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eIF3 subunit M regulates blood meal digestion in Rhodnius prolixus affecting ecdysis, reproduction, and survival

Insect Science 2023年第5期30卷 1282-1292页

作者： Pilar Ameijeiras Natalia Capriotti Sheila Ons pedro l.Oliveira Marcos Sterkel laboratorio de Neurobiología de Insectos(lNI) Centro Regional de Estudios GenómicosFacultad de Ciencias ExactasUniversidad Nacional de La PlataCENEXACONICETLa PlataBuenos AiresArgentina Instituto de Bioquímica Médica leopoldo de Meis Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular(INCT-EM) Rio de JaneiroBrazil

In triatomines,blood-feeding triggers many physiological processes including post embryonic development and *** feeding habits,such as hematophagy,can shape gene functions to meet the challenges of each type of *** gut of blood-sucking insects faces particular challenges after feeding due to the quantity and the quality of the food ingested.A comparison of transcriptomic and proteomic data indicates that post transcriptional regulation of gene expression is crucial in the triatomine *** was proposed that eukaryotic translation initiation factor 3 subunit m(eIF3m)and eIF3e define 2 different eIF3 complexes with a distinct affinity for the different mRNAs,thus selecting the set of mRNAs to be translated and constituting a post transcriptional mode of regulation of gene *** the eIF3m is mainly expressed in the gut,we evaluated its relevance in Rhodnius prolixus physiology through RNA interference-mediated gene *** knockdown of eIF3m reduced the digestion rate,affecting the processes triggered by a blood *** silencing inhibited molting and caused premature death in nymphs while impaired ovary development,oviposition and increased resistance to starvation in adult *** survival of males after feeding(resistance to starvation)was not affected by eIF3m *** information regarding the eIF3m function in insects is scarce and the phenotypes observed in *** upon eIF3m silencing are different and more severe than those previously described in Drosophila melanogaster,indicating a pleiotropic role of this gene in triatomines.

关键词： egg hatching hematophagous vectors lifespan oviposition post embryonic development starvation resistance

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Interplay among cellular polarization,lipoprotein metabolism and hepatitis C virus entry

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World Journal of Gastroenterology 2011年第22期17卷 2683-2690页

作者： Ignacio Benedicto Francisca Molina-Jiménez Ricardo Moreno-Otero Manuel lópez-Cabrera pedro l Majano Molecular Biology Unit Hospital Universitario de la Princesa Instituto de Investigación Sanitaria Princesa (IP) Madrid 28006 Spain CIBERehd Instituto de Salud Car- los Ⅲ Madrid 28029 Spain liver Unit Hospital Universitario de la Princesa Instituto de Investigación Sanitaria Princesa (IP) Madrid 28006 Spain Centro de Biología Molecular Severo Ochoa CSIC-UAM Madrid 28049 Spain

Hepatitis C virus (HCV) infects more than three million new individuals worldwide each year. In a high percent age of patients, acute infections become chronic, eventually progressing to fibrosis, cirrhosis, and hepatocellular carcinoma. Given the lack of effective prophylactic or therapeutic vaccines, and the limited sustained virological response rates to current therapies, new approaches are needed to prevent, control, and clear HCV *** into the host cell, being the first step of the viral cycle, is a potential target for the design of new antiviral compounds. Despite the recent discovery of the tight junction-associated proteins claudin-1 and occludin as HCV co-receptors, which is an important step towards the understanding of HCV entry, the precise mechanisms are still largely unknown. In addition, increasing evidence indicates that tools that are broadly employed to study HCV infection do not accurately reflect the real process in terms of viral particle composition and host cell phenotype. Thus, systems that more closely mimic natural infection are urgently required to elucidate the mechanisms of HCV entry, which will in turn help to design antiviral strategies against this part of the infection process.

