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Tips and tricks for cannabinoid receptor 1 detection, interaction and interpretation

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Neural Regeneration Research 2021年第8期16卷 1535-1536页

作者： pedro F.Esteban Eduardo Molina-Holgado Laboratory of Neuroinflammation Hospital Nacional de Parapléjicos(SESCAM)ToledoSpain

Proteomic approaches are currently used to explore and identify interacting partners of proteins involved in diverse biological processes or with therapeutic *** cannabinoid receptor 1,cB_1,is the main mediator of cannabinoids effects in the central nervous *** role of the endocannabinoid system in development and physiology and as a target of pharmacological and cellular therapies is the subject of intense ***。

关键词： potential. interaction intense

Dual regulation of SnRK2 signaling by Raf-like MAPKKKs

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Molecular Plant 2022年第8期15卷 1260-1262页

作者： Gaston A.Pizzio pedro L.Rodriguez Institutode Biologia Molecular y celularde Plantas Consejo Superior de Investigaciones Cientificas-Universidad Politecnica de Valencia46022 ValenciaSpain

Plants must adapt to unfavorable growth conditions such as drought,salinity,or extreme temperature and,in addition,need the flexibility to resume growth when conditions become *** of extracellular environmental stress and signal transduction rely on pathways that in many cases use phosphorylation of target proteins to amplify and transmit the extracellular signal.

关键词： SnRK2 extracellular resume

Quantifying relationships between rooting traits and water uptake under drought in Mediterranean barley and durum wheat

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Journal of Integrative Plant Biology 2014年第5期56卷 455-469页

作者： pedro carvalho Sayed Azam-Ali M.John Foulkes Division of Plant and crop Sciences University of Nottingham Sutton Bonington Campus The University of Nottingham Malaysia Campus Jalan Broga Semenyih Selangor Darul

In Mediterranean regions drought is the major factor limiting spring barley and durum wheat grain yields. This study aimed to compare spring barley and durum wheat root and shoot responses to drought and quantify relationships between root traits and water uptake under terminal *** spring barley（Hordeum vulgare L. cv. Rum） and two durum wheat Mediterranean cultivars（Triticum turgidum L. var durum cvs Hourani and Karim） were examined in soil‐column experiments under well watered and drought conditions. Root system architecture traits, water uptake, and plant growth were measured. Barley aerial biomass and grain yields were higher than for durum wheat cultivars in well watered conditions. Drought decreased grain yield more for barley（47%） than durum wheat（30%, Hourani）. Root‐to‐shoot dry matter ratio increased for durum wheat under drought but not for barley, and root weight increased for wheat in response todrought but decreased for barley. The critical root length density（RLD） and root volume density（RVD） for 90% available water capture for wheat were similar to（cv. Hourani） or lower than（cv. Karim） for barley depending on wheat cultivar. For both species, RVD accounted for a slightly higher proportion of phenotypic variation in water uptake under drought than RLD.

关键词： Barley Mediterranean root architecture root length density root traits root volume density water wheat

contemporaneous assembly of Western Gondwana and final Rodinia break-up:Implications for the supercontinent cycle

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Geoscience Frontiers 2017年第6期8卷 1431-1445页

作者： Sebastián Oriolo pedro Oyhantcabal Klaus Wemmer Siegfried Siegesmund Geoscience center Georg-August-Universitat GottingenGoldschmidtstrae 337077 GottingenGermany Departamento de Geología Facultad de CienciasUniversidad de la RepúblicaMontevideoUruguay

Geological,geochronological and isotopic data are integrated in order to present a revised model for the Neoproterozoic evolution of Western *** the classical geodynamic scenario assumed for the period 800-700 Ma is related to Rodinia break-up and the consequent opening of major oceanic basins,a significantly different tectonic evolution can be inferred for most Western Gondwana *** cratons occupied a marginal position in the southern hemisphere with respect to Rodinia and recorded subduction with back-arc extension,island arc development and limited formation of oceanic crust in internal *** period was thus characterized by increased crustal growth in Western Gondwana,resulting from addition of juvenile continental crust along convergent *** contrast,crustal reworking and metacratonization were dominant during the subsequent assembly of *** Rio de la Plata,congo-Sao Francisco,West African and Amazonian cratons collided at ca.630-600 Ma along the West Gondwana *** events overlap in time with the onset of the opening of the Iapetus Ocean at ca.610-600 Ma,which gave rise to the separation of Baltica,Laurentia and Amazonia and resulted from the final Rodinia *** East African/Antarctic Orogen recorded the subsequent amalgamation of Western and Eastern Gondwana after ca.580 Ma,contemporaneously with the beginning of subduction in the Terra Australis Orogen along the southern Gondwana ***,the Kalahari craton was lately incorporated during the Late Ediacaran-Early *** proposed Gondwana evolution rules out the existence of Pannotia,as the final Gondwana amalgamation postdates latest connections between Laurentia and ***,a combination of introversion and extroversion is proposed for the assembly of *** contemporaneous record of final Rodinia break-up and Gondwana assembly has major implications for the supercontinent cycle,as supercontinent amalgamation and break-

关键词： Brasiliano-Pan-African Orogeny Neoproterozoic collisional tectonics Pannotia Metacratonization Introversion-extroversion

Parameter control of Genetic Algorithms by Learning and Simulation of Bayesian Networks——A case Study for the Optimal Ordering of Tables

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Journal of computer Science & Technology 2013年第4期28卷 720-731页

