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Functions of nuclear factor Y in nervous system development,function and health

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Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： pedro Moreira Roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

Brain scarring in infants:immunological insights from a neonatal hypoxic-ischemic encephalopathy model

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Neural Regeneration Research 2025年第10期20卷 2909-2910页

作者： pedro Moreno Pimentel-Coelho Carlos Chagas Filho Biophysics Institute Federal University of Rio de JaneiroRio de JaneiroBrazil

Neonatal hypoxic-ischemic encephalopathy(HIE)is a significant cause of disability in *** brain function and accelerating neurological recovery may require a combination of neuroprotective and pro-regenerative treatments at different stages of *** the first hours after the neonatal insult are the most critical period for neuroprotection,the existence of secondary and tertiary mechanisms of brain injury offers the possibility of preventing delayed neurodegeneration in the subsequent days,weeks,or months(Levison et al.,2022).

关键词： neonatal protective hypoxic

Application of data science in the prediction of solar energy for the Amazon basin:a study case

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Clean Energy 2023年第6期7卷 1344-1355页

作者： AndréLuis Ferreira Marques Márcio JoséTeixeira Felipe valencia de Almeida pedro Luiz Pizzigatti Corrêa Polytechnic School of the University of Sao Paulo Av.Prof.Luciano Gualberto380-ButantaSao Paulo-SP05508-010Brazil Institute of Physics of the University of Sao Paulo Brazil

The need for renewable energy sources has challenged most countries to comply with environmental protection actions and to handle climate *** energy figures as a natural option,despite its *** has a green energy matrix with significant expansion of solar form in recent *** preserve the Amazon basin,the use of solar energy can help communities and cities improve their living standards without new hydroelectric units or even to burn biomass,avoiding harsh environmental *** novelty of this work is using data science with machine-learning tools to predict the solar incidence(W.h/m^(2))in four cities in Amazonas state(north-west Brazil),using data from NASA satellites within the period of ***-tree-based models and vector autoregressive(time-series)models were used with three time aggregations:day,week and *** predictor model can aid in the economic assessment of solar energy in the Amazon basin and the use of satellite data was encouraged by the lack of data from ground *** mean absolute error was selected as the output indicator,with the lowest values obtained close to 0.20,from the adaptive boosting and light gradient boosting algorithms,in the same order of magnitude of similar references.

关键词： solar energy renewable energy Amazon basin machine learning time series data science decision-trees ensemble vector autoregression

Enhancement of a foaming formulation with a zwitterionic surfactant for gas mobility control in harsh reservoir conditions

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Petroleum Science 2021年第5期18卷 1409-1426页

作者： Miguel Angel Roncoroni pedro Romero Jesús Montes Guido Bascialla Rosario Rodríguez Ramón Rodríguez Pons-Esparver Luis Felipe Mazadiego María Flor García-mayoral Universidad Politécnica de Madrid MadridSpain CEPSA Research Center MadridSpain CEPSA E&P MadridSpain

This work presents the design of a robust foam formulation that tolerates harsh reservoir conditions(high salinity,high divalent ion concentration,high temperature,light oil,and hydrocarbon injection gas)in a sandstone *** this,we selected anionic Alpha Olefin Sulfonate(AOS)surfactants and studied their synergistic effects in mixtures with zwitterionic betaines to enhance foam *** laboratory workflow used to define the best formulation followed a de-risking approach in three consecutive ***,(phase 1)the main surfactant(AOS)was selected among a series of commercial candidates in static ***,(phase 2)the betaine booster to be combined with the previously selected AOS was chosen and their ratio optimized in static ***,(phase 3)the surfactant/booster ratio was optimized under dynamic conditions in a porous medium in the absence and the presence of *** a result of this study,a mixture of an AOS C14-C16 and cocamidopropyl hydroxysultaine(CAPHS)was selected as the one having the best *** designed formulation was proven to be robust in a wide range of *** generated a strong and stable foam at reservoir conditions,overcoming variations in salinity and foam quality,and tolerated the presence of oil.

关键词： Gas mobility control Foam enhanced oil recovery(EOR) Foam stability High temperature high salinity reservoir Surfactant formulation

QUANTUM FINANCIAL ECONOMICS——RISK AND RETURNS

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Journal of Systems Science & Complexity 2013年第2期26卷 187-200页

作者： GONCALVES Carlos pedro Instituto Superior de Ciencias Socials e Politicas-Technical University of Lisbon

Financial volatility risk and its relation to a business cycle-related intrinsic time is addressed through a multiple round evolutionary quantum game equilibrium leading to turbulence and multifractal signatures in the financial returns and in the risk *** model is simulated and the results are compared with actual financial volatility data.

关键词： Business cycle dynamics intrinsic time quantum chaotic volatility quantum financialeconomics.