关键词： Cellular polarization Tight junctions lipoprotein metabolism Hepatitis C virus

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Pharmaceutical applications of spouted beds: A review on solid dosage forms

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Particuology 2019年第1期17卷 126-136页

作者： luis Alexandre pedro de Freitas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto University of Sao PauloVia do Cafe s/n. Campus USPRibeirao Preto14040-903Sao Paulo. Brazil

Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological characteristics of pharmaceutical solid forms. Particle properties like morphology, size, porosity, flowability, and dissolution rate can be improved by managing geometric and operational conditions for spouting. Drying is probably the most disseminated operation for pharmaceutical processing in SBs, and many studies have investigated drying of medicinal plant extracts such as achiote (Bixa orellana sp.), guarana (Paullinia cupana sp.), passion flower (Passiflora alata D.), and rosemary (Rosmarinus officinalis l.) with excellent pharmacotechnical and stability results. Another important application is coating of tablets and gelatin capsules, and previous studies have shown that SBs and spout–fluid beds may be advantageous over traditional pan coating, especially for polymeric film coating. Recently, an alternative process for improving drug bioavailability has involved preparation of β-cyclodextrin inclusion complexes in SBs. The first study to propose SBs for this pharmaceutical application explored the advantage of obtaining solid forms of inclusion complexes in just one step, and obtained expressive increases in drug solubility. The technique has been applied in subsequent studies on inclusion complexes of the medication carvedilol and uxi (Endopleura uchi l.) extracts.

关键词： Coating Drying Granulation Inclusion Microencapsulation

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Assessment of Intangible losses in Earthquake Engineering

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Open Journal of Civil Engineering 2024年第3期14卷 469-485页

作者： Jaime García-Pérez Orlando Díaz-lópez Eric García-lópez Instituto de Ingeniera Ingeniera Estructural Edif 2 Universidad Nacional Autnoma de Mxico Ciudad Universitaria Mexico City Mxico Cobertizo San pedro Mrtir s/n Facultad de Ciencias Jurdicas y Sociales Universidad de Castilla-La Mancha Toledo Espaa

In order to find optimum design parameters in earthquake engineering, an objective function is optimized. This function comprises the initial cost of a structure and the cost due to the damage of earthquakes. Intangible losses may be included in the latter, such as how much society is willing to invest to preserve a human life. In this paper, the expression of the objective function is developed in terms of the seismic design coefficient, and the aforementioned intangible loss is calculated from both the individual point of view and that of society. The calculation of the intangible is based on utility curves. Finally, optimum seismic design coefficients are calculated for a firm ground site.

关键词： Seismic Risk Optimum Coefficients Structural Reliability Intangible losses Utility

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Deadly oasis:Recurrent annihilation of Cretaceous desert bryophyte colonies;the role of solar,climate and lithospheric forcing

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Geoscience Frontiers 2021年第1期12卷 1-12页

作者： Juan pedro Rodríguez-lópeza Eduardo Barrón Daniel Peyrot Gary B.Hughes Department of Geology.Faculty of Science.United Arab Emirates University.50009.Al Ain Abu DhabiUnited Arab Emirates Instituto Geológico y Minero de Espana(IGME) Ríos Rosas 23E-28003MadridSpain School of Earth and Environment University of Western Australia.6101CrawleyWestern AustraliaAustralia Centre for Energy Geosciences University of Western Australia.6101CrawleyWestern AustraliaAustralia Physics Department University of CaliforniaSanta BarbaraCA93106USA

Many oases(wet interdunes)are sedimentary systems characterized by high-frequency water-level oscillations,marked changes in salinity and intense biological activity at their *** are considered to be one of the most challenging environments on Earth for ecosystem *** dynamic,depositional settings are usually unfavourable for fossilization and subsequent preservation of vegetal *** paper describes bryophyte(liverwort)assemblages occurring in three successive horizons interpreted to represent(i)recurrent early successional phases of biological soil crust colonization of wet interdune margins or(ii)exceptional preservation of floating or riparian liverworts in oasis pond waters associated with a progressive fall of the interdune water *** record of in situ colonization surfaces characterized by delicate(***-free)three-dimensional structures represents an exceptional type of preservation herein associated with a rapid variation in phreatic interdune water level and the subsequent establishment of anoxic and reducing *** occurrence of exceptionally preserved liverwort colonies coincides with the sedimentary record of,at least,three seismite levels in the *** gathered from the site suggests that the water table of the oasis was controlled by a combination of(i)a positive creation of accommodation space due to subsidence associated with movement on syn-sedimentary extensional faults,and(ii)the rise and fall of the oasis water table controlled by the oscillations of the groundwater system due to orbital changes which appear to drive the variability of the climate *** groundwater levels flooded the oasis soil crusts and lead to the exceptional recurrent preservation of liverwort colonies at the oasis ***,considering the hypothesis of floating or riparian liverworts in the oasis pond waters,the fall in the level of the oasis water table placed the floating liverworts in contact with the

