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Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni Ana Júlio Celestino santos-Buelga Ana M.Gonzalez-Paramas Patrícia Filipe Patricia Rijo Sofia A.Costa Lima Salette Reis Angela Fernandes Isabel C.F.R.Ferreira Virginia Fernandez-Ruiz Patricia Morales Guido Flamini Lotfi Achour pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia CBIOS-Research Center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacao de Montanha(CIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly Centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly Center for Marine Sciences(CCMar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of Chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with EC_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surface were *** and DSC were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA

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Assessment of Short-term Acupuncture Effect Through Electro-conductivity Variation of Yuan-Source Acupoints

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 48-52页

作者： Daniel Cerqueira Ribeiro André António Moura dos santos Rui pedro Loureiro Rui Miguel Gonalves Jorge Pereira Machado Institute of Biomedical Sciences Abel Salazar-University of Porto (ICBAS-UP) Center for Research on Natural Medicine (CIMN)

Objective: To demonstrate that acupuncture has an instant effect in equilibrating the imbalanced electrical conductivity of Yuan-Source acupoints after intervention on the Luo-Connecting acupoint(one-side) of the same ***: The experiment was designed as a randomized blinded control trial, with 56 volunteers. Reactive Electrical Permeable Points(REPP-mostly Yuan points) were measured in terms of electrical conductivity. Patients with a split-meridian(difference between left and right measurement) were randomly included in the control or experimental group. After five minutes of needle insertion in a Luo acupoint, the needle was removed and REPP were re-measured twice within a five minutes ***: From the 56 volunteers, 32 had a valid Split-Meridian Difference(SMD > 20 μA) and were included in the study. The results indicate that after the third measurement(15 minutes-M3), 100% of the experimental group had SMD 20 μA, at M3, when compared with the initial measurement(M1). Results obtained between the experimental and control group are significantly different(p< 0.001).Conclusions: The present exploratory work indicates that there is evidence of instant body response to acupuncture that can be detected by changes in the electro-conductivity of specific acupoints.

关键词： SMD Source

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Chemical Exposure Hazardous for Fish Hyphessobrycon eques through the Incorrect Release of Oil in Amazon Region

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Journal of Fisheries Science 2020年第2期2卷 19-23页

作者： Natalino da Costa Sousa Arthur dos santos da Silva Keber santos Costa Junior Francisco Alex Lima Barros Geisy Correa de Oliveira pedro Rodrigo Nery de Souza Claudmilson Rodrigues de Mesquita Bruna de jesus santos Alexander Damaceno Lima santos Winnícius Muniz dos santos Sá Nayara Siqueira dos santos Márcia Valéria Silva do Couto Federal University of Pará(UFPA) Campus BragançaAlameda Leandro RibeiroBragança68600-000PABrazil Federal University of Pará(UFPA) Campus de TucuruíRua Itaipu36-Vila PermanenteTucuruí68464-000PABrazil Federal University of de Sergipe(UFS) Av.Marechal Rondons/n-Jardim Rosa ElzeSão Cristóvão49100-000SEBrasil Faculdade Pio Décimo Av.Pres.Tancredo Neves 5655-Jabotiana49095-000Aracaju–SE.Brazil

Incorrect discard of oil used by fishing ship in the brazilian north region has become a common *** the possible hazard to the aquatic organisms,still missing scientific data about their ***,this study aimed to evaluate the stress and lethality caused by lubricant oil(FSAOLU)on fish Hyphessobrycon ***,it was used six different concentration diluted in water(0,22,24,26,28,30 and 32%of oil)and three replaces during 96 *** the end or during the experiment(with dying fish),it was collected blood samples(cutting the caudal fin)to determine physiological *** FSAOLU showed mean lethal dose(LD50-96h)of 27.36%,classified as toxic causing alterations in glucose values from the 26%.The greater dilution of FSAOLU(32%)increased 115%in glucose values when compared to the ***,lubricant oil when discarded in water,it present hazard to the aquatic organisms causing stress and mortality for fish being necessary adequate management to discard of this residue.

