The results obtained reflect the highest spatio-temporal correlation values with the first variability mode in all cases, indicating that the usual regime conditions are predominant and have a greater coupling with the precipitation variability in the analyzed temporal scale. In addition, they suggest that the candidates that explain the transport of moisture at low levels, as well as the gradients between the middle and lower troposphere, show the most robust associations. In the same way, the surface temperature of tropical Atlantic Sea, the flow related to Quasi-Biennial Oscillation and the thermodynamic indices, K Index and Galvez-Davison Index, present good degrees of association, for which reason they can be considered the most recommendable for carrying out forecasting experiments.

关键词： Principal Component Maximun Covariance Predictors ERA5

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同位素微量试验法检测新化合物抗恶性疟原虫活性试验

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中国寄生虫学与寄生虫病杂志 2009年第1期27卷 83-86页

作者：陈兆国 Alicia MORENO Agustin benito Marta MORENO pedro J.BERZOSA Aida de lUCIO Eva MOYANO 中国农业科学院上海兽医研究所农业部动物寄生虫学重点开放实验室上海200232 西班牙卡洛斯三世健康研究院国家微生物中心马德里28220

将连续培养的恶性疟原虫克隆系Dd2和3D7用6%山梨醇作2次同步处理。处理后第2代原虫用健康人红细胞稀释至红细胞比容为2.5%、原虫血症为0.5%,并加入2μCi/ml8-3H-次黄嘌呤,利用同位素微量试验法检测20个新化合物的抗疟原虫活性。结果显... 详细信息

将连续培养的恶性疟原虫克隆系Dd2和3D7用6%山梨醇作2次同步处理。处理后第2代原虫用健康人红细胞稀释至红细胞比容为2.5%、原虫血症为0.5%,并加入2μCi/ml8-3H-次黄嘌呤,利用同位素微量试验法检测20个新化合物的抗疟原虫活性。结果显示20个新化合物均无明显的抗疟原虫活性;对照药物氯喹和奎宁显示出良好的抗疟活性,表明同位素微量试验法是一个稳定、可靠的体外筛选新抗疟药的方法。

关键词：恶性疟原虫抗疟药同位素微量试验法

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Gold Supported on Metal Oxides for Carbon Monoxide Oxidation

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Nano Research 2011年第2期4卷 180-193页

作者： Sonia A. C. Carabineiro Nina Bogdanchikova Miguel Avalos-Borja Alexey Pestryakov pedro B. Tavares Jose l. Figueiredo laboratário de Catálise e Materiais Associate Laboratory LSRE/LCM Departamento de Engenharia Química Faculdade de Engenharia Universidade do Porto 4200-465 Porto Portugal Universidad Nacional Autónoma de México Centro de Nanociencias y Nanotecnologia Carretera Tijuana-Ensenada 22800 Ensenada Baja California México Tomsk Polytechnic University 30 Lenin Avenue Tomsk 634050 Russia Universidade de Trás-os-Montes e Alto Douro Centro de Quimica-Vila Real Departamento de Química 5001-911 Vila Real Portugal

Au 被装载了(1% wt ) 在不同广告上，氧化物支持(CuO， la2O3， Y2O3， NiO ) 由三个不同方法：两倍受精(暗淡) ，液体阶段减少的免职(lPRD ) ，和 ultrasonication (美国) 。样品被 N2 吸附描述在 ? 196 ??  ??????  ??  ? 洠... 详细信息

Au 被装载了(1% wt ) 在不同广告上，氧化物支持(CuO， la2O3， Y2O3， NiO ) 由三个不同方法：两倍受精(暗淡) ，液体阶段减少的免职(lPRD ) ，和 ultrasonication (美国) 。样品被 N2 吸附描述在 ? 196 ??  ??????  ??  ? 洠浡業汬牡 ?  ???? 猠'T 業牣吗？

关键词：金属氧化物一氧化碳氧化黄金 Au纳米粒子 X射线荧光光谱仪透射电子显微镜选区电子衍射程序升温还原

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SACI Protocol: Preliminary Guidelines for the Development of Digital Health Technologies for Clinical Trials in Brazil

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E-Health Telecommunication Systems and Networks 2022年第3期11卷 85-100页

作者： lídia Maria lourençön Rodrigues Agia Jorge luiz Dias Agia Rui pedro Charters lopes Rijo Valdes Roberto Bollela Domingos Alves Department of Social Medicine Ribeir&#227 o Preto Medical School University of S&#227 o Paulo Ribeir&#227 o Preto Brazil Postgraduate Program in Production Engineering UNIP S&#227 o Paulo Brazil Polytechnic Institute of leiria Leiria Portugal Department of Internal Medicine Ribeir&#227 o Preto Medical School University of S&#227 o Paulo Ribeir&#227 o Preto Brazil