关键词： Oasis Cretaceous liverworts Colonies Extensional tectonics Solar cyclicity

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Structural and photoluminescent properties of the MgGa_(2)O_(4):Co^(2+)ceramic compound revisited after two decades

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Journal of Advanced Ceramics 2015年第4期4卷 267-271页

作者： S.S.pedro M.A.F.M.DA SIlVA A.lÓPEZ,l.P.SOSMAN Instituto de Física Universidade do Estado do Rio de JaneiroRJ 20550-900Brazil

In this work,we revisit and show how the structural and photoluminescent properties of the MgGa_(2)O_(4) ceramic compound have been kept unchanged for more than two *** obtained results confirm the high quality,radiative efficiency,and chemical stability of this ceramic,proving that the material is a strong candidate to be used in optical device applications with relatively long useful life.

关键词： ceramic compound cobalt solid-state reaction photoluminescence

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large dinosaur egg accumulations and their significance for understanding nesting behaviour

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Geoscience Frontiers 2024年第5期15卷 467-488页

作者： l.Ezquerro R.Coimbra B.Bauluz C.Núñez-lahuerta T.Román-Berdiel M.Moreno-Azanza Departamento de Geodinámica Estratigrafía y PaleontologíaFacultad de Ciencias GeológicasUniversidad Complutense de MadridC/JoséAntonio Novais1228040MadridSpain Aragosaurus-IUCA:Recursos Geológicos y Paleoambientales.Departamento de Ciencias de la Tierra.Facultad de Ciencias Universidad de ZaragozaC/Pedro Cerbuna 1250009 ZaragozaSpain Museu da lourinha LourinhaPortugal GeoBioTec Department of Earth SciencesNOVA School of Science and TechnologyUniversidade Nova de LisboaCaparicaPortugal GeoBioTec Departamento de GeocienciasUniversidade de AveiroAveiroPortugal Insitut Catalàde Paleoecologia Humana i EvolucióSocial(IPHES-CERCA) Zona Educacional 4Campus Sescelades URV(Edifici W3)43007 TarragonaSpain Departament d´Història i Història de l´Art Universitat Rovira i VirgiliAv.Catalunya 3543002 TarragonaSpain Geotransfer IUCA Departamento de Ciencias de La TierraFacultad de CienciasUniversidad de ZaragozaZaragozaSpain

The accurate identification of dinosaur egg accumulations as nests or clutches is crucial for understanding the reproductive behaviour of these extinct ***,existing methods often rely on the presence of complete eggs and embryo remains,and sedimentological criteria that are only applicable to well-structured *** this study,we introduce an innovative approach to characterize egg accumulations in structureless sediments,where traditional nest structures may not be *** methodology employs a unique combination of sedimentological,taphonomic,geochemical,and geophysical proxies for the study of egg *** applied this approach to the egg accumulation from Paimogo(Jurassic,Portugal),traditionally interpreted as a *** findings reveal that the Paimogo egg assemblage is a secondary deposit,resulting from a flooding event in a fluvial plain that dismantled several allosauroid and crocodylomorph *** eggshell vapor conductance results,coupled with sedimentological evidence,suggest that allosauroid dinosaurs buried their eggs in the dry terrain of overbank areas close to a main channel during the breeding season,likely during the dry season to prevent the embryos from *** research underscores the necessity of multidisciplinary approaches in interpreting egg accumulations and offers a novel methodology for studying these accumulations in structureless *** findings provide new insights into the breeding behaviour and nesting preferences of these extinct organisms,contributing to our understanding of dinosaur ecology.

关键词： Breeding behaviour Theropod Taphonomy Stable isotopes Magnetic susceptibility Jurassic

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Searching for ductile superconducting Heusler X_(2)YZ compounds

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npj Computational Materials 2023年第1期9卷 919-927页

作者： Noah Hoffmann Tiago F.T.Cerqueira pedro Borlido Antonio Sanna Jonathan Schmidt Miguel A.l.Marques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099 HalleGermany CFisUC Department of PhysicsUniversity of CoimbraRua Larga 3004-516 CoimbraPortugal Max-Planck-Institut für Mikrostrukturphysik Weinberg 2D-06120 HalleGermany

Heusler compounds attract a great deal of attention from researchers thanks to a wealth of interesting properties,among which is *** we perform an extensive study of the superconducting and elastic properties of the cubic(full-)Heusler family using a mixture of ab initio methods,as well as interpretable and predictive machine-learning *** analyzing the statistical distributions of these properties and comparing them to anti-perovskites,we recognize universal behaviors that should be common to all conventional superconductors while others turn out to be specific to the material *** total,we discover a total of eight hypothetical materials with critical temperatures above 10 K to be compared with the current record of T_(c)=4.7 K in this ***,we expect most of these materials to be highly ductile,making them potential candidates for the manufacture of wires and tapes for superconducting magnets.

关键词： ductile compounds superconducting

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Decomposition and stabilization of organic matter in an old-growth tropical riparian forest:effects of soil properties and vegetation structure

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Forest Ecosystems 2021年第1期8卷 173-181页

作者： pedro Henrique de Godoy Fernandes Andréa lúcia Teixeira de Souza Marcel Okamoto Tanaka Renata Sebastiani Graduate Program in Environmental Sciences Federal University of São CarlosSão CarlosSPBrazil Department of Environmental Sciences(DCAm) Federal University of São CarlosSão CarlosSPBrazil Department of Nature Mathematicsand Education SciencesFederal University of São CarlosSão CarlosSPBrazil

Background:Nutrient cycling in tropical forests has a large importance for primary productivity,and decomposition of litterfall is a major process influencing nutrient balance in forest *** large-scale factors strongly influence decomposition patterns,small-scale factors can have major influences,especially in old-growth forests that have high structural complexity and strong plant-soil *** we evaluated the effects of forest structure and soil properties on decomposition rates and stabilization of soil organic matter using the Tea Bag Index(TBI)in an old-growth riparian forest in southeastern *** data sets were described separately using Principal Components Analysis(PCA).The main axes for each analysis,together with soil physical properties(clay content and soil moisture),were used to construct structural equations models that evaluated the different parameters of the TBI,decomposition rates and stabilization *** best model was selected using Akaike’s ***:Forest structure and soil physical and chemical properties presented large variation among plots within the studied *** content was strongly correlated with soil moisture and the first PCA axis of soil chemical properties,and model selection indicated that clay content was a better predictor than this *** rates presented a large variation among tea bags(0.009 and 0.098 g·g^(−1)·d−1)and were positively related with forest structure,as characterized by higher basal area,tree density and larger *** stabilization factor varied between 0.211–0.426 and was related to forest stratification and soil clay ***:The old-growth forest studied presented high heterogeneity in both forest structure and soil properties at small spatial scales,that influenced decomposition processes and probably contributed to small-scale variation in nutrient *** rates were only influenced by forest structure,whereas the stabilizat

关键词： Tea bag index Forest structure Carbon fixation Nutrient cycling

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Exchange-correlation functionals for band gaps of solids:benchmark,reparametrization and machine learning

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npj Computational Materials 2020年第1期6卷 869-885页

作者： pedro Borlido Jonathan Schmidt Ahmad W.Huran Fabien Tran Miguel A.l.Marques Silvana Botti Institut für Festkörpertheorie und-optik Friedrich-Schiller-Universität Jena and European Theoretical Spectroscopy FacilityMax-Wien-Platz 107743 JenaGermany Institut für Physik Martin-Luther-Universität Halle-Wittenberg06099 HalleGermany Institute of Materials Chemistry Vienna University of TechnologyGetreidemarkt 9/165-TC1060 ViennaAustria

We conducted a large-scale density-functional theory study on the influence of the exchange-correlation functional in the calculation of electronic band gaps of ***,we use the large materials data set that we have recently proposed to benchmark 21 different functionals,with a particular focus on approximations of the meta-generalized-gradient *** these data with the results for 12 functionals in our previous work,we can analyze in detail the characteristics of each approximation and identify its strong and/or weak *** confirming that mBJ,HlE16 and HSE06 are the most accurate functionals for band gap calculations,we reveal several other interesting functionals,chief among which are the local Slater potential approximation,the GGA AK13lDA,and the meta-GGAs HlE17 and *** also compare the computational efficiency of these different *** on these data,we investigate the potential for improvement of a promising subset of functionals by varying their internal *** identified optimal parameters yield a family of functionals fitted for the calculation of band ***,we demonstrate how to train machine learning models for accurate band gap prediction,using as input structural and composition data,as well as approximate band gaps obtained from density-functional theory.

关键词： theory functionals solids

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