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Areas with evidence of equity and their progress on mortality from tuberculosis in an endemic municipality of southeast Brazil

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Infectious Diseases of Poverty 2017年第1期6卷 1185-1195页

作者： Mellina YAMAMURA Marcelino SANTOS NETO Francisco CHIARAVALLOTI NETO Luiz henrique ARROYO Antonio Carlos Vieira RAMOS Ana Angelica Rego de QUEIROZ Aylana de souza BELCHIOR Danielle Talita dos SANTOS Juliane de Almeida CRISPIM Ione Carvalho PINTO Severina Alice da Costa UCHOA Regina Celia FIORATI Ricardo Alexandre ARCENCIO School of Nursing of the University of Sao Paulo Ribeirao Preto Campus(EERP/USP)Ribeirao retoSPBrazil Federal University of Maranhao(UFMA) Sao LuísMABrazil School of Public Health of the University of Sao Paulo(FSP/USP) Sao PauloSPBrazil Federal University of Rio Grande do Norte(UFRN) NatalRNBrazil School of Medicine of the University of Sao Paulo Ribeirao Preto Campus(FMRP/USP)Ribeirao PretoSPBrazil

Background:In Brazil,people still fall ill and die from tuberculosis(TB),and this can be explained by the significant impasse in the equity of distribution of therapeutic resources to the population as a *** aim was to identify geographical areas which have shown progress in terms of equity(of income,schooling and urban occupancy)and test its effect on mortality from TB in a municipality of southeast ***:It is an ecological study considering TB as the basic cause for deaths registered between 2006 and 2013 on the Mortality Information System and other variables obtained through the demographic Census of the Brazilian Institute of Geography and Statistics(2010).The geographical area for analysis comprised the areas of coverage of the health *** indicators have been constructed through the Principal Component Analysis(PCA).The cases were geocoded and the annual mortality rate from TB was calculated with smoothing using the local empirical Bayesian *** linear regression was then *** was confirmation of the existence of spatial dependence of residue through the application of the Global Moran I test,and application of the Models with Global Spatial Effects,to identify the best standard of spatial ***:The mortality rates ranged from 0.00 to 2.8 deaths per 100,000 people,per *** the PCA,three indicators were constructed,and designated as indicators of income,social inequality,and social *** multiple linear regression,the indicator of social equity was statistically significant(Pdependence(Moran I=0.21,P=0.003455).The best model to deal with existing spatial dependence was the Spatial Lag ***:The better social conditions have shown progress in reducing mortality from TB,thereby reinforcing the achievement of Sustainable development *** addition,cartography was also applied,which can be replicated

关键词： Tuberculosis Spatial analysis Mortality Cause of death

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Numerical Study of the Influence of Elements inside the Wheelhouse on the Passenger Vehicle Aerodynamic

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Open Journal of Fluid Dynamics 2015年第2期5卷 199-207页

作者： Edvaldo Angelo Gabriel Angelo pedro henrique Di Giovanni Santos delvonei Alves de Andrade Grupo de Simulaç o Numérica (GSN) Universidade Presbiteriana Mackenzie S&#227 o Paulo Brazil department of Mechanical Engineering Centro Universitário da Funda&#231 o Educacional Inaciana Padre Sabóia de Medeiros (FEI) S&#227 o Bernardo do Campo Brazil Instituto de Pesquisas Energéticas e Nucleares IPEN CNEN/SP Universidade de S&#227 o Paulo S&#227 o Paulo Brazil

Models for the study of computational fluid dynamics in vehicles to determine aerodynamic loads usually take into account only the geometry of the body. Several constructive elements such as the wheel geometry or suspension components are disregarded in the computational models. This work presents the study of the aerodynamics of a one-fourth model passenger vehicle, which contains the wheelhouse interior elements. The goal is to identify the aerodynamic loads produced by these components and their effect on the flow dynamics. Wheel and tire set, brake components, suspension and drive shaft are contemplated. Computer simulations were performed to the vehicle speed varying from 0 to 120 km/h and included the rotation of the tire and wheel assembly, considering the tire geometry in dynamic conditions. The computational model is solved by the finite volume method, wherein the computational domain is divided into tetrahedral and hexahedral elements. The turbulence model used is the standard k −ε.

