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The Origin of Patterning Systems in Bilateria——Insights from the Hox and ParaHox Genes in Acoelomorpha

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Genomics, Proteomics & Bioinformatics 2011年第3期9卷 65-76页

作者： Eduardo Moreno Jon Permanyer pedro Martinez Department of Genetics University of Barcelona 08028-Barcelona Spain Catalan Institute for Research and Advanced Studies (ICREA) 08010-Barcelona Spain

Hox and ParaHox genes constitute two families of developmental regulators that pattern the Anterior-Posterior body axis in all bilaterians. The members of these two groups of genes are usually arranged in genomic clusters and work in a coordinated fashion, both in space and in time. While the mechanistic aspects of their action are relatively well known, it is still unclear how these systems evolved. For instance, we still need a proper model of how the Hox and ParaHox clusters were assembled over time. This problem is due to the shortage of information on gene complements for many taxa （mainly basal metazoans） and the lack of a consensus phylogenetic model of animal relationships to which we can relate our new findings. Recently, several studies have shown that the Acoelomorpha most probably represent the first offshoot of the Bilateria. This finding has prompted us, and others, to study the Hox and ParaHox complements in these animals, as well as their activity during development. In this review, we analyze how the current knowledge of Hox and ParaHox genes in the Acoelomorpha is shaping our view of bilaterian evolution.

关键词： Hox-ParaHox Acoelomorpha Bilateria cluster transposon Hox code

Evaluation of suitable reference genes for normalization of quantitative real-time PCR analysis in rice plants under Xanthomonas oryzae ***--infection and melatonin supplementation

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食物生产加工与营养(英文) 2020年第1期2卷 207-216页

作者： Xian Chen pedro Laborda Yan Dong Fengquan Liu Institute of Plant Protection Jiangsu Key Laboratory for Food Quality and Safety–State Key Laboratory Cultivation Base of Ministry of Science and TechnologyJiangsu Academy of Agricultural SciencesNanjing 210014PR China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Zhejiang Academy of Agricultural SciencesHangzhou 310021PR China School of Life Sciences Nantong UniversityNantong 226019PR China

Exogenous melatonin(MT)was found to be an interesting tool for enhancing the resistance of rice to ***(Xoo)-caused bacterial blight(BB).However,the accurate comparison of the expression levels across samples was a challenging *** this work,the stability of 10 common used housekeeping genes under Xoo-infection and MT supplementation in rice was analyzed using quantitative real-time PCR(qRT-PCR),and algorithms geNorm,NormFinder and *** results indicated that most reference genes remained stable in Xoo-infected rice plants,while a number of reference genes were affected by MT *** all studied genes,the transcript levels of 18S(18S ribosomal RNA)and UBC(Ubiquitin-conjugating enzyme E2)remained unaltered by Xoo infection,while UBC and UBQ5(Ubiquitin 5)were the most stable genes when examining simultaneous Xoo-infection and MT supplementation,demonstrating that UBC is a suitable reference gene for qRT-PCR data normalization in rice under Xoo-infection and MT supplementation.

关键词： Rice Xanthomonas oryzae pv.oryzae Melatonin qRT-PCR Reference genes

Quasi-Optimal Convergence Rate of an AFEM for Quasi-Linear Problems of Monotone Type

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Numerical Mathematics(Theory,Methods and Applications) 2012年第2期5卷 131-156页

作者： Eduardo M.Garau pedro Morin Carlos Zuppa Departamento de Matemática Facultad de Ingeniería Química and Instituto de Matemática Aplicada del Litoral(Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Científicas y Técnicas).Güemes 3450.S3000GLN Santa FeArgentina Departamento de Matemática Facultad de Ciencias Físico Matemáticas y NaturalesUniversidad Nacional de San LuisChacabuco 918D5700BWT San LuisArgentina

We prove the quasi-optimal convergence of a standard adaptive finite element method(AFEM)for a class of nonlinear elliptic second-order equations of monotone *** adaptive algorithm is based on residual-type a posteriori error estimators and Dörfler’s strategy is assumed for *** first prove a contraction property for a suitable definition of total error,analogous to the one used by Diening and Kreuzer(2008)and equivalent to the total error defined by Cascón ***.(2008).This contraction implies linear convergence of the discrete solutions to the exact solution in the usual H1 Sobolev ***,we use this contraction to derive the optimal complexity of the *** results are based on ideas from Diening and Kreuzer and extend the theory from Cascón *** a class of nonlinear problems which stem from strongly monotone and Lipschitz operators.