Distributed Energy Resource Scheduling with Focus on Demand Response Complex Contracts

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Journal of Modern Power Systems and Clean Energy 2021年第5期9卷 1172-1182页

作者： pedro Faria Zita Vale GECAD–Research Group on Intelligent Engineering and Computing for Advanced Innovation and Development R.Dr.António Bernardino de Almeida4314249-015PortoPortugal Polytechnic of Porto R.Dr.António Bernardino de Almeida4314249-015PortoPortugal

Demand response(DR)is a flexible way to improve distributed energy resource *** innovative contribution of this paper is to include complex contracts in the model,which can accommodate the constraints according to the special expectations of each *** contracts are included in the optimization of distributed energy resource scheduling to dispatch DR according to the expectations of ***-period DR events are *** this way,consumers can specify the limits on the time,power,and remuneration regarding participation in DR events,which has not been considered in the *** state of the art treats these aspects separately or uses a statistical approach,without providing consumers with options to combine their preferences regarding different aspects of their flexibility *** model has been validated for 218 consumers using several scenarios and different types of distributed generation,showing that it is possible to increase DR with respect to the preferences of consumers.

关键词： Complex contracts demand response distributed generation virtual power player

Synthetic Time Series Generation Model for Analysis of Power System Operation and Expansion with High Renewable Energy Penetration

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Journal of Modern Power Systems and Clean Energy 2021年第4期9卷 849-858页

作者： Rodrigo Palma-Behnke Jorge Vega-Herrera Felipe valencia Oscar Nunez-Mata Energy Center Department of Electrical EngineeringFaculty of Mathematical and Physical SciencesUniversity of ChileSantiagoChile Department of Electrical Engineering University of AntofagastaAntofagastaChile School of Electrical Engineering University of Costa RicaSan PedroCosta Rica

The increasing integration of renewable energy sources into current power systems has posed the challenge of adequately representing the statistical properties associated with their variable power generation. In this paper, a novel procedure is proposed to select a proper synthetic time series generation model for renewable energy sources to analyze power system problems. The procedure takes advantage of the objective of the specific analysis to be performed and the statistical characteristics of the available time series. The aim is to determine the suitable model to be used for generating synthetic time series of renewable energy sources. A set of indicators is proposed to verify that the statistical properties of synthetic time series fit the statistical properties of the original data. The proposal can be integrated into systematic tools available for data analysis without compromising the representation of the statistical properties of the original time series. The procedure is tested using real data from the New Zealand power system in a mid-term analysis on integrating wind power plants into the power system. The results show that the proposed procedure reduces the error obtained in analyzing power systems compared with reference models.

关键词： Time series analysis renewable energy source solar energy stochastic process statistical analysis wind energy

CAPTURING COMPLEX,NON-LINEAR TEAM BEHAVIOURS DURING COMPETITIVE FOOTBALL PERFORMANCE

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Journal of Systems Science & Complexity 2013年第1期26卷 62-72页

作者： DUARTE Ricardo ARAUJO Duarte FOLGADO Hugo ESTEVES pedro MARQUES pedro DAVIDS Keith Faculty of Human Kinetics Technical University of Lisbon School of Science and Technology University of Evora Department of Performance Analysis Manchester City FCUnited Kingdom School of Human Movement Studies Queensland University of Technologies

This study investigated changes in the complexity （magnitude and structure of variability） of the collective behaviours of association football teams during competitive performance. Raw positional data from an entire competitive match between two professional teams were obtained with the ProZone tracking system. Five compound positional variables were used to investigate the collective patterns of performance of each team including： surface and geometrical centre. Analyses involve the coefficient （ApEn）, as well as the linear association between both area, stretch index, team length, team width, of variation （%CV） and approximate entropy parameters. Collective measures successfully captured the idiosyncratic behaviours of each team and their variations across the six time periods of the match. Key events such as goals scored and game breaks （such as half time and full time） seemed to influence the collective patterns of performance. While ApEn values significantly decreased during each half, the %CV increased. Teams seem to become more regular and predictable, but with increased magnitudes of variation in their organisational shape over the natural course of a match.

关键词： Association football complexity social collective system variability.

Pharmaceutical applications of spouted beds: A review on solid dosage forms

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Particuology 2019年第1期17卷 126-136页

作者： Luis Alexandre pedro de Freitas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto University of Sao PauloVia do Cafe s/n. Campus USPRibeirao Preto14040-903Sao Paulo. Brazil

Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological characteristics of pharmaceutical solid forms. Particle properties like morphology, size, porosity, flowability, and dissolution rate can be improved by managing geometric and operational conditions for spouting. Drying is probably the most disseminated operation for pharmaceutical processing in SBs, and many studies have investigated drying of medicinal plant extracts such as achiote (Bixa orellana sp.), guarana (Paullinia cupana sp.), passion flower (Passiflora alata D.), and rosemary (Rosmarinus officinalis L.) with excellent pharmacotechnical and stability results. Another important application is coating of tablets and gelatin capsules, and previous studies have shown that SBs and spout–fluid beds may be advantageous over traditional pan coating, especially for polymeric film coating. Recently, an alternative process for improving drug bioavailability has involved preparation of β-cyclodextrin inclusion complexes in SBs. The first study to propose SBs for this pharmaceutical application explored the advantage of obtaining solid forms of inclusion complexes in just one step, and obtained expressive increases in drug solubility. The technique has been applied in subsequent studies on inclusion complexes of the medication carvedilol and uxi (Endopleura uchi L.) extracts.

关键词： Coating Drying Granulation Inclusion Microencapsulation