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Discovery of marageing steels: machine learning vs. physical metallurgical modelling

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Journal of Materials Science & Technology 2021年第28期87卷 258-268页

作者： Chunguang Shen Chenchong Wang pedro E.J.Rivera-Díaz-del-Castillo Dake Xu Qian Zhang Chi Zhang Wei Xu State Key laboratory of Rolling and Automation Northeastern UniversityShenyang110819China Department of Engineering Lancaster UniversityLA14YKLancasterUK Key laboratory of Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

Physical metallurgical(PM)and data-driven approaches can be independently applied to alloy *** technology is a field of physical metallurgy around which some of the most comprehensive understanding has been developed,with vast models on the relationship between composition,processing,microstructure and *** have been applied to the design of new steel alloys in the pursuit of grades of improved *** the advent of rapid computing and low-cost data storage,a wealth of data has become available to a suite of modelling techniques referred to as machine learning(ML).ML is being emergingly applied in materials discovery while it requires data mining with its adoption being limited by insufficient high-quality datasets,often leading to unrealistic materials design predictions outside the boundaries of the intended *** is therefore required to appraise the strength and weaknesses of PM and ML approach,to assess the real design power of each towards designing novel steel *** work incorporates models and datasets from well-established literature on marageing *** genetic algorithm(GA)with PM models to optimise the parameters adopted for each dataset to maximise the prediction accuracy of PM models,and the results were compared with ML *** results indicate that PM approaches provide a clearer picture of the overall composition-microstructureproperties relationship but are highly sensitive to the alloy system and hence lack on exploration ability of new *** conversely provides little explicit physical insight whilst yielding a stronger prediction accuracy for large-scale *** PM/ML approaches provide solutions maximising accuracy,while leading to a clearer physical picture and the desired properties.

关键词： Machine learning Physical metallurgy Small sample problem Marageing steel

Relationship between lipoprotein （a） and micro/macro complications in type 2 diabetes mellitus： a forgotten target

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Journal of Geriatric Cardiology 2015年第2期12卷 93-99页

作者： Rocio Toro Eduardo Segura Jesfis Millan Nunez-Cortes Juan Carlos pedro-Botet Maribel Quezada-Feijoo Alipio Mangas Department of Medicine Cfdiz University School of Medicine Cdtdiz 11002 C/ Dr Marahon S/N Cadiz Spain Department of Internal Medicine University Hospital Puerta del Mar Cadiz 11002 Ana de Viya S/N Cadiz Spain Department of Internal Medicine University Hospital Gregorio Maranon Madrid28007 C/Doctor Esquerdo 46 Madrid Spain Department of Internal Medicine University Hospital del Mar Barcelona 08003 Passeig Marltim 25-29 Barcelona Spain Department of Cardiology Cruz Roja Hospital Madrid 28003 Av. de la Reina Victoria 22-26 Madrid Spain

ObjectivesIncreased 脂蛋白(a) 浆液集中似乎是一个心血管的风险因素；这没在 extracoronary 动脉粥样硬化复杂并发症被证实。我们因此希望获得更深的卓见 into ；在脂蛋白(a) 的血浆集中和类型 2 糖尿病 mellitus 并且到的微... 详细信息

ObjectivesIncreased 脂蛋白(a) 浆液集中似乎是一个心血管的风险因素；这没在 extracoronary 动脉粥样硬化复杂并发症被证实。我们因此希望获得更深的卓见 into ；在脂蛋白(a) 的血浆集中和类型 2 糖尿病 mellitus 并且到的微脉管、宏脉管的复杂并发症之间的关系在这 *** 识别可能的差别是描述的观察代表性的研究。二 -- 有类型 2 糖尿病 mellitus 的 117 个老病人从内部药 outclinic 被包括。人体测量的数据，分析数据(象高血压的胰岛素保守，基础、饭后的肽 C， glycosylated 血红素，肾的参数，类脂化合物侧面和临床的数据，肥胖，微 -- 并且 macrovascular 复杂并发症是 *** 根据类型被组织进化的 2 糖尿病 mellitus 时间。脂蛋白(a) 的吝啬的血浆集中是 22.2 ±；17.3 mg/dL (22.1 ±；为男性的 15.9 mg/dL，和 22.1 ±；为女性的 18.4 mg/dL ) 。有高血压，冠的心疾病，脑血管的事故， microalbuminuria 和 proteinuria 的病人介绍了脂蛋白(a) 的统计上重要的增加的水平。同样，有 hyperlipoprotein (a) 的病人(≥；30 mg/dL ) 脲和全部的胆固醇的介绍显著地增加的层次。在 multivariate 回归模型，脂蛋白(a) 的水平断然与冠的心疾病和糖尿病的 nephropathy 被相关(P <；0.01 并且 P <；0.005，分别地) 脂蛋白(a) 的血浆层次的 .ConclusionsThe 举起与冠的心疾病和 diabe tic nephropathy 的发展被联系。因此，我们认为脂蛋白(a) 的决心可以是在有类型 2 糖尿病 mellitus 的病人的脉管的复杂并发症的一个预示的标记。