关键词： quasilinear elliptic equations adaptive finite element methods optimality

Immunotherapy in biliary tract cancers:Current evidence and future perspectives

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1446-1455页

作者： pedro Luiz Serrano Uson Junior Raphael LC Araujo Center for Personalized Medicine Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Department of Surgery Universidade Federal de São PauloSão Paulo 04039-002Brazil Department of Oncology Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil

Bile duct tumors are comprised of tumors that originate from both intrahepatic and extrahepatic bile ducts and gallbladder *** are aggressive tumors and chemotherapy is still the main treatment for advanced-stage disease and most of these cases have a poor overall *** are aimed at treatments with better outcomes and less toxicity which makes immunotherapy an area of significant *** Food and Drug Administration approvals of immune checkpoint inhibitors(ICI)for agnostic tumors based on biomarkers such as microsatellite instability-high and tumor mutation burden-high are important steps in the treatment of patients with advanced bile duct *** limited responses with isolated checkpoint inhibitors in later lines of systemic treatment in advanced disease,drug combination strategies have been demonstrating encouraging results to enhance ICI efficacy.

关键词： Biliary tract cancer Cholangiocarcinoma Anti-programmed cell death protein-1 Anti-programmed death ligand-1 Microsatellite instability high Tumor mutational burden high

New perspectives in iron chelation therapy for the treatment of Parkinson’s disease

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Neural Regeneration Research 2019年第11期14卷 1905-1906页

作者： Marco T. Nunez pedro Chana-Cuevas Faculty of Sciences Universidad de ChileSantiagoChile Movement Disorders Center Universidad de Santiago de ChileSantiagoChile

Neurodegenerative diseases with an iron accumulation component: A wide variety of neurological diseases are characterized by the accumulation of iron in different areas of the central nervous system, include Parkinson’s disease, Huntington disease, Alzheimer’s disease, Friedreich’s ataxia, amyotrophic lateral sclerosis, pantothenate kinase-associated neurodegeneration and other neuropathologies associated with brain iron accumulation (Hayflick et al., 2018).

关键词： Parkinson Huntington Friedreich Alzheimer

Automatic detection of Acacia longifolia invasive species based on UAV-acquired aerial imagery

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Information Processing in Agriculture 2022年第2期9卷 276-287页

作者： Carolina Goncalves pedro Santana Tomas Brandao Magno Guedes ISCTE-Instituto Universitario de Lisboa Portugal Instituto de Telecomunicacoes LisboaPortugal Information Sciences and Technologies and Architecture Research Center(ISTAR-IUL) LisboaPortugal IntRoSys SA Portugal

The Acacia longifolia species is known for its rapid growth and dissemination,causing loss of biodiversity in the affected *** order to avoid the uncontrolled spread of this species,it is important to effectively monitor its distribution on the agroforestry *** this purpose,this paper proposes the use of Convolutional Neural Networks(CNN)for the detection of Acacia longifolia,from images acquired by an unmanned aerial *** models based on the same CNN architecture were *** classifies image patches into one of nine possible classes,which are later converted into a binary model;this model presented an accuracy of 98:6%and 98:5%in the validation and training sets,*** second model was trained directly for binary classification and showed an accuracy of 98:8%and 98:7%for the validation and test sets,*** results show that the use of multiple classes,useful to provide the aerial vehicle with richer semantic information regarding the environment,does not hamper the accuracy of Acacia longifolia detection in the classifier’s primary *** presented system also includes a method for increasing classification’s accuracy by consulting an expert to review the model’s predictions on an automatically selected sub-set of the samples.

关键词： Pattern recognition Convolutional neural networks Invasive plants Acacia longifolia

A noncoding secret to stay young—protecting T_(reg)cells to keep the balance in the liver

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Science China(Life Sciences) 2023年第11期66卷 2694-2696页

作者： Hiep Tai Nguyen pedro J.Batista Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesda MD 20892 USA

The liver plays a crucial role in maintaining whole-body metabolic homeostasis and harbors a distinct immune environment(Robinson et al.,2016).However,during the aging process,the liver undergoes structural and functional changes that can disrupt the delicate balance between the immune system and liver *** age-related alterations can lead to increased susceptibility to metabolic diseases,including non-alcoholic fatty liver disease(NAFLD),and impairments in immune cell regulation and tissue repair(Albillos et al.,2022;Anstee et al.,2019).

关键词： al. alterations homeostasis

Multi-Objective Particle Swarm Optimization(MOPSO) for a Distributed Energy System Integrated with Energy Storage

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Journal of Thermal Science 2019年第6期28卷 1221-1235页

作者： ZHANG Jian CHO Heejin MAGO pedro J. ZHANG Hongguang YANG Fubin Mechanical Engineering Department Mississippi State UniversityMississippi StateMS39762USA College of Environmental and Energy Engineering Beijing University of TechnologyBeijing 100124China

Distributed energy systems are considered as a promising technology for sustainable development and have become a popular research topic in the areas of building energy systems. This work presents a case study of optimizing an integrated distributed energy system consisting of combined heat and power(CHP), photovoltaics(PV), and electric and/or thermal energy storage for a hospital and large hotel buildings located in Texas and California. First, simulation models for all subsystems, which are developed individually, are integrated together according to a control strategy designed to satisfy both the electric and thermal energy requirements of a building. Subsequently, a multi-objective particle swarm optimization(MOPSO) is employed to obtain an optimal design of each subsystem. The objectives of the optimization are to minimize the simple payback period(PBP) and maximize the reduction of carbon dioxide emissions(RCDE). Finally, the energy performance for the selected building types and locations are analyzed after the optimization. Results indicate that the proposed optimization method could be applied to determine an optimal design of distributed energy systems, which reaches a trade-off between the economic and environmental performance for different buildings. With the presented distributed energy system, a peak shaving in electricity of about 300 kW and a reduction in boiler fuel consumption of 610 kW could be attained for the hospital building located in California for a winter day. For the summer and transition seasons, electricity peak shaving of 800 kW and 600 kW could be achieved, respectively.

关键词： multi-objective particle swarm optimization distributed energy system payback period carbon dioxide emission

Topological Minors in Bipartite Graphs

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Acta Mathematica Sinica,English Series 2011年第11期27卷 2085-2100页

作者： Camino BALBUENA Martin CERA pedro GARCIA-VAZQUEZ Juan Carlos VALENZUELA Departament de Matematica Aplicada III Universitat Politecnica de Catalunya C/ Jordi Girona 1-3 （ Edifici C2 Despatx 302） 08034 Barcelona Spain Departamento de Matemdtica Aplicada I Universidad de SeviUa EUIT Agrlcola Ctra. Utrera Kin. 1 41013 Sevilla Spain Departamento de Matemdtica Aplicada I Universidad de Sevilla ETS Arquitectura Avda. Reina Mercedes 2 41012 Sevilla Spain Departamento de Matemdticas Universidad de Cddiz EPS Algeciras Avda. Ramdn Puyol s/n 11202 Algeciras Spain

For a bipartite graph G on m and n vertices, respectively, in its vertices classes, and for integers s andt such that 2≤ s ≤ t, 0≤ m-s ≤ n-t, andre＋n≤ 2s＋t-1, we prove that if G has at least mn- （2（m - s）＋ n - t） edges then it contains a subdivision of the complete bipartite K（s,t） with s vertices in the m-class and t vertices in the n-class. Furthermore, we characterize the corresponding extremal bipartite graphs with mn- （2（m - s）＋ n - t ＋ 1） edges for this topological Turan type problem.

关键词： Bipartite graphs extremal graph theory topological minor