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Epilepsy Focus Localization in Patients Utilizing BOLD Differences Related to Regional Metabolic Dynamics

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Open Journal of Radiology 2019年第3期9卷 163-175页

作者： Byron Bernal Magno R. Guillen pedro valdes Prasanna Jayakar Nolan Altman Michael Duchowny Jorge Riera Brain Institute Nicklaus Children’s Hospital Miami FL USA Radiology Department Miami FL USA Department of Pediatric School of Medicine Florida International University Miami FL USA Department of Biomedical School of Medicine Florida International University Miami FL USA

This paper presents a theoretical elaboration aimed to explain the correlation found between a new rs-fMRI modality and electrophysiology and nuclear medicine neuroimaging, performed to localize epileptogenic brain areas. We present in detail the clinical history, and electrophysiological and neuroimaging results of one child with intractable epilepsy, who was submitted for Phase-1 work-up as candidate for epilepsy surgery. The patient underwent a thorough workup including video-telemetry, ictal and interictal nuclear medicine imaging, resting-state fMRI, EEG-fMRI, intracranial electroencephalography (ECoG), deep electrode implantation, and resective surgery. Electrophysiology and neuroimaging findings were concordant with findings provided by the resting-state mean signal. The patient became seizure-free after the resection of the target area. A theoretical discussion is provided that considers the presence of a stable BOLD effect explaining the findings of the observed resting-state mean signal. This stable BOLD is linked to low regional metabolism usually present in the epileptogenic area during interictal periods, coupled with low oxygen extraction. Low oxygen extraction leaves more oxygen for the draining venule and consequently increases the BOLD signal.

关键词： BOLD fMRI rs-fMRI Brain MRI Epilepsy PET

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中古合作,促进全球精准脑健康

国际人才交流 2022年第8期 17-21页

作者： pedro A.valdes-Sosa 张佳艺(译) 中国电子科技大学生命科学与技术学院

我出生在美国,父亲在美行医。古巴革命胜利后,我的家人于1962年回到了古巴。我们全家都希望为创造一个新的、更公正的社会作出贡献。20世纪80年代末,古巴神经科学中心与中国建立合作20世纪60年代末,作为一名医学生,我与纽约大学的Erwin ... 详细信息

我出生在美国,父亲在美行医。古巴革命胜利后,我的家人于1962年回到了古巴。我们全家都希望为创造一个新的、更公正的社会作出贡献。20世纪80年代末,古巴神经科学中心与中国建立合作20世纪60年代末,作为一名医学生,我与纽约大学的Erwin Roy John教授一起,利用古巴的第一台计算机(1970年)开创了量化脑电图(qEEG)技术。时至今日,我们的目标仍是创造一种在群体层面协助诊断和管理大脑疾病的工具。1977年,我们在《自然》上发表了一篇神经计量学的论文,这即是我们本次合作的成果。我需要继续强化医学训练,这促使我从医学专业毕业后开始学习数学。后来,我领导的团队为世界上首批qEEG设备之一,即MEDICID系统构建了硬件和软件。

关键词：纽约大学医学专业神经科学古巴革命计量学协助诊断脑健康脑电图

Dissociation of the N400 component between linguistic and non-linguistic processing: A source analysis study

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World Journal of Neuroscience 2014年第1期4卷 25-39页

作者： Anne Gallagher Renée Béland Phetsamone Vannasing Maria Luisa Bringas pedro valdes Sosa Nelson J. Trujillo-Barreto John Connolly Maryse Lassonde Centre de Recherche en Neuropsychologie et Cognition Psychologie Department University of Montreal Montreal Canada Centro de Neurosciencias Havana Cuba CHU Ste-Justine Research Center Montreal Canada International Center for Neurological Rehabilitation (CIREN) Havana Cuba Language Memory & Brain Laboratories Department of Linguistics & Languages McMaster University Hamilton Canada

The N400 component is commonly associated with the detection of linguistic incongruity. A few studies have shown that the N400 can also be elicited by non-linguistic stimuli. Different spatiotemporal patterns were observed between the typical Linguistic N400 and the Non-linguistic N400, suggesting distinct brain generators. The aim of this study was to investigate the presence of an N400 in response to linguistic and non-linguistic stimuli, and to specify anatomical sources of both N400s using a novel analysis method: the Bayesian Model Averaging (BMA) distributed source model. Picture-word and environmental soundpicture associations, either congruent or incongruent, were presented to ten young healthy adults while highdensity ERP recordings were made. Standard electrophysiological analyses confirmed that the N400 was not specific to linguistic incongruity but was also elicited by environmental sound-picture incongruities. Different topographic distributions were obtained for the Linguistic N400 and Non-linguistic N400. BMA analysis showed that the Linguistic N400 generators were mostly located in the left superior temporal gyrus, whereas the sources of the Non-linguistic N400 were identified mostly in the right middle and superior temporal gyri. Detection of linguistic incongruities recruited cerebral areas commonly associated with language processing, whereas non-linguistic incongruities recruited right cerebral regions usually associated with auditory processing of non-linguistic stimuli. The Linguistic and Non-linguistic N400s appear to be elicited by similar cognitive mechanisms assumed by different cerebral areas depending on the type of material to be processed. The present findings support the existence of parallel pathways for the processing of linguistic and non-linguistic incongruities.

关键词： Event-Related Potentials Incongruity Semantic Environmental Sounds Distributed Source Model BMA

Bidirectional Control of Absence Seizures by the Basal Ganglia:A Computational Evidence

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Bidirectional Control of Absence Seizures by the Basal Gangl...

Functions of nuclear factor Y in nervous system development,function and health

第二届全国神经动力学学术会议

作者： Mingming Chen Daqing Guo Tiebin Wang Wei Jing Yang Xia Peng Xu Cheng Luo pedro A.valdes-Sosa Dezhong Yao Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and TechnologyUniversity of Electronic Science and Technology of China Cuban Neuroscience Center

Absence epilepsy is believed to be highly associated with the abnormal interactions between the cerebral cortex and *** the direct coupling,anatomical evidence indicates that the cerebral cortex and thalamus also communicate indirectly through an important intermediate bridge-basal *** has been thus postulated that the basal ganglia might play key roles in the modulation of absence seizures,but the relevant biophysical mechanisms still not be completely *** a computational model(see Figure 1),we demonstrate here that the typical absence seizure activities can be controlled and modulated by the direct GABAergic projections from the substantia nigra pars reticulata(SNr)to either the thalamic reticular nucleus(TRN)or the specific relay nuclei(SRN)of thalamus,through different biophysical *** certain conditions,these two types of seizure control are observed to coexist in the same *** importantly,due to the competition between the inhibitory SNr-TRN and SNr-SRN pathways,we find that both decreasing and increasing the activation of SNr neurons from the normal level may considerably suppress the generation of typical 2-4 Hz spike-and-slow wave discharges in the coexistence region(see Figure 2).Taken together,these results highlight the bidirectional functional roles of basal ganglia in controlling and modulating absence seizures,and might provide novel insights into the therapeutic treatments of this brain disorder.

关键词： Absence seizures Basal ganglia Substantia nigra pars reticulate Bidirectional control

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Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： pedro Moreira Roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

Brain scarring in infants:immunological insights from a neonatal hypoxic-ischemic encephalopathy model

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Neural Regeneration Research 2025年第10期20卷 2909-2910页

作者： pedro Moreno Pimentel-Coelho Carlos Chagas Filho Biophysics Institute Federal University of Rio de JaneiroRio de JaneiroBrazil

Neonatal hypoxic-ischemic encephalopathy(HIE)is a significant cause of disability in *** brain function and accelerating neurological recovery may require a combination of neuroprotective and pro-regenerative treatments at different stages of *** the first hours after the neonatal insult are the most critical period for neuroprotection,the existence of secondary and tertiary mechanisms of brain injury offers the possibility of preventing delayed neurodegeneration in the subsequent days,weeks,or months(Levison et al.,2022).