关键词：脂蛋白(a) 2型糖尿病并发症微观宏观心血管疾病高血压患者遗忘

Constraint Analysis and Bladder Wall Low-Dose-Constraint Reduction in Five-Fraction Urethra-Sparing Prostate SBRT

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2021年第3期10卷 132-148页

作者： Alejandro Prado Inés Flores Ángel Montero Miguel Ángel de la Casa Leyre Alonso Jaime Martí pedro Fernández-Letón Carmen Rubio Medical Physics and Radiation Protection Department Hospital Universitario HM Sanchinarro HM Hospitales Madrid Spain Medical Physics and Radiation Protection Department Hospital General de la Defensa Gómez Ulla Madrid Spain Radiation Oncology Department Hospital Universitario HM Sanchinarro HM Hospitales Madrid Spain

Aim: To compare and analyze dose constraints and target coverage results and to reduce Bladder Wall (Bwall) V18.12 for prostate Stereotactic-Body Radiation Therapy (SBRT) when Seminal Vesicles (SSVV) are included or not. Several indicators based on intersection volumes are obtained to predict constraint fulfillment. Background: Due to prostate’s low alpha-beta ratio and the possibility of increasing the therapeutic ratio several moderate and extreme hypofractionation schemes have been proposed. The scheme selected was a fivefraction urethra-sparing prostate SBRT. Materials and Methods: 150 patients divided into two groups according to the inclusion of SSVV in PTV or not were analyzed. Histograms, average values, standard deviations and degrees of fulfillment were obtained for each constraint or goal and group. A possible reduction of the Bwall V18.12 was addressed by re-optimizing fifty randomly chosen patients. Predictors of constraint fulfilling were obtained by using the intersections of Bwall and Rectum Wall (Rwall) with the PTV. Results: Significant differences in Rwall V32.62 and V29 were obtained when evaluating the influence of SSVV inclusion. A reduction of 12% in the Bwall V18.12 constraint was achieved without compromising coverage and OARs doses. No dependence on the inclusion of SSVV was found. Conclusions: Statistically significant differences have been found in Rwall intermediate-dose constraint when SSVV was included. A reduction of 12% in the Bwall V18.12 constraint has been achieved without compromising the PTV coverage and the rest of OARs constraints. Constraint fulfillment predictors could be useful to evaluate the feasibility of prostate SBRT prior to the planning process for every single patient.

关键词： Prostate SBRT Urethra Sparing Bladder Wall Rectum Wall Seminal Vesicles

Dominant Macroalgae in Bahía de Cochinos, Matanzas, Cuba

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American Journal of Plant Sciences 2022年第6期13卷 797-814页

作者： Yusimí Alfonso Patricia González Sánchez Hansel Caballero Aragón pedro Chevalier Jhoana Díaz-larrea Ruben Cabrera Acuario Nacional de Cuba La Habana Cuba Unidad Iztapalapa Departamento de Hidrobiología Universidad Autónoma Metropolitana Cd de México México Gabinete de Arqueología Oficina del Historiador de la Ciudad Habana Vieja Cuba

