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Extracts of the seaweed Bifurcaria bifurcata display antifungal activity against human dermatophyte fungi

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journal of Oceanology and Limnology 2019年第3期37卷 848-854页

作者： carvalho G.Loic SILVA Raquel GONCALVES j.Maria BATISTA T.Maria PEREIRA Leonel Environmental and Biochemical Sciences Group the James Hutton InstituteDundee DD2 5DAScotlandUK Institute of Mechanical Process and Energy EngineeringSchool of Engineering and Physical SciencesHeriot Watt UniversityEdinburgh EH14 4ASScotlandUK MARE (Marine and Environmental Sciences Centre) Department of Life SciencesFaculty of Sciences and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal CIEPQPF Department of Chemical EngineeringFaculty of Science and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal

Bifurcaria bifurcata is a seaweed of the Order Fucales(Ochrophyta,Phaeophyceae)that can be found all year round along the Portuguese Atlantic *** it is considered edible in some countries,its biotechnological potential has not yet been assessed in detail and here we report its antimicrobial potential against human dermatophyte *** samples were harvested from Baleal Island(Peniche,Portugal)harvested in winter(BbPe);from Aguda Beach(Arcozelo,Vila Nova de Gaia,Portugal),harvested in autumn(BbAg)and a sample obtained by culturing the Aguda sample under laboratory conditions(BbLC).A broth macrodilution assay was applied to determine the MIC(minimum inhibitory concentration)and MLC(minimum lethal concentration)of the *** *** show that the BbPe MeOH extracts were the most effective and had higher antifungal activity against all the tested dermatophyte strains than the BbLC and BaAg extracts[Epidermophyton floccosum FF9(100–200μg/mL MIC;200μg/mL MLC),Microsporum canis FF1(400μg/mL MIC;≥400μg/mL MLC),Trichophyton mentagrophytes FF7(100μg/mL MIC;>800μg/mL MLC),*** CECT 2908(800μg/mL MIC;≥800μg/mL MLC),*** *** CECT 2958(800μg/mL MIC;≥800μg/mL MLC),*** CECT 2794(200μg/mL MIC;≥400μg/mL MLC)].In fact,only *** FF9 was sensitive to BbAg and BbLC MeOH *** our knowledge,this is the first report of antifungal activity of *** against human dermatophyte fungi.

关键词： seaweed Bifurcaria bifurcata bioactivity antifungal dermatophytes minimum inhibitory concentration minimum lethal concentration

Development of a warning score for early detection of colorectal anastomotic leakage:Hype or hope?

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World journal of Gastrointestinal Surgery 2022年第11期14卷 1297-1309页

作者： Nuno j G Rama Óscar Lourenço Patrícia C Motta Lima Maria pedro S Guarino Diana Parente Ricardo Castro Ana Bento Anabela Rocha Fernando Castro-Poças joão Pimentel Division of Colorectal Surgical Leiria Hospital CentreLeiria 2410-021Portugal Abel Salazar Biomedical Institute University of OportoOporto 4099-002Portugal Center for Innovative Care and Health Technology(ciTechCare) Polytechnic of LeiriaLeiria 2410-541Portugal Faculty of Economics CeBERUniversity of CoimbraCoimbra 3000-137Portugal Division of Clinical Pathology Leiria Hospital CentreLeiria 2410-541Portugal Division of Surgical Oporto Hospital CentreOporto 4099-001Portugal Department of Gastroenterology Santo António HospitalPorto Hospital CenterOporto 4099-001Portugal Institute of Biomedical Sciences Abel Salazar University of OPortoOporto 4099-001Portugal Faculty of Medicine University of CoimbraCoimbra 3004-531Portugal Division of Surgical Montes Claros HospitalCoimbra 3030-320Portugal

BACKGROUND Colorectal anastomotic leakage(CAL),a severe postoperative complication,is associated with high morbidity,hospital readmission,and overall healthcare *** detection of CAL remains a challenge in clinical ***,some decision models have been developed to increase the diagnostic accuracy of this *** To develop a score based on easily accessible variables to detect CAL *** Based on the least absolute shrinkage and selection operator method,a predictive classification system was developed[Early ColoRectAL Leakage(E-CRALL)score]from a prospective observational,single center cohort,carried out in a colorectal division from a non-academic *** score performance and CAL threshold from postoperative day(POD)3 to POD5 were *** on a precise analytical decision model,the standard clinical practice was compared with the E-CRALL adoption on POD3,POD4,or POD5.A cost-minimization analysis was conducted,on the assumption that all alternatives delivered similar health-related *** In this study,396 patients who underwent colorectal resection surgery with anastomosis,and 6.3%(n=25)developed *** of the patients who developed CAL(n=23;92%)were diagnosed during the first hospital admission,with a median time of diagnosis of 9.0±6.8 *** POD3 to POD5,the area under the receiver operating characteristic curve of the E-CRALL score was 0.82,0.84,and 0.95,*** POD5,if a threshold of 8.29 was chosen,87.4%of anastomotic failures were identified with E-CRALL ***,score usage could anticipate CAL diagnosis in an average of 5.2 d and 4.1 d,if used on POD3 and POD5,*** of score adoption,episode comprehensive costs were markedly greater(up to four times)in patients who developed CAL in comparison with patients who did not develop ***,the use of the E-CRALL warning score was associated with cost savings of€421442.20,with most(92.9%)of the savings from patients

关键词： Anastomotic leakage Colorectal Surgery Biomarkers Score Costs

Pupil apodization for increasing data storage density

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Chinese Optics Letters 2009年第8期7卷 720-723页

作者： Vidal F.Canales pedro j.Valle jose E.Oti Manuel P.Cagigal Department of Física Aplicada University of CantabriaLos Castros S/NSantander 39005Spain AOTEK S.COOP. Bo San Andrés 19Arrasate-Mondragón 20500Spain

We introduce a technique for increasing density in optical data storage systems. This technique is based on the use of a superresolving filter at the pupil of a confocal readout system. The main characteristic of this confocal readout system is that the light beam traverses twice through the pupil filter. We describe how to analyze the system performance for general filters, but we focus the study on filters with no focus displacement. Although the storage density attainable depends on the filter characteristics, we show that the storage density can be easily duplicated.

关键词： Pupil apodization for increasing data storage density PSF data

New Dinosaur Tracks from the Lower Barremian of Portugal (Areia do Mastro Formation, Cape Espichel)

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journal of Geoscience and Environment Protection 2021年第1期9卷 84-96页

作者： Silvério D. Figueiredo Carlos Neto de carvalho pedro P. Cunha Ismar de Sousa carvalho Instituto Politécnico de Tomar CGeo-UC Unidade Departamental de Arqueologia Conserva&ccedil ã o e Restauro e Património Quinta do Contador-Estrada da Serra Tomar Portugal Serviç o de Geologia do Município de Idanha-a-Nova Geopark Naturtejo Mundial da UNESCO Avenida Joaquim Mor&atilde o Idanha-a-Nova IDL Instituto Dom Luiz Faculdade de Ciências da Universidade de Lisboa Campo Grande Lisboa Universidade de Coimbra MARE Dep. Ciências da Terra R. Sílvio Lima Coimbra Portugal Universidade Federal do Rio de janeiro Instituto de Geociências CCMN Cidade Universitária Ilha do Fund&atilde o Rio de Janeiro Brasil

We present a new tracksite with multiple dinosaur tracks from the lowermost Barremian (Lower Cretaceous) of the Cape Espichel (Sesimbra, Portugal). The tracks are localized on three beds on the top carbonate beds of the Areia do Mastro Formation. Those bioclastic, nodular limestones were deposited in a very shallow subtidal-intertidal, restricted lagoon environment. The track surfaces are very dinoturbated, with a substantial number of tracks. Several tracks assign to sauropods, ornithopods and theropods dinosaurs were recorded. Due to heavy bioturbation and the preservation conditions, it is not possible to define trackways;some preliminary work done on the tracks could disclose some behaviours of their producers. Several species of carnivore and herbivore dinosaurs crossed that large area at different times. Herbivores may have used the lagoon margin as passage between feeding spots, while carnivores frequented the area to hunt in groups or individually.

关键词： Trampled Surface Dinosaurs Locomotion Behavior Lower Cretaceous Cape Espichel Portugal Iberia

Modelling fuel loads of understorey vegetation and forest floor components in pine stands in NW Spain

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Forest Ecosystems 2022年第6期9卷 775-789页

作者： jose A.Vega Stefano Arellano-Perez juan Gabriel Alvarez-Gonzalez Cristina Fernandez Enrique jimenez pedro Cuinas jose María Fernandez-Alonso Daniel j.Vega-Nieva Fernando Castedo-Dorado Cecilia Alonso-Rego Teresa Fontúrbel Ana Daría Ruiz-Gonzalez Centro de Investigacion Forestal de Lourizan PO Box 12736080PontevedraSpain Unidad de Gestion Ambiental y Forestal Sostenible(UXAFORES) Departamento de Ingeniería AgroforestalEscuela Politecnica Superior de IngenieríaUniversidad de Santiago de CompostelaCampus Universitario s/n27002LugoSpain Facultad de Ciencias Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Blvd.Durango s/nCol.Valle del Sur34120DurangoMexico Departamento de Ingeniería y Ciencias Agrarias Universidad de LeonCampus de Ponferrada24401PonferradaSpain

In this study,310 destructively sampled plots were used to develop two equation systems for the three main pine species in NW Spain(***;*** and ***):one for estimating loads of understorey fuel components by size and condition(live and dead)and another one for forest floor *** systems of equations were simultaneously fitted for estimating fuel loads using overstorey,understorey and forest floor variables as *** systems of equations included both the effect of pine species and the effect of understorey compositions dominated by ferns-brambles or by woody species,due to their obvious structural and physiological *** general,the goodness-of-fit statistics indicated that the estimates were reasonably robust and accurate for all of the fuel *** best results were obtained for total understorey vegetation,total forest floor and raw humus fuel loads,with more than 76%of the observed variability explained,whereas the poorest results were obtained for coarse fuel loads of understory vegetation with a 53%of observed variability *** reduce the overall costs associated with the field inventories necessary for operational use of the models,the additive systems were fitted again using only overstorey variables as potential *** relationships for fine(<6 mm)and total understorey vegetation and total forest floor fuel loads were obtained,indicating the complexity of the forest overstorey-understorey and overstorey-forest floor ***,these models explained around 52%of the observed ***,equations estimating the total understorey vegetation and the total forest floor fuel loads based only on canopy cover were *** models explained only 26%-32%of the observed variability;however,their main advantage is that although understorey vegetation in forested landscapes is largely invisible to remote sensing,canopy cover can be estimated with moderate accuracy,allowin

关键词： Area-based approach Additive equation systems Live and dead fine fuel Pinus pinaster Pinus radiata Pinus sylvestris

Plant performance and morphofunctional differentiation in response to edaphic variation in Iberian columbines: cues for range distribution?

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journal of Plant Ecology 2014年第4期7卷 403-412页

作者： jesús M.Bastida pedro j.Rey julio M.Alcántara Departamento de Biología Animal Biología Vegetal y EcologíaUniversidad de JaénParaje Las Lagunillas s/n.E-23071 JaénSpain

Aims Experimental studies of the response to environmental variation of closely related taxa are needed to understand the mechanisms underly-ing phenotypic divergence,habitat segregation and range span within a radiating *** explored the magnitude of phenotypic differenti-ation and adaptive plasticity in relation to edaphic variation and its sig-nificance for habitat segregation and range span in Iberian *** We performed a common garden experiment varying soil type(cal-careous ***)and depth(rocky-shallow ***)with two pairs of widespread and narrowly distributed subspecies of Iberian columbines:Aquilegia vulgaris(*** and nevadensis)and Aquilegia pyrenaica(*** and cazorlensis).We com-pared tolerance to edaphic variation,trait differentiation and adaptive plasticity of 10 morpho-functional traits between species and distri-bution ***,we obtained estimates of the competitive environment faced by each taxon in two to four populations per *** Findingsresults partially support hypotheses of higher competitive ability and tolerance to edaphic variation in widespread than in narrow endemic *** the species level,the widely distributed taxon was the most tolerant to edaphic *** species,no consistent pattern emerged since the population from the most widespread subspecies was the most tolerant in *** but not in *** were differentiated in many traits at species and range ***,the pattern of differentiation does not fully support the hypothesis of higher specialization and stress toler-ance in narrow *** plasticity was generally low,the results support the hypothesis of adaptive plasticity in widespread but not in restricted taxa at least at species *** differences(adaptive plasticity and competitive ability among others)may have contributed to phenotypic divergence and edaphic niche segregation,as well as to differen

关键词： Aquilegia habitat differentiation phenotypic divergence phenotypic plasticity endemism

Discovery of marageing steels: machine learning vs. physical metallurgical modelling

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journal of Materials Science & Technology 2021年第28期87卷 258-268页

作者： Chunguang Shen Chenchong Wang pedro E.j.Rivera-Díaz-del-Castillo Dake Xu Qian Zhang Chi Zhang Wei Xu State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China Department of Engineering Lancaster UniversityLA14YKLancasterUK Key Laboratory of Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