In the last decade, evidence-based medical practice has been supported on a large scale by computerized decision support tools, aiming to reduce diagnostic and therapeutic uncertainty, complementing the actions of the health professional. With technological developments, it is now possible to consider these systems as part of clinical intervention, both for the diagnosis and treatment of diseases. The literature has described the implementation of e-health tools, that is, technological innovations in the health area such as software, applications, serious games, among others, as a strategy to improve the process and adherence to treatment. However, there is still no standardized instrument in Brazil that can be used to guide the development, from the research phase, and the implementation of these tools as a health intervention, also impacting patient outcomes. With the objective of investigating a new therapeutic and preventive form, based on intervention with a computerized system, this work proposes the creation of guidelines for the registration and implementation of e-health tools as a clinical intervention. The proposal aims to be able to assist in the reporting standardization from the development stage to the application of the e-health tool helping in the treatment of diseases, registering all the experience lived in the research and applying it in different contexts of health.

关键词： Reporting Guidelines Clinical Trials Digital Health E-Health

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Minimizing sperm oxidative stress using nanotechnology for breeding programs in rams

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2395-2410页

作者： Alejandro Jurado‑Campos pedro Javier Soria‑Meneses Maria Arenas‑Moreira Carlos Alonso‑Moreno Virginia Rodriguez‑Robledo Ana Josefa Soler Jose Julian Garde Maria del Rocio Fernandez‑Santos SaBio IREC(CSIC-UClM-JCCM) Campus UniversitarioS/N02071 AlbaceteSpain. Departamento de Quimica Inorganica Organica Y Bioquimica‑Centro de Innovacion en Quimica Avanzada(ORFEO‑CINQA)Facultad de FarmaciaUniversidad de Castilla-La Mancha02008 AlbaceteSpain. Centro Regional de Investigacion Biomedicas Unidad nanoDrugUniversidad de Castilla-La Mancha02008 AlbaceteSpain. Facultad de Farmacia Universidad de Castilla La Mancha02071 AlbaceteSpain.

Background Artificial insemination(AI)is a routine breeding technology in animal ***,the temperature-sensitive nature and short fertile lifespan of ram sperm samples hamper its use in *** this sense,nanotechnology is an interesting tool to improve sperm protection due to the development of nanomaterials for AI,which could be used as delivery *** this work,we explored the feasibility of vitamin E nanoemulsion(NE)for improving sperm quality during *** With the aim of evaluating this proposal,ejaculates of 7 mature rams of Manchega breed were collected by artificial vagina and extended to 60×10^(6)spz/ml in *** containing control and NE(12 mmol/l)with and without exogenous oxidative stress(100μmol/l Fe2+/ascorbate)were stored at 22 and 15℃and motility(CASA),viability(YO-PRO/PI),acrosomal integrity(PNA-FITC/PI),mitochondrial membrane potential(Mitotracker Deep Red 633),lipoperoxidation(C11 BODIPY 581/591),intracellular reactive oxygen species(ROS)production and DNA status(SCSAR)monitored during 96 *** results show that NE could be used to maintain ram spermatozoa during transport at 15 and 22℃for up to 96 h,with no appreciable loss of kinematic and physiological characteristics of freshly collected *** The storage of ram spermatozoa in liquid form for 2-5 d with vitamin E nanoemulsions may lead more flexibility to breeders in AI *** view of the potential and high versatility of these nanodevices,further studies are being carried out to assess the proposed sperm preservation medium on fertility after artificial insemination.

关键词： Breeding technology Nanoemulsions Nanotechnology Sperm oxidative stress Vitamin E

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Quantifying relationships between rooting traits and water uptake under drought in Mediterranean barley and durum wheat

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Journal of Integrative Plant Biology 2014年第5期56卷 455-469页

作者： pedro Carvalho Sayed Azam-Ali M.John Foulkes Division of Plant and Crop Sciences University of Nottingham Sutton Bonington Campus The University of Nottingham Malaysia Campus Jalan Broga Semenyih Selangor Darul

In Mediterranean regions drought is the major factor limiting spring barley and durum wheat grain yields. This study aimed to compare spring barley and durum wheat root and shoot responses to drought and quantify relationships between root traits and water uptake under terminal *** spring barley（Hordeum vulgare l. cv. Rum） and two durum wheat Mediterranean cultivars（Triticum turgidum l. var durum cvs Hourani and Karim） were examined in soil‐column experiments under well watered and drought conditions. Root system architecture traits, water uptake, and plant growth were measured. Barley aerial biomass and grain yields were higher than for durum wheat cultivars in well watered conditions. Drought decreased grain yield more for barley（47%） than durum wheat（30%, Hourani）. Root‐to‐shoot dry matter ratio increased for durum wheat under drought but not for barley, and root weight increased for wheat in response todrought but decreased for barley. The critical root length density（RlD） and root volume density（RVD） for 90% available water capture for wheat were similar to（cv. Hourani） or lower than（cv. Karim） for barley depending on wheat cultivar. For both species, RVD accounted for a slightly higher proportion of phenotypic variation in water uptake under drought than RlD.

关键词： Barley Mediterranean root architecture root length density root traits root volume density water wheat

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Potential of video games for the promotion of neuroadaptation to multifocal intraocular lenses: a narrative review

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1782-1787页

作者： Maria Begona Coco-Martin pedro lValenzuela Miguel JMaldonado-lópez Alejandro Santos-lozano Ainhoa Molina-Martin David P Pinero Research Unit Hospital Clínico Universitario de Valladolid.ICSCYLValladolid 47003Spain Grupo de Cirugía Refractivay Rehabilitación Visual.Instituto Universitario de Oftalmobiología Aplicada(IOBA) Universidad de ValladolidValladolid 47011Spain Physiology Unit Systems Biology DepartmentUniversity of AlcaláMadrid 28801Spain Grupo de Investigación i+Health Departamento de Ciencias de la SaludUniversidad Europea Miguel de CervantesValladolid 47012Spain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain Department of Ophthalmology(IMQO-Oftalmar) Vithas Medimar International HospitalAlicante 03016Spain

Multifocal intraocular lenses(IOls) are currently usually implanted for the treatment of cataracts because they have been proved to be superior to monofocal IOls with respect to spectacle independence. In turn, they are associated with a higher prevalence of dysphotopsia symptoms that is one of the most common causes of patient dissatisfaction. Neuroadaptation seems to play a major role in the optimal adaptation to multifocal IOls. In this context, the development of strategies that facilitate the neuroadaptation process to multifocality might be an effective strategy to reduce patients' dissatisfaction. Video games have been proved to be effective for the improvement of visual acuity and for the promotion of neuroplasticity in elderly subjects and other populations with cortical-related visual impairment. This narrative review highlights the physiological potential of video games as a perceptual strategy to improve visual acuity and promote neuroplasticity in patients using multifocalIOls, although research is still needed to confirm these benefits in this specific population, with only one comparative study to this date providing evidence of them.

关键词： multifocal intraocular lens dysphotopsia photic phenomena halos video games neuroadaptation neuroplasticity

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What can a heavy U(1)B-l Z'boson do to the muon(g-2)u anomaly and to a new Higgs boson mass?

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Chinese Physics C 2021年第1期45卷 32-46页

作者： Antonio P.Morais Roman Pasechnik J.pedro Rodrigues Departamenlo de Fisica da Universidade de Aveiro and CIDMA Campus de Santiago 3810-183 AveiroPortugal Department of Astronomy and Theoretical Physics Lund UniversitySE 223-62 LundSweden Nuclear Physics Institute ASCR 25068 RezCzech Republic Departamento de Fisica CFMUniversidade Federal de Santa CatarinaC.P.476CEP 88.040-900FlorianopolisSCBrazil

The minimal U(1)B_l extension of the Standard Model(B-l-SM)offers an explanation for neutrino mass generatio n via a seesaw mechanism;it also offers two new physics states,namely an extra Higgs bos on and a new Z'gauge *** emerge nee of a second Higgs particle as well as a new Z'gauge boson,both lin ked to the breaking of a local U(1)B_l symmetry,makes the B-l-SM rather constrained by direct searches in large Hadron Collider(lHC)*** investigate the phenomenological status of the B-l-SM by confr on ting the new physics predictions with the lHC and electroweak precision *** into account the current bounds from direct lHC searches,we demonstrate that the prediction for the muon(g-2)u anomaly in the B-l-SM yields at most a contribution of approximately 8.9×10^-12,which represents a tension of 3.28 standard deviations,with the current 1σuncertainty,by means of a Z'boson if its mass is in the range of 6.3 to 6.5 TeV,within the reach of future lHC *** means that the B-l-SM,with heavy yet allowed Z‘bos on mass range,in practice,does not resolve the tension between the observed anomaly in the muon(g-2)u and the theoretical prediction in the Standard *** a heavy Z'boson also implies that the minimal value for the new Higgs mass is of the order of 400 GeV.

关键词： beyond Standard Model Higgs physics gauge extensions of the Standard Model Z'boson

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