关键词： neonatal protective hypoxic

Touristic urbanization and greening of coastal dune fields:A long-term assessment of a temperate sandy barrier of Argentina

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Journal of Geographical Sciences 2025年第1期 206-230页

作者： GARZO pedro Andrés DADON José Roberto ISLA Federico Ignacio Instituto de Investigaciones Marinas y Costeras (IIMyC-CONICET/UNMDP) Instituto de Geología de Costas y del Cuaternario Dr.Enrique J.Schnack (IGCC-CIC/UNMDP) Universidad de Buenos Aires Facultad de Arquitectura Dise?o y Urbanismo Centro de Investigaciones Gestión de Espacios Costeros (GEC-FADU/UBA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world. However, a century ago, they were considered hazardous environments due to their great dynamic nature. As a result, stabilization practices were considered necessary. The systematic introduction of fast-growing exotic trees helped stabilize the sand, making it easier for tourism urbanization to take place, but also leading to erosion processes. This paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina. This complex region includes urban resorts, afforestation zones, and protected areas. A GIS-based geospatial analysis was conducted using a large satellite database(> 350 images), and the future evolution of the vegetation was modeled. The results revealed two primary spatiotemporal patterns associated with a gradual expansion of vegetation cover, accompanied by a concurrent reduction in sandy areas. In 1986, the dune area comprised 75% more surface than vegetation, whereas in 2021, it represented 60% less than vegetation. Furthermore, the 2050 scenario suggests a potential 40% reduction of dunes in certain areas. It is necessary to enhance management actions aimed at maintaining dune mobility and ensuring local and regional sediment balance. Long-term management strategies must focus on restoring native plant communities and controlling invasive species, and avoiding new dune fixation initiatives based on the introduction of exotic species.

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QUANTUM FINANCIAL ECONOMICS——RISK AND RETURNS

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Journal of Systems Science & Complexity 2013年第2期26卷 187-200页

作者： GONCALVES Carlos pedro Instituto Superior de Ciencias Socials e Politicas-Technical University of Lisbon

Financial volatility risk and its relation to a business cycle-related intrinsic time is addressed through a multiple round evolutionary quantum game equilibrium leading to turbulence and multifractal signatures in the financial returns and in the risk *** model is simulated and the results are compared with actual financial volatility data.

关键词： Business cycle dynamics intrinsic time quantum chaotic volatility quantum financialeconomics.

Distributed Energy Resource Scheduling with Focus on Demand Response Complex Contracts

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Journal of Modern Power Systems and Clean Energy 2021年第5期9卷 1172-1182页

作者： pedro Faria Zita Vale GECAD–Research Group on Intelligent Engineering and Computing for Advanced Innovation and Development R.Dr.António Bernardino de Almeida4314249-015PortoPortugal Polytechnic of Porto R.Dr.António Bernardino de Almeida4314249-015PortoPortugal

Demand response(DR)is a flexible way to improve distributed energy resource *** innovative contribution of this paper is to include complex contracts in the model,which can accommodate the constraints according to the special expectations of each *** contracts are included in the optimization of distributed energy resource scheduling to dispatch DR according to the expectations of ***-period DR events are *** this way,consumers can specify the limits on the time,power,and remuneration regarding participation in DR events,which has not been considered in the *** state of the art treats these aspects separately or uses a statistical approach,without providing consumers with options to combine their preferences regarding different aspects of their flexibility *** model has been validated for 218 consumers using several scenarios and different types of distributed generation,showing that it is possible to increase DR with respect to the preferences of consumers.

关键词： Complex contracts demand response distributed generation virtual power player