Physical metallurgical(PM)and data-driven approaches can be independently applied to alloy *** technology is a field of physical metallurgy around which some of the most comprehensive understanding has been developed,with vast models on the relationship between composition,processing,microstructure and *** have been applied to the design of new steel alloys in the pursuit of grades of improved *** the advent of rapid computing and low-cost data storage,a wealth of data has become available to a suite of modelling techniques referred to as machine learning(ML).ML is being emergingly applied in materials discovery while it requires data mining with its adoption being limited by insufficient high-quality datasets,often leading to unrealistic materials design predictions outside the boundaries of the intended *** is therefore required to appraise the strength and weaknesses of PM and ML approach,to assess the real design power of each towards designing novel steel *** work incorporates models and datasets from well-established literature on marageing *** genetic algorithm(GA)with PM models to optimise the parameters adopted for each dataset to maximise the prediction accuracy of PM models,and the results were compared with ML *** results indicate that PM approaches provide a clearer picture of the overall composition-microstructureproperties relationship but are highly sensitive to the alloy system and hence lack on exploration ability of new *** conversely provides little explicit physical insight whilst yielding a stronger prediction accuracy for large-scale *** PM/ML approaches provide solutions maximising accuracy,while leading to a clearer physical picture and the desired properties.

关键词： Machine learning Physical metallurgy Small sample problem Marageing steel

Statins for primary cardiovascular prevention in the elderly

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journal of Geriatric Cardiology 2015年第4期12卷 431-438页

作者： juan pedro-Botet Elisenda Climent juan j Chillarón Rocio Toro David Benaiges juana A Flores-Le Roux Lipid and Vascular Risk Unit Endocrinology department Hospital del Mar. Spain Department of Medicine School of Medicine. Cáldiz University Cádiz Spain

老人口全球正在增加，与题目 >；组成快成长的年龄组的 65 岁。而且，老脸心血管的疾病死亡和病态的最大的风险和负担。尽管老病人，特别地那些更旧的 >；75，很好没在评估类脂化合物阴沉的治疗的使随机化的临床的审判被... 详细信息

老人口全球正在增加，与题目 >；组成快成长的年龄组的 65 岁。而且，老脸心血管的疾病死亡和病态的最大的风险和负担。尽管老病人，特别地那些更旧的 >；75，很好没在评估类脂化合物阴沉的治疗的使随机化的临床的审判被代表，在更老的个人在主要预防支持 statin 治疗的使用的可得到的证据主要从亚群分析和 hoc 以后的数据被导出。在另一方面，老病人经常有要求并发的药的一个高数字的多重合作病态；这可以为药药相互作用增加风险，从而减少 statin 的潜在的好处治疗。这评论的目的是关于 statin 使用介绍相关文学在为他们的主要心血管的疾病老，与治疗的联系风险和好处。

关键词：心血管疾病他汀类药物中老年人预防药物相互作用药物治疗年龄组世界范围

Thermal and structural properties of Nd2O3-doped calcium boroaluminate glasses

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journal of Rare Earths 2016年第5期34卷 521-528页

作者： j.D.M.Dias G.H.A.Melo T.A.Lodi j.O.carvalho P.F.Facanha Filho M.j.Barboza A.Steimacher F.pedrochi Centro de Ciencias Sociais Saude e TecnologiaUniversidade Federal do Maranhao-Imperatriz MA Instituto Federal de Educaceo Ciencia e Tecnologia do Maranhao Campus Imperatriz-Imperatriz-MA Instituto Federal de Educacao Ciencia e Tecnologia do Tocantins Campus Araguaina-Araguaina-TO

Nd^3＋ doped CaO-Al2O-B2O3-CaF2 glasses were prepared by conventional melt-quenching technique,and their structural and thermal properties were *** amorphous nature of these samples was confirmed by X-ray diffraction（XRD）.The measured density showed an increase with Nd2O3 doping,at the expense of *** spectra presented changes with addition of Nd2O3,which indicated that the network structure of the glasses studied presented various borate groups,such as tetraborates,metaborates,ortho-borates and pyroborates *** N4 values calculated from FTIR spectra revealed that incorporation of Nd2O3 into glass network converted the structural units from BO4 to *** the analysis of DTA curves,we verified that Tg increased with the addition of Nd2O3;it was similar to the behavior caused by modifier oxides in the structure of borate *** that,the calculated glass stability Tx–Tg for doped samples presented a decrease if compared to the undoped *** heat and thermal conductivity did not present significant changes with Nd2O3 concentration,up to 2.30 mol.%.The results of density,DTA,Raman and FTIR reinforced the idea that Nd2O3 acted as network modifier.

关键词： Nd^3+ Nd^3+ doped glass borate glasses glass structure thermal properties rare earths