Spatial-temporal variations of macroalgae were analyzed in a study conducted in Cueva de Los Peces (CP) and Punta Perdiz (PP), two dive sites located on the eastern coast of Bahía de Cochinos. The most conspicuous species found from 3 to 20 m depths were present in the biotopes of ridges and shallow and deep terraces. Sampling was carried out in September 2014, and March and October 2016 by autonomous diving and direct methods. Qualitative visual censuses and quantitative analyzes were used to estimate the coverage (%) of the genera according to the AGRRA methodology with the use of the 10 m linear transect and quadrats as the sampling unit. The first list of macroalgae for the area is offered that includes 49 taxa of which 10 were Rhodophyta, 10 Ochrophyta (Phaeophyceae), and 29 Chlorophyta. The dominant genera during the study period were Halimeda, Dictyota, Lobophora, and Udotea. Spatial differences were found regarding the specific composition. Temporal variations were evidenced in terms of the relative abundance of the genera present, which reveals temporal changes in the qualitative structure, where some species replace others. The information obtained is pioneering and can serve as a comparative baseline for future monitoring of the area.

关键词： Cuba Macroalgae Spatial-Temporal Variations Species List

In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals

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Translational Neurodegeneration 2014年第1期3卷 34-39页

作者： Eduardo Rigon Zimmer Antoine Leuzy Venkat Bhat Serge Gauthier pedro Rosa-Neto Translational Neuroimaging laboratory(TNL) McGill Center for Studies in AgingDouglas Mental Health University InstituteMcGill University6875 La Salle Blv-FBC room 3149MontrealQCH4H 1R3Canada Montreal Neurological Institute(MNI) MontrealCanada Department of Biochemistry Federal University of Rio Grande do Sul(UFRGS)Porto AlegreBrazil Department of Psychiatry McGill UniversityMontrealBrazil

Hyperphosphorylation of the tau protein leading to the formation of neurofibrillary tangles(NFTs)is a common feature in a wide range of neurodegenerative diseases known as tauopathies,which include Alzheimer’s disease(AD)and the frontotemporal dementias(FTDs).Although heavily investigated,the mechanisms underlying the pathogenesis and progression of tauopathies have yet to be fully *** this context,several rodent models have been developed that successfully recapitulate the behavioral and neurochemical features of tau pathology,aiming to achieve a better understanding of the link between tau and *** date,behavioral and biochemical parameters assessed using these models have been conducted using a combination of memory tasks and invasive methods such as cerebrospinal fluid(CSF)sampling or post-mortem ***,several novel positron emission tomography(PET)radiopharmaceuticals targeting tau tangles have been developed,allowing for non-invasive in vivo quantification of tau *** with tau transgenic models and micro-PET,these tracers hold the promise of advancing the development of theoretical models and advancing our understanding of the natural history of AD and non-AD *** this review,we briefly describe some of the most important insights for understanding the biological basis of tau pathology,and shed light on the opportunity for improved modeling of tau pathology using a combination of tau-radiopharmaceuticals and animal models.

关键词： Positron emission tomography Tau molecular agents Tau rodent models Tauopathies

Unpaved rural roads as source areas of sediment in a watershed of the Brazilian semi-arid region

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International Journal of Sediment Research 2019年第5期34卷 475-485页

作者： Teresa Raquel Lima Farias pedro Henrique Augusto Medeiros Joaquín Navarro-Hevia José Carlos de Araújo Federal Institute of Education Science and Technology of Ceará University of Valladolid Campus La Yutera Federal University of Ceará Department of Agricultural Engineering Campus do Pici

Approximately 80% of the road network in Brazil is unpaved and shows evidences of a high erosion potential. In the semi-arid Caatinga Biome in the northeast of the country, a monitoring programme has been done for two years in order to analyze runoff and sediment production from unpaved rural roadways and from embankments. Sediment production ranged from 0.30 to 0.92 Mg/ha yr, higher than in undisturbed areas, but generally lower than that reported for unpaved roads in other regions. However,this is a semi-arid area with low rainfall and runoff and, hence, with a limited hydrological connectivity and sediment production. Sediment production on an embankment with no vegetation was around ten times higher than on an embankment with vegetation. On the road surface, annual sediment production(normalized for gradient) in a section with traffic was three times higher than for a road surface without traffic. In addition, events that occurred after roadway maintenance activities generated peaks of sediment concentration of over 5000 mg/L. These results suggest that sediment production from roads and embankments with bare surfaces is at least one order of magnitude higher than in undisturbed catchment areas. Maintenance activity and vehicle traffic contribute to an increase in sediment availability and impact on the sediment concentration, but less intensely on sediment loads, which depend on the runoff magnitude of the events occurring after roadway maintenance. It was also found that the natural vegetation of the semi-arid region potentially captures sediment on roadway embankments; thereby playing an important role in breaking connectivity between the sediment flow from unpaved roads and the natural drainage system of the catchment.

关键词： Sediment production Caatinga vegetation Road maintenance Embankment

High-throughput analysis of Fröhlich-type polaron models

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npj Computational Materials 2023年第1期9卷 817-829页

作者： pedro Miguel M.C.de Melo Joao C.de Abreu Bogdan Guster Matteo Giantomassi Zeila Zanolli Xavier Gonze Matthieu J.Verstraete Chemistry Department Debye Institute for Nanomaterials Science and European Theoretical Spectroscopy FacilityCondensed Matter and InterfacesUtrecht UniversityPO Box 80.0003508 TA UtrechtThe Netherlands Nanomat/Q-MAT/CESAM and European Theoretical Spectroscopy Facility Universitéde LiègeB-4000 LiègeBelgium UCLouvain Institute of Condensed Matter and Nanosciences(IMCN)Chemin desÉtoiles 8B-1348 Louvain-la-NeuveBelgium

The electron–phonon interaction is central to condensed matter,*** electrical resistance,superconductivity or the formation of polarons,and has a strong impact on observables such as band gaps or optical *** most common framework for band energy corrections is the Fröhlich model,which often agrees qualitatively with experiments in polar materials,but has limits for complex cases.A generalized version includes anisotropic and degenerate electron bands,and multiple *** this work,we identify trends and outliers for the Fröhlich models on 1260 *** test the limits of the Fröhlich models and their perturbative treatment,in particular the large polaron *** our extended dataset most materials host perturbative large polarons,but there are many instances that are non-perturbative and/or localize on distances of a few bond *** find a variety of behaviors,and analyze extreme cases with huge zero-point renormalization using the first-principles Allen-Heine-Cardona approach.

关键词： materials polaron correction

Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni Ana Júlio Celestino Santos-Buelga Ana M.Gonzalez-Paramas Patrícia Filipe Patricia Rijo Sofia A.Costa Lima Salette Reis Angela Fernandes Isabel C.F.R.Ferreira Virginia Fernandez-Ruiz Patricia Morales Guido Flamini Lotfi Achour pedro Fonte laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia CBIOS-Research Center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal laQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacao de Montanha(CIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly Centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly Center for Marine Sciences(CCMar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of Chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with EC_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surface were *** and DSC were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA

Gold Supported on Metal Oxides for Carbon Monoxide Oxidation

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Nano Research 2011年第2期4卷 180-193页

作者： Sonia A. C. Carabineiro Nina Bogdanchikova Miguel Avalos-Borja Alexey Pestryakov pedro B. Tavares Jose L. Figueiredo laboratário de Catálise e Materiais Associate Laboratory LSRE/LCM Departamento de Engenharia Química Faculdade de Engenharia Universidade do Porto 4200-465 Porto Portugal Universidad Nacional Autónoma de México Centro de Nanociencias y Nanotecnologia Carretera Tijuana-Ensenada 22800 Ensenada Baja California México Tomsk Polytechnic University 30 Lenin Avenue Tomsk 634050 Russia Universidade de Trás-os-Montes e Alto Douro Centro de Quimica-Vila Real Departamento de Química 5001-911 Vila Real Portugal

Au 被装载了(1% wt ) 在不同广告上，氧化物支持(CuO， la2O3， Y2O3， NiO ) 由三个不同方法：两倍受精(暗淡) ，液体阶段减少的免职(LPRD ) ，和 ultrasonication (美国) 。样品被 N2 吸附描述在 ? 196 ??  ??????  ??  ? 洠... 详细信息

Au 被装载了(1% wt ) 在不同广告上，氧化物支持(CuO， la2O3， Y2O3， NiO ) 由三个不同方法：两倍受精(暗淡) ，液体阶段减少的免职(LPRD ) ，和 ultrasonication (美国) 。样品被 N2 吸附描述在 ? 196 ??  ??????  ??  ? 洠浡業汬牡 ?  ???? 猠'T 業牣吗？

关键词：金属氧化物一氧化碳氧化黄金 Au纳米粒子 X射线荧光光谱仪透射电子显微镜选区电子衍射程序升温还原