关键词： Computational Fluid Dynamics Wheelhouse Aerodynamics Vehicle Aerodynamics

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Rheumatoid arthritis: Nuclear medicine state-of-the-art imaging

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World Journal of Orthopedics 2014年第3期5卷 312-318页

作者： Paulo henrique Rosado-de-Castro Sergio Augusto Lopes de souza Dangelo Alexandre Lea Mirian barbosa da Fonseca Bianca Gutfilen departamento de Radiologia Hospital Universitário Clementino Fraga FilhoUniversidade Federal do Rio de JaneiroRio de Janeiro 21941-913Brazil Instituto Nacional de Traumatologia e Ortopedia Rio de Janeiro 20940-070Brazil

Rheumatoid arthritis(RA)is an autoimmune disease,which is associated with systemic and chronic inflammation of the joints,resulting in synovitis and pannus *** several decades,the assessment of RA has been limited to conventional radiography,assisting in the diagnosis and monitoring of ***,conventional radiography has poor sensitivity in the detection of the inflammatory process that happens in the initial stages of *** the past years,new drugs that significantly decrease the progression of RA have allowed a more efficient *** Medicine provides functional assessment of physiological processes and therefore has significant potential for timely diagnosis and adequate follow-up of *** single photon emission computed tomography(SPECT)and positron emission tomography(PET)radiopharmaceuti-cals have been developed and applied in this *** use of hybrid imaging,which permits computed tomography(CT)and nuclear medicine data to be acquired and fused,has increased even more the diagnostic accuracy of Nuclear Medicine by providing anatomical localization in SPECT/CT and PET/CT *** recently,fusion of PET with magnetic resonance imaging(PET/MRI)was introduced in some centers and demonstrated great *** this article,we will review studies that have been published using Nuclear Medicine for RA and examine key topics in the area.

关键词： Rheumatoid arthritis Nuclear medicine Scintigraphy Single photon emission computed tomography Positron emission tomography

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The Use of the Stream Length-Gradient Index in Morphotectonic Analysis of Drainage Basins in Poços de Caldas Plateau, SE Brazil

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International Journal of Geosciences 2014年第11期5卷 1383-1394页

作者： Carolina Doranti-Tiritan Peter Christian Hackspacher Daniel henrique de souza Marli Carina Siqueira-Ribeiro Instituto de Geociências e Ciências Exatas UNESP Rio Claro Brazil

The Pocos de Caldas Plateau is formed by the alkaline intrusion of Pocos de Caldas and surrounding metamorphic basement. It is characterized as a remnant of the South American Planation Surface resulted from erosional events from Late Cretaceous-Paleogene transition. Pocos de Caldas Alkaline Massif (PCAM) was formed during alkaline volcanism event from the Late Cretaceous. It is located on the west side of the Mantiqueira Mountain Range, characterized by alkaline rocks and topography reaches over 1700 m high. A major feature of denudation is the development of the “circular drainage”, a particular feature of some caldera and other circular or concentric structural features. Recent tectonic movements may critically affect regional geomorphology by influencing river patterns and orientations. The morphometric analysis shows that some rivers are controlled by reactivated faults, however, in some regions the lithology has major influence in the rivers development.

关键词： Component Formatting Style Styling Insert

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Economic Feasibility of Canola Production in the Region of Campos Gerais, Paraná, Brazil

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American Journal of Plant Sciences 2018年第5期9卷 958-965页

作者： Eriton Luiz Mainardes Luiz Cláudio Garcia pedro henrique Weirich Neto Carlos Hugo Rocha Thiago Inagaki Natali Maidl de souza Guilherme pedrollo Mazer Jaime Alberti Gomes Ivan Cesar Furmann Moura éverson pedro Zeny State University of Ponta Grossa Campus Uvaranas Ponta Grossa Brasil

This study aimed to analyze the economic feasibility of canola production (Brassica napus var oleifera) for the region Campos Gerais-PR. We interviewed eight producers, and used information from four of them for economic analysis of agricultural crops in 2012, 2013 and 2014. The variables analyzed were: grain production cost, economical analysis (hurdle rate, net present value, internal rate of return, payback, lucratively index, profitability index and sensitivity analysis) and vegetable oil production costs. We compared the performance of canola, wheat (Triticum aestivum)—as the main crop in the autumn/winter—and soybean (Glycine max)—by liquidity in the world market. It was concluded that although the economic analysis indicates superior results of canola production compared to the wheat crop and vegetable oil production is more attractive financially than soybean, but the culture of canola is still insignificant in the region of Campos Gerais (PR). The producers interviewed pointed to limit the expansion of culture financing the limited farming, production technology in consolidation, the need for machine adjustments and canola be host of the white mold disease (Sclerotinia sclerotiorun).

关键词： Brassica napus Production Systems Profitability

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LC-ESI-IT-MS/MS and MALDI-TOF Approach:Identification of Natural Polymers from Rhizophora mangle Barks and determination of Their Analgesic and Anti-inflammatory Properties

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Natural Products and Bioprospecting 2019年第1期9卷 23-34页

作者： Leonardo Mendes de souza Mesquita Caroline Fabri Bittencourt Rodrigues Claudia Quintino da Rocha Mayara Silveira Bianchim Clenilson Martins Rodrigues Vanda Maria de Oliveira henrique Hessel Gaeta Mariana Novo Belchor Marcos Hikari Toyama Wagner Vilegas Laboratory of Bioprospection of Natural Products(LBPN) UNESP-Sao Paulo State University/Coastal Campus of Sao VicentePc¸a Infante Dom Henrique S/NSao VicenteSao Paulo CEP:11330-900Brazil Laborato´rio de Estudos Avanc¸ados em Fitomedicamentos(LEAF) UFMA-Federal University of MaranhaoAv.dos Portugueses1966-BacangaSao Luı´sMaranhao CEP:65080-805Brazil Embrapa Agroenergy Brazilian Agricultural Research CorporationW3 NortePqEBBrası´liaDF 70770-901Brazil

We recognize the chemical composition of the acetonic extract of Rhizophora mangle barks(AERM)using mass spectrometry analysis[liquid chromatography(LC)–ESI–IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS(MALDI-TOF)].Analgesic activity was evaluated by formalin and tail-flick experimental ***-inflammatory activity was performed by paw edema test induced by carrageenan and 48/80 *** first series of experiments involved[LC]–FIA–IT-MS/MS with 11 separated catechins derivatives until degree of polymerization 3(DP3).The spectra obtained by MALDI-TOF analysis of the AERM presented two homologous series:one based on polymers of m/z 288 Da increments(up to DP12)and another series based on polymers of m/z[288?162]Da increments(up to DP11).In addition to these series of flavan-3-ol,each DP had a subset of masses with a variation of-16 Da(homologous series of afzelechins-m/z 873–3465 Da)and +16 Da(homologous series of gallocatechins-m/z 905–3497 Da).A similar pattern with homologous series of gallocatechins and afzelechins could also be observed for a fifth and a sixth monohexoside series:glucogallocatechins(m/z 779–3371)and glucoafzelechins(m/z 747–3339).The intraperitoneal administration of different doses of AERM(50,150 and 300 lg mL^(-1))have a morphine-like effect and intense anti-inflammatory activity.

关键词： Catechins Tannins Morphine-likeeffect Anti-inflammatory Mangroves

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Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis

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World Journal of Gastroenterology 2023年第22期29卷 3440-3468页

作者： henrique Inhauser Riceti Magalhães Felipe Alexandre Machado Roberta Figueiroa souza Marcos Antônio Ferreira Caetano Vanessa Ribeiro Figliuolo Robson Coutinho-Silva Patricia Castelucci department of Surgery School of Veterinary Medicine and Animal SciencesUniversity of São PauloSão Paulo 05508-270Brazil department of Anatomy University of São PauloSão Paulo 05508-000Brazil Biophysics Institute Carlos Chagas Filho Federal University of Rio de JaneiroRio de Janeiro 21941-902Brazil

BACKGROUND The literature indicates that the enteric nervous system is affected in inflammatory bowel diseases(IBDs)and that the P2X7 receptor triggers neuronal ***,the mechanism by which enteric neurons are lost in IBDs is *** To study the role of the caspase-3 and nuclear factor kappa B(NF-κB)pathways in myenteric neurons in a P2X7 receptor knockout(KO)mouse model of *** Forty male wild-type(WT)C57BL/6 and P2X7 receptor KO mice were euthanized 24 h or 4 d after colitis induction by 2,4,6-trinitrobenzene sulfonic acid(colitis group).Mice in the sham groups were injected with *** mice were divided into eight groups(n=5):The WT sham 24 h and 4 d groups,the WT colitis 24 h and 4 d groups,the KO sham 24 h and 4 d groups,and the KO colitis 24 h and 4 d *** disease activity index(DAI)was analyzed,the distal colon was collected for immunohistochemistry analyses,and immunofluorescence was performed to identify neurons immunoreactive(ir)for calretinin,P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,and total NF-κ*** analyzed the number of calretinin-ir and P2X7 receptor-ir neurons per ganglion,the neuronal profile area(μm^(2)),and corrected total cell fluorescence(CTCF).RESULTS Cells double labeled for calretinin and P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,or total NF-κB were observed in the WT colitis 24 h and 4 d *** number of calretinin-ir neurons per ganglion was decreased in the WT colitis 24 h and 4 d groups compared to the WT sham 24 h and 4 d groups,respectively(2.10±0.13 vs 3.33±0.17,Pdecreased in the WT colitis 4 d group compared to the WT sham 4 d group(104.63±2.49 vs 117.41±1.14,P<0.01).The number of

关键词： Cell death Enteric nervous system Gastroenterology Inflammatory bowel diseases P2X7 receptor Purinergic signaling

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Study on Strategies for Methane Injection in a DISI （Direct Injection Spark Ignition） Engine

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Journal of Energy and Power Engineering 2014年第2期8卷 298-305页

作者： Fernanda P. Martins Francisco J. de souza pedro T. Lacava Claudia Regina de Andrade Aeronautical Technology Institute S6o Jos dos Campos SP12228-900 Brazil Federal University of Uberlfindia UFU Uberlfindia SP38408-100 Brazil

This paper deals with the application of two different injection strategies in a natural gas direct injection spark ignition single-cylinder engine model. The analysis includes the air flow characterization during compression stroke and also the charge stratification. Two different swirl ratios are applied and piston bowl effects are analyzed during the gas jet deflection towards the spark plug. Achieving wall-guided effect, consequently, the charge stratification in spark plug region is obtained. The goal is to study the mixture formation differences for a single and a bi pulsed CNG （compressed natural gas） injection profiles and check the evolution of the methane concentration at the spark plug at the start of combustion.

关键词： DISI (direct injection spark ignition) methane injection profile.

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Efflux Estimate of Greenhouse Effect Gases in Three Different Forest Formations and the Influence of Soil

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Journal of Environmental Science and Engineering(A) 2014年第6期3卷 305-311页

作者： Victor Satiro de Medeiros Marcos Gervasio Pereira Joao henrique Gaia Gomes David Rodrigues da Silva Maia Claudinei de souza Guimaraes department of Biochemical Engineering School of Chemistry Rio de Janeiro Federal University Rio de Janeiro 21949-900Brazil department of Soils Institute of Agronomy Rio de Janeiro Federal Rural University Rio de Janeiro 21930-330 Brazil

In carbon global cycle, the relationship between the terrestrial ecosystem and the atmosphere where there are, among others, gases that contribute to the greenhouse effect, has become object of relevant scientific interest. The content of organic matter in soil, expressed by its supplies as well as the organic matter degree of stability, are factors that can prevent the soil from acting as a drain and at the same time contribute for it to become a source of those gases. The variations in the way land is used in Brazil are factors responsible for the increase in emission of greenhouse effect gases. Based on these facts, this study was aimed to evaluate the CO2 and CH4 efflux using a gas retention chamber, and to associate these emissions to the organic carbon content in the soil. Two different areas were selected for the study, one in Tijuca Forest National Park, in a forest area, and the other at the Rio de Janeiro Federal Rural University campus. In the latter, the area was stratified in three sub areas according to the vegetation, use and water saturation degree. Samplings were performed during 8 months between 2013 and 2014.

关键词： Effiux estimate of greenhouse effect gases influence of soil and climate carbon global cycle.

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Can epigenetic and inflammatory biomarkers identify clinically aggressive prostate cancer?

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World Journal of Clinical Oncology 2020年第2期11卷 43-52页

作者： pedro Bargao Santos Hitendra Patel Rui henrique Ana Felix department of Urology Prof.Doutor Fernando Fonseca HospitalAmadora 2720-276Portugal department of Urology University Hospital North NorwayTromsø9019Norway department of Urology St George’s University HospitalsTootingLondon SW170QTUnited Kingdom departments of Pathology and Cancer Biology and Epigenetics Group-Research Center Portuguese Oncology Institute of PortoPorto 4200-072Portugal department of Pathology and Molecular Immunology Institute of Biomedical Sciences Abel SalazarUniversity of PortoPorto 4099-002Portugal department of Pathology Portuguese Oncology Institute of LisbonLisbon 1099-023Portugal department of Pathology NOVA Medical SchoolLisbon 1169-056Portugal

Prostate cancer(PCa)is a highly prevalent malignancy and constitutes a major cause of cancer-related morbidity and *** emerges through the acquisition of genetic and epigenetic *** modifications include DNA methylation,histone modifications and micro RNA *** generate heritable transformations in the expression of genes but do not change the DNA *** in DNA methylation(hypo and hypermethylation)are the most characterized in *** lead to genomic instability and inadequate gene *** and minor-specific modifications in chromatin recasting are involved in PCa,with signs suggesting a dysfunction of enzymes modified by *** RNA deregulation also contributes to the initiation of PCa,including involvement in androgen receptor signalization and *** influence of inflammation on prostate tumor carcinogenesis is currently much better *** discoveries about microbial species resident in the urinary tract suggest that these are the initiators of chronic inflammation,promoting prostate inflammatory atrophy and eventually leading to *** characterization of the relationship between the urinary microbiome and prostatic chronic inflammation will be crucial to develop plans for the prevention of *** prevalent nature of epigenetic and inflammatory alterations may provide potential biomarkers for PCa diagnosis,treatment decisions,evaluation of prognosis and posttreatment surveillance.

关键词： Prostate cancer Epigenetics DNA methylation Histone modifications Micro RNAs Inflammation Initiation and progression Prognosis

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