作者： concha Bielza Juan A. Fernndez del Pozo pedro Larranaga computational Intelligence Group Department of Artificial IntelligenceTechnical University of Madrid

Parameter setting for evolutionary algorithms is still an important issue in evolutionary computation. There are two main approaches to parameter setting： parameter tuning and parameter control. In this paper, we introduce self-adaptive parameter control of a genetic algorithm based on Bayesian network learning and simulation. The nodes of this Bayesian network are genetic algorithm parameters to be controlled. Its structure captures probabilistie conditional （in）dependence relationships between the parameters. They are learned from the best individuals, i.e., the best configurations of the genetic algorithm. Individuals are evaluated by running the genetic algorithm for the respective parameter configuration. Since all these runs are time-consuming tasks, each genetic algorithm uses a small-sized population and is stopped before convergence. In this way promising individuals should not be lost. Experiments with an optimal search problem for simultaneous row and column orderings yield the same optima as state-of-the-art methods but with a sharp reduction in computational time. Moreover, our approach can cope with as yet unsolved high-dimensional problems.

关键词： genetic algorithm estimation of distribution algorithm parameter control parameter setting Bayesian network

Molecular characterization of an extensively drug-resistant Acinetobacter baumannii isolated from a corn culture soil

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Pedosphere 2021年第6期31卷 973-976页

作者： Joao pedro Rueda FURLAN Eliana Guedes STEHLING Departamento de Analises clinicas Toxicologicas e BromatologicasFaculdade de CienciasFarmaceuticas de Ribeirao PretoUniversidade de Sao Paulo(USP)Ribeirao Preto SP 14040-903(Brazil)

Dear Editor,Soil is the most biodiverse habitat on Earth and it has been estimated that one gram of soil can contain up to one billion bacterial cells(Fierer,2017).The microorganisms of soil produce a wide variety of ... 详细信息

关键词： soil corn culture

Targeting epidermal growth factor receptor signaling to facilitate cortical injury repair?

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Neural Regeneration Research 2024年第5期19卷 935-936页

作者： Ricardo Gómez-Oliva pedro Nunez-Abades carmen castro Área de Fisiología Facultad de Medicina Universidad de CádizCadizSpain Instituto de Investigación e Innovación en Biomedicina de cádiz CadizSpain Departamento de Fisiología Facultad de FarmaciaUniversidad de SevillaSevilleSpain

The existence of neural stem cells(NSc)in specific areas of the adult mammalian brain leads to the generation of new neurons involved in homeostatic *** is the case of the NSc of the subventricular zone(SVZ)that produces olfactory bulb(OB)*** neurons integrate into circuits to modulate sensory information and participate in olfactory processing(Bragado Alonso et al.,2019).A series of hierarchical events need to take place to produce OB neurons from NSc of the ***,the activation of quiescent NSc is necessary to produce intermediate transit amplifying progenitors(TAP),which will generate *** latter are cells that maintain a proliferative phenotype while in an immature ***,once they initiate migration toward the OB,they progressively undergo their differentiation into neurons(Kjell et al.,2020).

关键词： ventricular maintain

Heme as an inducer of cerebral damage in hemorrhagic stroke:potential therapeutic implications

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Neural Regeneration Research 2022年第9期17卷 1961-1962页

作者： Luiz Ricardo da costa Vasconcellos pedro Moreno Pimentel-coelho cellular Signalling and cytoskeletal Function Laboratory The Francis Crick InstituteLondonUK Instituto de Biofísica carlos chagas Filho Universidade Federal do Rio de JaneiroInstituto Nacional de Ciência e Tecnologia em Medicina RegenerativaRio de JaneiroRJBrazil

Intracerebral hemorrhage(IcH)consists of the rupture of a cerebral artery leading to bleeding into the surrounding *** event has a primary phase of brain injury consisting of mechanical tissue damage due to the mass effect,followed by a secondary phase of brain injury triggered by the presence of blood components released at the site of bleeding(Bulters et al.,2018).Despite the high rates of mortality and morbidity from IcH,no effective treatment is available so far.

关键词： cerebral damage rupture

Forecasting and trading cryptocurrencies with machine learning under changing market conditions

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Financial Innovation 2021年第1期7卷 61-90页

作者： Helder Sebastiao pedro Godinho Univ coimbra CeBERFaculty of EconomicsAv.Dr.Dias da Silva1653004‑512 CoimbraPortugal

This study examines the predictability of three major cryptocurrencies—bitcoin,ethereum,and litecoin—and the profitability of trading strategies devised upon machine learning techniques(e.g.,linear models,random forests,and support vector machines).The models are validated in a period characterized by unprecedented turmoil and tested in a period of bear markets,allowing the assessment of whether the predictions are good even when the market direction changes between the validation and test *** classification and regression methods use attributes from trading and network activity for the period from August 15,2015 to March 03,2019,with the test sample beginning on April 13,*** the test period,five out of 18 individual models have success rates of less than 50%.The trading strategies are built on model *** ensemble assuming that five models produce identical signals(Ensemble 5)achieves the best performance for ethereum and litecoin,with annualized Sharpe ratios of 80.17%and 91.35%and annualized returns(after proportional round-trip trading costs of 0.5%)of 9.62%and 5.73%,*** positive results support the claim that machine learning provides robust techniques for exploring the predictability of cryptocurrencies and for devising profitable trading strategies in these markets,even under adverse market conditions.

关键词： Bitcoin Ethereum Litecoin Machine learning Forecasting Trading