关键词： Toxicity FSA Sensibility Stress

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Web-based system for training and dissemination of a magnification chromoendoscopy classification

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World Journal of Gastroenterology 2008年第46期14卷 7086-7092页

作者： Mário Jorge Dinis-Ribeiro Ricardo Cruz Correia Cristina santos Sónia Fernandes Ernesto Palhares Rui Almeida Silva pedro Amaro Miguel Areia Altamiro Costa-Pereira Luis Moreira-Dias Gastroenterology Department Portuguese Oncology Institute Center for Research in Information Systems and Health Technologies (CINTESIS)/Department of Biostatistics and Medical Informatics Porto Faculty of Medicine Gastroenterology Department Coimbra University Hospital

AIM： To evaluate the use of web-based technologies to assess the learning curve and reassess reproducibility of a simplified version of a classification for gastric magnification chromoendoscopy （MC）. METHODS： As part of a multicenter trial, a hybrid approach was taken using a CD-ROM, with 20 films of MC lasting 5 s each and an ＂autorun＂ file triggering a local HTML frameset referenced to a remote questionnaire through an Internet connection. Three endoscopists were asked to prospectively and independently classify 10 of these films randomly selected with at least 3 d apart. The answers were centrally stored and returned to participants together with adequate feedback with the right answer. RESULTS： For classification in 3 groups, both intra- [Cohen＇s kappa （K） = 0.79-1.00 to 0.89-1.00] and inter-observer agreement increased from 1st （moderate） to 6th observation （k = 0.94）. Also, agreement with reference increased in the last observations （0.90, 1.00 and 1.00, for observers A, B and C, respectively）. Validity of 100% was obtained by all observers at their 4th observation. When a 4th （sub）group was considered, inter-observer agreement was almost perfect （K = 0.92） at 6th observation. The relation with reference clearly improved into K （0.93-1.00） and sensitivity （75%-100%） at their 6th observations. CONCLUSION： This MC classification seems to be easily explainable and learnable as shown by excellent intra- and inter-observer agreement, and improved agreement with reference. A web system such as the one used in this study may be useful for endoscopic or other image based diagnostic procedures with respect to definition, education and dissemination.

关键词： Magnification Chromoendoscopy Reproducibility Learning curve

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Modeled Surface Observations for Spatial Analysis of Landscape Dynamics

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Journal of Geographic Information System 2013年第4期5卷 409-417页

作者： Manoel do Couto Fernandes Tata Lacale Canal dos santos pedro Henrique Ferreira Coura Paulo Marcio Leal de Menezes Alan Jose Salomao Graca Department of Geography Federal University of Rio de JaneiroRio de JaneiroBrazil

Landscape dynamics is a geoecological characteristic that defines changes in a landscape spatial structure and function during an established time scale. In this kind of analysis, geoprocessing is an essential tool, because it combines several technologies that help in this work. However, the majority of landscape dynamic investigations do not consider the dimensionality of the data and the information to be used, which is projected not measured from modeled (real) surface observations, and presents underestimated results, mainly in irregular relief landscapes. Considering that, this paper intends to assess the difference between observations on modeled and planimetric surfaces on the interpretation of landscape dynamics. The study was conducted in the massif of Tijuca, Rio de Janeiro (Brazil) using land use and soil cover maps of different times and a digital elevation models (DEM) generated based on a triangular irregular. The results show an increase of dynamic areas values when observations were carried out on modeled surface, as well as the deforestation rate (17.57% or 0.13 km2/year). This survey showed higher values in comparison with observations on planimetric surface, characterizing more realistic interpretations of how the structural elements and analyses made from these are structured in the landscape.

关键词： DEM Modeled Surface Landscape Change

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Primary Effusion Lymphoma in a HIV-1/2-Infected Patient

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World Journal of AIDS 2023年第3期13卷 116-124页

作者： Maria Caixas Lima pedro Vasques Andreia Paulos André Valente Joana santos Carla Antunes Matilde Gonçalves Maria Isabel Casella Nuno Luis José Poças Department of Infectious Diseases Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal Department of General Surgery Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal Department of Hematology Hospital de Santo António dos Capuchos Centro Hospitalar Lisboa Central Lisboa Portugal Department of Anatomical Pathology Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal

Background: Primary effusion lymphoma (PEL) is a lymphoid proliferation related to Kaposi sarcoma herpesvirus 8/human herpesvirus 8 (KSHV/HHV8) that affects mainly human immunodeficiency virus (HIV) infected individuals but can also occur in other immunodeficiency settings. It is characterized by lymphomatous effusions in different serous body cavities without the presence of a detectable tumor mass. The diagnosis is challenging and the clinical outcomes are poor. Aim: The aim of this paper is to report a rare case of PEL in a man who have sex with women (MSW) with HIV-1/2 infection, history of visceral Kaposi sarcoma (KS) and the development of a seronegative arthritis previous to the lymphoproliferative disease diagnosis. PEL presented with ascites, was treated with high-dose chemotherapy and autologous stem cell transplantation, with a good clinical outcome. Case Presentation: We describe a case of a 48-year-old HIV-1/2-infected patient from a high HHV8 seroprevalent country, hospitalized following a three-month history of increased abdominal volume and general constitutional symptoms. Laboratory data revealed normocytic normochromic anemia and a high level of lactate dehydrogenase. A diagnostic paracentesis was performed with cytology compatible with high-grade B-cell lymphoma. Peritoneal fluid cytology showed large lymphoid cells expressing leucocyte-common antigen CD45 without expression of the CD20 antigen (B-lymphocytes) and positivity for HHV8 by immunocytochemical staining, compatible with the diagnosis of PEL.

关键词： Primary Effusion Lymphoma Acquired Immunodeficiency Syndrome HIV-1 HIV-2 Kaposi Sarcoma Herpesvirus 8/Human Herpesvirus 8 People Living with HIV

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Turbulent Energy Budgets of a Ground Vortex Flow

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Journal of Mechanics Engineering and Automation 2013年第5期3卷 311-324页

作者： Jorge M.M. Barata pedro J.C.T. santos André R.R. Silva Diamantino F.G. Durāo Dept. of Aerospace Science University of Beira Interior Covilhgā 6200-001 Portugal Lusiada Institute for Research and Development Universidade Lusiada Lisbon 1349-001 Portugal

Turbulent kinetic energy budgets are presented for a highly curved flow generated by the collision of plane wall turbulent jet with a low-velocity boundary layer. The different terms are obtained in the vertical plane of symmetry by quadratic interpolation of the LDV （Laser Doppler Velocimetry） measurements, for a wall jet-to-boundary layer velocity ratio of 2. The results, which have relevance to flows encountered in powered-lift aircraft operating in ground effect, quantify the structure of the complex ground vortex flow. The analysis of turbulent energy equation terms using the measured data revealed that production by normal and shear stresses are both very important to the turbulent structure of the impact zone of the ground vortex. This is an indication that the modeling of turbulence of a ground vortex requires a good representation of the production by normal stresses which is most important in the collision zone.

关键词： V/STOL (vertical/short take-off and landing) ground vortex turbulence complex flows.

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Characterization and Evaluation of Bond Strength of Dental Polymer Systems Modified with Hydroxyapatite Nanoparticles

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Journal of Materials Science and Chemical Engineering 2013年第7期1卷 13-23页

作者： Vitor César Dumont Rafael Menezes Silva Luiz Edmundo Almeida-Júnior Juan pedro Bretas Roa Adriana Maria Botelho Maria Helena santos Department of Dentistry Federal University of Vales do Jequitinhonha and Mucuri Diamantina Brazil Department of Dentistry Federal University of Vales do Jequitinhonha and Mucuri Diamantina Brazil Advanced Biomaterial Center-BioMat UFVJM Diamantina Brazil Department of Dentistry Federal University of Vales do Jequitinhonha and Mucuri Diamantina Brazil Advanced Biomaterial Center-BioMat UFVJM Diamantina Brazil Institute of Science and Technology UFVJM Diamantina Brazil

The study modifies an adhesive system with hydroxyapatite nanoparticles as load, characterizing it and evaluate the effectiveness of its bond to dental structure. The middle thirds of healthy premolar tooth crowns were obtained, and each crown was sectioned vertically, resulting in two sections. The sections were divided into ten groups (n = 15), in which resin composite restorations were simulated: (G1E and G1D) conventional adhesive system (SAC);(G2E and G2D) SAC modified with HAP;(G3E and G3D) Primer modified with HAP;(G4E and G4D) monocomponent adhesive system;(G5E and G5D) self-etching adhesive system. The specimens were submitted to the microshear test and characterization technique. There was statistically significant difference (Kruskal-Wallis) between the groups (p 0.01). G3 presented the highest bond strength to enamel (64.40 MPa, ±7.36) and dentin (39.59 MPa, ±21.46). The majority of specimens were found adhesive fractures. Bond strength to enamel and dentin of the primer modified with HAP of SAC showed higher values.

