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Acetylcholinesterase and Cytotoxic Activity of Chemical Constituents of Clutia lanceolata Leaves and its Molecular Docking Study

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Natural Products and Bioprospecting 2016年第6期6卷 267-278页

作者： Mehtab Parveen faheem Ahmad Ali Mohammed Malla Shaista Azaz Mahboob Alam omer A.Basudan Manuela ramos Silva pedro S.Pereira Silva Department of Chemistry Aligarh Muslim UniversityAligarh 202002India Division of Bioscience Dongguk UniversityGyeongju 780-714Republic of Korea Pharmacognosy College of PharmacyKing Saud UniversityRiyadh 4451Saudi Arabia CfisUC Department of PhysicsUniversity of Coimbra3004-516 CoimbraPortugal

Phytochemical investigations of the ethanolic extract of leaves of Clutia lanceolata(family:Euphorbiaceae)resulted in the isolation of four compounds viz.3,4-dihydroxy-2-methylbenzoic acid(1),2,20-dihydroxy-1,10-binaphthyl(2),1,3,8-trihydroxy-6-methylanthracene-9,10-dione(3)and 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one(4).Although all the isolated compounds were known but this was the first report from this plant *** structures were established on the basis of chemical and physical evidences *** analysis,fT-Ir,1 H-NMr,13CNMr and mass spectral *** of compound 2 and 4 was further authenticated by single-crystal X-ray analysis and density functional theory *** isolated compounds(1–4)were screened for AChE enzyme inhibition assay in which compound 3 and 4 were found to be more potent AChE *** docking study of potent AChE inhibitor was performed to find the probable binding mode of the compounds into the active site of ***,the isolated compounds were also screened for in vivo cytotoxicity by brine shrimp lethality assay.

关键词： Clutia lanceolata X-ray crystallography AChE Molecular docking Cytotoxicity

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad f. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos f. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.f. Allen C.A. Allendes flores P.P. Allport A. Aloisio f. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.r. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli f. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-f. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan r. Astalos S. Atashi r.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu f. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.r. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan r. Balasubramanian E.M. Baldin P. Balek E. Ballabene f. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUArK GLUON TAGGING

Aluminum Toxicity:A Case Study on Tobacco(Nicotiana tabacum L.)

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Phyton-International Journal of Experimental Botany 2023年第1期92卷 165-192页

作者： Munir Ozturk Mert Metin Volkan Altay Tomonori Kawano Alvina Gul Bengu Turkyilmaz Unal Dilek Unal rouf Ahmad Bhat Moonisa Aslam Dervash Kristina Toderich Esra Koc pedro Garcia Caparros Andleeb Shahzadi Department of Botany and Centre for Environmental Studies Ege UniversityIzmir35100Turkiye Graduate School of Environmental Engineering The University of KitakyushuFukuoka808-0135Japan Department of Biology Faculty of Science and ArtsHatay Mustafa Kemal UniversityHatay31060Turkiye Atta-ur-rahman School of Applied Biosciences National University of Sciences&TechnologyIslamabad44000Pakistan Department of Biotechnology Faculty of Science and ArtsNigde Omer Halisdemir UniversityNigde51240Turkiye Department of Molecular Biology and Genetics Faculty of Science and ArtsUniversity of Bilecik Seyh EdebaliBilecik11230Turkiye Department of Environmental Science Sri Pratap CollegeCluster University SrinagarKashmir190008India Division of Environmental Sciences Sher-e-Kashmir University of Agricultural Sciences and TechnologyKashmir190025India International Platform for Dryland research and Education Tottori UniversityTottori680-0001Japan Department of Biology Faculty of ScienceAnkara UniversityAnkara06100Turkiye Department of Superior School Engineering University of AlmeríaAlmería04120Spain Department of Medical Pharmacology Cerrahpasa Medicine FacultyIstanbul University-CerrahpasaIstanbul34096Turkiye

