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Oncologic aspects of the decision-making process for surgical approach for colorectal liver metastases progressing during chemotherapy

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 877-886页

作者： Raphael L C Araujo Camila G C Y Carvalho Carlos T Maeda Jean Michel Milani Diogo G Bugano pedro Henrique Z de Moraes Marcelo M Linhares Department of Surgery Universidade Federal de São PauloSão Paulo 04024-002Brazil Department of Oncology Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Department of Surgical Oncology Hospital e Maternidade Brasil Rede D'Or São LuizSanto André09030-590São PauloBrazil

Colorectal cancer represents the third most diagnosed malignancy in the *** liver is the main site of metastatic disease,affected in 30%of patients with newly diagnosed *** resection is considered the only potentially curative treatment for colorectal liver metastasis(CRLM),with a 5-year survival rate ranging from 35%to 58%.However,up to 80%of patients have initially unresectable disease,due to extrahepatic disease or bilobar multiple liver *** availability of increasingly effective systemic chemotherapy has contributed to converting patients with initially unresectable liver metastases to resectable disease,improving long-term outcomes,and accessing tumor *** recent years,response to preoperative systemic chemotherapy before liver resection has been established as a major prognostic *** studies have demonstrated that patients with regression of hepatic metastases while on chemotherapy have improved outcomes when compared to patients with stabilization or progression of the *** if disease progression during chemotherapy represents an independent negative prognostic factor,some patients may still benefit from surgery,given the role of this modality as the main treatment with curative intent for patients with *** selected cases,based on size,the number of lesions,and tumor markers,surgery may be offered despite the less favorable prognosis and as an option for non-chemo responders.

关键词： Colorectal liver metastases Oncology Disease progression Surgery Liver resection Hepatectomy

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Sex-specific differences in white matter microvascular integrity after ischaemic stroke

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Stroke & Vascular Neurology 2019年第4期4卷 198-205页

作者： Mark R Etherton Ona Wu pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost Department of Neurology Massachusetts General Hospital and Harvard Medical SchoolBostonMassachusettsUSA Martinos Center for Biomedical Imaging Massachusetts General HospitalCharlestownMAUnited States Department of Radiology Massachusetts General Hospital and Harvard Medical SchoolBostonMAUnited States Medical School of Ribeirao Preto University of Sao PauloSao PauloBrazil Department of Human Neurosciences Sapienza University of RomeRomeItaly Institute of Psychology Leiden UniversityLeidenNetherlands Department of Neuroradiology Goethe-Universitat Frankfurt am MainFrankfurtGermany Department of Neurology Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUnited States Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRhode IslandUSA

background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment *** matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic *** aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic *** A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was *** the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)*** analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were *** 105 men and 79 women met inclusion criteria for *** no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) *** multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not *** In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural *** studies investigating sex-specific differences in white matter microvascular integrity are needed.

关键词： microvascular white coefficient

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Nodular Amyloidosis Overlapping and Polymyositis in a Patient with Skin Manifestations Lupus Fax: Case Report

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Journal of Biosciences and Medicines 2017年第11期5卷 33-40页

作者： Eneas Van Der Maas do Bem Filho Laiza Maria dos Santos Couto Antonio Luiz da Costa Soares Jr pedro paulo Andrade Thiago Sande Miguel Sebastiao Celio Horta Coelho Filho Daniel Almeida da Costa Livia Cristina de Melo Pino Thayro Van Der Maas do Bem The Medical School at the Center of Higher Education of Valenca ValencaBrazil

Amyloidosis is the result of fibrous and insoluble amyloid protein deposition in extracellular spaces of tissues and organs, including the skin. Through the analysis of medical records, clinical condition and laboratory tests, this article proposes a rare case report of an adult patient with symptoms and diagnosis of polymyositis, histopathology of nodular amyloidosis with skin lesions suggestive of lupus. The patient is still being followed at the dermatology clinic of Valença Medical School, in order to improve the prognosis and prevent the progression of existing symptoms.

关键词： Nodular Amyloidosis Polymyositis

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Diabetic and Prediabetic Profile of Patients in a Family Health Care Unit of Salvador, Northeastern Brazil

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Open Journal of Endocrine and Metabolic Diseases 2016年第1期6卷 66-71页

作者： João Zallio Coelho pedro Julião Zallio Coelho Sanchela Raiane Pereira de Oliveira Alex Farias Soares Jacqueline Novais Santana paulo Ricardo Bacelar Macedo Juliana Silveira de Freitas Danilo Guimarães Nogueira Andrade Mirella Hansen de Almeida Denise Rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School Sao Paulo Brazil Visiting Physician Joslin Diabetes Center Harvard University Boston USA Visiting Scientist Harvard T. H. Chan School of Public Health Harvard University Boston USA

Diabetes Mellitus is one of the most prevalent diseases in the world. In Brazil, 8.7% of the population between 20 and 79 years of age has diabetes, estimating 11.6 million diabetics. It is commonly associated with other co-morbidities such as hypertension, dyslipidemia and obesity, which put these patients into a high cardiovascular risk profile. This study was performed using the medical records of enrolled population attending a Family Health Unit of Alto do Coqueirinho, Salvador, Northeastern Brazil, consisting of one doctor, one nurse, one dentist, one nursing technician and six community health workers. Medical records and data provided by the system of the Primary Care Information (SIAB), showed total of 2495 patients. Considering the prevalence morbidities in this population, hypertension was present in 9.8% of patients and Type 2 Diabetes in only 3.6%. Since the prevalence of morbidities is the key indicator to the development of public health policies, it seems important a better knowledge on the prevalence rates of diabetes, prediabetes and its co-morbidities of this population. Future plans and projects for health professionals will be based on a consistent medical record.

关键词： Diabetes Prediabetes Comorbidities Family Health Unit

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Perspective on the use of synthetic biology in rudimentary food fermentations

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Systems Microbiology and Biomanufacturing 2023年第1期3卷 150-165页

作者： Alexander da Silva Vale Gilberto Vinícius de Melo Pereira Leonardo Martins Santana Dão pedro de Carvalho Neto Brigitte Sthepani Orozco Colonia Vanete Thomaz Soccol Bruna Leal Maske Carlos Ricardo Soccol Department of Bioprocess Engineering and Biotechnology Federal University of Paraná(UFPR)CuritibaPRBrazil Department of Genetics University of São Paulo(USP)Ribeirão PretoSPBrazil Federal Institute of Education Science and Technology of Paraná(IFPR)LondrinaPRBrazil

Rudimentary food fermentation can be defined as a spontaneous process of conversion of food components through enzy-matic action.A great variety of fermented foods are produced using spontaneous approaches;however,cocoa and coffee represent the most important agricultural commodities on international *** a manner to increase the efficiency of these processes,starter cultures have been developed and applied under field *** selection process begins with the recovery of microbial strains from spontaneous fermentation through phenotypic and metabolic ***,mutation-based breeding is used to develop and improve well-adapted starter *** advances in synthetic biology,especially in the last decade,the development of robust cellular fabrications with high fermentative capacity has become easier-largely due to the development of genomic approaches,such as next-generation sequencing techniques,CRISPR-Cas system and bioinformatics *** review brings prospects on the use of synthetic biology to design new robust strains for use in cocoa and coffee fermentations,but which can be extended to other rudimentary *** addition,metabolic traits and target genes(e.g.,UvrA,RecA,GPD1,and GPP2)are proposed as a starting point for the improvement of cocoa and coffee ***,the regulatory and safety requirements for these food crops are *** review aims to stimulate research on the process of fermentation and the associated synthetic biology tools to produce fermented food efficiently and sustainably.

关键词： Coffee fermentation Cocoa fermentation Starter cultures CRISPR-Cas Synthetic promoters

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Numerical Study of the Influence of Elements inside the Wheelhouse on the Passenger Vehicle Aerodynamic

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Open Journal of Fluid Dynamics 2015年第2期5卷 199-207页

作者： Edvaldo Angelo Gabriel Angelo pedro Henrique Di Giovanni Santos Delvonei Alves de Andrade Grupo de Simulaç o Numérica (GSN) Universidade Presbiteriana Mackenzie S&#227 o paulo Brazil Department of Mechanical Engineering Centro Universitário da Funda&#231 o Educacional Inaciana Padre Sabóia de Medeiros (FEI) S&#227 o Bernardo do Campo Brazil Instituto de Pesquisas Energéticas e Nucleares IPEN CNEN/SP Universidade de S&#227 o paulo S&#227 o paulo Brazil

Models for the study of computational fluid dynamics in vehicles to determine aerodynamic loads usually take into account only the geometry of the body. Several constructive elements such as the wheel geometry or suspension components are disregarded in the computational models. This work presents the study of the aerodynamics of a one-fourth model passenger vehicle, which contains the wheelhouse interior elements. The goal is to identify the aerodynamic loads produced by these components and their effect on the flow dynamics. Wheel and tire set, brake components, suspension and drive shaft are contemplated. Computer simulations were performed to the vehicle speed varying from 0 to 120 km/h and included the rotation of the tire and wheel assembly, considering the tire geometry in dynamic conditions. The computational model is solved by the finite volume method, wherein the computational domain is divided into tetrahedral and hexahedral elements. The turbulence model used is the standard k −ε.

关键词： Computational Fluid Dynamics Wheelhouse Aerodynamics Vehicle Aerodynamics

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Risk factors for blood transfusion and its prognostic implications in curative gastrectomy for gastric cancer

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World Journal of Gastrointestinal Surgery 2023年第4期15卷 643-654页

作者： Lucas Eiki Kawakami pedro Barzan Bonomi Marina Alessandra Pereira Fabrício Oliveira Carvalho Ulysses Ribeiro Jr Bruno Zilberstein Luciana Ribeiro Sampaio Luiz Augusto Carneiro-D'Albuquerque Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 01249000Brazil Blood Transfusion Unit Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 01249000Brazil

BACKGROUND Gastric cancer(GC)is still a prevalent neoplasm around the world and its main treatment modality is surgical *** need for perioperative blood transfusions is frequent,and there is a long-lasting debate regarding its impact on *** To evaluate the factors related to the risk of receiving red blood cell(RBC)transfusion and its influence on surgical and survival outcomes of patients with *** Patients who underwent curative resection for primary gastric adenocarcinoma at our Institute between 2009 and 2021 were retrospectively *** and surgical characteristics data were *** patients were divided into transfusion and non-transfusion groups for *** A total of 718 patients were included,and 189(26.3%)patients received perioperative RBC transfusion(23 intraoperatively,133 postoperatively,and 33 in both periods).Patients in the RBC transfusions group were older(P<0.001),and had morecomorbidities(P=0.014),American Society of Anesthesiologists classification III/IV(P<0.001),and lower preoperative hemoglobin(P<0.001)and albumin levels(P<0.001).Larger tumors(P<0.001)and advanced tumor node metastasis stage(P<0.001)were also associated with the RBCtransfusion *** rates of postoperative complications(POC)and 30-d and 90-d mortalitywere significantly higher in the RBC transfusion group than in the non-transfusion *** and albumin levels,total gastrectomy,open surgery,and the occurrence of POC werefactors associated with the RBC *** analysis demonstrated that the RBCtransfusions group had worse disease-free survival(DFS)and overall survival(OS)compared withpatients who did not receive transfusion(P<0.001 for both).In multivariate analysis,RBCtransfusion,major POC,pT3/T4 category,pN+,D1 lymphadenectomy,and total gastrectomywere independent risk factors related to worse DFS and *** RBC transfusion is associated with worse clinical condition

关键词： Stomach neoplasms Blood transfusion Red blood cells Postoperative complications Survival Prognosis

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Passivation of the Zinc Anode of a Crude Oil Vertical Separator Resulting in Corrosion

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材料科学与工程（中英文B版） 2016年第2期6卷 63-67页

作者： Femando Benedlcto Mamler Juan Manuel Pardal pedro paulo Barbosa Leite Marcone Freitas dos Reis Engineering School Federal Fluminense University (UFF) Niteroi Rio de Janeiro 24220-261 Brazil

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Sugarcane Vinasse, a Residue of Ethanol Industry: Toxic, Cytotoxic and Genotoxic Potential Using the Allium cepa Test

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Journal of Environmental Protection 2016年第5期7卷 602-612页

作者： Janaína pedro-Escher Cintya A. Christofoletti Yadira Ansoar-Rodríguez Carmem S. Fontanetti UNESP—S?o paulo State University Rio Claro Brazil UNIARARAS—Hermínio Ometto Foundation Araras Brazil Department of Pharmacology and Toxicology Pharmacy and Food Institute University of Havana Havana Cuba

The search for fuels to replace petroleum consumption has caused an increase in the production of biofuels worldwide. The ethanol, which comes from sugarcane, is an energy resource with low polluting potential, but its production generates other environmental problems. On average, 10 to 15 liters of vinasse are generated while preparing each liter of ethanol. Vinasse is the final by-product of the biomass distillation, mainly for the production of ethanol, from different cultures such as sugarcane. Because excessive quantities of vinasse are produced, alternatives have been required for use, for example as fertilizer, in a process known as fertigation. These excessive amounts of vinasse applied in soils have generated adverse effects on soil properties and to the organisms. This study carried out the toxic, cytotoxic and genotoxic potential of sugarcane vinasse obtained from two different harvests (Samples I and II), using the Allium cepa organism test. A. cepa seeds were exposed to raw vinasse (RV) and diluted in different concentrations: control soil + raw vinasse (SV);vinasse diluted in water at 50% + control soil (V 50%);vinasse diluted in water at 25% + control soil (V 25%);vinasse diluted in water at 12.5% + control soil (V 12.5%). The chemical characterization of vinasse samples showed a low pH and high concentration of potassium. The results demonstrate that the two RV samples tested are toxic, since no seeds germination was observed. The cytotoxic potential was observed in the sample II of SV and V (50%). All groups evaluated in samples I and II, induced chromosomal alterations, statistically significant compared with negative control. An increase in frequency of micronuclei in meristematic cells was observed in the SV (Sample I) and all groups evaluated in samples II. Based on the results it is concluded that the genetic material of the test-system was damaged when exposed to sugarcane vinasse, suggesting that one should be very careful in the use of this

关键词： Micronucleus Chromosome Aberrations Agroindustrial Residue

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艺术空间

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中国电梯 2019年第2期30卷 45-45页

作者： [巴西]pedro paulo Venzon 不详

一个故事讲述一个道理,一张照片展现已逝瞬间,一句问候加深彼此情谊,一条消息告知天南海北,一幅书画陶冶你我性情,一则名言涌动心底波澜,一个笑话带来欢歌笑语……

关键词：艺术空间照片名言书画

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