关键词： Nanostructures Composites Mechanical Properties Fracture

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Evolution of the Socio-cognitive Structure of Knowledge Management(1986–2015): An Author Co-citation Analysis

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Journal of Data and Information Science 2019年第2期4卷 36-55页

作者： Carlos Luis González-Valiente Magda León santos Ricardo Arencibia-Jorge Biblioteca Nacional de Cuba "José Martí" ave.Independencia Facultad de Comunicación Universidad de la Habana San Pedro entre Ermita y Avenida Independencia Empresa de Tecnologías de la Información

Purpose: The evolution of the socio-cognitive structure of the field of knowledge management(KM) during the period 1986–2015 is described. Design/methodology/approach: Records retrieved from Web of Science were submitted to author co-citation analysis(ACA) following a longitudinal perspective as of the following time slices: 1986–1996, 1997–2006, and 2007–2015. The top 10% of most cited first authors by sub-periods were mapped in bibliometric networks in order to interpret the communities formed and their ***: KM is a homogeneous field as indicated by networks results. Nine classical authors are identified since they are highly co-cited in each sub-period, highlighting Ikujiro Nonaka as the most influential authors in the field. The most significant communities in KM are devoted to strategic management, KM foundations, organisational learning and behaviour, and organisational theories. Major trends in the evolution of the intellectual structure of KM evidence a technological influence in 1986–1996, a strategic influence in 1997–2006, and finally a sociological influence in 2007–*** limitations: Describing a field from a single database can offer biases in terms of output coverage. Likewise, the conference proceedings and books were not used and the analysis was only based on first authors. However, the results obtained can be very useful to understand the evolution of KM *** implications: These results might be useful for managers and academicians to understand the evolution of KM field and to(re)define research activities and organisational ***/value: The novelty of this paper lies in considering ACA as a bibliometric technique to study KM research. In addition, our investigation has a wider time coverage than earlier articles.

关键词： Knowledge management Bibliometrics Author co-citation analysis Knowledge domain visualization Social network analysis Intellectual structure

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Presence of the Genes cagA, cagE, virB11 and Allelic Variation of vacA of Helicobacter pyloriAre Associated with the Activity of Gastritis

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Open Journal of Gastroenterology 2014年第11期4卷 347-355页

作者： pedro Pinheiro de Negreiros Bessa Francivandi Coelho Barbosa Ana Paula santos do Carmo Gildo Barreira Furtado Fernanda Capelo Barroso Silvia Helena Barem Rabenhosrt Laboratory of Molecular Genetics (LABGEM) Department of Pathology and Forensic Medicine Federal University of Ceara Fortaleza Brazil Hospital Universitário Walter Cantídeo—HUWC-UFC Fortaleza Brazil

Non-atrophic active chronic gastritis (ACG) is characterized by the presence of H. pylori in the gastric epithelium, known to be one of the first steps that precede progression to gastric adenocarcinoma. Inactive chronic gastritis (ICG) suggests that the patient has H. pylori gastritis, but this diagnosis is rarely made in routine histopathology. Clinical manifestations associated with H. pylori infection are potentially due to differences in virulence between strains;however, it is unclear if the progression of ACG to ICG depends on the H. pylori strain. The aim of this study was to compare the prevalence of the virulence factors of H. pylori found in patients with ACG and ICG, and its influence on the development of ICG. A significant association was observed between H. pylori detection by histological examination and the activity of gastritis (p 1 year) was reported by 28.6% of the ACG group and 42.5% of the ICG, while no evidence of association between long-term use of PPI and decreased inflammation was found in the patients studied. The genes cagA, cagE and virB11 were statistically associated with ACG (p = 0.01, p vacAs1 allele groups, ACG was associated with the most virulent group (p = 0.0015), while ICG was associated with the less virulent group (p < 0.001). The rate of co-infection was significantly higher in ICG than in ACG cases (p = 0.02). In conclusion, this study points to the role of virulent strains of H. pylori in the non-resolution of gastritis.

关键词： Active Chronic Gastritis Inactive Chronic Gastritis Helicobacter pylori Genotypes

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