Aluminum is an abundant metal in the earth’s crust that turns out to be toxic in acidic *** plants are affected by the presence of aluminum at the whole plant level,at the organ level,and at the cellular *** as a cash crop(Nicotiana tabacum L.)is a widely cultivated plant worldwide and is also a good model organism for *** there are many articles on Al-phytotoxicity in the literature,reviews on a single species that are economically and scientifically important are *** this article,we not only provide the biology associated with tobacco Al-toxicity,but also some essential information regarding the effects of this metal on other plant species(even animals).This review provides information on aluminum localization and uptake process by different staining techniques,as well as the effects of its toxicity at different compartment levels and the physiological consequences derived from *** addition,molecular studies in recent years have reported specific responses to Al toxicity,such as overexpression of various protective ***,this review discusses data on various organelle-based responses,cell death,and other mechanisms,data on tobacco plants and other kingdoms relevant to these studies.

关键词： Aluminum oxidative stress protective proteins rOS tobacco toxicity

加利福尼亚湾茎柔鱼(Dosidicus gigas)渔场声学调查方法

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中国农业科技导报 2022年第4期24卷 185-192页

作者：唐峰华吴祖立杨嘉樑黄洪亮蒋科技 ESTEfANIA Gonzalez Maiez Violeta ArrEOLA Juan pedro Vela 中国水产科学研究院东海水产研究所农业农村部远洋与极地渔业创新重点实验室上海200090 墨西哥国家渔业和水产养殖研究所瓜伊马斯85400墨西哥墨西哥鱿鱼理事会瓜伊马斯85400墨西哥

声学方法已成为海洋生物资源评估的重要手段,水声学调查与数据分析作为海洋生物资源声学评估的关键,直接影响渔业资源评估结果。通过对数据处理过程中的目标强度、噪声剔除、物种判别问题进行分析,探究墨西哥加利福尼亚湾的茎柔鱼(Dosid... 详细信息

声学方法已成为海洋生物资源评估的重要手段,水声学调查与数据分析作为海洋生物资源声学评估的关键,直接影响渔业资源评估结果。通过对数据处理过程中的目标强度、噪声剔除、物种判别问题进行分析,探究墨西哥加利福尼亚湾的茎柔鱼(Dosidicus gigas)资源水声学调查方法,进而为系统了解和掌握加利福尼亚湾渔场经济品种的资源量打下基础。调查所用数据由加利福尼亚湾中墨海上联合调查船“BIP-XI”安装的单波束回声测深仪Simrad ek60采集,并利用水声学数据处理软件与相关方法进行分析,采用标准球方法对38、120 kHz频率换能器进行了校正。通过积分阈值和信噪比估算方法剔除背景噪声发现,对于高频信号噪声剔除效果良好,120 kHz回波映像的变化比38 kHz更明显,前者噪声去除整体效果优于后者。将虚拟变量剔除背景噪声与优化积分阈方法相结合可剔除大部分噪声数据,减少数据复杂程度。经过海底与海表信号剔除、噪声剔除、频差法识别之后,调查区域内大部分无关噪声信号被剔除,最后使用频差法提取到了目标鱼种的信号。通过加利福尼亚湾茎柔鱼渔场声学调查方法,取得了大洋性鱿鱼类声学评估的初步进展,为后期资源调查奠定了基础。

关键词：加利福尼亚湾茎柔鱼资源评估声学调查频差法

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki fujinaka Ossama Y Mansour Mohamad Abdalkader Michael frankel Zhongming Qiu Allan Taylor pedro lylyk.omer f ek.r Laura Mechtouff Michel Piotin fabricio Oliveira Lima francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza r Al-Bayati Leonardo renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio fiorot rodrigo rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts romain Bourcier romain Guile Melanie Walker Malveeka Sharma Don frei Pascal Jabbour Nabeel Herial fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie randall Edgell Andre Beer-furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin pedro SC Magalhaes raghid Kikano Santiago Ortega-Gutierrez Mudassir farooqui Amal Abou-Hamden Tatsuo Amano ryoo Yamamoto Adrienne Weeks Elena A Cora rotem Sivan-Hoffmann roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez rivera James E Siegler Achmad fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong robert fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee roh Ken Wong Juan f Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro rodriguez Vasquez Luisa fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki fujimura roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,pf ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,prelative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid